MED18

Functionⁱ

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

GO - Molecular functionⁱ

transcription coregulator activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription by RNA polymerase II Source: InterPro
termination of RNA polymerase II transcription
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Reactomeⁱ

R-HSA-1989781 PPARA activates gene expression
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mediator of RNA polymerase II transcription subunit 18 Alternative name(s): Mediator complex subunit 18 p28b
Gene namesⁱ	Name:MED18
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000130772.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25944 MED18
MIMⁱ	612384 gene
neXtProtⁱ	NX_Q9BUE0

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	54797
Open Targets More...OpenTargetsⁱ	ENSG00000130772
PharmGKBⁱ	PA134884523

Polymorphism and mutation databases

BioMutaⁱ	MED18
DMDMⁱ	74752353

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000304742	1 – 208	Mediator of RNA polymerase II transcription subunit 18Add BLAST		208

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	66	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9BUE0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BUE0
PaxDbⁱ	Q9BUE0
PeptideAtlas More...PeptideAtlasⁱ	Q9BUE0
PRIDEⁱ	Q9BUE0
ProteomicsDBⁱ	79079

PTM databases

iPTMnetⁱ	Q9BUE0
PhosphoSitePlusⁱ	Q9BUE0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000130772 Expressed in 129 organ(s), highest expression level in blood
CleanExⁱ	HS_MED18
Genevisibleⁱ	Q9BUE0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA027429

HPAⁱ

HPA027429

Interactionⁱ

Subunit structureⁱ

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CAMK2B	Q13554	3	EBI-394640,EBI-1058722
HOMEZ	Q8IX15-3	3	EBI-394640,EBI-10172004
MED20	Q9H944	9	EBI-394640,EBI-394644
Med20	Q9R0X0	6	EBI-394640,EBI-398698	From Mus musculus.
MED22	Q15528	2	EBI-394640,EBI-394687
MED29	Q9NX70	5	EBI-394640,EBI-394656
TRIM39	Q9HCM9	3	EBI-394640,EBI-739510

Protein-protein interaction databases

BioGridⁱ	120156, 48 interactors
ComplexPortalⁱ	CPX-3227 Core mediator complex
CORUMⁱ	Q9BUE0
IntActⁱ	Q9BUE0, 24 interactors
STRINGⁱ	9606.ENSP00000362948

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BUE0
SMRⁱ	Q9BUE0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Mediator complex subunit 18 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3264 Eukaryota ENOG4110KT9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003312
HOVERGENⁱ	HBG105560
InParanoidⁱ	Q9BUE0
KEGG Orthology (KO) More...KOⁱ	K15135
OMAⁱ	PWQLRYI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0K0D
PhylomeDBⁱ	Q9BUE0
TreeFamⁱ	TF313246

Family and domain databases

InterProⁱ	View protein in InterPro IPR019095 Mediator_Med18
PANTHERⁱ	PTHR13321 PTHR13321, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09637 Med18, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9BUE0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEAPPVTMMP VTGGTINMME YLLQGSVLDH SLESLIHRLR GLCDNMEPET 
        60         70         80         90        100
FLDHEMVFLL KGQQASPFVL RARRSMDRAG APWHLRYLGQ PEMGDKNRHA 
       110        120        130        140        150
LVRNCVDIAT SENLTDFLME MGFRMDHEFV AKGHLFRKGI MKIMVYKIFR 
       160        170        180        190        200
ILVPGNTDST EALSLSYLVE LSVVAPAGQD MVSDDMKNFA EQLKPLVHLE 

KIDPKRLM

Length:208

Mass (Da):23,663

Last modified:June 1, 2001 - v1

Checksum:ⁱAE68984390532C33

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	148	I → T in BAA90910 (PubMed:14702039).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB107222 mRNA Translation: BAD06869.1 AK000052 mRNA Translation: BAA90910.1 AL353622 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07699.1 CH471059 Genomic DNA Translation: EAX07700.1 CH471059 Genomic DNA Translation: EAX07702.1 BC002694 mRNA Translation: AAH02694.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS322.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001120822.1, NM_001127350.1 NP_060108.2, NM_017638.2 XP_005245971.1, XM_005245914.4
UniGeneⁱ	Hs.479911

Genome annotation databases

Ensemblⁱ	ENST00000373842; ENSP00000362948; ENSG00000130772 ENST00000398997; ENSP00000381963; ENSG00000130772 ENST00000645794; ENSP00000494184; ENSG00000284944 ENST00000647352; ENSP00000494048; ENSG00000284944
GeneIDⁱ	54797
KEGGⁱ	hsa:54797
UCSC genome browser More...UCSCⁱ	uc001bpt.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BUE0	Mediator of RNA polymerase II transcription subunit 18		PANTR		248	UniRef100_Q9BUE0
Mediator of RNA polymerase II transcription subunit 18		PANPA		208
Mediator of RNA polymerase II transcription subunit 18		PONAB		208
Mediator of RNA polymerase II transcription subunit 18		GORGO		208
Mediator of RNA polymerase II transcription subunit 18		PANTR		208

Protein	Similar proteins		Species	Score	Length	Source
Q9BUE0	Mediator of RNA polymerase II transcription subunit 18		MOUSE		208	UniRef90_Q9BUE0
Mediator of RNA polymerase II transcription subunit 18		BOVIN		208
Mediator of RNA polymerase II transcription subunit 18		PANTR		248
Mediator of RNA polymerase II transcription subunit 18		PANPA		208
Mediator of RNA polymerase II transcription subunit 18		PONAB		208
+101

Protein	Similar proteins		Species	Score	Length	Source
Q9BUE0	Mediator of RNA polymerase II transcription subunit 18		BOVIN		208	UniRef50_Q9BUE0
Mediator of RNA polymerase II transcription subunit 18		MOUSE		208
Mediator of RNA polymerase II transcription subunit 18		XENLA		208
Mediator of RNA polymerase II transcription subunit 18		XENTR		208
Mediator of RNA polymerase II transcription subunit 18		PANTR		248
+147

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB107222 mRNA Translation: BAD06869.1 AK000052 mRNA Translation: BAA90910.1 AL353622 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07699.1 CH471059 Genomic DNA Translation: EAX07700.1 CH471059 Genomic DNA Translation: EAX07702.1 BC002694 mRNA Translation: AAH02694.1
CCDSⁱ	CCDS322.1
RefSeqⁱ	NP_001120822.1, NM_001127350.1 NP_060108.2, NM_017638.2 XP_005245971.1, XM_005245914.4
UniGeneⁱ	Hs.479911

3D structure databases

ProteinModelPortalⁱ	Q9BUE0
SMRⁱ	Q9BUE0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120156, 48 interactors
ComplexPortalⁱ	CPX-3227 Core mediator complex
CORUMⁱ	Q9BUE0
IntActⁱ	Q9BUE0, 24 interactors
STRINGⁱ	9606.ENSP00000362948

PTM databases

iPTMnetⁱ	Q9BUE0
PhosphoSitePlusⁱ	Q9BUE0

Polymorphism and mutation databases

BioMutaⁱ	MED18
DMDMⁱ	74752353

Proteomic databases

EPDⁱ	Q9BUE0
MaxQBⁱ	Q9BUE0
PaxDbⁱ	Q9BUE0
PeptideAtlasⁱ	Q9BUE0
PRIDEⁱ	Q9BUE0
ProteomicsDBⁱ	79079

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	54797
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000373842; ENSP00000362948; ENSG00000130772 ENST00000398997; ENSP00000381963; ENSG00000130772 ENST00000645794; ENSP00000494184; ENSG00000284944 ENST00000647352; ENSP00000494048; ENSG00000284944
GeneIDⁱ	54797
KEGGⁱ	hsa:54797
UCSCⁱ	uc001bpt.5 human

Organism-specific databases

CTDⁱ	54797
DisGeNETⁱ	54797
EuPathDBⁱ	HostDB:ENSG00000130772.13
GeneCardsⁱ	MED18
H-InvDBⁱ	HIX0000293
HGNCⁱ	HGNC:25944 MED18
HPAⁱ	HPA027429
MIMⁱ	612384 gene
neXtProtⁱ	NX_Q9BUE0
OpenTargetsⁱ	ENSG00000130772
PharmGKBⁱ	PA134884523
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3264 Eukaryota ENOG4110KT9 LUCA
GeneTreeⁱ	ENSGT00390000003312
HOVERGENⁱ	HBG105560
InParanoidⁱ	Q9BUE0
KOⁱ	K15135
OMAⁱ	PWQLRYI
OrthoDBⁱ	EOG091G0K0D
PhylomeDBⁱ	Q9BUE0
TreeFamⁱ	TF313246

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Reactomeⁱ

R-HSA-1989781 PPARA activates gene expression
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Miscellaneous databases

GenomeRNAiⁱ	54797
Protein Ontology More...PROⁱ	PR:Q9BUE0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000130772 Expressed in 129 organ(s), highest expression level in blood
CleanExⁱ	HS_MED18
Genevisibleⁱ	Q9BUE0 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019095 Mediator_Med18
PANTHERⁱ	PTHR13321 PTHR13321, 1 hit
Pfamⁱ	View protein in Pfam PF09637 Med18, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MED18_HUMAN
Accessionⁱ	Q9BUE0Primary (citable) accession number: Q9BUE0 Secondary accession number(s): D3DPM1, Q9NXU9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BUE0 (MED18_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Mediator of RNA polymerase II transcription subunit 18

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ