UniProtKB - Q9BUY5 (ZN426_HUMAN)
Protein
Zinc finger protein 426
Gene
ZNF426
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 146 – 174 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 29 | |
Zinc fingeri | 224 – 246 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 280 – 302 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 308 – 330 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 336 – 358 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 364 – 386 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 392 – 414 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 420 – 442 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 448 – 470 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 476 – 498 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 504 – 526 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 532 – 554 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9BUY5 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 426 |
Gene namesi | Name:ZNF426 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20725, ZNF426 |
neXtProti | NX_Q9BUY5 |
VEuPathDBi | HostDB:ENSG00000130818.10 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000130818 |
PharmGKBi | PA134991761 |
Miscellaneous databases
Pharosi | Q9BUY5, Tdark |
Genetic variation databases
BioMutai | ZNF426 |
DMDMi | 34925651 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047576 | 1 – 554 | Zinc finger protein 426Add BLAST | 554 |
Proteomic databases
EPDi | Q9BUY5 |
jPOSTi | Q9BUY5 |
MassIVEi | Q9BUY5 |
MaxQBi | Q9BUY5 |
PaxDbi | Q9BUY5 |
PeptideAtlasi | Q9BUY5 |
PRIDEi | Q9BUY5 |
ProteomicsDBi | 79143 |
PTM databases
iPTMneti | Q9BUY5 |
PhosphoSitePlusi | Q9BUY5 |
SwissPalmi | Q9BUY5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000130818, Expressed in prostate gland and 234 other tissues |
ExpressionAtlasi | Q9BUY5, baseline and differential |
Genevisiblei | Q9BUY5, HS |
Organism-specific databases
HPAi | ENSG00000130818, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9BUY5
Protein-protein interaction databases
BioGRIDi | 122536, 50 interactors |
IntActi | Q9BUY5, 46 interactors |
STRINGi | 9606.ENSP00000439017 |
Miscellaneous databases
RNActi | Q9BUY5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 112 | KRABPROSITE-ProRule annotationAdd BLAST | 71 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 146 – 174 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 29 | |
Zinc fingeri | 224 – 246 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 280 – 302 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 308 – 330 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 336 – 358 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 364 – 386 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 392 – 414 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 420 – 442 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 448 – 470 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 476 – 498 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 504 – 526 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 532 – 554 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163292 |
HOGENOMi | CLU_002678_44_3_1 |
InParanoidi | Q9BUY5 |
OMAi | WEMQLEA |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9BUY5 |
TreeFami | TF342172 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 11 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9BUY5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAADLSHGH YLSGDPVCLH EEKTPAGRIV ADCLTDCYQD SVTFDDVAVD
60 70 80 90 100
FTQEEWTLLD STQRSLYSDV MLENYKNLAT VGGQIIKPSL ISWLEQEESR
110 120 130 140 150
TVQGGVLQGW EMRLETQWSI LQQDFLRGQT SIGIQLEGKH NGRELCDCEQ
160 170 180 190 200
CGEVFSEHSC LKTHVRTQST GNTHDCNQYG KDFLTLCEKT STGEKLSEFN
210 220 230 240 250
QSEKIFSLTP NIVYQRTSTQ EKSFECSHCG KSFINESYLQ AHMRTHNGEK
260 270 280 290 300
LYEWRNYGPG FIDSTSLSVL IETLNAKKPY KCKECGKGYR YPAYLSIHMR
310 320 330 340 350
THTGEKPYEC KECGKAFNYS NSFQIHGRTH TGEKPYVCKE CGKAFTQYSG
360 370 380 390 400
LSMHVRSHSG DKPYECKECG KSFLTSSRLI QHIRTHTGEK PFVCVECGKA
410 420 430 440 450
FAVSSNLSGH LRTHTEEKAC ECKICGKVFG YPSCLNNHMR THSAQKPYTC
460 470 480 490 500
KECGKAFNYS THLKIHMRIH TGEKPYECKQ CGKAFSHSSS FQIHERTHTG
510 520 530 540 550
EKPYECKECG KAFTCSSSFR IHEKTHTEEK PYKCQQCGKA YSHPRSLRRH
EQIH
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7ER43 | K7ER43_HUMAN | Zinc finger protein 426 | ZNF426 | 516 | Annotation score: | ||
K7EME3 | K7EME3_HUMAN | Zinc finger protein 426 | ZNF426 | 118 | Annotation score: | ||
A0A1B0GUG0 | A0A1B0GUG0_HUMAN | Zinc finger protein 426 | ZNF426 | 47 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024214 | 4 | A → V. Corresponds to variant dbSNP:rs2042200Ensembl. | 1 | |
Natural variantiVAR_052824 | 219 | T → A. Corresponds to variant dbSNP:rs10420644Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK095759 mRNA Translation: BAG53124.1 CH471106 Genomic DNA Translation: EAW84039.1 BC001791 mRNA Translation: AAH01791.1 |
CCDSi | CCDS12215.1 |
RefSeqi | NP_001304984.1, NM_001318055.1 NP_001304985.1, NM_001318056.1 NP_077011.1, NM_024106.2 |
Genome annotation databases
Ensembli | ENST00000253115; ENSP00000253115; ENSG00000130818 ENST00000535489; ENSP00000439017; ENSG00000130818 |
GeneIDi | 79088 |
KEGGi | hsa:79088 |
UCSCi | uc002mlq.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK095759 mRNA Translation: BAG53124.1 CH471106 Genomic DNA Translation: EAW84039.1 BC001791 mRNA Translation: AAH01791.1 |
CCDSi | CCDS12215.1 |
RefSeqi | NP_001304984.1, NM_001318055.1 NP_001304985.1, NM_001318056.1 NP_077011.1, NM_024106.2 |
3D structure databases
SMRi | Q9BUY5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122536, 50 interactors |
IntActi | Q9BUY5, 46 interactors |
STRINGi | 9606.ENSP00000439017 |
PTM databases
iPTMneti | Q9BUY5 |
PhosphoSitePlusi | Q9BUY5 |
SwissPalmi | Q9BUY5 |
Genetic variation databases
BioMutai | ZNF426 |
DMDMi | 34925651 |
Proteomic databases
EPDi | Q9BUY5 |
jPOSTi | Q9BUY5 |
MassIVEi | Q9BUY5 |
MaxQBi | Q9BUY5 |
PaxDbi | Q9BUY5 |
PeptideAtlasi | Q9BUY5 |
PRIDEi | Q9BUY5 |
ProteomicsDBi | 79143 |
Protocols and materials databases
Antibodypediai | 12609, 131 antibodies |
DNASUi | 79088 |
Genome annotation databases
Ensembli | ENST00000253115; ENSP00000253115; ENSG00000130818 ENST00000535489; ENSP00000439017; ENSG00000130818 |
GeneIDi | 79088 |
KEGGi | hsa:79088 |
UCSCi | uc002mlq.4, human |
Organism-specific databases
CTDi | 79088 |
GeneCardsi | ZNF426 |
HGNCi | HGNC:20725, ZNF426 |
HPAi | ENSG00000130818, Low tissue specificity |
neXtProti | NX_Q9BUY5 |
OpenTargetsi | ENSG00000130818 |
PharmGKBi | PA134991761 |
VEuPathDBi | HostDB:ENSG00000130818.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163292 |
HOGENOMi | CLU_002678_44_3_1 |
InParanoidi | Q9BUY5 |
OMAi | WEMQLEA |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9BUY5 |
TreeFami | TF342172 |
Enzyme and pathway databases
PathwayCommonsi | Q9BUY5 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 79088, 4 hits in 1018 CRISPR screens |
ChiTaRSi | ZNF426, human |
GenomeRNAii | 79088 |
Pharosi | Q9BUY5, Tdark |
PROi | PR:Q9BUY5 |
RNActi | Q9BUY5, protein |
Gene expression databases
Bgeei | ENSG00000130818, Expressed in prostate gland and 234 other tissues |
ExpressionAtlasi | Q9BUY5, baseline and differential |
Genevisiblei | Q9BUY5, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 11 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN426_HUMAN | |
Accessioni | Q9BUY5Primary (citable) accession number: Q9BUY5 Secondary accession number(s): B3KTL2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2003 |
Last sequence update: | June 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports