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UniProtKB - Q9BUY7 (EFC11_HUMAN)

Entry version 146 (10 Feb 2021)
Sequence version 1 (01 Jun 2001)
Previous versions | rss
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Protein

EF-hand calcium-binding domain-containing protein 11

Gene

EFCAB11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi140 – 1511PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: GO_Central
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BUY7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
EF-hand calcium-binding domain-containing protein 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EFCAB11
Synonyms:C14orf143
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20357, EFCAB11

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BUY7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000140025.15

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		90141

Open Targets

More...OpenTargetsi		ENSG00000140025

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134875422

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BUY7, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		EFCAB11

Domain mapping of disease mutations (DMDM)

More...DMDMi		74762709

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002865801 – 163EF-hand calcium-binding domain-containing protein 11Add BLAST163

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BUY7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BUY7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BUY7

PeptideAtlas

More...PeptideAtlasi		Q9BUY7

PRoteomics IDEntifications database

More...PRIDEi		Q9BUY7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		33518
6693
79144 [Q9BUY7-1]
79145 [Q9BUY7-2]
79146 [Q9BUY7-3]
79147 [Q9BUY7-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BUY7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BUY7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000140025, Expressed in sperm and 208 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BUY7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BUY7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000140025, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124670, 12 interactors

Protein interaction database and analysis system

More...IntActi		Q9BUY7, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000326267

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BUY7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BUY7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 53EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini91 – 126EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini127 – 162EF-hand 3PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0027, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000004917

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_061288_22_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BUY7

Identification of Orthologs from Complete Genome Data

More...OMAi		VHYRGYL

Database of Orthologous Groups

More...OrthoDBi		1435392at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BUY7

TreeFam database of animal gene trees

More...TreeFami		TF329255

Family and domain databases

Conserved Domains Database

More...CDDi		cd00051, EFh, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13499, EF-hand_7, 1 hit
PF13833, EF-hand_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00054, EFh, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BUY7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFFSEARARS RTWEASPSEH RKWVEVFKAC DEDHKGYLSR EDFKTAVVML 
        60         70         80         90        100
FGYKPSKIEV DSVMSSINPN TSGILLEGFL NIVRKKKEAQ RYRNEVRHIF 
       110        120        130        140        150
TAFDTYYRGF LTLEDFKKAF RQVAPKLPER TVLEVFREVD RDSDGHVSFR 
       160 
DFEYALNYGQ KEA
Length:163
Mass (Da):19,225
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0939E2C3637707C2
GO
Isoform 2 (identifier: Q9BUY7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MFFSEARARSRTWEASPSEHRKWVE → M

Show »
Length:139
Mass (Da):16,293
Checksum:i64409983F8203C5C
GO
Isoform 3 (identifier: Q9BUY7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MFFSEARARSRTWEASPSEHRKWVE → M
     138-163: EVDRDSDGHVSFRDFEYALNYGQKEA → GIFSA

Show »
Length:118
Mass (Da):13,738
Checksum:i57DC52C7AF59755E
GO
Isoform 4 (identifier: Q9BUY7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-61: IEVD → KWIL
     62-163: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:61
Mass (Da):7,314
Checksum:i1FEE78F6847D687C
GO
Isoform 5 (identifier: Q9BUY7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-162: EVDRDSDGHVSFRDFEYALNYGQKE → GIFS

Show »
Length:142
Mass (Da):16,670
Checksum:iF5C8B3BC5BACAF96
GO
Isoform 6 (identifier: Q9BUY7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.

Show »
Length:115
Mass (Da):13,521
Checksum:i0B6B6CF1041319F1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YJX4H0YJX4_HUMAN
EF-hand calcium-binding domain-cont...
EFCAB11
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD62325 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03212915A → V. Corresponds to variant dbSNP:rs35435801Ensembl.1
Natural variantiVAR_03213031D → G. Corresponds to variant dbSNP:rs34486581Ensembl.1
Natural variantiVAR_03213145T → A. Corresponds to variant dbSNP:rs34911716Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0557291 – 48Missing in isoform 6. CuratedAdd BLAST48
Alternative sequenceiVSP_0251001 – 25MFFSE…RKWVE → M in isoform 2 and isoform 3. 2 PublicationsAdd BLAST25
Alternative sequenceiVSP_04108958 – 61IEVD → KWIL in isoform 4. 1 Publication4
Alternative sequenceiVSP_04109062 – 163Missing in isoform 4. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_025101138 – 163EVDRD…GQKEA → GIFSA in isoform 3. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_054591138 – 162EVDRD…YGQKE → GIFS in isoform 5. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX161414 mRNA Translation: CAD61889.1
BX247991 mRNA Translation: CAD62325.1 Sequence problems.
AK094740 mRNA Translation: BAG52922.1
AK298930 mRNA Translation: BAH12905.1
AL832321 mRNA Translation: CAD38616.1
AL137128 Genomic DNA No translation available.
AL137230 Genomic DNA No translation available.
AL163011 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81411.1
BC001787 mRNA Translation: AAH01787.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS61522.1 [Q9BUY7-6]
CCDS61523.1 [Q9BUY7-2]
CCDS61524.1 [Q9BUY7-3]
CCDS61525.1 [Q9BUY7-5]
CCDS9887.1 [Q9BUY7-1]

NCBI Reference Sequences

More...RefSeqi		NP_001271195.1, NM_001284266.1 [Q9BUY7-5]
NP_001271196.1, NM_001284267.1 [Q9BUY7-6]
NP_001271197.1, NM_001284268.1 [Q9BUY7-3]
NP_001271198.1, NM_001284269.1 [Q9BUY7-2]
NP_660274.1, NM_145231.3 [Q9BUY7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000316738; ENSP00000326267; ENSG00000140025 [Q9BUY7-1]
ENST00000538485; ENSP00000438072; ENSG00000140025 [Q9BUY7-5]
ENST00000555872; ENSP00000452320; ENSG00000140025 [Q9BUY7-2]
ENST00000556005; ENSP00000452143; ENSG00000140025 [Q9BUY7-3]
ENST00000556609; ENSP00000452335; ENSG00000140025 [Q9BUY7-6]
ENST00000556639; ENSP00000452397; ENSG00000140025 [Q9BUY7-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		90141

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:90141

UCSC genome browser

More...UCSCi		uc001xxs.5, human [Q9BUY7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX161414 mRNA Translation: CAD61889.1
BX247991 mRNA Translation: CAD62325.1 Sequence problems.
AK094740 mRNA Translation: BAG52922.1
AK298930 mRNA Translation: BAH12905.1
AL832321 mRNA Translation: CAD38616.1
AL137128 Genomic DNA No translation available.
AL137230 Genomic DNA No translation available.
AL163011 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81411.1
BC001787 mRNA Translation: AAH01787.1
CCDSiCCDS61522.1 [Q9BUY7-6]
CCDS61523.1 [Q9BUY7-2]
CCDS61524.1 [Q9BUY7-3]
CCDS61525.1 [Q9BUY7-5]
CCDS9887.1 [Q9BUY7-1]
RefSeqiNP_001271195.1, NM_001284266.1 [Q9BUY7-5]
NP_001271196.1, NM_001284267.1 [Q9BUY7-6]
NP_001271197.1, NM_001284268.1 [Q9BUY7-3]
NP_001271198.1, NM_001284269.1 [Q9BUY7-2]
NP_660274.1, NM_145231.3 [Q9BUY7-1]

3D structure databases

SMRiQ9BUY7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124670, 12 interactors
IntActiQ9BUY7, 3 interactors
STRINGi9606.ENSP00000326267

PTM databases

iPTMnetiQ9BUY7
PhosphoSitePlusiQ9BUY7

Genetic variation databases

BioMutaiEFCAB11
DMDMi74762709

Proteomic databases

MassIVEiQ9BUY7
MaxQBiQ9BUY7
PaxDbiQ9BUY7
PeptideAtlasiQ9BUY7
PRIDEiQ9BUY7
ProteomicsDBi33518
6693
79144 [Q9BUY7-1]
79145 [Q9BUY7-2]
79146 [Q9BUY7-3]
79147 [Q9BUY7-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		65215, 15 antibodies

The DNASU plasmid repository

More...DNASUi		90141

Genome annotation databases

EnsembliENST00000316738; ENSP00000326267; ENSG00000140025 [Q9BUY7-1]
ENST00000538485; ENSP00000438072; ENSG00000140025 [Q9BUY7-5]
ENST00000555872; ENSP00000452320; ENSG00000140025 [Q9BUY7-2]
ENST00000556005; ENSP00000452143; ENSG00000140025 [Q9BUY7-3]
ENST00000556609; ENSP00000452335; ENSG00000140025 [Q9BUY7-6]
ENST00000556639; ENSP00000452397; ENSG00000140025 [Q9BUY7-4]
GeneIDi90141
KEGGihsa:90141
UCSCiuc001xxs.5, human [Q9BUY7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		90141
DisGeNETi90141

GeneCards: human genes, protein and diseases

More...GeneCardsi		EFCAB11
HGNCiHGNC:20357, EFCAB11
HPAiENSG00000140025, Tissue enhanced (testis)
neXtProtiNX_Q9BUY7
OpenTargetsiENSG00000140025
PharmGKBiPA134875422
VEuPathDBiHostDB:ENSG00000140025.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0027, Eukaryota
GeneTreeiENSGT00390000004917
HOGENOMiCLU_061288_22_2_1
InParanoidiQ9BUY7
OMAiVHYRGYL
OrthoDBi1435392at2759
PhylomeDBiQ9BUY7
TreeFamiTF329255

Enzyme and pathway databases

PathwayCommonsiQ9BUY7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		90141, 1 hit in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		EFCAB11, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		90141
PharosiQ9BUY7, Tdark

Protein Ontology

More...PROi		PR:Q9BUY7
RNActiQ9BUY7, protein

Gene expression databases

BgeeiENSG00000140025, Expressed in sperm and 208 other tissues
ExpressionAtlasiQ9BUY7, baseline and differential
GenevisibleiQ9BUY7, HS

Family and domain databases

CDDicd00051, EFh, 1 hit
InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
PfamiView protein in Pfam
PF13499, EF-hand_7, 1 hit
PF13833, EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054, EFh, 3 hits
SUPFAMiSSF47473, SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEFC11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BUY7
Secondary accession number(s): B3KT10
, B7Z5G9, G3V5G1, Q86T09, Q86TV7, Q8NDQ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2001
Last modified: February 10, 2021
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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