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Entry version 149 (16 Oct 2019)
Sequence version 1 (01 Jun 2001)
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Protein

DNA-directed RNA polymerase III subunit RPC3

Gene

POLR3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner (PubMed:21358628).3 Publications

Miscellaneous

Antibodies against POLR3C have been found in the sera of patients with systemic sclerosis (SSc).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA-directed 5'-3' RNA polymerase activity Source: ProtInc
  • single-stranded DNA binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processAntiviral defense, Immunity, Innate immunity, Transcription

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-73780 RNA Polymerase III Chain Elongation
R-HSA-73980 RNA Polymerase III Transcription Termination
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC3
Short name:
RNA polymerase III subunit C3
Alternative name(s):
DNA-directed RNA polymerase III subunit C
RNA polymerase III 62 kDa subunit
Short name:
RPC62
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POLR3C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30076 POLR3C

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617454 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BUI4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi51 – 52KK → EE: Strongly decreased ssDNA-binding. No effect on interaction with POLR3F, POLR3G, nor with POLR3GL. 1 Publication2
Mutagenesisi312L → K: Loss of interaction with POLR3G and POLR3GL. No effect on interaction with POLR3F. 1 Publication1
Mutagenesisi357R → E: Strongly decreased ssDNA-binding. No effect on interaction with POLR3F, POLR3G, nor with POLR3GL. 1 Publication1
Mutagenesisi364 – 367RIFR → EIFE: Strongly decreased ssDNA-binding. No effect on interaction with POLR3F, POLR3G, nor with POLR3GL. 1 Publication4
Mutagenesisi389K → E: Strongly decreased ssDNA-binding. No effect on interaction with POLR3F, POLR3G, nor with POLR3GL. 1 Publication1
Mutagenesisi445 – 449NLIER → ALIEE: Strongly decreased ssDNA-binding. No effect on interaction with POLR3F, POLR3G, nor with POLR3GL. 1 Publication5
Mutagenesisi466 – 470RVEAI → EVEAF: Mild decrease in ssDNA-binding. No effect on interaction with POLR3F, POLR3G, nor with POLR3GL. 1 Publication5

Organism-specific databases

DisGeNET

More...
DisGeNETi
10623

Open Targets

More...
OpenTargetsi
ENSG00000186141

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134870963

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BUI4

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
POLR3C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
60393871

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000739631 – 534DNA-directed RNA polymerase III subunit RPC3Add BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei194PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BUI4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BUI4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BUI4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BUI4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BUI4

PeptideAtlas

More...
PeptideAtlasi
Q9BUI4

PRoteomics IDEntifications database

More...
PRIDEi
Q9BUI4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79088

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BUI4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BUI4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9BUI4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186141 Expressed in 208 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BUI4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BUI4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027508
HPA027516

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex (PubMed:9171375, PubMed:12391170). Directly interacts with POLR3G and POLR3GL (PubMed:24107381, PubMed:21358628, PubMed:26394183). Directly interacts with POLR3F/RPC39 (PubMed:26394183).

Interacts with GTF3C4 (PubMed:10523658).

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115868, 45 interactors

Database of interacting proteins

More...
DIPi
DIP-59078N

Protein interaction database and analysis system

More...
IntActi
Q9BUI4, 46 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000334564

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1534
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BUI4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9BUI4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2587 Eukaryota
ENOG410XPVH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002799

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000046475

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BUI4

KEGG Orthology (KO)

More...
KOi
K03023

Identification of Orthologs from Complete Genome Data

More...
OMAi
LRYPRYV

Database of Orthologous Groups

More...
OrthoDBi
809282at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BUI4

TreeFam database of animal gene trees

More...
TreeFami
TF103048

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013197 RNA_pol_III_RPC82-rel_HTH
IPR008806 RNA_pol_III_Rpc82_C
IPR039748 RPC3
IPR036388 WH-like_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12949 PTHR12949, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08221 HTH_9, 1 hit
PF05645 RNA_pol_Rpc82, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BUI4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTQAEIKLCS LLLQEHFGEI VEKIGVHLIR TGSQPLRVIA HDTGTSLDQV
60 70 80 90 100
KKALCVLVQH NLVSYQVHKR GVVEYEAQCS RVLRMLRYPR YIYTTKTLYS
110 120 130 140 150
DTGELIVEEL LLNGKLTMSA VVKKVADRLT ETMEDGKTMD YAEVSNTFVR
160 170 180 190 200
LADTHFVQRC PSVPTTENSD PGPPPPAPTL VINEKDMYLV PKLSLIGKGK
210 220 230 240 250
RRRSSDEDAA GEPKAKRPKY TTDNKEPIPD DGIYWQANLD RFHQHFRDQA
260 270 280 290 300
IVSAVANRMD QTSSEIVRTM LRMSEITTSS SAPFTQPLSS NEIFRSLPVG
310 320 330 340 350
YNISKQVLDQ YLTLLADDPL EFVGKSGDSG GGMYVINLHK ALASLATATL
360 370 380 390 400
ESVVQERFGS RCARIFRLVL QKKHIEQKQV EDFAMIPAKE AKDMLYKMLS
410 420 430 440 450
ENFMSLQEIP KTPDHAPSRT FYLYTVNILS AARMLLHRCY KSIANLIERR
460 470 480 490 500
QFETKENKRL LEKSQRVEAI IASMQATGAE EAQLQEIEEM ITAPERQQLE
510 520 530
TLKRNVNKLD ASEIQVDETI FLLESYIECT MKRQ
Length:534
Mass (Da):60,612
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E4CFEE295EE1A55
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PHH9E9PHH9_HUMAN
DNA-directed RNA polymerase III sub...
POLR3C
411Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti85 – 86ML → IV in AAB63675 (PubMed:9171375).Curated2
Sequence conflicti119 – 120SA → CT in AAB63675 (PubMed:9171375).Curated2
Sequence conflicti216 – 237KRPKY…IYWQA → RDQNILQITRXPFQMMGFIG RP in AAB63675 (PubMed:9171375).CuratedAdd BLAST22
Sequence conflicti289S → F in AAB63675 (PubMed:9171375).Curated1
Sequence conflicti343A → R in AAB63675 (PubMed:9171375).Curated1
Sequence conflicti366F → C in AAB63675 (PubMed:9171375).Curated1
Sequence conflicti387 – 389PAK → LQ in AAB63675 (PubMed:9171375).Curated3
Sequence conflicti401E → G in AAB63675 (PubMed:9171375).Curated1
Sequence conflicti436 – 437LH → FD in AAB63675 (PubMed:9171375).Curated2
Sequence conflicti517D → E in CAB41919 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019083243H → R1 PublicationCorresponds to variant dbSNP:rs1044697Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U93867 mRNA Translation: AAB63675.1
AY091463 mRNA Translation: AAM12033.1
AJ238221
, AJ238222, AJ238223, AJ238224, AJ238225, AJ238226, AJ238227, AJ238228, AJ238229, AJ238230, AJ238231, AJ238232, AJ238233, AJ238234 Genomic DNA Translation: CAB41919.1
BC002586 mRNA Translation: AAH02586.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS72864.1

NCBI Reference Sequences

More...
RefSeqi
NP_001290385.1, NM_001303456.1
NP_006459.3, NM_006468.7

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334163; ENSP00000334564; ENSG00000186141

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10623

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10623

UCSC genome browser

More...
UCSCi
uc001eoh.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93867 mRNA Translation: AAB63675.1
AY091463 mRNA Translation: AAM12033.1
AJ238221
, AJ238222, AJ238223, AJ238224, AJ238225, AJ238226, AJ238227, AJ238228, AJ238229, AJ238230, AJ238231, AJ238232, AJ238233, AJ238234 Genomic DNA Translation: CAB41919.1
BC002586 mRNA Translation: AAH02586.1
CCDSiCCDS72864.1
RefSeqiNP_001290385.1, NM_001303456.1
NP_006459.3, NM_006468.7

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XUBX-ray2.80A1-534[»]
2XV4X-ray2.95S1-534[»]
5AFQX-ray7.00A/B1-534[»]
SMRiQ9BUI4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi115868, 45 interactors
DIPiDIP-59078N
IntActiQ9BUI4, 46 interactors
STRINGi9606.ENSP00000334564

PTM databases

iPTMnetiQ9BUI4
PhosphoSitePlusiQ9BUI4
SwissPalmiQ9BUI4

Polymorphism and mutation databases

BioMutaiPOLR3C
DMDMi60393871

Proteomic databases

EPDiQ9BUI4
jPOSTiQ9BUI4
MassIVEiQ9BUI4
MaxQBiQ9BUI4
PaxDbiQ9BUI4
PeptideAtlasiQ9BUI4
PRIDEiQ9BUI4
ProteomicsDBi79088

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10623

Genome annotation databases

EnsembliENST00000334163; ENSP00000334564; ENSG00000186141
GeneIDi10623
KEGGihsa:10623
UCSCiuc001eoh.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10623
DisGeNETi10623

GeneCards: human genes, protein and diseases

More...
GeneCardsi
POLR3C
HGNCiHGNC:30076 POLR3C
HPAiHPA027508
HPA027516
MIMi617454 gene
neXtProtiNX_Q9BUI4
OpenTargetsiENSG00000186141
PharmGKBiPA134870963

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2587 Eukaryota
ENOG410XPVH LUCA
GeneTreeiENSGT00390000002799
HOGENOMiHOG000046475
InParanoidiQ9BUI4
KOiK03023
OMAiLRYPRYV
OrthoDBi809282at2759
PhylomeDBiQ9BUI4
TreeFamiTF103048

Enzyme and pathway databases

ReactomeiR-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-73780 RNA Polymerase III Chain Elongation
R-HSA-73980 RNA Polymerase III Transcription Termination
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
POLR3C human
EvolutionaryTraceiQ9BUI4

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
POLR3C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10623
PharosiQ9BUI4

Protein Ontology

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PROi
PR:Q9BUI4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000186141 Expressed in 208 organ(s), highest expression level in right testis
ExpressionAtlasiQ9BUI4 baseline and differential
GenevisibleiQ9BUI4 HS

Family and domain databases

Gene3Di1.10.10.10, 4 hits
InterProiView protein in InterPro
IPR013197 RNA_pol_III_RPC82-rel_HTH
IPR008806 RNA_pol_III_Rpc82_C
IPR039748 RPC3
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR12949 PTHR12949, 1 hit
PfamiView protein in Pfam
PF08221 HTH_9, 1 hit
PF05645 RNA_pol_Rpc82, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPC3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BUI4
Secondary accession number(s): O15317, Q9Y3R6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: June 1, 2001
Last modified: October 16, 2019
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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