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Entry version 175 (13 Feb 2019)
Sequence version 2 (21 Mar 2006)
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Protein

Heterogeneous nuclear ribonucleoprotein U-like protein 1

Gene

HNRNPUL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro.2 Publications

Miscellaneous

Its methylation is enhanced in the late phase of adenoviral infection.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • mRNA splicing, via spliceosome Source: Reactome
  • response to virus Source: ProtInc
  • RNA processing Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor, Ribonucleoprotein, RNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-72163 mRNA Splicing - Major Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein U-like protein 1
Alternative name(s):
Adenovirus early region 1B-associated protein 5
E1B-55 kDa-associated protein 5
Short name:
E1B-AP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HNRNPUL1
Synonyms:E1BAP5, HNRPUL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000105323.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17011 HNRNPUL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605800 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BUJ2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11100

Open Targets

More...
OpenTargetsi
ENSG00000105323

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162391519

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HNRNPUL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
90101344

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002275551 – 856Heterogeneous nuclear ribonucleoprotein U-like protein 1Add BLAST856

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki117Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki117Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki142Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki142Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki146Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki162Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei194PhosphoserineCombined sources1
Modified residuei209PhosphothreonineBy similarity1
Cross-linki270Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki449Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei512PhosphoserineCombined sources1
Cross-linki539Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei639Asymmetric dimethylarginineCombined sources1
Modified residuei645Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei645Omega-N-methylarginine; alternateBy similarity1
Modified residuei656Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei656Omega-N-methylarginine; alternateBy similarity1
Modified residuei661Omega-N-methylarginineBy similarity1
Modified residuei671Omega-N-methylarginineCombined sources1
Modified residuei718PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Methylated.2 Publications

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BUJ2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BUJ2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BUJ2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BUJ2

PeptideAtlas

More...
PeptideAtlasi
Q9BUJ2

PRoteomics IDEntifications database

More...
PRIDEi
Q9BUJ2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79090
79091 [Q9BUJ2-2]
79092 [Q9BUJ2-3]
79093 [Q9BUJ2-4]
79094 [Q9BUJ2-5]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9BUJ2-2 [Q9BUJ2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BUJ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BUJ2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9BUJ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000105323 Expressed in 236 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BUJ2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BUJ2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB046477
HPA046290
HPA049475

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the adenovirus type 5 (Ad5) E1B-55 kDa, BRD7, PRMT2, TP53 and NXF1. Associates with histones and BRD7.5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116281, 139 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9BUJ2

Database of interacting proteins

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DIPi
DIP-39419N

Protein interaction database and analysis system

More...
IntActi
Q9BUJ2, 74 interactors

Molecular INTeraction database

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MINTi
Q9BUJ2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000375863

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9BUJ2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BUJ2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 37SAPPROSITE-ProRule annotationAdd BLAST35
Domaini191 – 388B30.2/SPRYPROSITE-ProRule annotationAdd BLAST198
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati612 – 6141-13
Repeati620 – 6221-23
Repeati639 – 6411-33
Repeati645 – 6471-43
Repeati656 – 6581-53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 103Necessary for interaction with HRMT1L1Add BLAST103
Regioni213 – 856Necessary for interaction with TP531 PublicationAdd BLAST644
Regioni456 – 594Necessary for interaction with BRD7 and transcriptional activation1 PublicationAdd BLAST139
Regioni612 – 6585 X 3 AA repeats of R-G-GAdd BLAST47
Regioni612 – 658Necessary for transcription repressionAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi613 – 666Gly-richAdd BLAST54
Compositional biasi670 – 689Asn-richAdd BLAST20
Compositional biasi692 – 811Pro-richAdd BLAST120
Compositional biasi757 – 845Tyr-richAdd BLAST89
Compositional biasi806 – 832Gln-richAdd BLAST27

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RGG-box domain is methylated.

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2242 Eukaryota
ENOG410XSBV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157823

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG061101

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9BUJ2

KEGG Orthology (KO)

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KOi
K15047

Identification of Orthologs from Complete Genome Data

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OMAi
QAYRPEV

Database of Orthologous Groups

More...
OrthoDBi
778148at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BUJ2

TreeFam database of animal gene trees

More...
TreeFami
TF317301

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12884 SPRY_hnRNP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.720.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR027025 hnRNP_U-like_1
IPR027417 P-loop_NTPase
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
IPR003877 SPRY_dom
IPR035778 SPRY_hnRNP_U

The PANTHER Classification System

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PANTHERi
PTHR12381:SF41 PTHR12381:SF41, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02037 SAP, 1 hit
PF00622 SPRY, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00513 SAP, 1 hit
SM00449 SPRY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit
SSF52540 SSF52540, 1 hit
SSF68906 SSF68906, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50800 SAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BUJ2-1) [UniParc]FASTAAdd to basket
Also known as: Isoform a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVRRLKVNE LREELQRRGL DTRGLKAELA ERLQAALEAE EPDDERELDA
60 70 80 90 100
DDEPGRPGHI NEEVETEGGS ELEGTAQPPP PGLQPHAEPG GYSGPDGHYA
110 120 130 140 150
MDNITRQNQF YDTQVIKQEN ESGYERRPLE MEQQQAYRPE MKTEMKQGAP
160 170 180 190 200
TSFLPPEASQ LKPDRQQFQS RKRPYEENRG RGYFEHREDR RGRSPQPPAE
210 220 230 240 250
EDEDDFDDTL VAIDTYNCDL HFKVARDRSS GYPLTIEGFA YLWSGARASY
260 270 280 290 300
GVRRGRVCFE MKINEEISVK HLPSTEPDPH VVRIGWSLDS CSTQLGEEPF
310 320 330 340 350
SYGYGGTGKK STNSRFENYG DKFAENDVIG CFADFECGND VELSFTKNGK
360 370 380 390 400
WMGIAFRIQK EALGGQALYP HVLVKNCAVE FNFGQRAEPY CSVLPGFTFI
410 420 430 440 450
QHLPLSERIR GTVGPKSKAE CEILMMVGLP AAGKTTWAIK HAASNPSKKY
460 470 480 490 500
NILGTNAIMD KMRVMGLRRQ RNYAGRWDVL IQQATQCLNR LIQIAARKKR
510 520 530 540 550
NYILDQTNVY GSAQRRKMRP FEGFQRKAIV ICPTDEDLKD RTIKRTDEEG
560 570 580 590 600
KDVPDHAVLE MKANFTLPDV GDFLDEVLFI ELQREEADKL VRQYNEEGRK
610 620 630 640 650
AGPPPEKRFD NRGGGGFRGR GGGGGFQRYE NRGPPGGNRG GFQNRGGGSG
660 670 680 690 700
GGGNYRGGFN RSGGGGYSQN RWGNNNRDNN NSNNRGSYNR APQQQPPPQQ
710 720 730 740 750
PPPPQPPPQQ PPPPPSYSPA RNPPGASTYN KNSNIPGSSA NTSTPTVSSY
760 770 780 790 800
SPPQPSYSQP PYNQGGYSQG YTAPPPPPPP PPAYNYGSYG GYNPAPYTPP
810 820 830 840 850
PPPTAQTYPQ PSYNQYQQYA QQWNQYYQNQ GQWPPYYGNY DYGSYSGNTQ

GGTSTQ
Length:856
Mass (Da):95,739
Last modified:March 21, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E57C0271E5F3A77
GO
Isoform 2 (identifier: Q9BUJ2-2) [UniParc]FASTAAdd to basket
Also known as: Isoform b

The sequence of this isoform differs from the canonical sequence as follows:
     755-806: Missing.

Show »
Length:804
Mass (Da):90,292
Checksum:i05950AF9FAFD192F
GO
Isoform 3 (identifier: Q9BUJ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-77: Missing.
     263-333: Missing.
     754-754: Q → QSFGFFPSTFQ

Show »
Length:752
Mass (Da):84,500
Checksum:i207A6A67EFFFA299
GO
Isoform 4 (identifier: Q9BUJ2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.

Show »
Length:756
Mass (Da):84,794
Checksum:iB16C6EC86B997FFA
GO
Isoform 5 (identifier: Q9BUJ2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-460: Missing.
     461-562: KMRVMGLRRQ...VPDHAVLEMK → MGFCHVGQAG...CSLWGTSFLL
     754-754: Q → QSFGFFPSTFQ

Note: May be due to intron retention. No experimental confirmation available.
Show »
Length:390
Mass (Da):42,189
Checksum:iA86E13953F84279F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z4B8B7Z4B8_HUMAN
cDNA FLJ56481, highly similar to He...
HNRNPUL1
767Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRA5A0A0A0MRA5_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPUL1
766Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R3F1M0R3F1_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPUL1
641Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYZ0M0QYZ0_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPUL1
371Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0K8M0R0K8_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPUL1
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZV6M0QZV6_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPUL1
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R247M0R247_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPUL1
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYI8M0QYI8_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPUL1
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYM5M0QYM5_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPUL1
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1I2A0A087X1I2_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPUL1
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti27A → T in CAA07548 (PubMed:9733834).Curated1
Sequence conflicti508N → S in BAC86806 (PubMed:14702039).Curated1
Sequence conflicti619G → A in CAA07548 (PubMed:9733834).Curated1
Sequence conflicti625G → A in CAA07548 (PubMed:9733834).Curated1
Sequence conflicti662S → N in CAA07548 (PubMed:9733834).Curated1
Sequence conflicti691A → S in BAC86806 (PubMed:14702039).Curated1
Sequence conflicti773A → G in CAA07548 (PubMed:9733834).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02560691G → C1 PublicationCorresponds to variant dbSNP:rs17849624Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0175461 – 460Missing in isoform 5. 1 PublicationAdd BLAST460
Alternative sequenceiVSP_0175471 – 100Missing in isoform 4. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_01754835 – 77Missing in isoform 3. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_017549263 – 333Missing in isoform 3. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_017550461 – 562KMRVM…VLEMK → MGFCHVGQAGLELLTSGDPP ASASQSAGITGVSHRARPSV FVFLIHYSSFLHLLPSGRPL FWVEGTRLQKVLTSSSCSLW GTSFLL in isoform 5. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_017551754Q → QSFGFFPSTFQ in isoform 3 and isoform 5. 1 Publication1
Alternative sequenceiVSP_017552755 – 806Missing in isoform 2. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ007509 mRNA Translation: CAA07548.1
AK021455 mRNA Translation: BAB13831.1
AK022863 mRNA Translation: BAG51129.1
AK127057 mRNA Translation: BAC86806.1
AC011462 Genomic DNA No translation available.
AC011510 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57025.1
BC002564 mRNA Translation: AAH02564.1
BC009988 mRNA Translation: AAH09988.2
BC014232 mRNA Translation: AAH14232.1
BC027713 mRNA Translation: AAH27713.1
AL050146 mRNA Translation: CAB43291.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12576.1 [Q9BUJ2-1]
CCDS12577.1 [Q9BUJ2-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
T08776
T13159

NCBI Reference Sequences

More...
RefSeqi
NP_001308137.1, NM_001321208.1 [Q9BUJ2-4]
NP_001308140.1, NM_001321211.1 [Q9BUJ2-4]
NP_008971.2, NM_007040.5 [Q9BUJ2-1]
NP_653333.1, NM_144732.4 [Q9BUJ2-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.155218
Hs.718642

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000378215; ENSP00000367460; ENSG00000105323 [Q9BUJ2-3]
ENST00000392006; ENSP00000375863; ENSG00000105323 [Q9BUJ2-1]
ENST00000593587; ENSP00000472629; ENSG00000105323 [Q9BUJ2-4]
ENST00000595018; ENSP00000473132; ENSG00000105323 [Q9BUJ2-4]
ENST00000602130; ENSP00000470687; ENSG00000105323 [Q9BUJ2-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11100

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11100

UCSC genome browser

More...
UCSCi
uc002opz.5 human [Q9BUJ2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007509 mRNA Translation: CAA07548.1
AK021455 mRNA Translation: BAB13831.1
AK022863 mRNA Translation: BAG51129.1
AK127057 mRNA Translation: BAC86806.1
AC011462 Genomic DNA No translation available.
AC011510 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57025.1
BC002564 mRNA Translation: AAH02564.1
BC009988 mRNA Translation: AAH09988.2
BC014232 mRNA Translation: AAH14232.1
BC027713 mRNA Translation: AAH27713.1
AL050146 mRNA Translation: CAB43291.1
CCDSiCCDS12576.1 [Q9BUJ2-1]
CCDS12577.1 [Q9BUJ2-4]
PIRiT08776
T13159
RefSeqiNP_001308137.1, NM_001321208.1 [Q9BUJ2-4]
NP_001308140.1, NM_001321211.1 [Q9BUJ2-4]
NP_008971.2, NM_007040.5 [Q9BUJ2-1]
NP_653333.1, NM_144732.4 [Q9BUJ2-4]
UniGeneiHs.155218
Hs.718642

3D structure databases

ProteinModelPortaliQ9BUJ2
SMRiQ9BUJ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116281, 139 interactors
CORUMiQ9BUJ2
DIPiDIP-39419N
IntActiQ9BUJ2, 74 interactors
MINTiQ9BUJ2
STRINGi9606.ENSP00000375863

PTM databases

iPTMnetiQ9BUJ2
PhosphoSitePlusiQ9BUJ2
SwissPalmiQ9BUJ2

Polymorphism and mutation databases

BioMutaiHNRNPUL1
DMDMi90101344

Proteomic databases

EPDiQ9BUJ2
jPOSTiQ9BUJ2
MaxQBiQ9BUJ2
PaxDbiQ9BUJ2
PeptideAtlasiQ9BUJ2
PRIDEiQ9BUJ2
ProteomicsDBi79090
79091 [Q9BUJ2-2]
79092 [Q9BUJ2-3]
79093 [Q9BUJ2-4]
79094 [Q9BUJ2-5]
TopDownProteomicsiQ9BUJ2-2 [Q9BUJ2-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
11100
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378215; ENSP00000367460; ENSG00000105323 [Q9BUJ2-3]
ENST00000392006; ENSP00000375863; ENSG00000105323 [Q9BUJ2-1]
ENST00000593587; ENSP00000472629; ENSG00000105323 [Q9BUJ2-4]
ENST00000595018; ENSP00000473132; ENSG00000105323 [Q9BUJ2-4]
ENST00000602130; ENSP00000470687; ENSG00000105323 [Q9BUJ2-2]
GeneIDi11100
KEGGihsa:11100
UCSCiuc002opz.5 human [Q9BUJ2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11100
DisGeNETi11100
EuPathDBiHostDB:ENSG00000105323.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HNRNPUL1
HGNCiHGNC:17011 HNRNPUL1
HPAiCAB046477
HPA046290
HPA049475
MIMi605800 gene
neXtProtiNX_Q9BUJ2
OpenTargetsiENSG00000105323
PharmGKBiPA162391519

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2242 Eukaryota
ENOG410XSBV LUCA
GeneTreeiENSGT00940000157823
HOVERGENiHBG061101
InParanoidiQ9BUJ2
KOiK15047
OMAiQAYRPEV
OrthoDBi778148at2759
PhylomeDBiQ9BUJ2
TreeFamiTF317301

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HNRNPUL1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
HNRPUL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11100

Protein Ontology

More...
PROi
PR:Q9BUJ2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105323 Expressed in 236 organ(s), highest expression level in testis
ExpressionAtlasiQ9BUJ2 baseline and differential
GenevisibleiQ9BUJ2 HS

Family and domain databases

CDDicd12884 SPRY_hnRNP, 1 hit
Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR027025 hnRNP_U-like_1
IPR027417 P-loop_NTPase
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
IPR003877 SPRY_dom
IPR035778 SPRY_hnRNP_U
PANTHERiPTHR12381:SF41 PTHR12381:SF41, 1 hit
PfamiView protein in Pfam
PF02037 SAP, 1 hit
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00513 SAP, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF52540 SSF52540, 1 hit
SSF68906 SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50800 SAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHNRL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BUJ2
Secondary accession number(s): B3KMW7
, O76022, Q6ZSZ0, Q7L8P4, Q8N6Z4, Q96G37, Q9HAL3, Q9UG75
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: February 13, 2019
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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