UniProtKB - Q9BU70 (TRMO_HUMAN)
Protein
tRNA (adenine(37)-N6)-methyltransferase
Gene
TRMO
Organism
Homo sapiens (Human)
Status
Functioni
S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m6t6A37) of the tRNA anticodon loop of tRNA(Ser)(GCU) (PubMed:25063302). The methyl group of m6t6A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA (By similarity).By similarity1 Publication
GO - Molecular functioni
- tRNA (adenine) methyltransferase activity Source: GO_Central
- tRNA (adenine-N6-)-methyltransferase activity Source: UniProtKB
GO - Biological processi
- tRNA methylation Source: UniProtKB
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | tRNA processing |
Ligand | S-adenosyl-L-methionine |
Enzyme and pathway databases
PathwayCommonsi | Q9BU70 |
Names & Taxonomyi
Protein namesi | Recommended name: tRNA (adenine(37)-N6)-methyltransferaseCurated (EC:2.1.1.-1 Publication)Alternative name(s): tRNA methyltransferase O1 PublicationImported |
Gene namesi | ORF Names:HSPC219 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30967, TRMO |
neXtProti | NX_Q9BU70 |
VEuPathDBi | HostDB:ENSG00000136932.13 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 51531 |
OpenTargetsi | ENSG00000136932 |
PharmGKBi | PA134875112 |
Miscellaneous databases
Pharosi | Q9BU70, Tbio |
Genetic variation databases
BioMutai | TRMO |
DMDMi | 152112517 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000288886 | 1 – 441 | tRNA (adenine(37)-N6)-methyltransferaseAdd BLAST | 441 |
Proteomic databases
EPDi | Q9BU70 |
MassIVEi | Q9BU70 |
MaxQBi | Q9BU70 |
PaxDbi | Q9BU70 |
PeptideAtlasi | Q9BU70 |
PRIDEi | Q9BU70 |
ProteomicsDBi | 79058 |
PTM databases
iPTMneti | Q9BU70 |
PhosphoSitePlusi | Q9BU70 |
Expressioni
Gene expression databases
Bgeei | ENSG00000136932, Expressed in calcaneal tendon and 218 other tissues |
ExpressionAtlasi | Q9BU70, baseline and differential |
Genevisiblei | Q9BU70, HS |
Organism-specific databases
HPAi | ENSG00000136932, Low tissue specificity |
Interactioni
Binary interactionsi
Q9BU70
With | #Exp. | IntAct |
---|---|---|
SPATC1L - isoform 2 [Q9H0A9-2] | 5 | EBI-2652818,EBI-11995806 |
Protein-protein interaction databases
BioGRIDi | 119593, 7 interactors |
IntActi | Q9BU70, 28 interactors |
MINTi | Q9BU70 |
STRINGi | 9606.ENSP00000364260 |
Miscellaneous databases
RNActi | Q9BU70, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 168 | TsaA-likePROSITE-ProRule annotationAdd BLAST | 139 |
Phylogenomic databases
eggNOGi | KOG2942, Eukaryota |
GeneTreei | ENSGT00390000004643 |
HOGENOMi | CLU_013458_1_0_1 |
InParanoidi | Q9BU70 |
OMAi | RRKHCQD |
OrthoDBi | 1483097at2759 |
PhylomeDBi | Q9BU70 |
TreeFami | TF331670 |
Family and domain databases
CDDi | cd09281, UPF0066, 1 hit |
Gene3Di | 2.40.30.70, 1 hit |
InterProi | View protein in InterPro IPR023370, TrmO-like_N IPR023368, UPF0066_cons_site IPR040372, YaeB-like IPR036413, YaeB-like_sf IPR036414, YaeB_N_sf |
PANTHERi | PTHR12818, PTHR12818, 1 hit |
Pfami | View protein in Pfam PF01980, TrmO, 1 hit |
SUPFAMi | SSF118196, SSF118196, 2 hits |
TIGRFAMsi | TIGR00104, tRNA_TsaA, 1 hit |
PROSITEi | View protein in PROSITE PS01318, TSAA_1, 1 hit PS51668, TSAA_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q9BU70-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRGLEESGPR PTATPCGCVK PALETGNLLT EPVGYLESCF SAKNGTPRQP
60 70 80 90 100
SICSYSRACL RIRKRIFNNP EHSLMGLEQF SHVWILFVFH KNGHLSCKAK
110 120 130 140 150
VQPPRLNGAK TGVFSTRSPH RPNAIGLTLA KLEKVEGGAI YLSGIDMIHG
160 170 180 190 200
TPVLDIKPYI AEYDSPQNVM EPLADFNLQN NQHTPNTVSQ SDSKTDSCDQ
210 220 230 240 250
RQLSGCDEPQ PHHSTKRKPK CPEDRTSEEN YLTHSDTARI QQAFPMHREI
260 270 280 290 300
AVDFGLESRR DQSSSVAEEQ IGPYCPEKSF SEKGTDKKLE RVEGAAVLQG
310 320 330 340 350
SRAETQPMAP HCPAGRADGA PRSVVPAWVT EAPVATLEVR FTPHAEMDLG
360 370 380 390 400
QLSSQDVGQA SFKYFQSAEE AKRAIEAVLS ADPRSVYRRK LCQDRLFYFT
410 420 430 440
VDIAHVTCWF GDGFAEVLRI KPASEPVHMT GPVGSLVSLG S
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5T114 | Q5T114_HUMAN | Chromosome 9 open reading frame 156... | TRMO C9orf156, hCG_29948 | 295 | Annotation score: | ||
Q6Y2L2 | Q6Y2L2_HUMAN | LP4790 protein | TRMO | 185 | Annotation score: | ||
Q5T112 | Q5T112_HUMAN | tRNA (adenine(37)-N6)-methyltransfe... | TRMO | 159 | Annotation score: | ||
Q5T111 | Q5T111_HUMAN | tRNA (adenine(37)-N6)-methyltransfe... | TRMO | 172 | Annotation score: |
Sequence cautioni
The sequence AAF36139 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 341 | F → V in CAA60025 (PubMed:9153233).Curated | 1 | |
Sequence conflicti | 358 | G → D in BAA91013 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032527 | 7 | S → P2 PublicationsCorresponds to variant dbSNP:rs3183927Ensembl. | 1 | |
Natural variantiVAR_032528 | 252 | V → A. Corresponds to variant dbSNP:rs35606344Ensembl. | 1 | |
Natural variantiVAR_032529 | 324 | V → M. Corresponds to variant dbSNP:rs2282192Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000213 mRNA Translation: BAA91013.1 AL499604 Genomic DNA No translation available. BC002863 mRNA Translation: AAH02863.1 AF151053 mRNA Translation: AAF36139.1 Sequence problems. X86033 mRNA Translation: CAA60025.1 |
CCDSi | CCDS6730.1 |
RefSeqi | NP_001317654.1, NM_001330725.1 NP_057565.3, NM_016481.4 |
Genome annotation databases
Ensembli | ENST00000375119; ENSP00000364260; ENSG00000136932 |
GeneIDi | 51531 |
KEGGi | hsa:51531 |
UCSCi | uc004axv.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000213 mRNA Translation: BAA91013.1 AL499604 Genomic DNA No translation available. BC002863 mRNA Translation: AAH02863.1 AF151053 mRNA Translation: AAF36139.1 Sequence problems. X86033 mRNA Translation: CAA60025.1 |
CCDSi | CCDS6730.1 |
RefSeqi | NP_001317654.1, NM_001330725.1 NP_057565.3, NM_016481.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119593, 7 interactors |
IntActi | Q9BU70, 28 interactors |
MINTi | Q9BU70 |
STRINGi | 9606.ENSP00000364260 |
PTM databases
iPTMneti | Q9BU70 |
PhosphoSitePlusi | Q9BU70 |
Genetic variation databases
BioMutai | TRMO |
DMDMi | 152112517 |
Proteomic databases
EPDi | Q9BU70 |
MassIVEi | Q9BU70 |
MaxQBi | Q9BU70 |
PaxDbi | Q9BU70 |
PeptideAtlasi | Q9BU70 |
PRIDEi | Q9BU70 |
ProteomicsDBi | 79058 |
Protocols and materials databases
Antibodypediai | 28898, 161 antibodies |
DNASUi | 51531 |
Genome annotation databases
Ensembli | ENST00000375119; ENSP00000364260; ENSG00000136932 |
GeneIDi | 51531 |
KEGGi | hsa:51531 |
UCSCi | uc004axv.2, human |
Organism-specific databases
CTDi | 51531 |
DisGeNETi | 51531 |
GeneCardsi | TRMO |
HGNCi | HGNC:30967, TRMO |
HPAi | ENSG00000136932, Low tissue specificity |
neXtProti | NX_Q9BU70 |
OpenTargetsi | ENSG00000136932 |
PharmGKBi | PA134875112 |
VEuPathDBi | HostDB:ENSG00000136932.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2942, Eukaryota |
GeneTreei | ENSGT00390000004643 |
HOGENOMi | CLU_013458_1_0_1 |
InParanoidi | Q9BU70 |
OMAi | RRKHCQD |
OrthoDBi | 1483097at2759 |
PhylomeDBi | Q9BU70 |
TreeFami | TF331670 |
Enzyme and pathway databases
PathwayCommonsi | Q9BU70 |
Miscellaneous databases
BioGRID-ORCSi | 51531, 5 hits in 872 CRISPR screens |
GenomeRNAii | 51531 |
Pharosi | Q9BU70, Tbio |
PROi | PR:Q9BU70 |
RNActi | Q9BU70, protein |
Gene expression databases
Bgeei | ENSG00000136932, Expressed in calcaneal tendon and 218 other tissues |
ExpressionAtlasi | Q9BU70, baseline and differential |
Genevisiblei | Q9BU70, HS |
Family and domain databases
CDDi | cd09281, UPF0066, 1 hit |
Gene3Di | 2.40.30.70, 1 hit |
InterProi | View protein in InterPro IPR023370, TrmO-like_N IPR023368, UPF0066_cons_site IPR040372, YaeB-like IPR036413, YaeB-like_sf IPR036414, YaeB_N_sf |
PANTHERi | PTHR12818, PTHR12818, 1 hit |
Pfami | View protein in Pfam PF01980, TrmO, 1 hit |
SUPFAMi | SSF118196, SSF118196, 2 hits |
TIGRFAMsi | TIGR00104, tRNA_TsaA, 1 hit |
PROSITEi | View protein in PROSITE PS01318, TSAA_1, 1 hit PS51668, TSAA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRMO_HUMAN | |
Accessioni | Q9BU70Primary (citable) accession number: Q9BU70 Secondary accession number(s): Q5T113 Q9P0Q7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | May 29, 2007 | |
Last modified: | February 10, 2021 | |
This is version 130 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports