Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 139 (16 Oct 2019)
Sequence version 2 (01 Mar 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Transmembrane protein 70, mitochondrial

Gene

TMEM70

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in biogenesis of mitochondrial ATP synthase.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.96.1.1 the tmem70 (tmem70) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 70, mitochondrial
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM70
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26050 TMEM70

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612418 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BUB7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mitochondrial complex V deficiency, nuclear type 2 (MC5DN2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA mitochondrial disorder with heterogeneous clinical manifestations including dysmorphic features, psychomotor retardation, hypotonia, growth retardation, cardiomyopathy, enlarged liver, hypoplastic kidneys and elevated lactate levels in urine, plasma and cerebrospinal fluid.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_068847210T → P in MC5DN2. 1 Publication1

Keywords - Diseasei

Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...
DisGeNETi
54968

MalaCards human disease database

More...
MalaCardsi
TMEM70
MIMi614052 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000175606

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1194 TMEM70-related mitochondrial encephalo-cardio-myopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670783

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BUB7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM70

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74733203

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 81MitochondrionSequence analysisAdd BLAST81
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025147282 – 260Transmembrane protein 70, mitochondrialAdd BLAST179

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BUB7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BUB7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BUB7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BUB7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BUB7

PeptideAtlas

More...
PeptideAtlasi
Q9BUB7

PRoteomics IDEntifications database

More...
PRIDEi
Q9BUB7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19777
79075 [Q9BUB7-1]
79076 [Q9BUB7-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9BUB7-1 [Q9BUB7-1]
Q9BUB7-2 [Q9BUB7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BUB7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BUB7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9BUB7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000175606 Expressed in 232 organ(s), highest expression level in skeletal muscle tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BUB7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BUB7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB034226
HPA023187

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120305, 34 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BUB7, 28 interactors

Molecular INTeraction database

More...
MINTi
Q9BUB7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000312599

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM70 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4478 Eukaryota
ENOG4111HEE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018710

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000045718

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BUB7

KEGG Orthology (KO)

More...
KOi
K17966

Identification of Orthologs from Complete Genome Data

More...
OMAi
RAQIPVC

Database of Orthologous Groups

More...
OrthoDBi
1513532at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BUB7

TreeFam database of animal gene trees

More...
TreeFami
TF314656

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009724 TMEM70

The PANTHER Classification System

More...
PANTHERi
PTHR13281 PTHR13281, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06979 TMEM70, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BUB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLFLALGSPW AVELPLCGRR TALCAAAALR GPRASVSRAS SSSGPSGPVA
60 70 80 90 100
GWSTGPSGAA RLLRRPGRAQ IPVYWEGYVR FLNTPSDKSE DGRLIYTGNM
110 120 130 140 150
ARAVFGVKCF SYSTSLIGLT FLPYIFTQNN AISESVPLPI QIIFYGIMGS
160 170 180 190 200
FTVITPVLLH FITKGYVIRL YHEATTDTYK AITYNAMLAE TSTVFHQNDV
210 220 230 240 250
KIPDAKHVFT TFYAKTKSLL VNPVLFPNRE DYIHLMGYDK EEFILYMEET
260
SEEKRHKDDK
Length:260
Mass (Da):28,969
Last modified:March 1, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6206F853D18F12DC
GO
Isoform 2 (identifier: Q9BUB7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.

Note: No experimental confirmation available.
Show »
Length:161
Mass (Da):18,570
Checksum:i9672A5EBBB1FDC99
GO
Isoform 3 (identifier: Q9BUB7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-107: V → K
     108-260: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:107
Mass (Da):11,278
Checksum:i3A005E780B166F16
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D4PHA6D4PHA6_HUMAN
Transmembrane protein 70, mitochond...
TMEM70
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02768634A → P. Corresponds to variant dbSNP:rs8075EnsemblClinVar.1
Natural variantiVAR_068847210T → P in MC5DN2. 1 Publication1
Natural variantiVAR_034565228N → K. Corresponds to variant dbSNP:rs35564486EnsemblClinVar.1
Natural variantiVAR_027687250T → A1 PublicationCorresponds to variant dbSNP:rs1053079EnsemblClinVar.1
Natural variantiVAR_027688259D → E1 PublicationCorresponds to variant dbSNP:rs1053077EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0207591 – 99Missing in isoform 2. 1 PublicationAdd BLAST99
Alternative sequenceiVSP_054227107V → K in isoform 3. Curated1
Alternative sequenceiVSP_054228108 – 260Missing in isoform 3. CuratedAdd BLAST153

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK000540 mRNA Translation: BAA91240.1
AC022868 Genomic DNA No translation available.
BC002748 mRNA Translation: AAH02748.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47876.1 [Q9BUB7-3]
CCDS6215.1 [Q9BUB7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001035703.1, NM_001040613.2 [Q9BUB7-3]
NP_060336.3, NM_017866.5 [Q9BUB7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000312184; ENSP00000312599; ENSG00000175606 [Q9BUB7-1]
ENST00000517439; ENSP00000429467; ENSG00000175606 [Q9BUB7-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54968

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54968

UCSC genome browser

More...
UCSCi
uc003yab.4 human [Q9BUB7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000540 mRNA Translation: BAA91240.1
AC022868 Genomic DNA No translation available.
BC002748 mRNA Translation: AAH02748.2
CCDSiCCDS47876.1 [Q9BUB7-3]
CCDS6215.1 [Q9BUB7-1]
RefSeqiNP_001035703.1, NM_001040613.2 [Q9BUB7-3]
NP_060336.3, NM_017866.5 [Q9BUB7-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120305, 34 interactors
IntActiQ9BUB7, 28 interactors
MINTiQ9BUB7
STRINGi9606.ENSP00000312599

Protein family/group databases

TCDBi8.A.96.1.1 the tmem70 (tmem70) family

PTM databases

iPTMnetiQ9BUB7
PhosphoSitePlusiQ9BUB7
SwissPalmiQ9BUB7

Polymorphism and mutation databases

BioMutaiTMEM70
DMDMi74733203

Proteomic databases

EPDiQ9BUB7
jPOSTiQ9BUB7
MassIVEiQ9BUB7
MaxQBiQ9BUB7
PaxDbiQ9BUB7
PeptideAtlasiQ9BUB7
PRIDEiQ9BUB7
ProteomicsDBi19777
79075 [Q9BUB7-1]
79076 [Q9BUB7-2]
TopDownProteomicsiQ9BUB7-1 [Q9BUB7-1]
Q9BUB7-2 [Q9BUB7-2]

Genome annotation databases

EnsembliENST00000312184; ENSP00000312599; ENSG00000175606 [Q9BUB7-1]
ENST00000517439; ENSP00000429467; ENSG00000175606 [Q9BUB7-3]
GeneIDi54968
KEGGihsa:54968
UCSCiuc003yab.4 human [Q9BUB7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54968
DisGeNETi54968

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM70
HGNCiHGNC:26050 TMEM70
HPAiCAB034226
HPA023187
MalaCardsiTMEM70
MIMi612418 gene
614052 phenotype
neXtProtiNX_Q9BUB7
OpenTargetsiENSG00000175606
Orphaneti1194 TMEM70-related mitochondrial encephalo-cardio-myopathy
PharmGKBiPA142670783

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4478 Eukaryota
ENOG4111HEE LUCA
GeneTreeiENSGT00390000018710
HOGENOMiHOG000045718
InParanoidiQ9BUB7
KOiK17966
OMAiRAQIPVC
OrthoDBi1513532at2759
PhylomeDBiQ9BUB7
TreeFamiTF314656

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54968
PharosiQ9BUB7

Protein Ontology

More...
PROi
PR:Q9BUB7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000175606 Expressed in 232 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiQ9BUB7 baseline and differential
GenevisibleiQ9BUB7 HS

Family and domain databases

InterProiView protein in InterPro
IPR009724 TMEM70
PANTHERiPTHR13281 PTHR13281, 1 hit
PfamiView protein in Pfam
PF06979 TMEM70, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMM70_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BUB7
Secondary accession number(s): E9PDY9, Q9NWY5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2004
Last modified: October 16, 2019
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again