Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 138 (11 Dec 2019)
Sequence version 3 (23 Nov 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Spindlin interactor and repressor of chromatin-binding protein

Gene

SPINDOC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability. Represses the expression of a number of SPIN1-regulated genes and the SPIN1-mediated activation of the Wnt signaling pathway. Can also inhibit the histone methyl-binding abilities of SPIN2A, SPIN2B, SPIN3 and SPIN4 (PubMed:29061846).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spindlin interactor and repressor of chromatin-binding proteinCurated
Alternative name(s):
SPIN1-docking protein1 Publication
Short name:
SPIN-DOC1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPINDOC1 PublicationImported
Synonyms:C11orf84
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000168005.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25115 SPINDOC

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BUA3

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000168005

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162377769

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BUA3 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C11orf84

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74733196

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003215281 – 381Spindlin interactor and repressor of chromatin-binding proteinAdd BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki48Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei121PhosphoserineCombined sources1
Modified residuei148PhosphoserineCombined sources1
Cross-linki189Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki220Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei248PhosphoserineCombined sources1
Modified residuei251PhosphoserineCombined sources1
Cross-linki290Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki294Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei308PhosphoserineCombined sources1 Publication1
Modified residuei310PhosphoserineCombined sources1
Cross-linki374Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BUA3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BUA3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BUA3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BUA3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BUA3

PeptideAtlas

More...
PeptideAtlasi
Q9BUA3

PRoteomics IDEntifications database

More...
PRIDEi
Q9BUA3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79066

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BUA3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BUA3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168005 Expressed in 156 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BUA3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BUA3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040128
HPA050313

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SPIN1, SPIN2A, SPIN2B, SPIN3 and SPIN4 (PubMed:29061846).

Interacts with TCF7L2 in a SPIN1-dependent manner (PubMed:29061846).

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126827, 25 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BUA3, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000294244

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BUA3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BUA3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi147 – 252Pro-richAdd BLAST106

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IS1G Eukaryota
ENOG4111DW1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00410000025985

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111741

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BUA3

Identification of Orthologs from Complete Genome Data

More...
OMAi
KHPQGTK

Database of Orthologous Groups

More...
OrthoDBi
570589at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BUA3

TreeFam database of animal gene trees

More...
TreeFami
TF337165

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040647 SPIN-DOC_Znf-C2H2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18658 zf-C2H2_12, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9BUA3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALKAEGAAL DCFEVTLKCE EGEDEEEAMV VAVIPRPEPM LRVTQQEKTP
60 70 80 90 100
PPRPSPLEAG SDGCEEPKQQ VSWEQEFLVG SSPGGSGRAL CMVCGAEIRA
110 120 130 140 150
PSADTARSHI LEQHPHTLDL SPSEKSNILE AWSEGVALLQ DVRAEQPSPP
160 170 180 190 200
NSDSGQDAHP DPDANPDAAR MPAEIVVLLD SEDNPSLPKR SRPRGLRPLE
210 220 230 240 250
LPAVPATEPG NKKPRGQRWK EPPGEEPVRK KRGRPMTKNL DPDPEPPSPD
260 270 280 290 300
SPTETFAAPA EVRHFTDGSF PAGFVLQLFS HTQLRGPDSK DSPKDREVAE
310 320 330 340 350
GGLPRAESPS PAPPPGLRGT LDLQVIRVRM EEPPAVSLLQ DWSRHPQGTK
360 370 380
RVGAGDTSDW PTVLSESSTT VAGKPEKGNG V
Length:381
Mass (Da):41,037
Last modified:November 23, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC8AB56B1B224D73
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YGY5H0YGY5_HUMAN
Spindlin interactor and repressor o...
SPINDOC
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGK9H0YGK9_HUMAN
Spindlin interactor and repressor o...
SPINDOC
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06160758E → Q. Corresponds to variant dbSNP:rs35875163Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471076 Genomic DNA Translation: EAW74172.1
BC002782 mRNA Translation: AAH02782.3
BC007540 mRNA Translation: AAH07540.2
BC056402 mRNA Translation: AAH56402.1
CR749697 mRNA Translation: CAH18477.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31594.1

NCBI Reference Sequences

More...
RefSeqi
NP_612480.1, NM_138471.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000294244; ENSP00000294244; ENSG00000168005

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
144097

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:144097

UCSC genome browser

More...
UCSCi
uc001nxt.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471076 Genomic DNA Translation: EAW74172.1
BC002782 mRNA Translation: AAH02782.3
BC007540 mRNA Translation: AAH07540.2
BC056402 mRNA Translation: AAH56402.1
CR749697 mRNA Translation: CAH18477.1
CCDSiCCDS31594.1
RefSeqiNP_612480.1, NM_138471.2

3D structure databases

SMRiQ9BUA3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi126827, 25 interactors
IntActiQ9BUA3, 10 interactors
STRINGi9606.ENSP00000294244

PTM databases

iPTMnetiQ9BUA3
PhosphoSitePlusiQ9BUA3

Polymorphism and mutation databases

BioMutaiC11orf84
DMDMi74733196

Proteomic databases

EPDiQ9BUA3
jPOSTiQ9BUA3
MassIVEiQ9BUA3
MaxQBiQ9BUA3
PaxDbiQ9BUA3
PeptideAtlasiQ9BUA3
PRIDEiQ9BUA3
ProteomicsDBi79066

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
144097

Genome annotation databases

EnsembliENST00000294244; ENSP00000294244; ENSG00000168005
GeneIDi144097
KEGGihsa:144097
UCSCiuc001nxt.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
144097
EuPathDBiHostDB:ENSG00000168005.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPINDOC
HGNCiHGNC:25115 SPINDOC
HPAiHPA040128
HPA050313
neXtProtiNX_Q9BUA3
OpenTargetsiENSG00000168005
PharmGKBiPA162377769

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IS1G Eukaryota
ENOG4111DW1 LUCA
GeneTreeiENSGT00410000025985
HOGENOMiHOG000111741
InParanoidiQ9BUA3
OMAiKHPQGTK
OrthoDBi570589at2759
PhylomeDBiQ9BUA3
TreeFamiTF337165

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C11orf84 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
144097
PharosiQ9BUA3 Tdark

Protein Ontology

More...
PROi
PR:Q9BUA3
RNActiQ9BUA3 protein

Gene expression databases

BgeeiENSG00000168005 Expressed in 156 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ9BUA3 baseline and differential
GenevisibleiQ9BUA3 HS

Family and domain databases

InterProiView protein in InterPro
IPR040647 SPIN-DOC_Znf-C2H2
PfamiView protein in Pfam
PF18658 zf-C2H2_12, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPNDC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BUA3
Secondary accession number(s): Q68CV7, Q6PHS2, Q96IH0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 23, 2004
Last modified: December 11, 2019
This is version 138 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again