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Protein

Mediator of RNA polymerase II transcription subunit 18

Gene

MED18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 18
Alternative name(s):
Mediator complex subunit 18
p28b
Gene namesi
Name:MED18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000130772.13
HGNCiHGNC:25944 MED18
MIMi612384 gene
neXtProtiNX_Q9BUE0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54797
OpenTargetsiENSG00000130772
PharmGKBiPA134884523

Polymorphism and mutation databases

BioMutaiMED18
DMDMi74752353

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003047421 – 208Mediator of RNA polymerase II transcription subunit 18Add BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BUE0
MaxQBiQ9BUE0
PaxDbiQ9BUE0
PeptideAtlasiQ9BUE0
PRIDEiQ9BUE0
ProteomicsDBi79079

PTM databases

iPTMnetiQ9BUE0
PhosphoSitePlusiQ9BUE0

Expressioni

Gene expression databases

BgeeiENSG00000130772 Expressed in 129 organ(s), highest expression level in blood
CleanExiHS_MED18
GenevisibleiQ9BUE0 HS

Organism-specific databases

HPAiHPA027429

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi120156, 48 interactors
ComplexPortaliCPX-3227 Core mediator complex
CORUMiQ9BUE0
IntActiQ9BUE0, 24 interactors
STRINGi9606.ENSP00000362948

Structurei

3D structure databases

ProteinModelPortaliQ9BUE0
SMRiQ9BUE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 18 family.Curated

Phylogenomic databases

eggNOGiKOG3264 Eukaryota
ENOG4110KT9 LUCA
GeneTreeiENSGT00390000003312
HOVERGENiHBG105560
InParanoidiQ9BUE0
KOiK15135
OMAiPWQLRYI
OrthoDBiEOG091G0K0D
PhylomeDBiQ9BUE0
TreeFamiTF313246

Family and domain databases

InterProiView protein in InterPro
IPR019095 Mediator_Med18
PANTHERiPTHR13321 PTHR13321, 1 hit
PfamiView protein in Pfam
PF09637 Med18, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BUE0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAPPVTMMP VTGGTINMME YLLQGSVLDH SLESLIHRLR GLCDNMEPET
60 70 80 90 100
FLDHEMVFLL KGQQASPFVL RARRSMDRAG APWHLRYLGQ PEMGDKNRHA
110 120 130 140 150
LVRNCVDIAT SENLTDFLME MGFRMDHEFV AKGHLFRKGI MKIMVYKIFR
160 170 180 190 200
ILVPGNTDST EALSLSYLVE LSVVAPAGQD MVSDDMKNFA EQLKPLVHLE

KIDPKRLM
Length:208
Mass (Da):23,663
Last modified:June 1, 2001 - v1
Checksum:iAE68984390532C33
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148I → T in BAA90910 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB107222 mRNA Translation: BAD06869.1
AK000052 mRNA Translation: BAA90910.1
AL353622 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07699.1
CH471059 Genomic DNA Translation: EAX07700.1
CH471059 Genomic DNA Translation: EAX07702.1
BC002694 mRNA Translation: AAH02694.1
CCDSiCCDS322.1
RefSeqiNP_001120822.1, NM_001127350.1
NP_060108.2, NM_017638.2
XP_005245971.1, XM_005245914.4
UniGeneiHs.479911

Genome annotation databases

EnsembliENST00000373842; ENSP00000362948; ENSG00000130772
ENST00000398997; ENSP00000381963; ENSG00000130772
ENST00000645794; ENSP00000494184; ENSG00000284944
ENST00000647352; ENSP00000494048; ENSG00000284944
GeneIDi54797
KEGGihsa:54797
UCSCiuc001bpt.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB107222 mRNA Translation: BAD06869.1
AK000052 mRNA Translation: BAA90910.1
AL353622 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07699.1
CH471059 Genomic DNA Translation: EAX07700.1
CH471059 Genomic DNA Translation: EAX07702.1
BC002694 mRNA Translation: AAH02694.1
CCDSiCCDS322.1
RefSeqiNP_001120822.1, NM_001127350.1
NP_060108.2, NM_017638.2
XP_005245971.1, XM_005245914.4
UniGeneiHs.479911

3D structure databases

ProteinModelPortaliQ9BUE0
SMRiQ9BUE0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120156, 48 interactors
ComplexPortaliCPX-3227 Core mediator complex
CORUMiQ9BUE0
IntActiQ9BUE0, 24 interactors
STRINGi9606.ENSP00000362948

PTM databases

iPTMnetiQ9BUE0
PhosphoSitePlusiQ9BUE0

Polymorphism and mutation databases

BioMutaiMED18
DMDMi74752353

Proteomic databases

EPDiQ9BUE0
MaxQBiQ9BUE0
PaxDbiQ9BUE0
PeptideAtlasiQ9BUE0
PRIDEiQ9BUE0
ProteomicsDBi79079

Protocols and materials databases

DNASUi54797
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373842; ENSP00000362948; ENSG00000130772
ENST00000398997; ENSP00000381963; ENSG00000130772
ENST00000645794; ENSP00000494184; ENSG00000284944
ENST00000647352; ENSP00000494048; ENSG00000284944
GeneIDi54797
KEGGihsa:54797
UCSCiuc001bpt.5 human

Organism-specific databases

CTDi54797
DisGeNETi54797
EuPathDBiHostDB:ENSG00000130772.13
GeneCardsiMED18
H-InvDBiHIX0000293
HGNCiHGNC:25944 MED18
HPAiHPA027429
MIMi612384 gene
neXtProtiNX_Q9BUE0
OpenTargetsiENSG00000130772
PharmGKBiPA134884523
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3264 Eukaryota
ENOG4110KT9 LUCA
GeneTreeiENSGT00390000003312
HOVERGENiHBG105560
InParanoidiQ9BUE0
KOiK15135
OMAiPWQLRYI
OrthoDBiEOG091G0K0D
PhylomeDBiQ9BUE0
TreeFamiTF313246

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Miscellaneous databases

GenomeRNAii54797
PROiPR:Q9BUE0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130772 Expressed in 129 organ(s), highest expression level in blood
CleanExiHS_MED18
GenevisibleiQ9BUE0 HS

Family and domain databases

InterProiView protein in InterPro
IPR019095 Mediator_Med18
PANTHERiPTHR13321 PTHR13321, 1 hit
PfamiView protein in Pfam
PF09637 Med18, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMED18_HUMAN
AccessioniPrimary (citable) accession number: Q9BUE0
Secondary accession number(s): D3DPM1, Q9NXU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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