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Protein

Programmed cell death protein 10

Gene

PDCD10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity (PubMed:27807006). Important for cell migration, and for normal structure and assembly of the Golgi complex (PubMed:27807006). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity).By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAngiogenesis, Apoptosis

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9BUL8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Programmed cell death protein 10
Alternative name(s):
Cerebral cavernous malformations 3 protein
TF-1 cell apoptosis-related protein 15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDCD10
Synonyms:CCM3, TFAR15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000114209.14

Human Gene Nomenclature Database

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HGNCi
HGNC:8761 PDCD10

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609118 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9BUL8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cerebral cavernous malformations 3 (CCM3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA congenital vascular anomaly of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.
See also OMIM:603285

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi132K → D: Loss of interaction with CCM2 and PXN; when associated with D-139; D-172 and D-179. 1 Publication1
Mutagenesisi135A → D: Loss of interaction with CCM2. 1 Publication1
Mutagenesisi139K → D: Loss of interaction with CCM2 and PXN; when associated with D-132; D-172 and D-179. 1 Publication1
Mutagenesisi172K → D: Loss of interaction with CCM2 and PXN; when associated with D-132; D-139 and D-179. 1 Publication1
Mutagenesisi175S → D: Loss of interaction with CCM2. 1 Publication1
Mutagenesisi179K → D: Loss of interaction with CCM2 and PXN; when associated with D-132; D-139 and D-172. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
11235

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
PDCD10

MalaCards human disease database

More...
MalaCardsi
PDCD10
MIMi603285 phenotype

Open Targets

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OpenTargetsi
ENSG00000114209

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
221061 Familial cerebral cavernous malformation

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA33111

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PDCD10

Domain mapping of disease mutations (DMDM)

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DMDMi
74733232

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001875621 – 212Programmed cell death protein 10Add BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei179N6-acetyllysineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki186Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9BUL8

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9BUL8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9BUL8

PeptideAtlas

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PeptideAtlasi
Q9BUL8

PRoteomics IDEntifications database

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PRIDEi
Q9BUL8

ProteomicsDB human proteome resource

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ProteomicsDBi
79108

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q9BUL8

2D gel databases

USC-OGP 2-DE database

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OGPi
Q9BUL8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9BUL8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9BUL8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000114209 Expressed in 233 organ(s), highest expression level in bone marrow

CleanEx database of gene expression profiles

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CleanExi
HS_PDCD10

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BUL8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9BUL8 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA027095

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:20489202). Interacts (via C-terminus) with CCM2 (PubMed:17360971, PubMed:20489202). Interacts (via C-terminus) with PXN (PubMed:20489202). Interacts (via N-terminus) with STK25 (PubMed:17360971, PubMed:20332113). Interacts (via N-terminus) with STK26 (PubMed:17360971, PubMed:20332113, PubMed:27807006). Interacts (via N-terminus) with STK24 (PubMed:20332113, PubMed:27807006). Interacts with GOLGA2 (PubMed:20332113). Identified in a complex with KRIT1 and CCM2. Interacts with KDR/VEGFR2. Interaction with KDR/VEGFR2 is enhanced by stimulation with VEGFA (By similarity). Interacts with RIPOR1 (via C-terminus); this interaction is required for the association of RIPOR1 with either STK24 and STK26 kinases and occurs in a Rho-independent manner (PubMed:27807006).By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116400, 60 interactors

Database of interacting proteins

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DIPi
DIP-40607N

Protein interaction database and analysis system

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IntActi
Q9BUL8, 39 interactors

Molecular INTeraction database

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MINTi
Q9BUL8

STRING: functional protein association networks

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STRINGi
9606.ENSP00000376506

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1212
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9BUL8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BUL8

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9BUL8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PDCD10 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4025 Eukaryota
ENOG410XTA6 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000017913

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000007888

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052811

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9BUL8

KEGG Orthology (KO)

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KOi
K18269

Identification of Orthologs from Complete Genome Data

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OMAi
TMGDETP

Database of Orthologous Groups

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OrthoDBi
EOG091G0JQQ

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9BUL8

TreeFam database of animal gene trees

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TreeFami
TF105802

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009652 PDCD10

The PANTHER Classification System

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PANTHERi
PTHR13250 PTHR13250, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q9BUL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRMTMEEMKN EAETTSMVSM PLYAVMYPVF NELERVNLSA AQTLRAAFIK
60 70 80 90 100
AEKENPGLTQ DIIMKILEKK SVEVNFTESL LRMAADDVEE YMIERPEPEF
110 120 130 140 150
QDLNEKARAL KQILSKIPDE INDRVRFLQT IKDIASAIKE LLDTVNNVFK
160 170 180 190 200
KYQYQNRRAL EHQKKEFVKY SKSFSDTLKT YFKDGKAINV FVSANRLIHQ
210
TNLILQTFKT VA
Length:212
Mass (Da):24,702
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5AA613F71FAAEF56
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J363C9J363_HUMAN
Programmed cell death 10, isoform C...
PDCD10 hCG_27561
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J5C3C9J5C3_HUMAN
Programmed cell death protein 10
PDCD10
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JSA3C9JSA3_HUMAN
Programmed cell death protein 10
PDCD10
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J6F3C9J6F3_HUMAN
Programmed cell death protein 10
PDCD10
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JND6C9JND6_HUMAN
Programmed cell death protein 10
PDCD10
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDF3F8WDF3_HUMAN
Programmed cell death protein 10
PDCD10
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J932C9J932_HUMAN
Programmed cell death protein 10
PDCD10
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5M9H7C5M9_HUMAN
Programmed cell death protein 10
PDCD10
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_023578102D → A1 PublicationCorresponds to variant dbSNP:rs1129087Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF022385 mRNA Translation: AAB72225.1
CR457107 mRNA Translation: CAG33388.1
AK291130 mRNA Translation: BAF83819.1
AC079822 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78574.1
CH471052 Genomic DNA Translation: EAW78575.1
CH471052 Genomic DNA Translation: EAW78576.1
CH471052 Genomic DNA Translation: EAW78577.1
CH471052 Genomic DNA Translation: EAW78578.1
CH471052 Genomic DNA Translation: EAW78580.1
CH471052 Genomic DNA Translation: EAW78581.1
BC002506 mRNA Translation: AAH02506.1
BC016353 mRNA Translation: AAH16353.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3202.1

NCBI Reference Sequences

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RefSeqi
NP_009148.2, NM_007217.3
NP_665858.1, NM_145859.1
NP_665859.1, NM_145860.1
XP_005247143.1, XM_005247086.4
XP_005247144.1, XM_005247087.4
XP_005247145.1, XM_005247088.3
XP_006713548.1, XM_006713485.3
XP_011510670.1, XM_011512368.2
XP_011510671.1, XM_011512369.2
XP_016861133.1, XM_017005644.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.478150

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000392750; ENSP00000376506; ENSG00000114209
ENST00000461494; ENSP00000420021; ENSG00000114209
ENST00000470131; ENSP00000417202; ENSG00000114209
ENST00000473645; ENSP00000418317; ENSG00000114209
ENST00000497056; ENSP00000420553; ENSG00000114209

Database of genes from NCBI RefSeq genomes

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GeneIDi
11235

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:11235

UCSC genome browser

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UCSCi
uc003fex.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022385 mRNA Translation: AAB72225.1
CR457107 mRNA Translation: CAG33388.1
AK291130 mRNA Translation: BAF83819.1
AC079822 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78574.1
CH471052 Genomic DNA Translation: EAW78575.1
CH471052 Genomic DNA Translation: EAW78576.1
CH471052 Genomic DNA Translation: EAW78577.1
CH471052 Genomic DNA Translation: EAW78578.1
CH471052 Genomic DNA Translation: EAW78580.1
CH471052 Genomic DNA Translation: EAW78581.1
BC002506 mRNA Translation: AAH02506.1
BC016353 mRNA Translation: AAH16353.1
CCDSiCCDS3202.1
RefSeqiNP_009148.2, NM_007217.3
NP_665858.1, NM_145859.1
NP_665859.1, NM_145860.1
XP_005247143.1, XM_005247086.4
XP_005247144.1, XM_005247087.4
XP_005247145.1, XM_005247088.3
XP_006713548.1, XM_006713485.3
XP_011510670.1, XM_011512368.2
XP_011510671.1, XM_011512369.2
XP_016861133.1, XM_017005644.1
UniGeneiHs.478150

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AJMX-ray2.30A/B8-212[»]
3L8IX-ray2.50A/B/C/D1-212[»]
3L8JX-ray3.05A14-212[»]
3RQEX-ray2.80A/B/C/D1-212[»]
3RQFX-ray2.70A/B/C/D1-212[»]
3RQGX-ray2.50A/B/C/D1-212[»]
3W8HX-ray2.43A8-212[»]
3W8IX-ray2.40A8-212[»]
4GEHX-ray1.95A/C9-212[»]
4TVQX-ray2.80A/B/C/D1-212[»]
ProteinModelPortaliQ9BUL8
SMRiQ9BUL8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116400, 60 interactors
DIPiDIP-40607N
IntActiQ9BUL8, 39 interactors
MINTiQ9BUL8
STRINGi9606.ENSP00000376506

PTM databases

iPTMnetiQ9BUL8
PhosphoSitePlusiQ9BUL8

Polymorphism and mutation databases

BioMutaiPDCD10
DMDMi74733232

2D gel databases

OGPiQ9BUL8

Proteomic databases

EPDiQ9BUL8
MaxQBiQ9BUL8
PaxDbiQ9BUL8
PeptideAtlasiQ9BUL8
PRIDEiQ9BUL8
ProteomicsDBi79108
TopDownProteomicsiQ9BUL8

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
11235
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392750; ENSP00000376506; ENSG00000114209
ENST00000461494; ENSP00000420021; ENSG00000114209
ENST00000470131; ENSP00000417202; ENSG00000114209
ENST00000473645; ENSP00000418317; ENSG00000114209
ENST00000497056; ENSP00000420553; ENSG00000114209
GeneIDi11235
KEGGihsa:11235
UCSCiuc003fex.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
11235
DisGeNETi11235
EuPathDBiHostDB:ENSG00000114209.14

GeneCards: human genes, protein and diseases

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GeneCardsi
PDCD10
GeneReviewsiPDCD10
HGNCiHGNC:8761 PDCD10
HPAiHPA027095
MalaCardsiPDCD10
MIMi603285 phenotype
609118 gene
neXtProtiNX_Q9BUL8
OpenTargetsiENSG00000114209
Orphaneti221061 Familial cerebral cavernous malformation
PharmGKBiPA33111

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4025 Eukaryota
ENOG410XTA6 LUCA
GeneTreeiENSGT00390000017913
HOGENOMiHOG000007888
HOVERGENiHBG052811
InParanoidiQ9BUL8
KOiK18269
OMAiTMGDETP
OrthoDBiEOG091G0JQQ
PhylomeDBiQ9BUL8
TreeFamiTF105802

Enzyme and pathway databases

SIGNORiQ9BUL8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PDCD10 human
EvolutionaryTraceiQ9BUL8

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PDCD10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
11235

Protein Ontology

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PROi
PR:Q9BUL8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000114209 Expressed in 233 organ(s), highest expression level in bone marrow
CleanExiHS_PDCD10
ExpressionAtlasiQ9BUL8 baseline and differential
GenevisibleiQ9BUL8 HS

Family and domain databases

InterProiView protein in InterPro
IPR009652 PDCD10
PANTHERiPTHR13250 PTHR13250, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDC10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BUL8
Secondary accession number(s): A8K515, D3DNN5, O14811
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: June 1, 2001
Last modified: December 5, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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