G6PC3

Functionⁱ

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function.3 Publications

Caution

According to PubMed:12370122, it has no hydrolytic activity.Curated

Catalytic activityⁱ

D-glucose 6-phosphate + H₂O = D-glucose + phosphate.1 Publication

Activity regulationⁱ

Inhibited by vanadate.1 Publication

Kineticsⁱ

8 times less active compared to G6PC under the same experimental conditions.

Pathwayⁱ: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	79	SubstrateSequence analysis	1
Active siteⁱ	114	Proton donorSequence analysis	1
Binding siteⁱ	161	SubstrateSequence analysis	1
Active siteⁱ	167	Nucleophile1 Publication	1

GO - Molecular functionⁱ

glucose-6-phosphatase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25492228

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

gluconeogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
glucose 6-phosphate metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
glucose-6-phosphate transport Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Gluconeogenesis

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS13873-MONOMER
BRENDAⁱ	3.1.3.9 2681
Reactomeⁱ	R-HSA-3282872 Severe congenital neutropenia type 4 (G6PC3) R-HSA-70263 Gluconeogenesis
SABIO-RKⁱ	Q9BUM1
UniPathwayⁱ	UPA00138

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glucose-6-phosphatase 3 (EC:3.1.3.9) Short name: G-6-Pase 3 Short name: G6Pase 3 Alternative name(s): Glucose-6-phosphatase beta Short name: G6Pase-beta Ubiquitous glucose-6-phosphatase catalytic subunit-related protein
Gene namesⁱ	Name:G6PC3 Synonyms:UGRP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000141349.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24861 G6PC3
MIMⁱ	611045 gene
neXtProtⁱ	NX_Q9BUM1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 24	LumenalSequence analysisAdd BLAST	24
Transmembraneⁱ	25 – 45	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	46 – 54	CytoplasmicSequence analysis	9
Transmembraneⁱ	55 – 75	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	76 – 114	LumenalSequence analysisAdd BLAST	39
Transmembraneⁱ	115 – 135	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	136 – 146	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	147 – 164	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	165 – 169	LumenalSequence analysis	5
Transmembraneⁱ	170 – 186	HelicalSequence analysisAdd BLAST	17
Topological domainⁱ	187 – 197	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	198 – 218	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	219 – 254	LumenalSequence analysisAdd BLAST	36
Transmembraneⁱ	255 – 273	HelicalSequence analysisAdd BLAST	19
Topological domainⁱ	274 – 283	CytoplasmicSequence analysis	10
Transmembraneⁱ	284 – 304	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	305 – 307	LumenalSequence analysis	3
Transmembraneⁱ	308 – 328	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	329 – 346	CytoplasmicSequence analysisAdd BLAST	18

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Neutropenia, severe congenital 4, autosomal recessive (SCN4)10 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.

Dursun syndrome (DURSS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease characterized by pulmonary arterial hypertension, cardiac abnormalities including secundum-type atrial septal defect, intermittent neutropenia, lymphopenia, monocytosis and anemia.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	79	R → A: Loss of catalytic activity. 1 Publication	1
Mutagenesisⁱ	114	H → A: Loss of catalytic activity. 1 Publication	1
Mutagenesisⁱ	167	H → A: Loss of catalytic activity. 1 Publication	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	92579
MalaCards human disease database More...MalaCardsⁱ	G6PC3
MIMⁱ	612541 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000141349
Orphanetⁱ	331176 Autosomal recessive severe congenital neutropenia due to G6PC3 deficiency
PharmGKBⁱ	PA134968446

Polymorphism and mutation databases

BioMutaⁱ	G6PC3
DMDMⁱ	74733234

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000334512	1 – 346	Glucose-6-phosphatase 3Add BLAST		346

Proteomic databases

EPDⁱ	Q9BUM1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BUM1
PaxDbⁱ	Q9BUM1
PeptideAtlas More...PeptideAtlasⁱ	Q9BUM1
PRIDEⁱ	Q9BUM1
ProteomicsDBⁱ	79110

PTM databases

DEPODⁱ	Q9BUM1
iPTMnetⁱ	Q9BUM1
PhosphoSitePlusⁱ	Q9BUM1
SwissPalmⁱ	Q9BUM1

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed. Highly expressed in skeletal muscle, at intermediate levels in heart, brain, placenta, kidney, colon, thymus, spleen and pancreas. Also detected in testis, prostate, ovary, liver, lung, small intestine and peripheral blood lymphocytes.3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000141349 Expressed in 220 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_G6PC3
ExpressionAtlasⁱ	Q9BUM1 baseline and differential
Genevisibleⁱ	Q9BUM1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA067052

HPAⁱ

HPA067052

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000269097

STRINGⁱ

9606.ENSP00000269097

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BUM1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the glucose-6-phosphatase family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IDXG Eukaryota ENOG4110AJ7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046465
HOGENOMⁱ	HOG000264239
HOVERGENⁱ	HBG003560
InParanoidⁱ	Q9BUM1
KEGG Orthology (KO) More...KOⁱ	K01084
OMAⁱ	TLWPCLV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AXF
PhylomeDBⁱ	Q9BUM1
TreeFamⁱ	TF324388

Family and domain databases

InterProⁱ	View protein in InterPro IPR016275 Glucose-6-phosphatase IPR036938 P_Acid_Pase_2/haloperoxi_sf IPR000326 P_Acid_Pase_2/haloperoxidase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01569 PAP2, 1 hit
PIRSFⁱ	PIRSF000905 Glucose-6-phosphatase, 1 hit
SMARTⁱ	View protein in SMART SM00014 acidPPc, 1 hit
SUPFAMⁱ	SSF48317 SSF48317, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q9BUM1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MESTLGAGIV IAEALQNQLA WLENVWLWIT FLGDPKILFL FYFPAAYYAS 
        60         70         80         90        100
RRVGIAVLWI SLITEWLNLI FKWFLFGDRP FWWVHESGYY SQAPAQVHQF 
       110        120        130        140        150
PSSCETGPGS PSGHCMITGA ALWPIMTALS SQVATRARSR WVRVMPSLAY 
       160        170        180        190        200
CTFLLAVGLS RIFILAHFPH QVLAGLITGA VLGWLMTPRV PMERELSFYG 
       210        220        230        240        250
LTALALMLGT SLIYWTLFTL GLDLSWSISL AFKWCERPEW IHVDSRPFAS 
       260        270        280        290        300
LSRDSGAALG LGIALHSPCY AQVRRAQLGN GQKIACLVLA MGLLGPLDWL 
       310        320        330        340 
GHPPQISLFY IFNFLKYTLW PCLVLALVPW AVHMFSAQEA PPIHSS

Length:346

Mass (Da):38,735

Last modified:March 1, 2004 - v2

Checksum:ⁱ55C1F322E59C8439

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7ESE6	K7ESE6_HUMAN	Glucose-6-phosphatase 3 Glucose-6-phosphatase 3	G6PC3	243	Annotation score:
K7EQ13	K7EQ13_HUMAN	Glucose-6-phosphatase 3 Glucose-6-phosphatase 3	G6PC3	72	Annotation score:
K7ENK1	K7ENK1_HUMAN	Glucose-6-phosphatase 3 Glucose-6-phosphatase 3	G6PC3	73	Annotation score:
K7EJC5	K7EJC5_HUMAN	Glucose-6-phosphatase 3 Glucose-6-phosphatase 3	G6PC3	69	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_073174	44	P → L in SCN4; complete loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs762019955Ensembl.	1
Natural variantⁱVAR_072753	44	P → S in SCN4; complete loss of activity; purified neutrophils from patients have higher levels of spontaneous and staurosporine-induced apoptosis than controls. 3 PublicationsCorresponds to variant dbSNP:rs775224457EnsemblClinVar.	1
Natural variantⁱVAR_072754	59	W → R in SCN4. 1 PublicationCorresponds to variant dbSNP:rs752966267Ensembl.	1
Natural variantⁱVAR_072755	64 – 70	Missing in SCN4; purified neutrophils from patients have higher levels of spontaneous and staurosporine-induced apoptosis than controls. 1 Publication	7
Natural variantⁱVAR_073175	116	M → I in SCN4; complete loss of activity. 1 Publication	1
Natural variantⁱVAR_064508	116	M → K in SCN4; the patient also carries mutation Thr-166 in ELANE; complete loss of activity. 3 Publications	1
Natural variantⁱVAR_072756	116	M → T in SCN4; complete loss of activity. 2 Publications	1
Natural variantⁱVAR_064509	116	M → V in DURSS and SCN4; complete loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs267606834EnsemblClinVar.	1
Natural variantⁱVAR_073176	118	T → R in SCN4; complete loss of activity. 1 PublicationCorresponds to variant dbSNP:rs766706036Ensembl.	1
Natural variantⁱVAR_072757	139	S → I in SCN4; partial loss of activity. 2 Publications	1
Natural variantⁱVAR_072758	154	L → P in SCN4; complete loss of activity. 2 Publications	1
Natural variantⁱVAR_073177	161	R → Q in SCN4; complete loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs1485073209Ensembl.	1
Natural variantⁱVAR_055156	185	L → P in SCN4; complete loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs118203969EnsemblClinVar.	1
Natural variantⁱVAR_064510	189	R → Q in SCN4; partial loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs140294222EnsemblClinVar.	1
Natural variantⁱVAR_072759	208	L → R in SCN4; complete loss of activity. 2 Publications	1
Natural variantⁱVAR_043378	216	T → I. Corresponds to variant dbSNP:rs34406052EnsemblClinVar.	1
Natural variantⁱVAR_073178	253	R → C in SCN4. 1 PublicationCorresponds to variant dbSNP:rs765927570Ensembl.	1
Natural variantⁱVAR_055157	253	R → H in SCN4; complete loss of activity; peripheral-blood patient neutrophils have an increased rate of spontaneous apoptosis; transmission electron microscopy of patient bone marrow cells shows an enlarged rough endoplasmic reticulum in myeloid progenitor cells consistent with increased ER stress. 3 PublicationsCorresponds to variant dbSNP:rs118203968EnsemblClinVar.	1
Natural variantⁱVAR_072760	260	G → D in SCN4; complete loss of activity. 2 Publications	1
Natural variantⁱVAR_064511	260	G → R in SCN4; complete loss of activity. 4 PublicationsCorresponds to variant dbSNP:rs200478425EnsemblClinVar.	1
Natural variantⁱVAR_055158	262	G → R in SCN4. 1 PublicationCorresponds to variant dbSNP:rs118203971EnsemblClinVar.	1
Natural variantⁱVAR_072761	325	L → R in SCN4. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471178 Genomic DNA Translation: EAW51638.1 BC002494 mRNA Translation: AAH02494.2 BC021574 mRNA Translation: AAH21574.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11476.1
NCBI Reference Sequences More...RefSeqⁱ	NP_612396.1, NM_138387.3
UniGeneⁱ	Hs.294005

Genome annotation databases

Ensemblⁱ	ENST00000269097; ENSP00000269097; ENSG00000141349
GeneIDⁱ	92579
KEGGⁱ	hsa:92579
UCSC genome browser More...UCSCⁱ	uc002iex.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BUM1	Glucose-6-phosphatase 3		HUMAN		73	UniRef100_Q9BUM1
G6PC3 isoform 2		PANTR		73
G6PC3 isoform 2		PONAB		73
Glucose-6-phosphatase 3		HUMAN		72
G6PC3 isoform 3		PONAB		72
+2

Protein	Similar proteins		Species	Score	Length	Source
Q9BUM1	Glucose-6-phosphatase 3		BOVIN		346	UniRef90_Q9BUM1
Glucose-6-phosphatase 3		HUMAN		73
G6PC3 isoform 2		PANTR		73
G6PC3 isoform 2		PONAB		73
glucose-6-phosphatase 3		URSMA		416
+81

Protein	Similar proteins		Species	Score	Length	Source
Q9BUM1	Glucose-6-phosphatase 3		BOVIN		346	UniRef50_Q9BUM1
Glucose-6-phosphatase 3		HUMAN		73
G6PC3 isoform 2		PANTR		73
G6PC3 isoform 2		PONAB		73
glucose-6-phosphatase 3		URSMA		416
+93

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471178 Genomic DNA Translation: EAW51638.1 BC002494 mRNA Translation: AAH02494.2 BC021574 mRNA Translation: AAH21574.1
CCDSⁱ	CCDS11476.1
RefSeqⁱ	NP_612396.1, NM_138387.3
UniGeneⁱ	Hs.294005

3D structure databases

ProteinModelPortalⁱ	Q9BUM1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000269097

STRINGⁱ

9606.ENSP00000269097

PTM databases

DEPODⁱ	Q9BUM1
iPTMnetⁱ	Q9BUM1
PhosphoSitePlusⁱ	Q9BUM1
SwissPalmⁱ	Q9BUM1

Polymorphism and mutation databases

BioMutaⁱ	G6PC3
DMDMⁱ	74733234

Proteomic databases

EPDⁱ	Q9BUM1
MaxQBⁱ	Q9BUM1
PaxDbⁱ	Q9BUM1
PeptideAtlasⁱ	Q9BUM1
PRIDEⁱ	Q9BUM1
ProteomicsDBⁱ	79110

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000269097; ENSP00000269097; ENSG00000141349
GeneIDⁱ	92579
KEGGⁱ	hsa:92579
UCSCⁱ	uc002iex.4 human

Organism-specific databases

CTDⁱ	92579
DisGeNETⁱ	92579
EuPathDBⁱ	HostDB:ENSG00000141349.8
GeneCardsⁱ	G6PC3
H-InvDBⁱ	HIX0013874
HGNCⁱ	HGNC:24861 G6PC3
HPAⁱ	HPA067052
MalaCardsⁱ	G6PC3
MIMⁱ	611045 gene 612541 phenotype
neXtProtⁱ	NX_Q9BUM1
OpenTargetsⁱ	ENSG00000141349
Orphanetⁱ	331176 Autosomal recessive severe congenital neutropenia due to G6PC3 deficiency
PharmGKBⁱ	PA134968446
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IDXG Eukaryota ENOG4110AJ7 LUCA
GeneTreeⁱ	ENSGT00510000046465
HOGENOMⁱ	HOG000264239
HOVERGENⁱ	HBG003560
InParanoidⁱ	Q9BUM1
KOⁱ	K01084
OMAⁱ	TLWPCLV
OrthoDBⁱ	EOG091G0AXF
PhylomeDBⁱ	Q9BUM1
TreeFamⁱ	TF324388

Enzyme and pathway databases

UniPathwayⁱ	UPA00138
BioCycⁱ	MetaCyc:HS13873-MONOMER
BRENDAⁱ	3.1.3.9 2681
Reactomeⁱ	R-HSA-3282872 Severe congenital neutropenia type 4 (G6PC3) R-HSA-70263 Gluconeogenesis
SABIO-RKⁱ	Q9BUM1

Miscellaneous databases

ChiTaRSⁱ	G6PC3 human
GeneWikiⁱ	G6PC3
GenomeRNAiⁱ	92579
Protein Ontology More...PROⁱ	PR:Q9BUM1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000141349 Expressed in 220 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_G6PC3
ExpressionAtlasⁱ	Q9BUM1 baseline and differential
Genevisibleⁱ	Q9BUM1 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR016275 Glucose-6-phosphatase IPR036938 P_Acid_Pase_2/haloperoxi_sf IPR000326 P_Acid_Pase_2/haloperoxidase
Pfamⁱ	View protein in Pfam PF01569 PAP2, 1 hit
PIRSFⁱ	PIRSF000905 Glucose-6-phosphatase, 1 hit
SMARTⁱ	View protein in SMART SM00014 acidPPc, 1 hit
SUPFAMⁱ	SSF48317 SSF48317, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G6PC3_HUMAN
Accessionⁱ	Q9BUM1Primary (citable) accession number: Q9BUM1 Secondary accession number(s): Q8WU15
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
	Last sequence update:	March 1, 2004
	Last modified:	November 7, 2018
	This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

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UniProtKB - Q9BUM1 (G6PC3_HUMAN)

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Glucose-6-phosphatase 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: gluconeogenesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Dursun syndrome (DURSS)1 PublicationManual assertion based on experiment iniRef.9"Mutations in the G6PC3 gene cause Dursun syndrome."Banka S., Newman W.G., Ozgul R.K., Dursun A.Am. J. Med. Genet. A 152:2609-2611(2010) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANT DURSS VAL-116.

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Kineticsⁱ

Pathwayⁱ: gluconeogenesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Dursun syndrome (DURSS)1 Publication

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ