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Protein

Protein ABHD14A

Gene

ABHD14A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Possible role in granule neuron development.By similarity

Caution

It is uncertain whether Met-1 or Met-30 is the initiator.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei171Charge relay systemBy similarity1
Active sitei222Charge relay systemBy similarity1
Active sitei249Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Protein family/group databases

ESTHERihuman-ABHD14A CIB-CCG1-interacting-factor-B
MEROPSiS33.981

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ABHD14ACurated (EC:3.-.-.-)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 14ACurated
Short name:
Abhydrolase domain-containing protein 14AImported
Gene namesi
Name:ABHD14AImported
ORF Names:UNQ1913/PRO4373
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000248487.8
HGNCiHGNC:24538 ABHD14A
neXtProtiNX_Q9BUJ0

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 55Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000248487
PharmGKBiPA142672659

Polymorphism and mutation databases

BioMutaiABHD14A
DMDMi143955271

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002822851 – 271Protein ABHD14AAdd BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9BUJ0
MaxQBiQ9BUJ0
PaxDbiQ9BUJ0
PeptideAtlasiQ9BUJ0
PRIDEiQ9BUJ0
ProteomicsDBi79089

PTM databases

iPTMnetiQ9BUJ0
PhosphoSitePlusiQ9BUJ0

Expressioni

Gene expression databases

BgeeiENSG00000248487
CleanExiHS_ABHD14A
ExpressionAtlasiQ9BUJ0 baseline and differential
GenevisibleiQ9BUJ0 HS

Organism-specific databases

HPAiHPA038153
HPA056913

Interactioni

Protein-protein interaction databases

BioGridi117383, 41 interactors
IntActiQ9BUJ0, 1 interactor
STRINGi9606.ENSP00000273596

Structurei

3D structure databases

ProteinModelPortaliQ9BUJ0
SMRiQ9BUJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. ABHD14 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWCE Eukaryota
COG0596 LUCA
GeneTreeiENSGT00510000046860
HOGENOMiHOG000028065
HOVERGENiHBG001936
InParanoidiQ9BUJ0
KOiK13706
OrthoDBiEOG091G0VZR
PhylomeDBiQ9BUJ0
TreeFamiTF314465

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
PfamiView protein in Pfam
PF12697 Abhydrolase_6, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BUJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGALCGCWF RLGGARPLIP LGPTVVQTSM SRSQVALLGL SLLLMLLLYV
60 70 80 90 100
GLPGPPEQTS CLWGDPNVTV LAGLTPGNSP IFYREVLPLN QAHRVEVVLL
110 120 130 140 150
HGKAFNSHTW EQLGTLQLLS QRGYRAVALD LPGFGNSAPS KEASTEAGRA
160 170 180 190 200
ALLERALRDL EVQNAVLVSP SLSGHYALPF LMRGHHQLHG FVPIAPTSTQ
210 220 230 240 250
NYTQEQFWAV KTPTLILYGE LDHILARESL RQLRHLPNHS VVKLRNAGHA
260 270
CYLHKPQDFH LVLLAFLDHL P
Length:271
Mass (Da):29,765
Last modified:April 3, 2007 - v2
Checksum:iB9CAF975D3208F10
GO

Sequence cautioni

The sequence AAQ88568 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159D → N in CAB43237 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03139032R → Q1 PublicationCorresponds to variant dbSNP:rs17849626Ensembl.1
Natural variantiVAR_03139161C → W. Corresponds to variant dbSNP:rs404527Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358201 mRNA Translation: AAQ88568.1 Different initiation.
AL050015 mRNA Translation: CAB43237.2
BC002571 mRNA Translation: AAH02571.1
CCDSiCCDS2843.1
PIRiT08702
RefSeqiNP_056222.2, NM_015407.4
UniGeneiHs.534400

Genome annotation databases

EnsembliENST00000273596; ENSP00000273596; ENSG00000248487
GeneIDi25864
KEGGihsa:25864
UCSCiuc003dco.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiABHEA_HUMAN
AccessioniPrimary (citable) accession number: Q9BUJ0
Secondary accession number(s): Q6UXU8, Q9Y3T7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: July 18, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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