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Protein

Brain-enriched guanylate kinase-associated protein

Gene

BEGAIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May sustain the structure of the postsynaptic density (PSD).

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-enriched guanylate kinase-associated protein
Gene namesi
Name:BEGAIN
Synonyms:KIAA1446
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000183092.15
HGNCiHGNC:24163 BEGAIN
neXtProtiNX_Q9BUH8

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57596
OpenTargetsiENSG00000183092
PharmGKBiPA162377453

Polymorphism and mutation databases

BioMutaiBEGAIN
DMDMi62511244

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000649041 – 593Brain-enriched guanylate kinase-associated proteinAdd BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei137PhosphotyrosineBy similarity1
Modified residuei200PhosphoserineCombined sources1
Modified residuei229PhosphoserineBy similarity1
Modified residuei246PhosphoserineCombined sources1
Modified residuei265PhosphoserineBy similarity1
Modified residuei346PhosphoserineCombined sources1
Modified residuei373PhosphoserineCombined sources1
Modified residuei381Asymmetric dimethylarginineBy similarity1
Modified residuei455PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Modified residuei475PhosphoserineBy similarity1
Modified residuei477PhosphoserineBy similarity1
Modified residuei500PhosphoserineCombined sources1
Modified residuei502PhosphoserineCombined sources1
Modified residuei506PhosphoserineCombined sources1
Modified residuei553PhosphoserineCombined sources1
Modified residuei563PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ9BUH8
PaxDbiQ9BUH8
PeptideAtlasiQ9BUH8
PRIDEiQ9BUH8
ProteomicsDBi79087

PTM databases

iPTMnetiQ9BUH8
PhosphoSitePlusiQ9BUH8

Expressioni

Gene expression databases

BgeeiENSG00000183092 Expressed in 120 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_BEGAIN
ExpressionAtlasiQ9BUH8 baseline and differential
GenevisibleiQ9BUH8 HS

Organism-specific databases

HPAiHPA002899

Interactioni

Subunit structurei

Interacts with DLG4 and DLGAP1 and forms a ternary complex.By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi121647, 34 interactors
IntActiQ9BUH8, 57 interactors
STRINGi9606.ENSP00000347301

Structurei

3D structure databases

ProteinModelPortaliQ9BUH8
SMRiQ9BUH8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IE5E Eukaryota
ENOG410ZCUQ LUCA
GeneTreeiENSGT00530000063778
HOGENOMiHOG000095194
HOVERGENiHBG050683
InParanoidiQ9BUH8
OrthoDBiEOG091G03KA
PhylomeDBiQ9BUH8
TreeFamiTF331612

Family and domain databases

InterProiView protein in InterPro
IPR033584 BEGAIN
PANTHERiPTHR28664:SF2 PTHR28664:SF2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q9BUH8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKLSALQEQ KGELRKRLSY TTHKLEKLET EFDSTRHYLE IELRRAQEEL
60 70 80 90 100
EKVTEKLRRI QSNYMALQRI NQELEDKLYR MGQHYEEEKR ALSHEIVALN
110 120 130 140 150
SHLLEAKVTI DKLSEDNELY RKDCNLAAQL LQCSQTYGRV HKVSELPSDF
160 170 180 190 200
QERVSLHMEK HGCSLPSPLC HPAYADSVPT CVIAKVLEKP DPASLSSRLS
210 220 230 240 250
DASARDLAFC DGVEKPGPRP PYKGDIYCSD TALYCPEERR RDRRPSVDAP
260 270 280 290 300
VTDVGFLRAQ NSTDSAAEEE EEAEAAAFPA GFQHEAFPSY AGSLPTSSSY
310 320 330 340 350
SSFSATSEEK EHAQASTLTA SQQAIYLNSR DELFDRKPPA TTYEGSPRFA
360 370 380 390 400
KATAAVAAPL EAEVAPGFGR TMSPYPAETF RFPASPGPQQ ALMPPNLWSL
410 420 430 440 450
RAKPGTARLP GEDMRGQWRP LSVEDIGAYS YPVSAAGRAS PCSFSERYYG
460 470 480 490 500
GAGGSPGKKA DGRASPLYAS YKADSFSEGD DLSQGHLAEP CFLRAGGDLS
510 520 530 540 550
LSPGRSADPL PGYAPSEGGD GDRLGVQLCG TASSPEPEQG SRDSLEPSSM
560 570 580 590
EASPEMHPAA RLSPQQAFPR TGGSGLSRKD SLTKAQLYGT LLN
Length:593
Mass (Da):64,803
Last modified:June 1, 2001 - v1
Checksum:iD4A25A463B8055F4
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GVM0A0A1B0GVM0_HUMAN
Brain-enriched guanylate kinase-ass...
BEGAIN
812Annotation score:
G3V3A2G3V3A2_HUMAN
Brain-enriched guanylate kinase-ass...
BEGAIN
169Annotation score:
G3V600G3V600_HUMAN
Brain-enriched guanylate kinase-ass...
BEGAIN
174Annotation score:
G3V536G3V536_HUMAN
Brain-enriched guanylate kinase-ass...
BEGAIN
287Annotation score:
G3V2K4G3V2K4_HUMAN
Brain-enriched guanylate kinase-ass...
BEGAIN
167Annotation score:
G3V3S3G3V3S3_HUMAN
Brain-enriched guanylate kinase-ass...
BEGAIN
299Annotation score:
A0A1B0GTT1A0A1B0GTT1_HUMAN
Brain-enriched guanylate kinase-ass...
BEGAIN
623Annotation score:

Sequence cautioni

The sequence BAA95970 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC002607 mRNA Translation: AAH02607.1
AB040879 mRNA Translation: BAA95970.1 Different initiation.
AL390162 mRNA Translation: CAB99094.1
CCDSiCCDS9962.1
PIRiT51877
RefSeqiNP_001153003.1, NM_001159531.1
NP_065887.1, NM_020836.3
XP_005267978.1, XM_005267921.3
XP_016877010.1, XM_017021521.1
UniGeneiHs.211751

Genome annotation databases

EnsembliENST00000355173; ENSP00000347301; ENSG00000183092
ENST00000443071; ENSP00000411124; ENSG00000183092
GeneIDi57596
KEGGihsa:57596
UCSCiuc001yhq.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC002607 mRNA Translation: AAH02607.1
AB040879 mRNA Translation: BAA95970.1 Different initiation.
AL390162 mRNA Translation: CAB99094.1
CCDSiCCDS9962.1
PIRiT51877
RefSeqiNP_001153003.1, NM_001159531.1
NP_065887.1, NM_020836.3
XP_005267978.1, XM_005267921.3
XP_016877010.1, XM_017021521.1
UniGeneiHs.211751

3D structure databases

ProteinModelPortaliQ9BUH8
SMRiQ9BUH8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121647, 34 interactors
IntActiQ9BUH8, 57 interactors
STRINGi9606.ENSP00000347301

PTM databases

iPTMnetiQ9BUH8
PhosphoSitePlusiQ9BUH8

Polymorphism and mutation databases

BioMutaiBEGAIN
DMDMi62511244

Proteomic databases

MaxQBiQ9BUH8
PaxDbiQ9BUH8
PeptideAtlasiQ9BUH8
PRIDEiQ9BUH8
ProteomicsDBi79087

Protocols and materials databases

DNASUi57596
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355173; ENSP00000347301; ENSG00000183092
ENST00000443071; ENSP00000411124; ENSG00000183092
GeneIDi57596
KEGGihsa:57596
UCSCiuc001yhq.4 human

Organism-specific databases

CTDi57596
DisGeNETi57596
EuPathDBiHostDB:ENSG00000183092.15
GeneCardsiBEGAIN
HGNCiHGNC:24163 BEGAIN
HPAiHPA002899
neXtProtiNX_Q9BUH8
OpenTargetsiENSG00000183092
PharmGKBiPA162377453
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE5E Eukaryota
ENOG410ZCUQ LUCA
GeneTreeiENSGT00530000063778
HOGENOMiHOG000095194
HOVERGENiHBG050683
InParanoidiQ9BUH8
OrthoDBiEOG091G03KA
PhylomeDBiQ9BUH8
TreeFamiTF331612

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRSiBEGAIN human
GeneWikiiBEGAIN
GenomeRNAii57596
PROiPR:Q9BUH8

Gene expression databases

BgeeiENSG00000183092 Expressed in 120 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_BEGAIN
ExpressionAtlasiQ9BUH8 baseline and differential
GenevisibleiQ9BUH8 HS

Family and domain databases

InterProiView protein in InterPro
IPR033584 BEGAIN
PANTHERiPTHR28664:SF2 PTHR28664:SF2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBEGIN_HUMAN
AccessioniPrimary (citable) accession number: Q9BUH8
Secondary accession number(s): Q9NPU3, Q9P282
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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