MKNK1

Functionⁱ

May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.4 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.2 Publications

Cofactorⁱ

Mg²⁺2 Publications

Activity regulationⁱ

Phosphorylated and activated by the p38 kinases and kinases in the Erk pathway.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	78	ATPPROSITE-ProRule annotation1 Publication		1
Active siteⁱ	211	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	55 – 63	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding
Source: UniProtKB
Inferred from direct assayⁱ
- 9155018
calcium-dependent protein serine/threonine kinase activity Source: GO_Central
calmodulin binding Source: GO_Central
calmodulin-dependent protein kinase activity Source: GO_Central
metal ion binding Source: UniProtKB-KW
protein serine/threonine kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 9155018

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

intracellular signal transduction
Source: UniProtKB
Inferred from direct assayⁱ
- 9155018
peptidyl-serine phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 17130135
protein autophosphorylation Source: GO_Central
protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 9155018
regulation of translation Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Translation regulation
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1295596 Spry regulation of FGF signaling
SignaLinkⁱ	Q9BUB5
SIGNORⁱ	Q9BUB5

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: MAP kinase-interacting serine/threonine-protein kinase 1 (EC:2.7.11.12 Publications) Alternative name(s): MAP kinase signal-integrating kinase 1 Short name: MAPK signal-integrating kinase 1 Short name: Mnk1
Gene namesⁱ	Name:MKNK1 Synonyms:MNK1
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000079277.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7110 MKNK1
MIMⁱ	606724 gene
neXtProtⁱ	NX_Q9BUB5

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	78	K → M: Loss of kinase activity; when associated with D-232. 1 Publication	1
Mutagenesisⁱ	232	D → A: Loss of kinase activity; when associated with K-78. 1 Publication	1
Mutagenesisⁱ	250	T → A: Loss of kinase activity; when associated with T-255. 1 Publication	1
Mutagenesisⁱ	255	T → A: Loss of kinase activity; when associated with T-250. 1 Publication	1
Mutagenesisⁱ	385	T → D: Constitutively active. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8569
Open Targets More...OpenTargetsⁱ	ENSG00000079277
PharmGKBⁱ	PA30829

Chemistry databases

ChEMBLⁱ	CHEMBL4718
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2104

Polymorphism and mutation databases

BioMutaⁱ	MKNK1
DMDMⁱ	30316115

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086334	1 – 465	MAP kinase-interacting serine/threonine-protein kinase 1Add BLAST		465

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	39	PhosphoserineCombined sources	1
Modified residueⁱ	221	PhosphoserineCombined sources	1
Modified residueⁱ	226	PhosphoserineCombined sources	1
Modified residueⁱ	250	Phosphothreonine1 Publication	1
Modified residueⁱ	255	Phosphothreonine1 Publication	1
Modified residueⁱ	385	PhosphothreonineCombined sources1 Publication	1
Modified residueⁱ	460	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase. MAPK3/ERK1 is one of the kinases which activate MKNK1/MNK1. Phosphorylation by PAK2 leads to a reduced phosphorylation of EIF4G1.4 Publications

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9BUB5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BUB5
PaxDbⁱ	Q9BUB5
PeptideAtlas More...PeptideAtlasⁱ	Q9BUB5
PRIDEⁱ	Q9BUB5
ProteomicsDBⁱ	79072 79073 [Q9BUB5-2] 79074 [Q9BUB5-3]

PTM databases

iPTMnetⁱ	Q9BUB5
PhosphoSitePlusⁱ	Q9BUB5

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000079277 Expressed in 225 organ(s), highest expression level in body of pancreas
CleanExⁱ	HS_MKNK1
ExpressionAtlasⁱ	Q9BUB5 baseline and differential
Genevisibleⁱ	Q9BUB5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB027355 CAB037310 HPA071293

HPAⁱ

CAB027355
CAB037310
HPA071293

Interactionⁱ

Subunit structureⁱ

Interacts with the C-terminal regions of EIF4G1 and EIF4G2. Also binds to dephosphorylated ERK1 and ERK2, and to the p38 kinases.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MAPK1	P28482	4	EBI-73837,EBI-959949
MAPK14	Q16539	3	EBI-73837,EBI-73946

GO - Molecular functionⁱ

calmodulin binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114138, 49 interactors
CORUMⁱ	Q9BUB5
ELMⁱ	Q9BUB5
IntActⁱ	Q9BUB5, 43 interactors
Molecular INTeraction database More...MINTⁱ	Q9BUB5
STRINGⁱ	9606.ENSP00000361014

Chemistry databases

BindingDBⁱ

Q9BUB5

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	44 – 46	Combined sources	3
Beta strandⁱ	48 – 57	Combined sources	10
Beta strandⁱ	59 – 68	Combined sources	10
Turnⁱ	69 – 71	Combined sources	3
Beta strandⁱ	74 – 81	Combined sources	8
Helixⁱ	87 – 101	Combined sources	15
Beta strandⁱ	110 – 115	Combined sources	6
Beta strandⁱ	117 – 125	Combined sources	9
Helixⁱ	132 – 139	Combined sources	8
Helixⁱ	144 – 163	Combined sources	20
Helixⁱ	214 – 216	Combined sources	3
Beta strandⁱ	217 – 220	Combined sources	4
Beta strandⁱ	227 – 230	Combined sources	4
Beta strandⁱ	271 – 274	Combined sources	4
Helixⁱ	277 – 296	Combined sources	20
Helixⁱ	337 – 340	Combined sources	4
Beta strandⁱ	341 – 343	Combined sources	3
Helixⁱ	345 – 354	Combined sources	10
Turnⁱ	359 – 361	Combined sources	3
Helixⁱ	365 – 370	Combined sources	6
Turnⁱ	372 – 375	Combined sources	4
Helixⁱ	439 – 441	Combined sources	3
Helixⁱ	443 – 449	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9BUB5
SMRⁱ	Q9BUB5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9BUB5

EvolutionaryTraceⁱ

Q9BUB5

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	49 – 374	Protein kinasePROSITE-ProRule annotationAdd BLAST		326

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0607 Eukaryota ENOG410XQA9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140876
HOVERGENⁱ	HBG106949
InParanoidⁱ	Q9BUB5
KEGG Orthology (KO) More...KOⁱ	K04372
OMAⁱ	EWRCISE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0G1X
PhylomeDBⁱ	Q9BUB5
TreeFamⁱ	TF314050

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 2 hits
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show all Align All

Isoform 11 Publication (identifier: Q9BUB5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSSQKLEKP IEMGSSEPLP IADGDRRRKK KRRGRATDSL PGKFEDMYKL 
        60         70         80         90        100
TSELLGEGAY AKVQGAVSLQ NGKEYAVKII EKQAGHSRSR VFREVETLYQ 
       110        120        130        140        150
CQGNKNILEL IEFFEDDTRF YLVFEKLQGG SILAHIQKQK HFNEREASRV 
       160        170        180        190        200
VRDVAAALDF LHTKDKVSLC HLGWSAMAPS GLTAAPTSLG SSDPPTSASQ 
       210        220        230        240        250
VAGTTGIAHR DLKPENILCE SPEKVSPVKI CDFDLGSGMK LNNSCTPITT 
       260        270        280        290        300
PELTTPCGSA EYMAPEVVEV FTDQATFYDK RCDLWSLGVV LYIMLSGYPP 
       310        320        330        340        350
FVGHCGADCG WDRGEVCRVC QNKLFESIQE GKYEFPDKDW AHISSEAKDL 
       360        370        380        390        400
ISKLLVRDAK QRLSAAQVLQ HPWVQGQAPE KGLPTPQVLQ RNSSTMDLTL 
       410        420        430        440        450
FAAEAIALNR QLSQHEENEL AEEPEALADG LCSMKLSPPC KSRLARRRAL 
       460 
AQAGRGEDRS PPTAL

Length:465

Mass (Da):51,342

Last modified:June 1, 2001 - v1

Checksum:ⁱCAE225C35DCB2B43

GO

Isoform 21 Publication (identifier: Q9BUB5-2) [UniParc]FASTA Add to basket

Also known as: MNK1a

The sequence of this isoform differs from the canonical sequence as follows:
165-205: Missing.

« Hide

        10         20         30         40         50
MVSSQKLEKP IEMGSSEPLP IADGDRRRKK KRRGRATDSL PGKFEDMYKL 
        60         70         80         90        100
TSELLGEGAY AKVQGAVSLQ NGKEYAVKII EKQAGHSRSR VFREVETLYQ 
       110        120        130        140        150
CQGNKNILEL IEFFEDDTRF YLVFEKLQGG SILAHIQKQK HFNEREASRV 
       160        170        180        190        200
VRDVAAALDF LHTKGIAHRD LKPENILCES PEKVSPVKIC DFDLGSGMKL 
       210        220        230        240        250
NNSCTPITTP ELTTPCGSAE YMAPEVVEVF TDQATFYDKR CDLWSLGVVL 
       260        270        280        290        300
YIMLSGYPPF VGHCGADCGW DRGEVCRVCQ NKLFESIQEG KYEFPDKDWA 
       310        320        330        340        350
HISSEAKDLI SKLLVRDAKQ RLSAAQVLQH PWVQGQAPEK GLPTPQVLQR 
       360        370        380        390        400
NSSTMDLTLF AAEAIALNRQ LSQHEENELA EEPEALADGL CSMKLSPPCK 
       410        420 
SRLARRRALA QAGRGEDRSP PTAL

Show »

Length:424

Mass (Da):47,402

Checksum:ⁱDB39E49EC0BED990

GO

Isoform 3 (identifier: Q9BUB5-3) [UniParc]FASTA Add to basket

Also known as: MNK1b

The sequence of this isoform differs from the canonical sequence as follows:
165-205: Missing.
377-465: QAPEKGLPTP...GEDRSPPTAL → EQQHNGPDALRS

« Hide

        10         20         30         40         50
MVSSQKLEKP IEMGSSEPLP IADGDRRRKK KRRGRATDSL PGKFEDMYKL 
        60         70         80         90        100
TSELLGEGAY AKVQGAVSLQ NGKEYAVKII EKQAGHSRSR VFREVETLYQ 
       110        120        130        140        150
CQGNKNILEL IEFFEDDTRF YLVFEKLQGG SILAHIQKQK HFNEREASRV 
       160        170        180        190        200
VRDVAAALDF LHTKGIAHRD LKPENILCES PEKVSPVKIC DFDLGSGMKL 
       210        220        230        240        250
NNSCTPITTP ELTTPCGSAE YMAPEVVEVF TDQATFYDKR CDLWSLGVVL 
       260        270        280        290        300
YIMLSGYPPF VGHCGADCGW DRGEVCRVCQ NKLFESIQEG KYEFPDKDWA 
       310        320        330        340 
HISSEAKDLI SKLLVRDAKQ RLSAAQVLQH PWVQGEQQHN GPDALRS

Show »

Length:347

Mass (Da):39,104

Checksum:ⁱ1CCA03B12D39641F

GO

Computationally mapped potential isoform sequencesⁱ

There are 11 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	E9PIA0	E9PIA0_HUMAN	MAP kinase-interacting serine/threo... MAP kinase-interacting serine/threonine-protein kinase 1	MKNK1	178	Annotation score:
	Q7Z319	Q7Z319_HUMAN	MAP kinase-interacting serine/threo... MAP kinase-interacting serine/threonine-protein kinase 1	MKNK1 DKFZp686E14208	329	Annotation score:
	E9PMM8	E9PMM8_HUMAN	MAP kinase-interacting serine/threo... MAP kinase-interacting serine/threonine-protein kinase 1	MKNK1	118	Annotation score:
	E9PSE0	E9PSE0_HUMAN	MAP kinase-interacting serine/threo... MAP kinase-interacting serine/threonine-protein kinase 1	MKNK1	100	Annotation score:
	H0YE67	H0YE67_HUMAN	MAP kinase-interacting serine/threo... MAP kinase-interacting serine/threonine-protein kinase 1	MKNK1	85	Annotation score:
	E9PLE7	E9PLE7_HUMAN	MAP kinase-interacting serine/threo... MAP kinase-interacting serine/threonine-protein kinase 1	MKNK1	101	Annotation score:
	E9PN34	E9PN34_HUMAN	MAP kinase-interacting serine/threo... MAP kinase-interacting serine/threonine-protein kinase 1	MKNK1	91	Annotation score:
	E9PII5	E9PII5_HUMAN	MAP kinase-interacting serine/threo... MAP kinase-interacting serine/threonine-protein kinase 1	MKNK1	126	Annotation score:
	E9PQ26	E9PQ26_HUMAN	MAP kinase-interacting serine/threo... MAP kinase-interacting serine/threonine-protein kinase 1	MKNK1	56	Annotation score:
	E9PSC9	E9PSC9_HUMAN	MAP kinase-interacting serine/threo... MAP kinase-interacting serine/threonine-protein kinase 1	MKNK1	60	Annotation score:
There is more potential isoformShow all

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_040801	49	K → Q1 PublicationCorresponds to variant dbSNP:rs56351860Ensembl.	1
Natural variantⁱVAR_040802	158	L → V1 PublicationCorresponds to variant dbSNP:rs56408722Ensembl.	1
Natural variantⁱVAR_040803	308	D → N1 PublicationCorresponds to variant dbSNP:rs55791614Ensembl.	1
Natural variantⁱVAR_040804	446	R → Q1 PublicationCorresponds to variant dbSNP:rs34881418Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_007352	165 – 205	Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST		41
Alternative sequenceⁱVSP_017515	377 – 465	QAPEK…PPTAL → EQQHNGPDALRS in isoform 3. 1 PublicationAdd BLAST		89

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB000409 mRNA Translation: BAA19885.1 AY355461 mRNA Translation: AAQ84219.1 AL136373 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06900.1 CH471059 Genomic DNA Translation: EAX06902.1 CH471059 Genomic DNA Translation: EAX06904.1 CH471059 Genomic DNA Translation: EAX06905.1 BC002755 mRNA Translation: AAH02755.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001129025.1, NM_001135553.2 NP_003675.2, NM_003684.5 NP_945324.1, NM_198973.3 XP_006711063.1, XM_006711000.1 [Q9BUB5-2] XP_016858148.1, XM_017002659.1 [Q9BUB5-3]
UniGeneⁱ	Hs.371594

Genome annotation databases

Ensemblⁱ	ENST00000371945; ENSP00000361013; ENSG00000079277 [Q9BUB5-2] ENST00000371946; ENSP00000361014; ENSG00000079277 [Q9BUB5-1] ENST00000428112; ENSP00000411135; ENSG00000079277 [Q9BUB5-3]
GeneIDⁱ	8569
KEGGⁱ	hsa:8569
UCSC genome browser More...UCSCⁱ	uc001cqb.5 human [Q9BUB5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase 1 (Fragment)		HUMAN		100	UniRef100_Q9BUB5
MAP kinase-interacting serine/threonine-protein kinase 1 (Fragment)		HUMAN		101
UPI000CF9A422		HUMAN		453
Q9BUB5-2	MAP kinase-interacting serine/threonine-protein kinase 1 (Fragment)		HUMAN		178	UniRef100_Q9BUB5-2
UPI0000205048		HUMAN		412

Protein	Similar proteins		Species	Score	Length	Source
Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase 1 (Fragment)		HUMAN		100	UniRef90_Q9BUB5
Uncharacterized protein		MACMU		467
Uncharacterized protein		MACFA		467
MAP kinase interacting serine/threonine kinase 1		PANTR		465
Uncharacterized protein		CERAT		465
+22
Q9BUB5-2	MAP kinase-interacting serine/threonine-protein kinase 1		MOUSE		427	UniRef90_Q9BUB5-2
MAP kinase-interacting serine/threonine-protein kinase 1		BOVIN		420
MAP kinase-interacting serine/threonine-protein kinase 1 (Fragment)		HUMAN		178
Uncharacterized protein		MACNE		520
Uncharacterized protein		AOTNA		429
+140
Q9BUB5-3	Uncharacterized protein		PROCO		348	UniRef90_Q9BUB5-3
cDNA FLJ77058, highly similar to Homo sapiens MAP kinase interacting serine/threonine kinase 1 (MKNK1), transcript variant 2, mRNA		HUMAN		347
MAP kinase interacting serine/threonine kinase 1		SAIBB		347
Uncharacterized protein		PAPAN		347
Uncharacterized protein		MANLE		347
+42

Protein	Similar proteins		Species	Score	Length	Source
Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase 1 (Fragment)		HUMAN		100	UniRef50_Q9BUB5
Uncharacterized protein		MACMU		467
Uncharacterized protein		MACFA		467
Uncharacterized protein		MACNE		465
Uncharacterized protein		PANPA		465
+57
Q9BUB5-2	MAP kinase-interacting serine/threonine-protein kinase 1		MOUSE		427	UniRef50_Q9BUB5-2
MAP kinase-interacting serine/threonine-protein kinase 1		BOVIN		420
MAP kinase-interacting serine/threonine-protein kinase 1		RAT		413
MAP kinase-interacting serine/threonine-protein kinase 2		XENTR		466
MAP kinase-interacting serine/threonine-protein kinase 2		XENLA		467
+708
Q9BUB5-3	Uncharacterized protein		PROCO		348	UniRef50_Q9BUB5-3
Uncharacterized protein		Cebus capucinus imitator		347
Uncharacterized protein		CALJA		347
Uncharacterized protein		NOMLE		347
MKNK1 isoform 7 (Fragment)		PONAB		347
+43

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB000409 mRNA Translation: BAA19885.1 AY355461 mRNA Translation: AAQ84219.1 AL136373 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06900.1 CH471059 Genomic DNA Translation: EAX06902.1 CH471059 Genomic DNA Translation: EAX06904.1 CH471059 Genomic DNA Translation: EAX06905.1 BC002755 mRNA Translation: AAH02755.1
RefSeqⁱ	NP_001129025.1, NM_001135553.2 NP_003675.2, NM_003684.5 NP_945324.1, NM_198973.3 XP_006711063.1, XM_006711000.1 [Q9BUB5-2] XP_016858148.1, XM_017002659.1 [Q9BUB5-3]
UniGeneⁱ	Hs.371594

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2HW6	X-ray	2.50	A/B	37-382	[»]
	2Y9Q	X-ray	1.55	B	434-451	[»]
	5WVD	X-ray	3.00	A/B	37-382	[»]
ProteinModelPortalⁱ	Q9BUB5
SMRⁱ	Q9BUB5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114138, 49 interactors
CORUMⁱ	Q9BUB5
ELMⁱ	Q9BUB5
IntActⁱ	Q9BUB5, 43 interactors
MINTⁱ	Q9BUB5
STRINGⁱ	9606.ENSP00000361014

Chemistry databases

BindingDBⁱ	Q9BUB5
ChEMBLⁱ	CHEMBL4718
GuidetoPHARMACOLOGYⁱ	2104

PTM databases

iPTMnetⁱ	Q9BUB5
PhosphoSitePlusⁱ	Q9BUB5

Polymorphism and mutation databases

BioMutaⁱ	MKNK1
DMDMⁱ	30316115

Proteomic databases

EPDⁱ	Q9BUB5
MaxQBⁱ	Q9BUB5
PaxDbⁱ	Q9BUB5
PeptideAtlasⁱ	Q9BUB5
PRIDEⁱ	Q9BUB5
ProteomicsDBⁱ	79072 79073 [Q9BUB5-2] 79074 [Q9BUB5-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8569
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000371945; ENSP00000361013; ENSG00000079277 [Q9BUB5-2] ENST00000371946; ENSP00000361014; ENSG00000079277 [Q9BUB5-1] ENST00000428112; ENSP00000411135; ENSG00000079277 [Q9BUB5-3]
GeneIDⁱ	8569
KEGGⁱ	hsa:8569
UCSCⁱ	uc001cqb.5 human [Q9BUB5-1]

Organism-specific databases

CTDⁱ	8569
DisGeNETⁱ	8569
EuPathDBⁱ	HostDB:ENSG00000079277.19
GeneCardsⁱ	MKNK1
HGNCⁱ	HGNC:7110 MKNK1
HPAⁱ	CAB027355 CAB037310 HPA071293
MIMⁱ	606724 gene
neXtProtⁱ	NX_Q9BUB5
OpenTargetsⁱ	ENSG00000079277
PharmGKBⁱ	PA30829
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0607 Eukaryota ENOG410XQA9 LUCA
GeneTreeⁱ	ENSGT00900000140876
HOVERGENⁱ	HBG106949
InParanoidⁱ	Q9BUB5
KOⁱ	K04372
OMAⁱ	EWRCISE
OrthoDBⁱ	EOG091G0G1X
PhylomeDBⁱ	Q9BUB5
TreeFamⁱ	TF314050

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1295596 Spry regulation of FGF signaling
SignaLinkⁱ	Q9BUB5
SIGNORⁱ	Q9BUB5

Miscellaneous databases

ChiTaRSⁱ	MKNK1 human
EvolutionaryTraceⁱ	Q9BUB5
GeneWikiⁱ	MKNK1
GenomeRNAiⁱ	8569
Protein Ontology More...PROⁱ	PR:Q9BUB5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000079277 Expressed in 225 organ(s), highest expression level in body of pancreas
CleanExⁱ	HS_MKNK1
ExpressionAtlasⁱ	Q9BUB5 baseline and differential
Genevisibleⁱ	Q9BUB5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 2 hits
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MKNK1_HUMAN
Accessionⁱ	Q9BUB5Primary (citable) accession number: Q9BUB5 Secondary accession number(s): D3DQ20 , D3DQ21, O00312, Q5TC06, Q5TC07, Q6V0N6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 30, 2003
	Last sequence update:	June 1, 2001
	Last modified:	September 12, 2018
	This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - Q9BUB5 (MKNK1_HUMAN)

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MAP kinase-interacting serine/threonine-protein kinase 1

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Gene expression databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ