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Protein

WD repeat-containing protein 18

Gene

WDR18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211).2 Publications

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
SignaLinkiQ9BV38

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 18
Gene namesi
Name:WDR18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000065268.10
HGNCiHGNC:17956 WDR18
neXtProtiNX_Q9BV38

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000065268
PharmGKBiPA38269

Polymorphism and mutation databases

BioMutaiWDR18
DMDMi143811475

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513651 – 432WD repeat-containing protein 18Add BLAST432

Proteomic databases

EPDiQ9BV38
MaxQBiQ9BV38
PaxDbiQ9BV38
PeptideAtlasiQ9BV38
PRIDEiQ9BV38
ProteomicsDBi79165
TopDownProteomicsiQ9BV38

PTM databases

iPTMnetiQ9BV38
PhosphoSitePlusiQ9BV38

Expressioni

Gene expression databases

BgeeiENSG00000065268 Expressed in 146 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_WDR18
ExpressionAtlasiQ9BV38 baseline and differential
GenevisibleiQ9BV38 HS

Organism-specific databases

HPAiHPA050193
HPA050200

Interactioni

Subunit structurei

Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9. Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles (PubMed:21326211).2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi121517, 51 interactors
CORUMiQ9BV38
IntActiQ9BV38, 31 interactors
MINTiQ9BV38
STRINGi9606.ENSP00000251289

Structurei

3D structure databases

ProteinModelPortaliQ9BV38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati36 – 75WD 1Add BLAST40
Repeati78 – 116WD 2Add BLAST39
Repeati119 – 158WD 3Add BLAST40
Repeati170 – 211WD 4Add BLAST42
Repeati213 – 257WD 5Add BLAST45
Repeati267 – 306WD 6Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat IPI3/WDR18 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410INVM Eukaryota
ENOG410ZP68 LUCA
GeneTreeiENSGT00390000000289
HOGENOMiHOG000046506
HOVERGENiHBG059735
InParanoidiQ9BV38
KOiK14829
OMAiHVQAVSC
OrthoDBiEOG091G06V1
PhylomeDBiQ9BV38
TreeFamiTF313046

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR026987 Wdr18_C_dom
PfamiView protein in Pfam
PF00400 WD40, 3 hits
PF14077 WD40_alt, 1 hit
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q9BV38-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPMEVAVC TDSAAPMWSC IVWELHSGAN LLTYRGGQAG PRGLALLNGE
60 70 80 90 100
YLLAAQLGKN YISAWELQRK DQLQQKIMCP GPVTCLTASP NGLYVLAGVA
110 120 130 140 150
ESIHLWEVST GNLLVILSRH YQDVSCLQFT GDSSHFISGG KDCLVLVWSL
160 170 180 190 200
CSVLQADPSR IPAPRHVWSH HALPITDLHC GFGGPLARVA TSSLDQTVKL
210 220 230 240 250
WEVSSGELLL SVLFDVSIMA VTMDLAEHHM FCGGSEGSIF QVDLFTWPGQ
260 270 280 290 300
RERSFHPEQD AGKVFKGHRN QVTCLSVSTD GSVLLSGSHD ETVRLWDVQS
310 320 330 340 350
KQCIRTVALK GPVTNAAILL APVSMLSSDF RPSLPLPHFN KHLLGAEHGD
360 370 380 390 400
EPRHGGLTLR LGLHQQGSEP SYLDRTEQLQ AVLCSTMEKS VLGGQDQLRV
410 420 430
RVTELEDEVR NLRKINRDLF DFSTRFITRP AK
Length:432
Mass (Da):47,405
Last modified:April 3, 2007 - v2
Checksum:i0E00FA0DF124F82C
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQC1U3KQC1_HUMAN
WD repeat-containing protein 18
WDR18
394Annotation score:
A0A0A0MQU0A0A0A0MQU0_HUMAN
WD repeat-containing protein 18
WDR18
429Annotation score:
K7EIR0K7EIR0_HUMAN
WD repeat-containing protein 18
WDR18
409Annotation score:
U3KQK3U3KQK3_HUMAN
WD repeat-containing protein 18
WDR18
48Annotation score:
K7EML4K7EML4_HUMAN
WD repeat-containing protein 18
WDR18
268Annotation score:
K7EKX5K7EKX5_HUMAN
WD repeat-containing protein 18
WDR18
152Annotation score:
A0A087X237A0A087X237_HUMAN
WD repeat-containing protein 18
WDR18
144Annotation score:

Sequence cautioni

The sequence AAC12679 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198 – 199Missing in AAC12679 (PubMed:15057824).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031577172A → T1 PublicationCorresponds to variant dbSNP:rs2158367Ensembl.1
Natural variantiVAR_031578213L → F. Corresponds to variant dbSNP:rs35068100Ensembl.1
Natural variantiVAR_031579264V → I. Corresponds to variant dbSNP:rs11538683Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004528 Genomic DNA Translation: AAC12679.1 Different initiation.
BC000040 mRNA Translation: AAH00040.2
BC001648 mRNA Translation: AAH01648.1
CCDSiCCDS12051.1
RefSeqiNP_077005.2, NM_024100.3
UniGeneiHs.325321

Genome annotation databases

EnsembliENST00000585809; ENSP00000476117; ENSG00000065268
GeneIDi57418
KEGGihsa:57418
UCSCiuc002lqm.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004528 Genomic DNA Translation: AAC12679.1 Different initiation.
BC000040 mRNA Translation: AAH00040.2
BC001648 mRNA Translation: AAH01648.1
CCDSiCCDS12051.1
RefSeqiNP_077005.2, NM_024100.3
UniGeneiHs.325321

3D structure databases

ProteinModelPortaliQ9BV38
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121517, 51 interactors
CORUMiQ9BV38
IntActiQ9BV38, 31 interactors
MINTiQ9BV38
STRINGi9606.ENSP00000251289

PTM databases

iPTMnetiQ9BV38
PhosphoSitePlusiQ9BV38

Polymorphism and mutation databases

BioMutaiWDR18
DMDMi143811475

Proteomic databases

EPDiQ9BV38
MaxQBiQ9BV38
PaxDbiQ9BV38
PeptideAtlasiQ9BV38
PRIDEiQ9BV38
ProteomicsDBi79165
TopDownProteomicsiQ9BV38

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000585809; ENSP00000476117; ENSG00000065268
GeneIDi57418
KEGGihsa:57418
UCSCiuc002lqm.2 human

Organism-specific databases

CTDi57418
EuPathDBiHostDB:ENSG00000065268.10
GeneCardsiWDR18
HGNCiHGNC:17956 WDR18
HPAiHPA050193
HPA050200
neXtProtiNX_Q9BV38
OpenTargetsiENSG00000065268
PharmGKBiPA38269
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INVM Eukaryota
ENOG410ZP68 LUCA
GeneTreeiENSGT00390000000289
HOGENOMiHOG000046506
HOVERGENiHBG059735
InParanoidiQ9BV38
KOiK14829
OMAiHVQAVSC
OrthoDBiEOG091G06V1
PhylomeDBiQ9BV38
TreeFamiTF313046

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
SignaLinkiQ9BV38

Miscellaneous databases

ChiTaRSiWDR18 human
GenomeRNAii57418
PROiPR:Q9BV38

Gene expression databases

BgeeiENSG00000065268 Expressed in 146 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_WDR18
ExpressionAtlasiQ9BV38 baseline and differential
GenevisibleiQ9BV38 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR026987 Wdr18_C_dom
PfamiView protein in Pfam
PF00400 WD40, 3 hits
PF14077 WD40_alt, 1 hit
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDR18_HUMAN
AccessioniPrimary (citable) accession number: Q9BV38
Secondary accession number(s): O60390, Q9BWR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: April 3, 2007
Last modified: November 7, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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