UniProtKB - Q9BUE0 (MED18_HUMAN)
Mediator of RNA polymerase II transcription subunit 18
MED18
Functioni
GO - Molecular functioni
- transcription coregulator activity Source: GO_Central
- ubiquitin protein ligase activity Source: Ensembl
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
- termination of RNA polymerase II transcription Source: GO_Central
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9BUE0 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-381340, Transcriptional regulation of white adipocyte differentiation |
Names & Taxonomyi
Protein namesi | Recommended name: Mediator of RNA polymerase II transcription subunit 18Alternative name(s): Mediator complex subunit 18 p28b |
Gene namesi | Name:MED18 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25944, MED18 |
MIMi | 612384, gene |
neXtProti | NX_Q9BUE0 |
VEuPathDBi | HostDB:ENSG00000130772.13 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- core mediator complex Source: GO_Central
- mediator complex Source: MGI
Other locations
- ubiquitin ligase complex Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 54797 |
OpenTargetsi | ENSG00000130772 |
PharmGKBi | PA134884523 |
Miscellaneous databases
Pharosi | Q9BUE0, Tbio |
Genetic variation databases
BioMutai | MED18 |
DMDMi | 74752353 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000304742 | 1 – 208 | Mediator of RNA polymerase II transcription subunit 18Add BLAST | 208 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 66 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9BUE0 |
jPOSTi | Q9BUE0 |
MassIVEi | Q9BUE0 |
MaxQBi | Q9BUE0 |
PaxDbi | Q9BUE0 |
PeptideAtlasi | Q9BUE0 |
PRIDEi | Q9BUE0 |
ProteomicsDBi | 79079 |
PTM databases
iPTMneti | Q9BUE0 |
MetOSitei | Q9BUE0 |
PhosphoSitePlusi | Q9BUE0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000130772, Expressed in blood and 151 other tissues |
Genevisiblei | Q9BUE0, HS |
Organism-specific databases
HPAi | ENSG00000130772, Low tissue specificity |
Interactioni
Subunit structurei
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
2 PublicationsBinary interactionsi
Hide detailsQ9BUE0
Protein-protein interaction databases
BioGRIDi | 120156, 54 interactors |
ComplexPortali | CPX-3227, Core mediator complex |
CORUMi | Q9BUE0 |
IntActi | Q9BUE0, 62 interactors |
MINTi | Q9BUE0 |
STRINGi | 9606.ENSP00000362948 |
Miscellaneous databases
RNActi | Q9BUE0, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3264, Eukaryota |
GeneTreei | ENSGT00390000003312 |
HOGENOMi | CLU_084570_0_0_1 |
InParanoidi | Q9BUE0 |
OMAi | PWQLRYI |
OrthoDBi | 1140930at2759 |
PhylomeDBi | Q9BUE0 |
TreeFami | TF313246 |
Family and domain databases
InterProi | View protein in InterPro IPR019095, Mediator_Med18 |
PANTHERi | PTHR13321, PTHR13321, 1 hit |
Pfami | View protein in Pfam PF09637, Med18, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MEAPPVTMMP VTGGTINMME YLLQGSVLDH SLESLIHRLR GLCDNMEPET
60 70 80 90 100
FLDHEMVFLL KGQQASPFVL RARRSMDRAG APWHLRYLGQ PEMGDKNRHA
110 120 130 140 150
LVRNCVDIAT SENLTDFLME MGFRMDHEFV AKGHLFRKGI MKIMVYKIFR
160 170 180 190 200
ILVPGNTDST EALSLSYLVE LSVVAPAGQD MVSDDMKNFA EQLKPLVHLE
KIDPKRLM
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 148 | I → T in BAA90910 (PubMed:14702039).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB107222 mRNA Translation: BAD06869.1 AK000052 mRNA Translation: BAA90910.1 AL353622 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07699.1 CH471059 Genomic DNA Translation: EAX07700.1 CH471059 Genomic DNA Translation: EAX07702.1 BC002694 mRNA Translation: AAH02694.1 |
CCDSi | CCDS322.1 |
RefSeqi | NP_001120822.1, NM_001127350.1 NP_060108.2, NM_017638.2 XP_005245971.1, XM_005245914.4 |
Genome annotation databases
Ensembli | ENST00000373842; ENSP00000362948; ENSG00000130772 ENST00000398997; ENSP00000381963; ENSG00000130772 ENST00000645794; ENSP00000494184; ENSG00000284944 ENST00000647352; ENSP00000494048; ENSG00000284944 |
GeneIDi | 54797 |
KEGGi | hsa:54797 |
UCSCi | uc001bpt.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB107222 mRNA Translation: BAD06869.1 AK000052 mRNA Translation: BAA90910.1 AL353622 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07699.1 CH471059 Genomic DNA Translation: EAX07700.1 CH471059 Genomic DNA Translation: EAX07702.1 BC002694 mRNA Translation: AAH02694.1 |
CCDSi | CCDS322.1 |
RefSeqi | NP_001120822.1, NM_001127350.1 NP_060108.2, NM_017638.2 XP_005245971.1, XM_005245914.4 |
3D structure databases
SMRi | Q9BUE0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120156, 54 interactors |
ComplexPortali | CPX-3227, Core mediator complex |
CORUMi | Q9BUE0 |
IntActi | Q9BUE0, 62 interactors |
MINTi | Q9BUE0 |
STRINGi | 9606.ENSP00000362948 |
PTM databases
iPTMneti | Q9BUE0 |
MetOSitei | Q9BUE0 |
PhosphoSitePlusi | Q9BUE0 |
Genetic variation databases
BioMutai | MED18 |
DMDMi | 74752353 |
Proteomic databases
EPDi | Q9BUE0 |
jPOSTi | Q9BUE0 |
MassIVEi | Q9BUE0 |
MaxQBi | Q9BUE0 |
PaxDbi | Q9BUE0 |
PeptideAtlasi | Q9BUE0 |
PRIDEi | Q9BUE0 |
ProteomicsDBi | 79079 |
Protocols and materials databases
Antibodypediai | 30928, 221 antibodies |
DNASUi | 54797 |
Genome annotation databases
Ensembli | ENST00000373842; ENSP00000362948; ENSG00000130772 ENST00000398997; ENSP00000381963; ENSG00000130772 ENST00000645794; ENSP00000494184; ENSG00000284944 ENST00000647352; ENSP00000494048; ENSG00000284944 |
GeneIDi | 54797 |
KEGGi | hsa:54797 |
UCSCi | uc001bpt.5, human |
Organism-specific databases
CTDi | 54797 |
DisGeNETi | 54797 |
GeneCardsi | MED18 |
HGNCi | HGNC:25944, MED18 |
HPAi | ENSG00000130772, Low tissue specificity |
MIMi | 612384, gene |
neXtProti | NX_Q9BUE0 |
OpenTargetsi | ENSG00000130772 |
PharmGKBi | PA134884523 |
VEuPathDBi | HostDB:ENSG00000130772.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3264, Eukaryota |
GeneTreei | ENSGT00390000003312 |
HOGENOMi | CLU_084570_0_0_1 |
InParanoidi | Q9BUE0 |
OMAi | PWQLRYI |
OrthoDBi | 1140930at2759 |
PhylomeDBi | Q9BUE0 |
TreeFami | TF313246 |
Enzyme and pathway databases
PathwayCommonsi | Q9BUE0 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-381340, Transcriptional regulation of white adipocyte differentiation |
Miscellaneous databases
BioGRID-ORCSi | 54797, 617 hits in 1007 CRISPR screens |
GenomeRNAii | 54797 |
Pharosi | Q9BUE0, Tbio |
PROi | PR:Q9BUE0 |
RNActi | Q9BUE0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000130772, Expressed in blood and 151 other tissues |
Genevisiblei | Q9BUE0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019095, Mediator_Med18 |
PANTHERi | PTHR13321, PTHR13321, 1 hit |
Pfami | View protein in Pfam PF09637, Med18, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MED18_HUMAN | |
Accessioni | Q9BUE0Primary (citable) accession number: Q9BUE0 Secondary accession number(s): D3DPM1, Q9NXU9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families