Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Arginine/serine-rich protein 1

Gene

RSRP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine/serine-rich protein 1
Gene namesi
Name:RSRP1
Synonyms:C1orf63
ORF Names:HT033, NPD014
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117616.17
HGNCiHGNC:25234 RSRP1
neXtProtiNX_Q9BUV0

Pathology & Biotechi

Organism-specific databases

DisGeNETi57035
OpenTargetsiENSG00000117616
PharmGKBiPA142672513

Polymorphism and mutation databases

BioMutaiC1orf63
DMDMi156630464

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002976171 – 290Arginine/serine-rich protein 1Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineBy similarity1
Modified residuei135Omega-N-methylarginineBy similarity1
Modified residuei274PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ9BUV0
PaxDbiQ9BUV0
PeptideAtlasiQ9BUV0
PRIDEiQ9BUV0
ProteomicsDBi79133
79134 [Q9BUV0-2]
79135 [Q9BUV0-3]

PTM databases

iPTMnetiQ9BUV0
PhosphoSitePlusiQ9BUV0

Expressioni

Gene expression databases

BgeeiENSG00000117616 Expressed in 235 organ(s), highest expression level in endometrium
CleanExiHS_C1orf63
ExpressionAtlasiQ9BUV0 baseline and differential
GenevisibleiQ9BUV0 HS

Organism-specific databases

HPAiHPA058992
HPA067651

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi121332, 22 interactors
IntActiQ9BUV0, 17 interactors
MINTiQ9BUV0
STRINGi9606.ENSP00000243189

Structurei

3D structure databases

ProteinModelPortaliQ9BUV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi18 – 169Arg/Ser-richAdd BLAST152

Sequence similaritiesi

Belongs to the RSRP family.Curated

Phylogenomic databases

eggNOGiENOG410JBP1 Eukaryota
ENOG410Z5YZ LUCA
GeneTreeiENSGT00730000111390
HOGENOMiHOG000111224
InParanoidiQ9BUV0
OMAiQQRSIAF
OrthoDBiEOG091G10K3
PhylomeDBiQ9BUV0
TreeFamiTF338669

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BUV0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNYVNDMWP GSPQEKDSPS TSRSGGSSRL SSRSRSRSFS RSSRSHSRVS
60 70 80 90 100
SRFSSRSRRS KSRSRSRRRH QRKYRRYSRS YSRSRSRSRS RRYRERRYGF
110 120 130 140 150
TRRYYRSPSR YRSRSRSRSR SRGRSYCGRA YAIARGQRYY GFGRTVYPEE
160 170 180 190 200
HSRWRDRSRT RSRSRTPFRL SEKDRMELLE IAKTNAAKAL GTTNIDLPAS
210 220 230 240 250
LRTVPSAKET SRGIGVSSNG AKPELSEKVT EDGTRNPNEK PTQQRSIAFS
260 270 280 290
SNNSVAKPIQ KSAKAATEEA SSRSPKIDQK KSPYGLWIPI
Note: No experimental confirmation available.
Length:290
Mass (Da):33,613
Last modified:August 21, 2007 - v2
Checksum:iE729EA9895672216
GO
Isoform 2 (identifier: Q9BUV0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-290: LSEKVTEDGT...KSPYGLWIPI → VSILGLSEQNFQKANCQI

Show »
Length:242
Mass (Da):28,364
Checksum:iCCB829DCFDE406A4
GO
Isoform 3 (identifier: Q9BUV0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-226: LS → KS
     227-290: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:226
Mass (Da):26,605
Checksum:iFA6252B925D84FDC
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BTJ0H3BTJ0_HUMAN
Arginine/serine-rich protein 1
RSRP1
226Annotation score:
H3BP33H3BP33_HUMAN
Arginine/serine-rich protein 1
RSRP1
183Annotation score:
H3BMX3H3BMX3_HUMAN
Arginine/serine-rich protein 1
RSRP1
129Annotation score:
H3BT33H3BT33_HUMAN
Arginine/serine-rich protein 1
RSRP1
96Annotation score:
H3BVB7H3BVB7_HUMAN
Arginine/serine-rich protein 1
RSRP1
89Annotation score:
H3BMN1H3BMN1_HUMAN
Arginine/serine-rich protein 1
RSRP1
84Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034655147Y → H. Corresponds to variant dbSNP:rs34619962Ensembl.1
Natural variantiVAR_034656239E → G1 PublicationCorresponds to variant dbSNP:rs1043879Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027305225 – 290LSEKV…LWIPI → VSILGLSEQNFQKANCQI in isoform 2. 3 PublicationsAdd BLAST66
Alternative sequenceiVSP_027306225 – 226LS → KS in isoform 3. 1 Publication2
Alternative sequenceiVSP_027307227 – 290Missing in isoform 3. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027318 mRNA Translation: BAB55038.1
AK292532 mRNA Translation: BAF85221.1
AF247168 mRNA Translation: AAG44543.1
AF267856 mRNA Translation: AAG44725.1
AL031432 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95157.1
BC001892 mRNA Translation: AAH01892.1
BC041843 mRNA Translation: AAH41843.1
BC065040 mRNA Translation: AAH65040.1
CCDSiCCDS260.1 [Q9BUV0-1]
RefSeqiNP_001308701.1, NM_001321772.1 [Q9BUV0-1]
NP_064713.3, NM_020317.4 [Q9BUV0-1]
XP_011540099.1, XM_011541797.1 [Q9BUV0-1]
UniGeneiHs.259412
Hs.692443

Genome annotation databases

EnsembliENST00000243189; ENSP00000243189; ENSG00000117616 [Q9BUV0-1]
ENST00000431849; ENSP00000391510; ENSG00000117616 [Q9BUV0-2]
ENST00000473314; ENSP00000457582; ENSG00000117616 [Q9BUV0-3]
GeneIDi57035
KEGGihsa:57035
UCSCiuc001bjw.4 human [Q9BUV0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027318 mRNA Translation: BAB55038.1
AK292532 mRNA Translation: BAF85221.1
AF247168 mRNA Translation: AAG44543.1
AF267856 mRNA Translation: AAG44725.1
AL031432 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95157.1
BC001892 mRNA Translation: AAH01892.1
BC041843 mRNA Translation: AAH41843.1
BC065040 mRNA Translation: AAH65040.1
CCDSiCCDS260.1 [Q9BUV0-1]
RefSeqiNP_001308701.1, NM_001321772.1 [Q9BUV0-1]
NP_064713.3, NM_020317.4 [Q9BUV0-1]
XP_011540099.1, XM_011541797.1 [Q9BUV0-1]
UniGeneiHs.259412
Hs.692443

3D structure databases

ProteinModelPortaliQ9BUV0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121332, 22 interactors
IntActiQ9BUV0, 17 interactors
MINTiQ9BUV0
STRINGi9606.ENSP00000243189

PTM databases

iPTMnetiQ9BUV0
PhosphoSitePlusiQ9BUV0

Polymorphism and mutation databases

BioMutaiC1orf63
DMDMi156630464

Proteomic databases

MaxQBiQ9BUV0
PaxDbiQ9BUV0
PeptideAtlasiQ9BUV0
PRIDEiQ9BUV0
ProteomicsDBi79133
79134 [Q9BUV0-2]
79135 [Q9BUV0-3]

Protocols and materials databases

DNASUi57035
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243189; ENSP00000243189; ENSG00000117616 [Q9BUV0-1]
ENST00000431849; ENSP00000391510; ENSG00000117616 [Q9BUV0-2]
ENST00000473314; ENSP00000457582; ENSG00000117616 [Q9BUV0-3]
GeneIDi57035
KEGGihsa:57035
UCSCiuc001bjw.4 human [Q9BUV0-1]

Organism-specific databases

CTDi57035
DisGeNETi57035
EuPathDBiHostDB:ENSG00000117616.17
GeneCardsiRSRP1
HGNCiHGNC:25234 RSRP1
HPAiHPA058992
HPA067651
neXtProtiNX_Q9BUV0
OpenTargetsiENSG00000117616
PharmGKBiPA142672513
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JBP1 Eukaryota
ENOG410Z5YZ LUCA
GeneTreeiENSGT00730000111390
HOGENOMiHOG000111224
InParanoidiQ9BUV0
OMAiQQRSIAF
OrthoDBiEOG091G10K3
PhylomeDBiQ9BUV0
TreeFamiTF338669

Miscellaneous databases

ChiTaRSiRSRP1 human
GenomeRNAii57035
PROiPR:Q9BUV0

Gene expression databases

BgeeiENSG00000117616 Expressed in 235 organ(s), highest expression level in endometrium
CleanExiHS_C1orf63
ExpressionAtlasiQ9BUV0 baseline and differential
GenevisibleiQ9BUV0 HS

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiRSRP1_HUMAN
AccessioniPrimary (citable) accession number: Q9BUV0
Secondary accession number(s): A8K917
, Q49AA4, Q5TH71, Q9GZP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: November 7, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again