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Protein

Coiled-coil domain-containing protein 32

Gene

CCDC32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 32
Gene namesi
Name:CCDC32Imported
Synonyms:C15orf57Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000128891.15
HGNCiHGNC:28295 CCDC32
neXtProtiNX_Q9BV29

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000128891
PharmGKBiPA162378234

Polymorphism and mutation databases

BioMutaiC15orf57
DMDMi74733283

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002989371 – 185Coiled-coil domain-containing protein 32Add BLAST185

Proteomic databases

EPDiQ9BV29
MaxQBiQ9BV29
PaxDbiQ9BV29
PeptideAtlasiQ9BV29
PRIDEiQ9BV29
ProteomicsDBi79155
79156 [Q9BV29-2]
79157 [Q9BV29-3]

PTM databases

iPTMnetiQ9BV29
PhosphoSitePlusiQ9BV29

Expressioni

Gene expression databases

BgeeiENSG00000128891
CleanExiHS_C15orf57
ExpressionAtlasiQ9BV29 baseline and differential
GenevisibleiQ9BV29 HS

Organism-specific databases

HPAiHPA041688

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
POT1Q9NUX52EBI-2874058,EBI-752420

Protein-protein interaction databases

BioGridi124713, 14 interactors
IntActiQ9BV29, 5 interactors
STRINGi9606.ENSP00000452773

Structurei

3D structure databases

ProteinModelPortaliQ9BV29
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili78 – 98Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IWBU Eukaryota
ENOG41124NX LUCA
GeneTreeiENSGT00390000014780
HOGENOMiHOG000111860
HOVERGENiHBG054261
InParanoidiQ9BV29
OMAiHLKRWLQ
PhylomeDBiQ9BV29
TreeFamiTF332102

Family and domain databases

InterProiView protein in InterPro
IPR028039 CCDC32
PANTHERiPTHR31800 PTHR31800, 1 hit
PfamiView protein in Pfam
PF14989 CCDC32, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BV29-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMFESADST ATRSGQDLWA EICSCLPNPE QEDGANNAFS DSFVDSCPEG
60 70 80 90 100
EGQREVADFA VQPAVKPWAP LQDSEVYLAS LEKKLRRIKG LNQEVTSKDM
110 120 130 140 150
LRTLAQAKKE CWDRFLQEKL ASEFFVDGLD SDESTLEHFK RWLQPDKVAV
160 170 180
STEEVQYLIP PESQVEKPVA EDEPAAGDKP AAAEQ
Length:185
Mass (Da):20,656
Last modified:March 1, 2004 - v2
Checksum:i3965B8A4FBC06651
GO
Isoform 2 (identifier: Q9BV29-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRGSGLRFQM

Note: No experimental confirmation available.
Show »
Length:194
Mass (Da):21,689
Checksum:i0EECCDFE2F6031C1
GO
Isoform 3 (identifier: Q9BV29-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-134: S → R
     135-185: Missing.

Note: No experimental confirmation available.
Show »
Length:134
Mass (Da):15,070
Checksum:i5E88B930877E0EBE
GO

Sequence cautioni

The sequence CAD89911 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0347432K → I2 PublicationsCorresponds to variant dbSNP:rs10152546Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0274851M → MRGSGLRFQM in isoform 2. 1 Publication1
Alternative sequenceiVSP_027486134S → R in isoform 3. 1 Publication1
Alternative sequenceiVSP_027487135 – 185Missing in isoform 3. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092214 mRNA Translation: BAC03831.1
AK098781 mRNA Translation: BAC05411.1
AK293079 mRNA Translation: BAF85768.1
AL832032 mRNA Translation: CAD89911.1 Different initiation.
CH471125 Genomic DNA Translation: EAW92421.1
BC001673 mRNA Translation: AAH01673.2
CCDSiCCDS10060.1 [Q9BV29-1]
CCDS42022.1 [Q9BV29-2]
CCDS73706.1 [Q9BV29-3]
RefSeqiNP_001074260.1, NM_001080791.2 [Q9BV29-2]
NP_001074261.1, NM_001080792.2 [Q9BV29-1]
NP_001276061.1, NM_001289132.1 [Q9BV29-3]
NP_443081.1, NM_052849.3 [Q9BV29-1]
UniGeneiHs.654661

Genome annotation databases

EnsembliENST00000358005; ENSP00000350695; ENSG00000128891 [Q9BV29-1]
ENST00000416810; ENSP00000397515; ENSG00000128891 [Q9BV29-1]
ENST00000558750; ENSP00000452773; ENSG00000128891 [Q9BV29-2]
ENST00000558871; ENSP00000452657; ENSG00000128891 [Q9BV29-3]
ENST00000559153; ENSP00000453607; ENSG00000128891 [Q9BV29-1]
ENST00000559291; ENSP00000453226; ENSG00000128891 [Q9BV29-1]
ENST00000561011; ENSP00000454049; ENSG00000128891 [Q9BV29-3]
GeneIDi90416
KEGGihsa:90416
UCSCiuc001zma.3 human [Q9BV29-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCCD32_HUMAN
AccessioniPrimary (citable) accession number: Q9BV29
Secondary accession number(s): A8KAL4
, Q86TC4, Q8N788, Q8NAR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2004
Last modified: July 18, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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