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UniProtKB - Q9BUL5 (PHF23_HUMAN)
Protein
PHD finger protein 23
Gene
PHF23
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 339 – 387 | PHD-typeAdd BLAST | 49 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- autophagy Source: UniProtKB-KW
- negative regulation of autophagosome assembly Source: GO_Central
- negative regulation of autophagosome maturation Source: GO_Central
- positive regulation of protein ubiquitination Source: GO_Central
Keywordsi
Biological process | Autophagy, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9BUL5 |
SignaLinki | Q9BUL5 |
Names & Taxonomyi
Protein namesi | Recommended name: PHD finger protein 231 PublicationAlternative name(s): PDH-containing protein JUNE-1By similarity |
Gene namesi | Name:PHF231 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28428, PHF23 |
MIMi | 612910, gene |
neXtProti | NX_Q9BUL5 |
VEuPathDBi | HostDB:ENSG00000040633 |
Subcellular locationi
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving PHF23 is found in a patient with acute myeloid leukemia (AML). Translocation t(11;17)(p15;p13) with NUP98.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 120 – 121 | Breakpoint for translocation to form NUP98-PHF23 oncogene | 2 |
Organism-specific databases
DisGeNETi | 79142 |
OpenTargetsi | ENSG00000040633 |
PharmGKBi | PA142671175 |
Miscellaneous databases
Pharosi | Q9BUL5, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2424508 |
Genetic variation databases
BioMutai | PHF23 |
DMDMi | 74733231 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000302830 | 1 – 403 | PHD finger protein 23Add BLAST | 403 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 124 | PhosphoserineCombined sources | 1 | |
Modified residuei | 147 | PhosphoserineCombined sources | 1 | |
Modified residuei | 150 | PhosphoserineCombined sources | 1 | |
Modified residuei | 165 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 315 | PhosphoserineCombined sources | 1 | |
Modified residuei | 316 | PhosphoserineCombined sources | 1 | |
Modified residuei | 317 | PhosphoserineCombined sources | 1 | |
Modified residuei | 400 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9BUL5 |
jPOSTi | Q9BUL5 |
MassIVEi | Q9BUL5 |
MaxQBi | Q9BUL5 |
PaxDbi | Q9BUL5 |
PeptideAtlasi | Q9BUL5 |
PRIDEi | Q9BUL5 |
ProteomicsDBi | 3757 4541 79106 [Q9BUL5-1] 79107 [Q9BUL5-2] |
PTM databases
iPTMneti | Q9BUL5 |
PhosphoSitePlusi | Q9BUL5 |
Expressioni
Tissue specificityi
Widely expressed in human tissues and various cell lines.1 Publication
Gene expression databases
Bgeei | ENSG00000040633, Expressed in blood and 208 other tissues |
ExpressionAtlasi | Q9BUL5, baseline and differential |
Genevisiblei | Q9BUL5, HS |
Organism-specific databases
HPAi | ENSG00000040633, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with LRSAM1.
1 PublicationBinary interactionsi
Q9BUL5
Protein-protein interaction databases
BioGRIDi | 122561, 23 interactors |
IntActi | Q9BUL5, 25 interactors |
MINTi | Q9BUL5 |
STRINGi | 9606.ENSP00000322579 |
Chemistry databases
BindingDBi | Q9BUL5 |
Miscellaneous databases
RNActi | Q9BUL5, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q9BUL5 |
SMRi | Q9BUL5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 30 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 50 – 123 | DisorderedSequence analysisAdd BLAST | 74 | |
Regioni | 139 – 321 | DisorderedSequence analysisAdd BLAST | 183 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 108 – 122 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 244 – 264 | Acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 272 – 291 | Pro residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 301 – 316 | Polar residuesSequence analysisAdd BLAST | 16 |
Domaini
The PHD-type zinc-finger domain is required for interaction with LRSAM1 and negative regulation of autophagy.1 Publication
Sequence similaritiesi
Belongs to the PHF23 family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 339 – 387 | PHD-typeAdd BLAST | 49 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG1844, Eukaryota |
GeneTreei | ENSGT00530000063882 |
HOGENOMi | CLU_047981_1_0_1 |
InParanoidi | Q9BUL5 |
OMAi | SGHKKDP |
OrthoDBi | 982722at2759 |
PhylomeDBi | Q9BUL5 |
TreeFami | TF331373 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00628, PHD, 1 hit |
SMARTi | View protein in SMART SM00249, PHD, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9BUL5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLEAMAEPSP EDPPPTLKPE TQPPEKRRRT IEDFNKFCSF VLAYAGYIPP
60 70 80 90 100
SKEESDWPAS GSSSPLRGES AADSDGWDSA PSDLRTIQTF VKKAKSSKRR
110 120 130 140 150
AAQAGPTQPG PPRSTFSRLQ APDSATLLEK MKLKDSLFDL DGPKVASPLS
160 170 180 190 200
PTSLTHTSRP PAALTPVPLS QGDLSHPPRK KDRKNRKLGP GAGAGFGVLR
210 220 230 240 250
RPRPTPGDGE KRSRIKKSKK RKLKKAERGD RLPPPGPPQA PPSDTDSEEE
260 270 280 290 300
EEEEEEEEEE EMATVVGGEA PVPVLPTPPE APRPPATVHP EGVPPADSES
310 320 330 340 350
KEVGSTETSQ DGDASSSEGE MRVMDEDIMV ESGDDSWDLI TCYCRKPFAG
360 370 380 390 400
RPMIECSLCG TWIHLSCAKI KKTNVPDFFY CQKCKELRPE ARRLGGPPKS
GEP
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L1N0 | I3L1N0_HUMAN | PHD finger protein 23 | PHF23 hCG_42023 | 273 | Annotation score: | ||
I3L410 | I3L410_HUMAN | PHD finger protein 23 | PHF23 | 201 | Annotation score: | ||
I3L0X3 | I3L0X3_HUMAN | PHD finger protein 23 | PHF23 | 36 | Annotation score: | ||
I3L4Q4 | I3L4Q4_HUMAN | PHD finger protein 23 | PHF23 | 203 | Annotation score: | ||
I3L0Y2 | I3L0Y2_HUMAN | PHD finger protein 23 | PHF23 | 186 | Annotation score: | ||
A0A087WVQ2 | A0A087WVQ2_HUMAN | PHD finger protein 23 | PHF23 | 158 | Annotation score: | ||
I3L2W6 | I3L2W6_HUMAN | PHD finger protein 23 | PHF23 | 59 | Annotation score: |
Sequence cautioni
The sequence ABK59096 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15498 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 390 | E → D in BAB15498 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057218 | 1 – 11 | MLEAMAEPSPE → MPGDCRR in isoform 4. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_056058 | 54 – 120 | Missing in isoform 3. 1 PublicationAdd BLAST | 67 | |
Alternative sequenceiVSP_027962 | 150 – 158 | SPTSLTHTS → SRPCAANTP in isoform 2. 1 Publication | 9 | |
Alternative sequenceiVSP_027963 | 159 – 403 | Missing in isoform 2. 1 PublicationAdd BLAST | 245 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF071958 mRNA Translation: ABK59096.1 Different initiation. EF071959 mRNA Translation: ABK59097.1 AY099328 mRNA Translation: AAM44129.1 AK026537 mRNA Translation: BAB15498.1 Frameshift. AK074766 mRNA Translation: BAC11192.1 AK122901 mRNA Translation: BAG53790.1 AK297040 mRNA Translation: BAG59568.1 AC120057 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90241.1 CH471108 Genomic DNA Translation: EAW90242.1 CH471108 Genomic DNA Translation: EAW90243.1 BC002509 mRNA Translation: AAH02509.1 BC008630 mRNA Translation: AAH08630.1 |
CCDSi | CCDS42250.1 [Q9BUL5-1] CCDS67143.1 [Q9BUL5-4] CCDS67144.1 [Q9BUL5-3] |
RefSeqi | NP_001271446.1, NM_001284517.1 [Q9BUL5-3] NP_001271447.1, NM_001284518.1 [Q9BUL5-4] NP_077273.2, NM_024297.2 [Q9BUL5-1] |
Genome annotation databases
Ensembli | ENST00000320316.8; ENSP00000322579.3; ENSG00000040633.13 ENST00000454255.6; ENSP00000414607.2; ENSG00000040633.13 [Q9BUL5-4] ENST00000571362.5; ENSP00000460738.1; ENSG00000040633.13 [Q9BUL5-3] |
GeneIDi | 79142 |
KEGGi | hsa:79142 |
MANE-Selecti | ENST00000320316.8; ENSP00000322579.3; NM_024297.3; NP_077273.2 |
UCSCi | uc002gfa.3, human [Q9BUL5-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF071958 mRNA Translation: ABK59096.1 Different initiation. EF071959 mRNA Translation: ABK59097.1 AY099328 mRNA Translation: AAM44129.1 AK026537 mRNA Translation: BAB15498.1 Frameshift. AK074766 mRNA Translation: BAC11192.1 AK122901 mRNA Translation: BAG53790.1 AK297040 mRNA Translation: BAG59568.1 AC120057 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90241.1 CH471108 Genomic DNA Translation: EAW90242.1 CH471108 Genomic DNA Translation: EAW90243.1 BC002509 mRNA Translation: AAH02509.1 BC008630 mRNA Translation: AAH08630.1 |
CCDSi | CCDS42250.1 [Q9BUL5-1] CCDS67143.1 [Q9BUL5-4] CCDS67144.1 [Q9BUL5-3] |
RefSeqi | NP_001271446.1, NM_001284517.1 [Q9BUL5-3] NP_001271447.1, NM_001284518.1 [Q9BUL5-4] NP_077273.2, NM_024297.2 [Q9BUL5-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6WXK | X-ray | 2.90 | A/B/C/D/E | 338-393 | [»] | |
AlphaFoldDBi | Q9BUL5 | |||||
SMRi | Q9BUL5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 122561, 23 interactors |
IntActi | Q9BUL5, 25 interactors |
MINTi | Q9BUL5 |
STRINGi | 9606.ENSP00000322579 |
Chemistry databases
BindingDBi | Q9BUL5 |
ChEMBLi | CHEMBL2424508 |
PTM databases
iPTMneti | Q9BUL5 |
PhosphoSitePlusi | Q9BUL5 |
Genetic variation databases
BioMutai | PHF23 |
DMDMi | 74733231 |
Proteomic databases
EPDi | Q9BUL5 |
jPOSTi | Q9BUL5 |
MassIVEi | Q9BUL5 |
MaxQBi | Q9BUL5 |
PaxDbi | Q9BUL5 |
PeptideAtlasi | Q9BUL5 |
PRIDEi | Q9BUL5 |
ProteomicsDBi | 3757 4541 79106 [Q9BUL5-1] 79107 [Q9BUL5-2] |
Protocols and materials databases
Antibodypediai | 23960, 52 antibodies from 14 providers |
DNASUi | 79142 |
Genome annotation databases
Ensembli | ENST00000320316.8; ENSP00000322579.3; ENSG00000040633.13 ENST00000454255.6; ENSP00000414607.2; ENSG00000040633.13 [Q9BUL5-4] ENST00000571362.5; ENSP00000460738.1; ENSG00000040633.13 [Q9BUL5-3] |
GeneIDi | 79142 |
KEGGi | hsa:79142 |
MANE-Selecti | ENST00000320316.8; ENSP00000322579.3; NM_024297.3; NP_077273.2 |
UCSCi | uc002gfa.3, human [Q9BUL5-1] |
Organism-specific databases
CTDi | 79142 |
DisGeNETi | 79142 |
GeneCardsi | PHF23 |
HGNCi | HGNC:28428, PHF23 |
HPAi | ENSG00000040633, Low tissue specificity |
MIMi | 612910, gene |
neXtProti | NX_Q9BUL5 |
OpenTargetsi | ENSG00000040633 |
PharmGKBi | PA142671175 |
VEuPathDBi | HostDB:ENSG00000040633 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1844, Eukaryota |
GeneTreei | ENSGT00530000063882 |
HOGENOMi | CLU_047981_1_0_1 |
InParanoidi | Q9BUL5 |
OMAi | SGHKKDP |
OrthoDBi | 982722at2759 |
PhylomeDBi | Q9BUL5 |
TreeFami | TF331373 |
Enzyme and pathway databases
PathwayCommonsi | Q9BUL5 |
SignaLinki | Q9BUL5 |
Miscellaneous databases
BioGRID-ORCSi | 79142, 87 hits in 1089 CRISPR screens |
ChiTaRSi | PHF23, human |
GenomeRNAii | 79142 |
Pharosi | Q9BUL5, Tbio |
PROi | PR:Q9BUL5 |
RNActi | Q9BUL5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000040633, Expressed in blood and 208 other tissues |
ExpressionAtlasi | Q9BUL5, baseline and differential |
Genevisiblei | Q9BUL5, HS |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00628, PHD, 1 hit |
SMARTi | View protein in SMART SM00249, PHD, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PHF23_HUMAN | |
Accessioni | Q9BUL5Primary (citable) accession number: Q9BUL5 Secondary accession number(s): A1DZ74 Q9H5X0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families