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Protein

tRNA (adenine(37)-N6)-methyltransferase

Gene

TRMO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m6t6A37) of the tRNA anticodon loop of tRNA(Ser)(GCU) (PubMed:25063302). The methyl group of m6t6A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA (By similarity).By similarity1 Publication

GO - Molecular functioni

  • tRNA (adenine-N6-)-methyltransferase activity Source: UniProtKB

GO - Biological processi

  • tRNA methylation Source: UniProtKB

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (adenine(37)-N6)-methyltransferaseCurated (EC:2.1.1.-1 Publication)
Alternative name(s):
tRNA methyltransferase O1 PublicationImported
Gene namesi
Name:TRMO1 PublicationImported
Synonyms:C9orf156
ORF Names:HSPC219
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136932.13
HGNCiHGNC:30967 TRMO
neXtProtiNX_Q9BU70

Pathology & Biotechi

Organism-specific databases

DisGeNETi51531
OpenTargetsiENSG00000136932
PharmGKBiPA134875112

Polymorphism and mutation databases

BioMutaiC9orf156
DMDMi152112517

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002888861 – 441tRNA (adenine(37)-N6)-methyltransferaseAdd BLAST441

Proteomic databases

EPDiQ9BU70
MaxQBiQ9BU70
PaxDbiQ9BU70
PeptideAtlasiQ9BU70
PRIDEiQ9BU70
ProteomicsDBi79058

PTM databases

iPTMnetiQ9BU70
PhosphoSitePlusiQ9BU70

Expressioni

Gene expression databases

BgeeiENSG00000136932
CleanExiHS_C9orf156
ExpressionAtlasiQ9BU70 baseline and differential
GenevisibleiQ9BU70 HS

Organism-specific databases

HPAiHPA021281
HPA052197

Interactioni

Protein-protein interaction databases

BioGridi119593, 6 interactors
IntActiQ9BU70, 24 interactors
MINTiQ9BU70
STRINGi9606.ENSP00000364260

Structurei

3D structure databases

ProteinModelPortaliQ9BU70
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 168TsaA-likePROSITE-ProRule annotationAdd BLAST139

Phylogenomic databases

eggNOGiKOG2942 Eukaryota
COG1720 LUCA
GeneTreeiENSGT00390000004643
HOGENOMiHOG000231645
HOVERGENiHBG054288
InParanoidiQ9BU70
OMAiFKYFQSA
OrthoDBiEOG091G0DXG
PhylomeDBiQ9BU70
TreeFamiTF331670

Family and domain databases

CDDicd09281 UPF0066, 1 hit
Gene3Di2.40.30.70, 1 hit
InterProiView protein in InterPro
IPR023368 UPF0066_cons_site
IPR023370 YaeB-like_N
IPR036413 YaeB-like_sf
IPR036414 YaeB_N_sf
PfamiView protein in Pfam
PF01980 UPF0066, 1 hit
SUPFAMiSSF118196 SSF118196, 2 hits
TIGRFAMsiTIGR00104 tRNA_TsaA, 1 hit
PROSITEiView protein in PROSITE
PS01318 TSAA_1, 1 hit
PS51668 TSAA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BU70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGLEESGPR PTATPCGCVK PALETGNLLT EPVGYLESCF SAKNGTPRQP
60 70 80 90 100
SICSYSRACL RIRKRIFNNP EHSLMGLEQF SHVWILFVFH KNGHLSCKAK
110 120 130 140 150
VQPPRLNGAK TGVFSTRSPH RPNAIGLTLA KLEKVEGGAI YLSGIDMIHG
160 170 180 190 200
TPVLDIKPYI AEYDSPQNVM EPLADFNLQN NQHTPNTVSQ SDSKTDSCDQ
210 220 230 240 250
RQLSGCDEPQ PHHSTKRKPK CPEDRTSEEN YLTHSDTARI QQAFPMHREI
260 270 280 290 300
AVDFGLESRR DQSSSVAEEQ IGPYCPEKSF SEKGTDKKLE RVEGAAVLQG
310 320 330 340 350
SRAETQPMAP HCPAGRADGA PRSVVPAWVT EAPVATLEVR FTPHAEMDLG
360 370 380 390 400
QLSSQDVGQA SFKYFQSAEE AKRAIEAVLS ADPRSVYRRK LCQDRLFYFT
410 420 430 440
VDIAHVTCWF GDGFAEVLRI KPASEPVHMT GPVGSLVSLG S
Length:441
Mass (Da):48,587
Last modified:May 29, 2007 - v2
Checksum:i84E6CF8BD294EDD2
GO

Sequence cautioni

The sequence AAF36139 differs from that shown. Contaminating sequence.Curated
The sequence AAF36139 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti341F → V in CAA60025 (PubMed:9153233).Curated1
Sequence conflicti358G → D in BAA91013 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0325277S → P2 PublicationsCorresponds to variant dbSNP:rs3183927Ensembl.1
Natural variantiVAR_032528252V → A. Corresponds to variant dbSNP:rs35606344Ensembl.1
Natural variantiVAR_032529324V → M. Corresponds to variant dbSNP:rs2282192Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000213 mRNA Translation: BAA91013.1
AL499604 Genomic DNA No translation available.
BC002863 mRNA Translation: AAH02863.1
AF151053 mRNA Translation: AAF36139.1 Sequence problems.
X86033 mRNA Translation: CAA60025.1
CCDSiCCDS6730.1
RefSeqiNP_001317654.1, NM_001330725.1
NP_057565.3, NM_016481.4
UniGeneiHs.9196

Genome annotation databases

EnsembliENST00000375119; ENSP00000364260; ENSG00000136932
GeneIDi51531
KEGGihsa:51531
UCSCiuc004axv.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRMO_HUMAN
AccessioniPrimary (citable) accession number: Q9BU70
Secondary accession number(s): Q5T113
, Q86SK0, Q9NXJ7, Q9P0Q7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: July 18, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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