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Protein

Oxidoreductase HTATIP2

Gene

HTATIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.4 Publications

Caution

Was originally (PubMed:9482853 and PubMed:10698937) thought to be a transcriptional coregulator with protein kinase activity. However, crystal structure reveals a short chain dehydrogenase/reductase fold binding NADPH rather than ATP.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei131Substrate1 Publication1
Active sitei143Proton acceptor1 Publication1
Active sitei1471 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 52NADP1 PublicationAdd BLAST34

GO - Molecular functioni

  • oxidoreductase activity Source: UniProtKB-KW
  • transcription coactivator activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Oxidoreductase
Biological processAngiogenesis, Apoptosis, Differentiation, Host-virus interaction
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Oxidoreductase HTATIP2 (EC:1.1.1.-)
Alternative name(s):
30 kDa HIV-1 TAT-interacting protein
HIV-1 TAT-interactive protein 2
Gene namesi
Name:HTATIP2Imported
Synonyms:CC3Imported, TIP301 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000109854.13
HGNCiHGNC:16637 HTATIP2
MIMi605628 gene
neXtProtiNX_Q9BUP3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi28 – 31GETG → VETA: Loss of proapoptotic and metastatis-inhibiting effect. 1 Publication4
Mutagenesisi106R → H: Loss of association with nucleus. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi10553
OpenTargetsiENSG00000109854
PharmGKBiPA29539

Polymorphism and mutation databases

BioMutaiHTATIP2
DMDMi317373366

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000725442 – 242Oxidoreductase HTATIP2Add BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BUP3
MaxQBiQ9BUP3
PaxDbiQ9BUP3
PeptideAtlasiQ9BUP3
PRIDEiQ9BUP3
ProteomicsDBi79117
79118 [Q9BUP3-2]
79119 [Q9BUP3-3]

PTM databases

iPTMnetiQ9BUP3
PhosphoSitePlusiQ9BUP3
SwissPalmiQ9BUP3

Expressioni

Tissue specificityi

Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas.2 Publications

Gene expression databases

BgeeiENSG00000109854 Expressed in 228 organ(s), highest expression level in jejunal mucosa
CleanExiHS_HTATIP2
ExpressionAtlasiQ9BUP3 baseline and differential
GenevisibleiQ9BUP3 HS

Organism-specific databases

HPAiHPA006417
HPA024321

Interactioni

Subunit structurei

Monomer. Binds nuclear transport receptors XPO4, IPO5/RANBP5, IPO7, IPO9 and KPNB1 as well as GCN1L1/GCN1 and LRPPRC probably through their HEAT repeats. Binds NCOA5/CIA. Isoform 2 binds the proteasome subunit PSMD4/s5a through its N-terminus.2 Publications
(Microbial infection) Interacts with HIV-1 Tat (via activation domain).1 Publication

Protein-protein interaction databases

BioGridi115804, 11 interactors
IntActiQ9BUP3, 18 interactors
STRINGi9606.ENSP00000392985

Structurei

Secondary structure

1242
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BUP3
SMRiQ9BUP3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BUP3

Family & Domainsi

Domaini

Unique C-terminus confers high proteasome-dependent instability to isoform 2.1 Publication

Phylogenomic databases

eggNOGiKOG4039 Eukaryota
COG0702 LUCA
GeneTreeiENSGT00390000008184
HOVERGENiHBG052833
InParanoidiQ9BUP3
KOiK17290
OMAiYSIFRPG
OrthoDBiEOG091G0S5T
PhylomeDBiQ9BUP3
TreeFamiTF312849

Family and domain databases

InterProiView protein in InterPro
IPR016040 NAD(P)-bd_dom
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF13460 NAD_binding_10, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q9BUP3-1) [UniParc]FASTAAdd to basket
Also known as: CC31 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAETEALSKL REDFRMQNKS VFILGASGET GRVLLKEILE QGLFSKVTLI
60 70 80 90 100
GRRKLTFDEE AYKNVNQEVV DFEKLDDYAS AFQGHDVGFC CLGTTRGKAG
110 120 130 140 150
AEGFVRVDRD YVLKSAELAK AGGCKHFNLL SSKGADKSSN FLYLQVKGEV
160 170 180 190 200
EAKVEELKFD RYSVFRPGVL LCDRQESRPG EWLVRKFFGS LPDSWASGHS
210 220 230 240
VPVVTVVRAM LNNVVRPRDK QMELLENKAI HDLGKAHGSL KP
Length:242
Mass (Da):27,049
Last modified:January 11, 2011 - v2
Checksum:i6A26E4A095243678
GO
Isoform 2Curated1 Publication (identifier: Q9BUP3-2) [UniParc]FASTAAdd to basket
Also known as: TC31 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     102-133: EGFVRVDRDYVLKSAELAKAGGCKHFNLLSSK → VRKAYALFPFCWPVISRILFLLTLFLCACCNA
     134-242: Missing.

Note: Mutagenesis of Leu-154 and Leu-157 or Cys-158, Cys-160 and Cys-161 abolishes antiapoptotic effect.
Show »
Length:133
Mass (Da):14,914
Checksum:iD5C06E44FAE16E82
GO
Isoform 3 (identifier: Q9BUP3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGPAALSAAAAAALAAALLLLRREDPGPGAGPSM

Show »
Length:276
Mass (Da):30,131
Checksum:i655FB91EC4F33B34
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PI87E9PI87_HUMAN
Oxidoreductase HTATIP2
HTATIP2
196Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87V → F in CAG33102 (Ref. 5) Curated1
Sequence conflicti170L → P in BAD96730 (Ref. 6) Curated1
Sequence conflicti182W → R in AAC39694 (PubMed:9482853).Curated1
Sequence conflicti187F → L in AAB84360 (PubMed:9174052).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023713106R → S in a hepatocellular carcinoma sample. 1 Publication1
Natural variantiVAR_023714108D → Y in a hepatocellular carcinoma sample. 1 Publication1
Natural variantiVAR_023715116A → T in a hepatocellular carcinoma sample. 1 PublicationCorresponds to variant dbSNP:rs761113892Ensembl.1
Natural variantiVAR_023716134G → V in a hepatocellular carcinoma sample; reduces protein stability. 1 Publication1
Natural variantiVAR_023717144L → I in a hepatocellular carcinoma sample. 1 Publication1
Natural variantiVAR_023718197S → R Highly associated with hepatocellular carcinoma (HCC) progression. Combined sources3 PublicationsCorresponds to variant dbSNP:rs3824886Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0383391M → MAGPAALSAAAAAALAAALL LLRREDPGPGAGPSM in isoform 3. 1 Publication1
Alternative sequenceiVSP_051864102 – 133EGFVR…LLSSK → VRKAYALFPFCWPVISRILF LLTLFLCACCNA in isoform 2. 2 PublicationsAdd BLAST32
Alternative sequenceiVSP_051865134 – 242Missing in isoform 2. 2 PublicationsAdd BLAST109

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69161 mRNA Translation: AAB84360.1
AF039103 mRNA Translation: AAC39694.1
AF092095 mRNA Translation: AAC78331.1
AK292092 mRNA Translation: BAF84781.1
CR456821 mRNA Translation: CAG33102.1
AK223010 mRNA Translation: BAD96730.1
AK222969 mRNA Translation: BAD96689.1
AC025972 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68338.1
CH471064 Genomic DNA Translation: EAW68339.1
BC002439 mRNA Translation: AAH02439.2
BC015358 mRNA Translation: AAH15358.1
CCDSiCCDS44553.1 [Q9BUP3-3]
CCDS53613.1 [Q9BUP3-2]
CCDS7852.1 [Q9BUP3-1]
RefSeqiNP_001091990.1, NM_001098520.1 [Q9BUP3-3]
NP_001091991.1, NM_001098521.1 [Q9BUP3-1]
NP_001091992.1, NM_001098522.1 [Q9BUP3-1]
NP_001091993.1, NM_001098523.1 [Q9BUP3-2]
NP_006401.3, NM_006410.4 [Q9BUP3-1]
UniGeneiHs.90753

Genome annotation databases

EnsembliENST00000419348; ENSP00000392985; ENSG00000109854 [Q9BUP3-3]
ENST00000421577; ENSP00000397752; ENSG00000109854 [Q9BUP3-1]
ENST00000443524; ENSP00000387876; ENSG00000109854 [Q9BUP3-1]
ENST00000451739; ENSP00000394259; ENSG00000109854 [Q9BUP3-1]
ENST00000530266; ENSP00000436548; ENSG00000109854 [Q9BUP3-2]
ENST00000532081; ENSP00000432107; ENSG00000109854 [Q9BUP3-2]
ENST00000532505; ENSP00000432338; ENSG00000109854 [Q9BUP3-2]
GeneIDi10553
KEGGihsa:10553
UCSCiuc001mpx.3 human [Q9BUP3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69161 mRNA Translation: AAB84360.1
AF039103 mRNA Translation: AAC39694.1
AF092095 mRNA Translation: AAC78331.1
AK292092 mRNA Translation: BAF84781.1
CR456821 mRNA Translation: CAG33102.1
AK223010 mRNA Translation: BAD96730.1
AK222969 mRNA Translation: BAD96689.1
AC025972 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68338.1
CH471064 Genomic DNA Translation: EAW68339.1
BC002439 mRNA Translation: AAH02439.2
BC015358 mRNA Translation: AAH15358.1
CCDSiCCDS44553.1 [Q9BUP3-3]
CCDS53613.1 [Q9BUP3-2]
CCDS7852.1 [Q9BUP3-1]
RefSeqiNP_001091990.1, NM_001098520.1 [Q9BUP3-3]
NP_001091991.1, NM_001098521.1 [Q9BUP3-1]
NP_001091992.1, NM_001098522.1 [Q9BUP3-1]
NP_001091993.1, NM_001098523.1 [Q9BUP3-2]
NP_006401.3, NM_006410.4 [Q9BUP3-1]
UniGeneiHs.90753

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BKAX-ray1.70A1-242[»]
ProteinModelPortaliQ9BUP3
SMRiQ9BUP3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115804, 11 interactors
IntActiQ9BUP3, 18 interactors
STRINGi9606.ENSP00000392985

PTM databases

iPTMnetiQ9BUP3
PhosphoSitePlusiQ9BUP3
SwissPalmiQ9BUP3

Polymorphism and mutation databases

BioMutaiHTATIP2
DMDMi317373366

Proteomic databases

EPDiQ9BUP3
MaxQBiQ9BUP3
PaxDbiQ9BUP3
PeptideAtlasiQ9BUP3
PRIDEiQ9BUP3
ProteomicsDBi79117
79118 [Q9BUP3-2]
79119 [Q9BUP3-3]

Protocols and materials databases

DNASUi10553
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000419348; ENSP00000392985; ENSG00000109854 [Q9BUP3-3]
ENST00000421577; ENSP00000397752; ENSG00000109854 [Q9BUP3-1]
ENST00000443524; ENSP00000387876; ENSG00000109854 [Q9BUP3-1]
ENST00000451739; ENSP00000394259; ENSG00000109854 [Q9BUP3-1]
ENST00000530266; ENSP00000436548; ENSG00000109854 [Q9BUP3-2]
ENST00000532081; ENSP00000432107; ENSG00000109854 [Q9BUP3-2]
ENST00000532505; ENSP00000432338; ENSG00000109854 [Q9BUP3-2]
GeneIDi10553
KEGGihsa:10553
UCSCiuc001mpx.3 human [Q9BUP3-1]

Organism-specific databases

CTDi10553
DisGeNETi10553
EuPathDBiHostDB:ENSG00000109854.13
GeneCardsiHTATIP2
HGNCiHGNC:16637 HTATIP2
HPAiHPA006417
HPA024321
MIMi605628 gene
neXtProtiNX_Q9BUP3
OpenTargetsiENSG00000109854
PharmGKBiPA29539
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4039 Eukaryota
COG0702 LUCA
GeneTreeiENSGT00390000008184
HOVERGENiHBG052833
InParanoidiQ9BUP3
KOiK17290
OMAiYSIFRPG
OrthoDBiEOG091G0S5T
PhylomeDBiQ9BUP3
TreeFamiTF312849

Miscellaneous databases

EvolutionaryTraceiQ9BUP3
GeneWikiiHTATIP2
GenomeRNAii10553
PROiPR:Q9BUP3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109854 Expressed in 228 organ(s), highest expression level in jejunal mucosa
CleanExiHS_HTATIP2
ExpressionAtlasiQ9BUP3 baseline and differential
GenevisibleiQ9BUP3 HS

Family and domain databases

InterProiView protein in InterPro
IPR016040 NAD(P)-bd_dom
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF13460 NAD_binding_10, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHTAI2_HUMAN
AccessioniPrimary (citable) accession number: Q9BUP3
Secondary accession number(s): A8K7S7
, D3DQY8, O15383, O60520, O95345, Q53GC1, Q53GG2, Q6IBI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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