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Protein

3-hydroxybutyrate dehydrogenase type 2

Gene

BDH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria (By similarity). Also acts as a 3-hydroxybutyrate dehydrogenase (PubMed:16380372).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=60 µM for NAD1 Publication
  2. KM=10 mM for R-hydroxybutyrate1 Publication
  1. Vmax=82 nmol/min/mg enzyme (at 30 degrees Celsius)1 Publication

pH dependencei

Optimum pH is 7.5-9.0.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Siderophore biosynthesis

This protein is involved in Siderophore biosynthesis.By similarity
View all proteins of this organism that are known to be involved in Siderophore biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei37NADCombined sources1 Publication1
Binding sitei58NADCombined sources1 Publication1
Binding sitei144SubstrateCurated1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei147Proton acceptorPROSITE-ProRule annotation1
Binding sitei151NADCombined sources1 Publication1
Binding sitei188SubstrateCurated1
Binding sitei205SubstrateCurated1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi16 – 18NADCombined sources1 Publication3
Nucleotide bindingi180 – 184NADCombined sources1 Publication5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS08987-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-77111 Synthesis of Ketone Bodies

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q9BUT1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3-hydroxybutyrate dehydrogenase type 2 (EC:1.1.1.-, EC:1.1.1.301 Publication)
Alternative name(s):
Dehydrogenase/reductase SDR family member 6
Oxidoreductase UCPA
R-beta-hydroxybutyrate dehydrogenase
Short chain dehydrogenase/reductase family 15C member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BDH2
Synonyms:DHRS61 Publication, SDR15C1
ORF Names:UNQ6308/PRO20933
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000164039.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:32389 BDH2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BUT1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
56898

Open Targets

More...
OpenTargetsi
ENSG00000164039

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672559

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BDH2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
125987797

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000425801 – 2453-hydroxybutyrate dehydrogenase type 2Add BLAST245

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9BUT1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BUT1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BUT1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BUT1

PeptideAtlas

More...
PeptideAtlasi
Q9BUT1

PRoteomics IDEntifications database

More...
PRIDEi
Q9BUT1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79125
79126 [Q9BUT1-2]
79127 [Q9BUT1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BUT1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BUT1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in liver (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by low iron levels, and down-regulated by elevated iron levels.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164039 Expressed in 91 organ(s), highest expression level in adult mammalian kidney

CleanEx database of gene expression profiles

More...
CleanExi
HS_BDH2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BUT1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BUT1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036028
HPA036029

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121228, 12 interactors

Protein interaction database and analysis system

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IntActi
Q9BUT1, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000296424

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1245
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AG5X-ray1.84A/B/C/D1-245[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9BUT1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BUT1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9BUT1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0725 Eukaryota
COG1028 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156721

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG002145

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BUT1

KEGG Orthology (KO)

More...
KOi
K00019

Identification of Orthologs from Complete Genome Data

More...
OMAi
CREFGAY

Database of Orthologous Groups

More...
OrthoDBi
1226147at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BUT1

TreeFam database of animal gene trees

More...
TreeFami
TF328795

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00081 GDHRDH
PR00080 SDRFAMILY

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00061 ADH_SHORT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BUT1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRLDGKVII LTAAAQGIGQ AAALAFAREG AKVIATDINE SKLQELEKYP
60 70 80 90 100
GIQTRVLDVT KKKQIDQFAN EVERLDVLFN VAGFVHHGTV LDCEEKDWDF
110 120 130 140 150
SMNLNVRSMY LMIKAFLPKM LAQKSGNIIN MSSVASSVKG VVNRCVYSTT
160 170 180 190 200
KAAVIGLTKS VAADFIQQGI RCNCVCPGTV DTPSLQERIQ ARGNPEEARN
210 220 230 240
DFLKRQKTGR FATAEEIAML CVYLASDESA YVTGNPVIID GGWSL
Length:245
Mass (Da):26,724
Last modified:February 6, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6E10E9DF9304107
GO
Isoform 2 (identifier: Q9BUT1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-245: VVNRCVYSTT...PVIIDGGWSL → GSVSFRGLRCSYTHIIKSSAFGNRHSRDYNFKY

Show »
Length:173
Mass (Da):19,209
Checksum:i23BD76240A349C5F
GO
Isoform 3 (identifier: Q9BUT1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.

Show »
Length:144
Mass (Da):15,626
Checksum:i84FAF6A1B536C6B8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9U8D6R9U8_HUMAN
3-hydroxybutyrate dehydrogenase typ...
BDH2
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIR6D6RIR6_HUMAN
3-hydroxybutyrate dehydrogenase typ...
BDH2
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFG2D6RFG2_HUMAN
3-hydroxybutyrate dehydrogenase typ...
BDH2
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBF6D6RBF6_HUMAN
3-hydroxybutyrate dehydrogenase typ...
BDH2
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti95E → V in BAF82849 (PubMed:14702039).Curated1
Sequence conflicti161V → L in AAQ89200 (PubMed:12975309).Curated1
Sequence conflicti203L → P in BAF82849 (PubMed:14702039).Curated1
Sequence conflicti230A → T in AAH95414 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02360270N → S4 PublicationsCorresponds to variant dbSNP:rs1054707Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0397811 – 101Missing in isoform 3. 1 PublicationAdd BLAST101
Alternative sequenceiVSP_015859141 – 245VVNRC…GGWSL → GSVSFRGLRCSYTHIIKSSA FGNRHSRDYNFKY in isoform 2. 3 PublicationsAdd BLAST105

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF164790 mRNA Translation: AAF80754.1
AY358841 mRNA Translation: AAQ89200.1
CR457309 mRNA Translation: CAG33590.1
AK023323 mRNA Translation: BAB14526.1
AK290160 mRNA Translation: BAF82849.1
AK300626 mRNA Translation: BAG62318.1
AC097485 Genomic DNA No translation available.
BC037277 mRNA Translation: AAH37277.1
BC001953 mRNA Translation: AAH01953.1
BC095414 mRNA Translation: AAH95414.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3663.1 [Q9BUT1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_064524.3, NM_020139.3 [Q9BUT1-1]
XP_011530430.1, XM_011532128.2 [Q9BUT1-1]
XP_016863951.1, XM_017008462.1 [Q9BUT1-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.124696

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000296424; ENSP00000296424; ENSG00000164039 [Q9BUT1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56898

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56898

UCSC genome browser

More...
UCSCi
uc003hwz.4 human [Q9BUT1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164790 mRNA Translation: AAF80754.1
AY358841 mRNA Translation: AAQ89200.1
CR457309 mRNA Translation: CAG33590.1
AK023323 mRNA Translation: BAB14526.1
AK290160 mRNA Translation: BAF82849.1
AK300626 mRNA Translation: BAG62318.1
AC097485 Genomic DNA No translation available.
BC037277 mRNA Translation: AAH37277.1
BC001953 mRNA Translation: AAH01953.1
BC095414 mRNA Translation: AAH95414.1
CCDSiCCDS3663.1 [Q9BUT1-1]
RefSeqiNP_064524.3, NM_020139.3 [Q9BUT1-1]
XP_011530430.1, XM_011532128.2 [Q9BUT1-1]
XP_016863951.1, XM_017008462.1 [Q9BUT1-1]
UniGeneiHs.124696

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AG5X-ray1.84A/B/C/D1-245[»]
ProteinModelPortaliQ9BUT1
SMRiQ9BUT1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121228, 12 interactors
IntActiQ9BUT1, 1 interactor
STRINGi9606.ENSP00000296424

PTM databases

iPTMnetiQ9BUT1
PhosphoSitePlusiQ9BUT1

Polymorphism and mutation databases

BioMutaiBDH2
DMDMi125987797

Proteomic databases

EPDiQ9BUT1
jPOSTiQ9BUT1
MaxQBiQ9BUT1
PaxDbiQ9BUT1
PeptideAtlasiQ9BUT1
PRIDEiQ9BUT1
ProteomicsDBi79125
79126 [Q9BUT1-2]
79127 [Q9BUT1-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296424; ENSP00000296424; ENSG00000164039 [Q9BUT1-1]
GeneIDi56898
KEGGihsa:56898
UCSCiuc003hwz.4 human [Q9BUT1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56898
DisGeNETi56898
EuPathDBiHostDB:ENSG00000164039.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BDH2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0032960
HGNCiHGNC:32389 BDH2
HPAiHPA036028
HPA036029
neXtProtiNX_Q9BUT1
OpenTargetsiENSG00000164039
PharmGKBiPA142672559

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0725 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00940000156721
HOVERGENiHBG002145
InParanoidiQ9BUT1
KOiK00019
OMAiCREFGAY
OrthoDBi1226147at2759
PhylomeDBiQ9BUT1
TreeFamiTF328795

Enzyme and pathway databases

BioCyciMetaCyc:HS08987-MONOMER
ReactomeiR-HSA-77111 Synthesis of Ketone Bodies
SABIO-RKiQ9BUT1

Miscellaneous databases

EvolutionaryTraceiQ9BUT1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
56898

Protein Ontology

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PROi
PR:Q9BUT1

Gene expression databases

BgeeiENSG00000164039 Expressed in 91 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_BDH2
ExpressionAtlasiQ9BUT1 baseline and differential
GenevisibleiQ9BUT1 HS

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBDH2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BUT1
Secondary accession number(s): A8K295
, B4DUF6, Q503A0, Q6IA46, Q6UWD3, Q9H8S8, Q9NRX8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: February 6, 2007
Last modified: January 16, 2019
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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