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Protein

Multiple myeloma tumor-associated protein 2

Gene

MMTAG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple myeloma tumor-associated protein 2
Short name:
hMMTAG2
Gene namesi
Name:MMTAG2
Synonyms:C1orf35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143793.12
HGNCiHGNC:19032 C1orf35
neXtProtiNX_Q9BU76

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143793
PharmGKBiPA38781

Polymorphism and mutation databases

BioMutaiMMTAG2
DMDMi73621220

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000965181 – 263Multiple myeloma tumor-associated protein 2Add BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki104Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki113Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei123PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1
Modified residuei164PhosphoserineCombined sources1
Modified residuei215PhosphothreonineCombined sources1
Modified residuei216PhosphoserineCombined sources1
Modified residuei217PhosphoserineCombined sources1
Modified residuei219PhosphothreonineCombined sources1
Modified residuei220PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9BU76
MaxQBiQ9BU76
PaxDbiQ9BU76
PeptideAtlasiQ9BU76
PRIDEiQ9BU76
ProteomicsDBi79060
79061 [Q9BU76-2]
79062 [Q9BU76-3]
79063 [Q9BU76-4]

PTM databases

iPTMnetiQ9BU76
PhosphoSitePlusiQ9BU76

Expressioni

Gene expression databases

BgeeiENSG00000143793 Expressed in 200 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_C1orf35
GenevisibleiQ9BU76 HS

Organism-specific databases

HPAiHPA046175

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi122586, 29 interactors
IntActiQ9BU76, 54 interactors
MINTiQ9BU76
STRINGi9606.ENSP00000272139

Structurei

3D structure databases

ProteinModelPortaliQ9BU76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi184 – 206Lys-richAdd BLAST23
Compositional biasi226 – 229Poly-His4

Phylogenomic databases

eggNOGiKOG4520 Eukaryota
ENOG41123ER LUCA
GeneTreeiENSGT00390000005590
HOGENOMiHOG000242968
HOVERGENiHBG066325
InParanoidiQ9BU76
OMAiHEKRERH
OrthoDBiEOG091G0LCC
PhylomeDBiQ9BU76
TreeFamiTF332234

Family and domain databases

InterProiView protein in InterPro
IPR019315 Kinase_phosphorylation_domain
IPR039207 MMTAG2-like
PANTHERiPTHR14580 PTHR14580, 1 hit
PfamiView protein in Pfam
PF10159 MMtag, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BU76-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFGSSRGGVR GGQDQFNWED VKTDKQRENY LGNSLMAPVG RWQKGRDLTW
60 70 80 90 100
YAKGRAPCAG PSREEELAAV REAEREALLA ALGYKNVKKQ PTGLSKEDFA
110 120 130 140 150
EVCKREGGDP EEKGVDRLLG LGSASGSVGR VAMSREDKEA AKLGLSVFTH
160 170 180 190 200
HRVESGGPGT SAASARRKPR AEDQTESSCE SHRKSKKEKK KKKKRKHKKE
210 220 230 240 250
KKKKDKEHRR PAEATSSPTS PERPRHHHHD SDSNSPCCKR RKRGHSGDRR
260
SPSRRWHDRG SEA
Length:263
Mass (Da):29,412
Last modified:June 1, 2001 - v1
Checksum:i51A7DEE260DBD787
GO
Isoform 2 (identifier: Q9BU76-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-141: SGSVGRVAMSREDKEAA → RCGRVSRGGQHWARLLG
     142-263: Missing.

Note: No experimental confirmation available.
Show »
Length:141
Mass (Da):15,521
Checksum:iF23E1755F88CF093
GO
Isoform 3 (identifier: Q9BU76-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-155: HHRVES → VIPRPA
     156-263: Missing.

Note: No experimental confirmation available.
Show »
Length:155
Mass (Da):16,842
Checksum:i437074D523DB3AA1
GO
Isoform 4 (identifier: Q9BU76-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-189: SCESHRKSKKEK → RGVSRVTLEERS
     190-263: Missing.

Note: No experimental confirmation available.
Show »
Length:189
Mass (Da):20,536
Checksum:iDBEC809E97848129
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29N → I in AAN15215 (PubMed:12545221).Curated1
Sequence conflicti154E → K in AAN15215 (PubMed:12545221).Curated1
Sequence conflicti262E → K in AAN15215 (PubMed:12545221).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015129125 – 141SGSVG…DKEAA → RCGRVSRGGQHWARLLG in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_015130142 – 263Missing in isoform 2. 1 PublicationAdd BLAST122
Alternative sequenceiVSP_015131150 – 155HHRVES → VIPRPA in isoform 3. 1 Publication6
Alternative sequenceiVSP_015132156 – 263Missing in isoform 3. 1 PublicationAdd BLAST108
Alternative sequenceiVSP_015133178 – 189SCESH…SKKEK → RGVSRVTLEERS in isoform 4. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_015134190 – 263Missing in isoform 4. 1 PublicationAdd BLAST74

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY137773 mRNA Translation: AAN15215.1
AK123377 mRNA Translation: BAC85598.1
AK126087 mRNA Translation: BAC86431.1
AL136379 Genomic DNA No translation available.
BC002843 mRNA Translation: AAH02843.1
BC062585 mRNA Translation: AAH62585.1
CCDSiCCDS1566.1 [Q9BU76-1]
RefSeqiNP_077295.1, NM_024319.3 [Q9BU76-1]
UniGeneiHs.445952

Genome annotation databases

EnsembliENST00000272139; ENSP00000272139; ENSG00000143793 [Q9BU76-1]
GeneIDi79169
KEGGihsa:79169
UCSCiuc001hrx.4 human [Q9BU76-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY137773 mRNA Translation: AAN15215.1
AK123377 mRNA Translation: BAC85598.1
AK126087 mRNA Translation: BAC86431.1
AL136379 Genomic DNA No translation available.
BC002843 mRNA Translation: AAH02843.1
BC062585 mRNA Translation: AAH62585.1
CCDSiCCDS1566.1 [Q9BU76-1]
RefSeqiNP_077295.1, NM_024319.3 [Q9BU76-1]
UniGeneiHs.445952

3D structure databases

ProteinModelPortaliQ9BU76
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122586, 29 interactors
IntActiQ9BU76, 54 interactors
MINTiQ9BU76
STRINGi9606.ENSP00000272139

PTM databases

iPTMnetiQ9BU76
PhosphoSitePlusiQ9BU76

Polymorphism and mutation databases

BioMutaiMMTAG2
DMDMi73621220

Proteomic databases

EPDiQ9BU76
MaxQBiQ9BU76
PaxDbiQ9BU76
PeptideAtlasiQ9BU76
PRIDEiQ9BU76
ProteomicsDBi79060
79061 [Q9BU76-2]
79062 [Q9BU76-3]
79063 [Q9BU76-4]

Protocols and materials databases

DNASUi79169
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272139; ENSP00000272139; ENSG00000143793 [Q9BU76-1]
GeneIDi79169
KEGGihsa:79169
UCSCiuc001hrx.4 human [Q9BU76-1]

Organism-specific databases

CTDi79169
EuPathDBiHostDB:ENSG00000143793.12
GeneCardsiC1orf35
HGNCiHGNC:19032 C1orf35
HPAiHPA046175
neXtProtiNX_Q9BU76
OpenTargetsiENSG00000143793
PharmGKBiPA38781
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4520 Eukaryota
ENOG41123ER LUCA
GeneTreeiENSGT00390000005590
HOGENOMiHOG000242968
HOVERGENiHBG066325
InParanoidiQ9BU76
OMAiHEKRERH
OrthoDBiEOG091G0LCC
PhylomeDBiQ9BU76
TreeFamiTF332234

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiC1orf35 human
GenomeRNAii79169
PROiPR:Q9BU76

Gene expression databases

BgeeiENSG00000143793 Expressed in 200 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_C1orf35
GenevisibleiQ9BU76 HS

Family and domain databases

InterProiView protein in InterPro
IPR019315 Kinase_phosphorylation_domain
IPR039207 MMTAG2-like
PANTHERiPTHR14580 PTHR14580, 1 hit
PfamiView protein in Pfam
PF10159 MMtag, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMMTA2_HUMAN
AccessioniPrimary (citable) accession number: Q9BU76
Secondary accession number(s): Q6P5Y0
, Q6ZTZ6, Q6ZWA6, Q8IZH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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