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Protein

Monoacylglycerol lipase ABHD6

Gene

ABHD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity).By similarity1 Publication

Catalytic activityi

Hydrolyzes glycerol monoesters of long-chain fatty acids.1 Publication

Kineticsi

  1. KM=159 µM for 2-arachidonoyglycerol1 Publication
  1. Vmax=45 nmol/min/mg enzyme toward 2-arachidonoyglycerol1 Publication

pH dependencei

Optimum pH is 7.2-9 with 2-arachidonoyglycerol as substrate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei148NucleophileBy similarity1 Publication1
Active sitei278Charge relay systemBy similarity1
Active sitei306Charge relay systemBy similarity1

GO - Molecular functioni

  • acylglycerol lipase activity Source: UniProtKB
  • phospholipase activity Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-HSA-426048 Arachidonate production from DAG

Protein family/group databases

ESTHERihuman-ABHD6 ABHD6-Lip

Chemistry databases

SwissLipidsiSLP:000001042

Names & Taxonomyi

Protein namesi
Recommended name:
Monoacylglycerol lipase ABHD6Curated (EC:3.1.1.231 Publication)
Alternative name(s):
2-arachidonoylglycerol hydrolaseBy similarity
Abhydrolase domain-containing protein 6Imported
Gene namesi
Name:ABHD6Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163686.13
HGNCiHGNC:21398 ABHD6
neXtProtiNX_Q9BV23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8ExtracellularSequence analysis8
Transmembranei9 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini30 – 337CytoplasmicSequence analysisAdd BLAST308

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi148S → A: Loss of 2-arachidonoyglycerol hydrolase activity. 1 Publication1

Organism-specific databases

DisGeNETi57406
OpenTargetsiENSG00000163686
PharmGKBiPA134916787

Chemistry databases

ChEMBLiCHEMBL2189127
GuidetoPHARMACOLOGYi2919

Polymorphism and mutation databases

BioMutaiABHD6
DMDMi74733280

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002815751 – 337Monoacylglycerol lipase ABHD6Add BLAST337

Proteomic databases

EPDiQ9BV23
MaxQBiQ9BV23
PaxDbiQ9BV23
PeptideAtlasiQ9BV23
PRIDEiQ9BV23
ProteomicsDBi79154

PTM databases

iPTMnetiQ9BV23
PhosphoSitePlusiQ9BV23

Expressioni

Gene expression databases

BgeeiENSG00000163686
CleanExiHS_ABHD6
ExpressionAtlasiQ9BV23 baseline and differential
GenevisibleiQ9BV23 HS

Organism-specific databases

HPAiHPA017283
HPA073225

Interactioni

Protein-protein interaction databases

BioGridi121508, 8 interactors
IntActiQ9BV23, 3 interactors
STRINGi9606.ENSP00000295962

Chemistry databases

BindingDBiQ9BV23

Structurei

3D structure databases

ProteinModelPortaliQ9BV23
SMRiQ9BV23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 313AB hydrolase-1Sequence analysisAdd BLAST242

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPFK Eukaryota
ENOG410XZ30 LUCA
GeneTreeiENSGT00510000047225
HOGENOMiHOG000008016
HOVERGENiHBG059524
InParanoidiQ9BV23
KOiK13700
OMAiCGHAAMM
OrthoDBiEOG091G0AHA
PhylomeDBiQ9BV23
TreeFamiTF331946

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR000639 Epox_hydrolase-like
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PRINTSiPR00111 ABHYDROLASE
PR00412 EPOXHYDRLASE
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BV23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLDVVNMFV IAGGTLAIPI LAFVASFLLW PSALIRIYYW YWRRTLGMQV
60 70 80 90 100
RYVHHEDYQF CYSFRGRPGH KPSILMLHGF SAHKDMWLSV VKFLPKNLHL
110 120 130 140 150
VCVDMPGHEG TTRSSLDDLS IDGQVKRIHQ FVECLKLNKK PFHLVGTSMG
160 170 180 190 200
GQVAGVYAAY YPSDVSSLCL VCPAGLQYST DNQFVQRLKE LQGSAAVEKI
210 220 230 240 250
PLIPSTPEEM SEMLQLCSYV RFKVPQQILQ GLVDVRIPHN NFYRKLFLEI
260 270 280 290 300
VSEKSRYSLH QNMDKIKVPT QIIWGKQDQV LDVSGADMLA KSIANCQVEL
310 320 330
LENCGHSVVM ERPRKTAKLI IDFLASVHNT DNNKKLD
Length:337
Mass (Da):38,331
Last modified:June 1, 2001 - v1
Checksum:iD87CEE8316F94910
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11I → T in BAD18771 (PubMed:14702039).Curated1
Sequence conflicti135L → P in BAD18771 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122983 mRNA Translation: BAG53832.1
AK172797 mRNA Translation: BAD18771.1
AK313168 mRNA Translation: BAG35986.1
AC098479 Genomic DNA No translation available.
AC137936 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65360.1
BC001698 mRNA Translation: AAH01698.1
CCDSiCCDS2887.1
RefSeqiNP_001307055.1, NM_001320126.1
NP_065727.4, NM_020676.6
UniGeneiHs.476454

Genome annotation databases

EnsembliENST00000295962; ENSP00000295962; ENSG00000163686
ENST00000478253; ENSP00000420315; ENSG00000163686
GeneIDi57406
KEGGihsa:57406
UCSCiuc003djs.4 human

Similar proteinsi

Entry informationi

Entry nameiABHD6_HUMAN
AccessioniPrimary (citable) accession number: Q9BV23
Secondary accession number(s): B2R7Y9, Q6ZMF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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