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Protein

Uncharacterized protein RAB5IF

Gene

RAB5IF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein RAB5IFCurated
Alternative name(s):
Rab5-interacting proteinImported
Short name:
RIP5Imported
Gene namesi
Name:RAB5IFImported
Synonyms:C20orf24Imported
ORF Names:PNAS-11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101084.16
HGNCiHGNC:15870 RAB5IF
neXtProtiNX_Q9BUV8

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101084
PharmGKBiPA25740

Polymorphism and mutation databases

BioMutaiC20orf24
DMDMi24211596

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000794151 – 137Uncharacterized protein RAB5IFAdd BLAST137

Proteomic databases

EPDiQ9BUV8
MaxQBiQ9BUV8
PaxDbiQ9BUV8
PeptideAtlasiQ9BUV8
PRIDEiQ9BUV8
ProteomicsDBi79136
79137 [Q9BUV8-2]
79138 [Q9BUV8-3]
79139 [Q9BUV8-4]
TopDownProteomicsiQ9BUV8-2 [Q9BUV8-2]
Q9BUV8-4 [Q9BUV8-4]

PTM databases

iPTMnetiQ9BUV8
PhosphoSitePlusiQ9BUV8

Expressioni

Gene expression databases

BgeeiENSG00000101084
CleanExiHS_C20orf24
ExpressionAtlasiQ9BUV8 baseline and differential
GenevisibleiQ9BUV8 HS

Organism-specific databases

HPAiHPA057387

Interactioni

Protein-protein interaction databases

BioGridi121015, 37 interactors
IntActiQ9BUV8, 45 interactors
STRINGi9606.ENSP00000341213

Structurei

3D structure databases

ProteinModelPortaliQ9BUV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3415 Eukaryota
ENOG41129XV LUCA
GeneTreeiENSGT00390000004786
HOGENOMiHOG000232040
HOVERGENiHBG051153
InParanoidiQ9BUV8
OMAiTWIIIYS
OrthoDBiEOG091G10IX
PhylomeDBiQ9BUV8

Family and domain databases

InterProiView protein in InterPro
IPR010742 Rab5ip
IPR029008 Rab5IP_fam
PANTHERiPTHR12906 PTHR12906, 1 hit
PfamiView protein in Pfam
PF07019 Rab5ip, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q9BUV8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGGRRKEEP PQPQLANGAL KVSVWSKVLR SDAAWEDKDE FLDVIYWFRQ
60 70 80 90 100
IIAVVLGVIW GVLPLRGFLG IAGFCLINAG VLYLYFSNYL QIDEEEYGGT
110 120 130
WELTKEGFMT SFALFMVCVA DSFTTGHLDH LLHCHPL
Length:137
Mass (Da):15,487
Last modified:June 1, 2001 - v1
Checksum:i4DC7A8E5D61B4C57
GO
Isoform 2 (identifier: Q9BUV8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-137: CVADSFTTGHLDHLLHCHPL → IWIIFYTAIHYD

Show »
Length:129
Mass (Da):14,825
Checksum:iDA8C4AC79B9AFD22
GO
Isoform 3 (identifier: Q9BUV8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-127: CVADSFTTGH → I

Show »
Length:128
Mass (Da):14,581
Checksum:iBB48F128EAA15C26
GO
Isoform 4 (identifier: Q9BUV8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-137: FCLINAGVLY...LDHLLHCHPL → KGHCCSGAVCVCDD

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:87
Mass (Da):9,530
Checksum:i77A8B6359FD3660A
GO
Isoform 5 (identifier: Q9BUV8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-137: FCLINAGVLY...LDHLLHCHPL → SFGSSFTLPS...ASVFSARVVT

Note: Gene prediction based on EST data.
Show »
Length:143
Mass (Da):15,893
Checksum:i51AE78E40CF4F979
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15 – 33LANGA…LRSDA → PWANGASKSPSGVRCCGRR in AAB50849 (PubMed:8824393).CuratedAdd BLAST19
Sequence conflicti95 – 100EEYGGT → GRILVAR in AAK07515 (Ref. 2) Curated6
Sequence conflicti100T → Q in AAB50849 (PubMed:8824393).Curated1
Sequence conflicti110T → P in AAB50849 (PubMed:8824393).Curated1
Sequence conflicti114 – 137LFMVC…HCHPL → IVHGHLLLLFTSHPYSMMVS DSK in AAB50849 (PubMed:8824393).CuratedAdd BLAST24
Sequence conflicti137L → FIT in AAK07515 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00379574 – 137FCLIN…HCHPL → KGHCCSGAVCVCDD in isoform 4. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_04723374 – 137FCLIN…HCHPL → SFGSSFTLPSIMTDGVQLPS APYPVQRTLLITAQELDRWG TPAPWNLEDPCFLDRESVCW ASVFSARVVT in isoform 5. CuratedAdd BLAST64
Alternative sequenceiVSP_003796118 – 137CVADS…HCHPL → IWIIFYTAIHYD in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_003797118 – 127CVADSFTTGH → I in isoform 3. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112213 mRNA Translation: AAF17201.1
AF274936 mRNA Translation: AAK07515.1
AL050318 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76122.1
CH471077 Genomic DNA Translation: EAW76120.1
CH471077 Genomic DNA Translation: EAW76123.1
CH471077 Genomic DNA Translation: EAW76124.1
BC001871 mRNA Translation: AAH01871.1
BC004446 mRNA Translation: AAH04446.1
S83364 mRNA Translation: AAB50849.1
CCDSiCCDS13279.1 [Q9BUV8-5]
CCDS13280.1 [Q9BUV8-2]
CCDS56190.1 [Q9BUV8-1]
RefSeqiNP_001186463.1, NM_001199534.1 [Q9BUV8-1]
NP_061328.1, NM_018840.4 [Q9BUV8-2]
NP_955777.1, NM_199483.2 [Q9BUV8-5]
UniGeneiHs.584985

Genome annotation databases

EnsembliENST00000342422; ENSP00000341213; ENSG00000101084 [Q9BUV8-5]
ENST00000344795; ENSP00000340164; ENSG00000101084 [Q9BUV8-2]
ENST00000373852; ENSP00000362958; ENSG00000101084 [Q9BUV8-1]
ENST00000483815; ENSP00000432510; ENSG00000101084 [Q9BUV8-4]
ENST00000492721; ENSP00000435871; ENSG00000101084 [Q9BUV8-4]
GeneIDi55969
KEGGihsa:55969
UCSCiuc002xfq.3 human [Q9BUV8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRAB5I_HUMAN
AccessioniPrimary (citable) accession number: Q9BUV8
Secondary accession number(s): E1P5U0
, O00605, Q5QPG6, Q5QPG7, Q9BT03, Q9BZU7, Q9UI05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2001
Last modified: July 18, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM

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