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Entry version 158 (12 Aug 2020)
Sequence version 1 (01 Jun 2001)
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Protein

Deoxyhypusine hydroxylase

Gene

DOHH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the hydroxylation of the N6-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine (PubMed:16533814, PubMed:16371467, PubMed:19706422). Hypusination is unique to mature eIF-5A factor and is essential for its function (By similarity).UniRule annotationBy similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+UniRule annotationCombined sources3 PublicationsNote: Binds 2 Fe2+ ions per subunit.UniRule annotationCombined sources3 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 8-8.5 at 37 degrees Celsius.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: eIF5A hypusination

This protein is involved in the pathway eIF5A hypusination, which is part of Protein modification.UniRule annotation3 Publications
View all proteins of this organism that are known to be involved in the pathway eIF5A hypusination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi56Iron 1UniRule annotationCombined sources2 Publications1
Metal bindingi89Iron 2UniRule annotationCombined sources2 Publications1
Metal bindingi90Iron 2UniRule annotationCombined sources2 Publications1
Metal bindingi207Iron 2UniRule annotationCombined sources2 Publications1
Metal bindingi240Iron 1UniRule annotationCombined sources2 Publications1
Metal bindingi241Iron 1UniRule annotationCombined sources2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processHypusine biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS05318-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.14.99.29, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9BU89

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-204626, Hypusine synthesis from eIF5A-lysine

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00354

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Deoxyhypusine hydroxylase1 PublicationUniRule annotation (EC:1.14.99.29UniRule annotation3 Publications)
Short name:
hDOHH1 Publication
Alternative name(s):
Deoxyhypusine dioxygenaseUniRule annotation
Deoxyhypusine monooxygenaseUniRule annotation
HEAT-like repeat-containing protein 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DOHHUniRule annotationImported
Synonyms:HLRC11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000129932.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28662, DOHH

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611262, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BU89

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi56H → A: Loss of deoxyhypusine monooxygenase activity. Loss of iron-binding. 1 Publication1
Mutagenesisi57E → A: Loss of deoxyhypusine monooxygenase activity. No effect on iron-binding. 1 Publication1
Mutagenesisi86M → A: Loss of iron-binding. 1 Publication1
Mutagenesisi86M → L: No effect on iron-binding. Loss of iron-binding; when associated with L-237. 1 Publication1
Mutagenesisi89H → A: Loss of deoxyhypusine monooxygenase activity. Loss of iron-binding. 1 Publication1
Mutagenesisi90E → A: Loss of deoxyhypusine monooxygenase activity. Loss of iron-binding. 1 Publication1
Mutagenesisi207H → A: Loss of deoxyhypusine monooxygenase activity. Loss of iron-binding. 1 Publication1
Mutagenesisi208E → A: Loss of deoxyhypusine monooxygenase activity. No effect on iron-binding. 1 Publication1
Mutagenesisi237M → L: Decreased iron-binding. Loss of iron-binding; when associated with L-86. 1 Publication1
Mutagenesisi240H → A: Loss of deoxyhypusine monooxygenase activity. Loss of iron-binding. 1 Publication1
Mutagenesisi241E → A: Loss of deoxyhypusine monooxygenase activity. Loss of iron-binding. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
83475

Open Targets

More...
OpenTargetsi
ENSG00000129932

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671678

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BU89, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DOHH

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74733193

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002485751 – 302Deoxyhypusine hydroxylaseAdd BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BU89

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BU89

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BU89

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BU89

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BU89

PeptideAtlas

More...
PeptideAtlasi
Q9BU89

PRoteomics IDEntifications database

More...
PRIDEi
Q9BU89

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79065

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BU89

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BU89

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000129932, Expressed in globus pallidus and 249 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BU89, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000129932, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123662, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BU89, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000398882

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BU89, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1302
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BU89

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati54 – 80HEAT-like PBS-type 1Add BLAST27
Repeati87 – 113HEAT-like PBS-type 2Add BLAST27
Repeati174 – 200HEAT-like PBS-type 3Add BLAST27
Repeati205 – 231HEAT-like PBS-type 4Add BLAST27
Repeati238 – 264HEAT-like PBS-type 5Add BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the deoxyhypusine hydroxylase family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0567, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00500000044957

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_053974_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BU89

KEGG Orthology (KO)

More...
KOi
K06072

Identification of Orthologs from Complete Genome Data

More...
OMAi
CEYENSP

Database of Orthologous Groups

More...
OrthoDBi
1441854at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BU89

TreeFam database of animal gene trees

More...
TreeFami
TF105626

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.10.10, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_03101, Deoxyhypusine_hydroxylase, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR027517, Deoxyhypusine_hydroxylase
IPR021133, HEAT_type_2
IPR004155, PBS_lyase_HEAT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00567, EZ_HEAT, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50077, HEAT_REPEAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BU89-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTEQEVDAI GQTLVDPKQP LQARFRALFT LRGLGGPGAI AWISQAFDDD
60 70 80 90 100
SALLKHELAY CLGQMQDARA IPMLVDVLQD TRQEPMVRHE AGEALGAIGD
110 120 130 140 150
PEVLEILKQY SSDPVIEVAE TCQLAVRRLE WLQQHGGEPA AGPYLSVDPA
160 170 180 190 200
PPAEERDVGR LREALLDESR PLFERYRAMF ALRNAGGEEA ALALAEGLHC
210 220 230 240 250
GSALFRHEVG YVLGQLQHEA AVPQLAAALA RCTENPMVRH ECAEALGAIA
260 270 280 290 300
RPACLAALQA HADDPERVVR ESCEVALDMY EHETGRAFQY ADGLEQLRGA

PS
Length:302
Mass (Da):32,904
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCDA86E5549B98A2F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F9ZGM7A0A5F9ZGM7_HUMAN
Deoxyhypusine hydroxylase
DOHH
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC005551 Genomic DNA Translation: AAC33193.1
AC093052 Genomic DNA No translation available.
BC002817 mRNA Translation: AAH02817.1
BC009863 mRNA Translation: AAH09863.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12108.1

NCBI Reference Sequences

More...
RefSeqi
NP_001138637.1, NM_001145165.1
NP_112594.1, NM_031304.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000427575; ENSP00000398882; ENSG00000129932
ENST00000672935; ENSP00000500806; ENSG00000129932

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
83475

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:83475

UCSC genome browser

More...
UCSCi
uc002lxs.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005551 Genomic DNA Translation: AAC33193.1
AC093052 Genomic DNA No translation available.
BC002817 mRNA Translation: AAH02817.1
BC009863 mRNA Translation: AAH09863.1
CCDSiCCDS12108.1
RefSeqiNP_001138637.1, NM_001145165.1
NP_112594.1, NM_031304.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D4ZX-ray1.70A/B1-289[»]
4D50X-ray1.70A/B1-289[»]
SMRiQ9BU89
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi123662, 15 interactors
IntActiQ9BU89, 7 interactors
STRINGi9606.ENSP00000398882

PTM databases

iPTMnetiQ9BU89
PhosphoSitePlusiQ9BU89

Polymorphism and mutation databases

BioMutaiDOHH
DMDMi74733193

Proteomic databases

EPDiQ9BU89
jPOSTiQ9BU89
MassIVEiQ9BU89
MaxQBiQ9BU89
PaxDbiQ9BU89
PeptideAtlasiQ9BU89
PRIDEiQ9BU89
ProteomicsDBi79065

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23208, 41 antibodies

Genome annotation databases

EnsembliENST00000427575; ENSP00000398882; ENSG00000129932
ENST00000672935; ENSP00000500806; ENSG00000129932
GeneIDi83475
KEGGihsa:83475
UCSCiuc002lxs.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
83475
DisGeNETi83475
EuPathDBiHostDB:ENSG00000129932.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DOHH
HGNCiHGNC:28662, DOHH
HPAiENSG00000129932, Low tissue specificity
MIMi611262, gene
neXtProtiNX_Q9BU89
OpenTargetsiENSG00000129932
PharmGKBiPA142671678

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0567, Eukaryota
GeneTreeiENSGT00500000044957
HOGENOMiCLU_053974_0_0_1
InParanoidiQ9BU89
KOiK06072
OMAiCEYENSP
OrthoDBi1441854at2759
PhylomeDBiQ9BU89
TreeFamiTF105626

Enzyme and pathway databases

UniPathwayiUPA00354
BioCyciMetaCyc:HS05318-MONOMER
BRENDAi1.14.99.29, 2681
PathwayCommonsiQ9BU89
ReactomeiR-HSA-204626, Hypusine synthesis from eIF5A-lysine

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
83475, 433 hits in 878 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
83475
PharosiQ9BU89, Tbio

Protein Ontology

More...
PROi
PR:Q9BU89
RNActiQ9BU89, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000129932, Expressed in globus pallidus and 249 other tissues
GenevisibleiQ9BU89, HS

Family and domain databases

Gene3Di1.25.10.10, 2 hits
HAMAPiMF_03101, Deoxyhypusine_hydroxylase, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR027517, Deoxyhypusine_hydroxylase
IPR021133, HEAT_type_2
IPR004155, PBS_lyase_HEAT
SMARTiView protein in SMART
SM00567, EZ_HEAT, 6 hits
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50077, HEAT_REPEAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDOHH_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BU89
Secondary accession number(s): O75265
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2001
Last modified: August 12, 2020
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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