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Entry version 152 (18 Sep 2019)
Sequence version 2 (11 Jan 2011)
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Protein

Oxidoreductase HTATIP2

Gene

HTATIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.4 Publications

Caution

Was originally (PubMed:9482853 and PubMed:10698937) thought to be a transcriptional coregulator with protein kinase activity. However, crystal structure reveals a short chain dehydrogenase/reductase fold binding NADPH rather than ATP.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei131Substrate1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei143Proton acceptor1 Publication1
Active sitei1471 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi19 – 52NADP1 PublicationAdd BLAST34

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Oxidoreductase
Biological processAngiogenesis, Apoptosis, Differentiation, Host-virus interaction
LigandNADP

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Oxidoreductase HTATIP2 (EC:1.1.1.-)
Alternative name(s):
30 kDa HIV-1 TAT-interacting protein
HIV-1 TAT-interactive protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HTATIP2Imported
Synonyms:CC3Imported, TIP301 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16637 HTATIP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605628 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BUP3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi28 – 31GETG → VETA: Loss of proapoptotic and metastatis-inhibiting effect. 1 Publication4
Mutagenesisi106R → H: Loss of association with nucleus. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...
DisGeNETi
10553

Open Targets

More...
OpenTargetsi
ENSG00000109854

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29539

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB11077 Polyethylene glycol 400

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HTATIP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373366

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000725442 – 242Oxidoreductase HTATIP2Add BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9BUP3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9BUP3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9BUP3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9BUP3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BUP3

PeptideAtlas

More...
PeptideAtlasi
Q9BUP3

PRoteomics IDEntifications database

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PRIDEi
Q9BUP3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79117 [Q9BUP3-1]
79118 [Q9BUP3-2]
79119 [Q9BUP3-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9BUP3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9BUP3

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q9BUP3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000109854 Expressed in 228 organ(s), highest expression level in jejunal mucosa

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BUP3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BUP3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006417
HPA024321

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Binds nuclear transport receptors XPO4, IPO5/RANBP5, IPO7, IPO9 and KPNB1 as well as GCN1L1/GCN1 and LRPPRC probably through their HEAT repeats. Binds NCOA5/CIA. Isoform 2 binds the proteasome subunit PSMD4/s5a through its N-terminus.

2 Publications

(Microbial infection)

Interacts with HIV-1 Tat (via activation domain).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
EMP3P548523EBI-13625358,EBI-3907816

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115804, 12 interactors

Protein interaction database and analysis system

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IntActi
Q9BUP3, 22 interactors

Molecular INTeraction database

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MINTi
Q9BUP3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000392985

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1242
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BUP3

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9BUP3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Unique C-terminus confers high proteasome-dependent instability to isoform 2.1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4039 Eukaryota
COG0702 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008184

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BUP3

KEGG Orthology (KO)

More...
KOi
K17290

Identification of Orthologs from Complete Genome Data

More...
OMAi
HLENPVG

Database of Orthologous Groups

More...
OrthoDBi
1601023at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BUP3

TreeFam database of animal gene trees

More...
TreeFami
TF312849

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016040 NAD(P)-bd_dom
IPR036291 NAD(P)-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13460 NAD_binding_10, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF51735 SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q9BUP3-1) [UniParc]FASTAAdd to basket
Also known as: CC31 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAETEALSKL REDFRMQNKS VFILGASGET GRVLLKEILE QGLFSKVTLI
60 70 80 90 100
GRRKLTFDEE AYKNVNQEVV DFEKLDDYAS AFQGHDVGFC CLGTTRGKAG
110 120 130 140 150
AEGFVRVDRD YVLKSAELAK AGGCKHFNLL SSKGADKSSN FLYLQVKGEV
160 170 180 190 200
EAKVEELKFD RYSVFRPGVL LCDRQESRPG EWLVRKFFGS LPDSWASGHS
210 220 230 240
VPVVTVVRAM LNNVVRPRDK QMELLENKAI HDLGKAHGSL KP
Length:242
Mass (Da):27,049
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A26E4A095243678
GO
Isoform 2Curated1 Publication (identifier: Q9BUP3-2) [UniParc]FASTAAdd to basket
Also known as: TC31 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     102-133: EGFVRVDRDYVLKSAELAKAGGCKHFNLLSSK → VRKAYALFPFCWPVISRILFLLTLFLCACCNA
     134-242: Missing.

Note: Mutagenesis of Leu-154 and Leu-157 or Cys-158, Cys-160 and Cys-161 abolishes antiapoptotic effect.
Show »
Length:133
Mass (Da):14,914
Checksum:iD5C06E44FAE16E82
GO
Isoform 3 (identifier: Q9BUP3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGPAALSAAAAAALAAALLLLRREDPGPGAGPSM

Show »
Length:276
Mass (Da):30,131
Checksum:i655FB91EC4F33B34
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PI87E9PI87_HUMAN
Oxidoreductase HTATIP2
HTATIP2
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti87V → F in CAG33102 (Ref. 5) Curated1
Sequence conflicti170L → P in BAD96730 (Ref. 6) Curated1
Sequence conflicti182W → R in AAC39694 (PubMed:9482853).Curated1
Sequence conflicti187F → L in AAB84360 (PubMed:9174052).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_023713106R → S in a hepatocellular carcinoma sample. 1 Publication1
Natural variantiVAR_023714108D → Y in a hepatocellular carcinoma sample. 1 Publication1
Natural variantiVAR_023715116A → T in a hepatocellular carcinoma sample. 1 PublicationCorresponds to variant dbSNP:rs761113892Ensembl.1
Natural variantiVAR_023716134G → V in a hepatocellular carcinoma sample; reduces protein stability. 1 Publication1
Natural variantiVAR_023717144L → I in a hepatocellular carcinoma sample. 1 Publication1
Natural variantiVAR_023718197S → R Highly associated with hepatocellular carcinoma (HCC) progression. Combined sources3 PublicationsCorresponds to variant dbSNP:rs3824886Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0383391M → MAGPAALSAAAAAALAAALL LLRREDPGPGAGPSM in isoform 3. 1 Publication1
Alternative sequenceiVSP_051864102 – 133EGFVR…LLSSK → VRKAYALFPFCWPVISRILF LLTLFLCACCNA in isoform 2. 2 PublicationsAdd BLAST32
Alternative sequenceiVSP_051865134 – 242Missing in isoform 2. 2 PublicationsAdd BLAST109

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U69161 mRNA Translation: AAB84360.1
AF039103 mRNA Translation: AAC39694.1
AF092095 mRNA Translation: AAC78331.1
AK292092 mRNA Translation: BAF84781.1
CR456821 mRNA Translation: CAG33102.1
AK223010 mRNA Translation: BAD96730.1
AK222969 mRNA Translation: BAD96689.1
AC025972 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68338.1
CH471064 Genomic DNA Translation: EAW68339.1
BC002439 mRNA Translation: AAH02439.2
BC015358 mRNA Translation: AAH15358.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44553.1 [Q9BUP3-3]
CCDS53613.1 [Q9BUP3-2]
CCDS7852.1 [Q9BUP3-1]

NCBI Reference Sequences

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RefSeqi
NP_001091990.1, NM_001098520.1 [Q9BUP3-3]
NP_001091991.1, NM_001098521.1 [Q9BUP3-1]
NP_001091992.1, NM_001098522.1 [Q9BUP3-1]
NP_001091993.1, NM_001098523.1 [Q9BUP3-2]
NP_006401.3, NM_006410.4 [Q9BUP3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000419348; ENSP00000392985; ENSG00000109854 [Q9BUP3-3]
ENST00000421577; ENSP00000397752; ENSG00000109854 [Q9BUP3-1]
ENST00000443524; ENSP00000387876; ENSG00000109854 [Q9BUP3-1]
ENST00000451739; ENSP00000394259; ENSG00000109854 [Q9BUP3-1]
ENST00000530266; ENSP00000436548; ENSG00000109854 [Q9BUP3-2]
ENST00000532081; ENSP00000432107; ENSG00000109854 [Q9BUP3-2]
ENST00000532505; ENSP00000432338; ENSG00000109854 [Q9BUP3-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10553

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10553

UCSC genome browser

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UCSCi
uc001mpx.3 human [Q9BUP3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69161 mRNA Translation: AAB84360.1
AF039103 mRNA Translation: AAC39694.1
AF092095 mRNA Translation: AAC78331.1
AK292092 mRNA Translation: BAF84781.1
CR456821 mRNA Translation: CAG33102.1
AK223010 mRNA Translation: BAD96730.1
AK222969 mRNA Translation: BAD96689.1
AC025972 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68338.1
CH471064 Genomic DNA Translation: EAW68339.1
BC002439 mRNA Translation: AAH02439.2
BC015358 mRNA Translation: AAH15358.1
CCDSiCCDS44553.1 [Q9BUP3-3]
CCDS53613.1 [Q9BUP3-2]
CCDS7852.1 [Q9BUP3-1]
RefSeqiNP_001091990.1, NM_001098520.1 [Q9BUP3-3]
NP_001091991.1, NM_001098521.1 [Q9BUP3-1]
NP_001091992.1, NM_001098522.1 [Q9BUP3-1]
NP_001091993.1, NM_001098523.1 [Q9BUP3-2]
NP_006401.3, NM_006410.4 [Q9BUP3-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BKAX-ray1.70A1-242[»]
SMRiQ9BUP3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115804, 12 interactors
IntActiQ9BUP3, 22 interactors
MINTiQ9BUP3
STRINGi9606.ENSP00000392985

Chemistry databases

DrugBankiDB11077 Polyethylene glycol 400

PTM databases

iPTMnetiQ9BUP3
PhosphoSitePlusiQ9BUP3
SwissPalmiQ9BUP3

Polymorphism and mutation databases

BioMutaiHTATIP2
DMDMi317373366

Proteomic databases

EPDiQ9BUP3
jPOSTiQ9BUP3
MassIVEiQ9BUP3
MaxQBiQ9BUP3
PaxDbiQ9BUP3
PeptideAtlasiQ9BUP3
PRIDEiQ9BUP3
ProteomicsDBi79117 [Q9BUP3-1]
79118 [Q9BUP3-2]
79119 [Q9BUP3-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
10553
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000419348; ENSP00000392985; ENSG00000109854 [Q9BUP3-3]
ENST00000421577; ENSP00000397752; ENSG00000109854 [Q9BUP3-1]
ENST00000443524; ENSP00000387876; ENSG00000109854 [Q9BUP3-1]
ENST00000451739; ENSP00000394259; ENSG00000109854 [Q9BUP3-1]
ENST00000530266; ENSP00000436548; ENSG00000109854 [Q9BUP3-2]
ENST00000532081; ENSP00000432107; ENSG00000109854 [Q9BUP3-2]
ENST00000532505; ENSP00000432338; ENSG00000109854 [Q9BUP3-2]
GeneIDi10553
KEGGihsa:10553
UCSCiuc001mpx.3 human [Q9BUP3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10553
DisGeNETi10553

GeneCards: human genes, protein and diseases

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GeneCardsi
HTATIP2
HGNCiHGNC:16637 HTATIP2
HPAiHPA006417
HPA024321
MIMi605628 gene
neXtProtiNX_Q9BUP3
OpenTargetsiENSG00000109854
PharmGKBiPA29539

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4039 Eukaryota
COG0702 LUCA
GeneTreeiENSGT00390000008184
InParanoidiQ9BUP3
KOiK17290
OMAiHLENPVG
OrthoDBi1601023at2759
PhylomeDBiQ9BUP3
TreeFamiTF312849

Miscellaneous databases

EvolutionaryTraceiQ9BUP3

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HTATIP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10553

Pharos

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Pharosi
Q9BUP3

Protein Ontology

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PROi
PR:Q9BUP3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000109854 Expressed in 228 organ(s), highest expression level in jejunal mucosa
ExpressionAtlasiQ9BUP3 baseline and differential
GenevisibleiQ9BUP3 HS

Family and domain databases

InterProiView protein in InterPro
IPR016040 NAD(P)-bd_dom
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF13460 NAD_binding_10, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHTAI2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BUP3
Secondary accession number(s): A8K7S7
, D3DQY8, O15383, O60520, O95345, Q53GC1, Q53GG2, Q6IBI3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: January 11, 2011
Last modified: September 18, 2019
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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