TRMO

Functionⁱ

S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m₆t₆A37) of the tRNA anticodon loop of tRNA(Ser)(GCU) (PubMed:25063302). The methyl group of m₆t₆A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

tRNA (adenine-N6-)-methyltransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 25063302

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

tRNA methylation
Source: UniProtKB
Inferred from direct assayⁱ
- 25063302

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Methyltransferase, Transferase
Biological process	tRNA processing
Ligand	S-adenosyl-L-methionine

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: tRNA (adenine(37)-N6)-methyltransferaseCurated (EC:2.1.1.-1 Publication) Alternative name(s): tRNA methyltransferase O1 PublicationImported
Gene namesⁱ	Name:TRMO1 PublicationImported Synonyms:C9orf156 ORF Names:HSPC219
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000136932.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30967 TRMO
neXtProtⁱ	NX_Q9BU70

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51531
Open Targets More...OpenTargetsⁱ	ENSG00000136932
PharmGKBⁱ	PA134875112

Polymorphism and mutation databases

BioMutaⁱ	C9orf156
DMDMⁱ	152112517

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000288886	1 – 441	tRNA (adenine(37)-N6)-methyltransferaseAdd BLAST		441

Proteomic databases

EPDⁱ	Q9BU70
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BU70
PaxDbⁱ	Q9BU70
PeptideAtlas More...PeptideAtlasⁱ	Q9BU70
PRIDEⁱ	Q9BU70
ProteomicsDBⁱ	79058

PTM databases

iPTMnetⁱ	Q9BU70
PhosphoSitePlusⁱ	Q9BU70

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000136932
CleanExⁱ	HS_C9orf156
ExpressionAtlasⁱ	Q9BU70 baseline and differential
Genevisibleⁱ	Q9BU70 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA021281 HPA052197

HPAⁱ

HPA021281
HPA052197

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	119593, 6 interactors
IntActⁱ	Q9BU70, 24 interactors
Molecular INTeraction database More...MINTⁱ	Q9BU70
STRINGⁱ	9606.ENSP00000364260

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BU70
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	30 – 168	TsaA-likePROSITE-ProRule annotationAdd BLAST		139

Phylogenomic databases

eggNOGⁱ	KOG2942 Eukaryota COG1720 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004643
HOGENOMⁱ	HOG000231645
HOVERGENⁱ	HBG054288
InParanoidⁱ	Q9BU70
OMAⁱ	FKYFQSA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DXG
PhylomeDBⁱ	Q9BU70
TreeFamⁱ	TF331670

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd09281 UPF0066, 1 hit
Gene3Dⁱ	2.40.30.70, 1 hit
InterProⁱ	View protein in InterPro IPR023368 UPF0066_cons_site IPR023370 YaeB-like_N IPR036413 YaeB-like_sf IPR036414 YaeB_N_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01980 UPF0066, 1 hit
SUPFAMⁱ	SSF118196 SSF118196, 2 hits
TIGRFAMsⁱ	TIGR00104 tRNA_TsaA, 1 hit
PROSITEⁱ	View protein in PROSITE PS01318 TSAA_1, 1 hit PS51668 TSAA_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9BU70-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRGLEESGPR PTATPCGCVK PALETGNLLT EPVGYLESCF SAKNGTPRQP 
        60         70         80         90        100
SICSYSRACL RIRKRIFNNP EHSLMGLEQF SHVWILFVFH KNGHLSCKAK 
       110        120        130        140        150
VQPPRLNGAK TGVFSTRSPH RPNAIGLTLA KLEKVEGGAI YLSGIDMIHG 
       160        170        180        190        200
TPVLDIKPYI AEYDSPQNVM EPLADFNLQN NQHTPNTVSQ SDSKTDSCDQ 
       210        220        230        240        250
RQLSGCDEPQ PHHSTKRKPK CPEDRTSEEN YLTHSDTARI QQAFPMHREI 
       260        270        280        290        300
AVDFGLESRR DQSSSVAEEQ IGPYCPEKSF SEKGTDKKLE RVEGAAVLQG 
       310        320        330        340        350
SRAETQPMAP HCPAGRADGA PRSVVPAWVT EAPVATLEVR FTPHAEMDLG 
       360        370        380        390        400
QLSSQDVGQA SFKYFQSAEE AKRAIEAVLS ADPRSVYRRK LCQDRLFYFT 
       410        420        430        440 
VDIAHVTCWF GDGFAEVLRI KPASEPVHMT GPVGSLVSLG S

Length:441

Mass (Da):48,587

Last modified:May 29, 2007 - v2

Checksum:ⁱ84E6CF8BD294EDD2

GO

Sequence cautionⁱ

The sequence AAF36139 differs from that shown. Contaminating sequence.Curated

The sequence AAF36139 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	341	F → V in CAA60025 (PubMed:9153233).Curated		1
Sequence conflictⁱ	358	G → D in BAA91013 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_032527	7	S → P2 PublicationsCorresponds to variant dbSNP:rs3183927Ensembl.	1
Natural variantⁱVAR_032528	252	V → A. Corresponds to variant dbSNP:rs35606344Ensembl.	1
Natural variantⁱVAR_032529	324	V → M. Corresponds to variant dbSNP:rs2282192Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK000213 mRNA Translation: BAA91013.1 AL499604 Genomic DNA No translation available. BC002863 mRNA Translation: AAH02863.1 AF151053 mRNA Translation: AAF36139.1 Sequence problems. X86033 mRNA Translation: CAA60025.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6730.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001317654.1, NM_001330725.1 NP_057565.3, NM_016481.4
UniGeneⁱ	Hs.9196

Genome annotation databases

Ensemblⁱ	ENST00000375119; ENSP00000364260; ENSG00000136932
GeneIDⁱ	51531
KEGGⁱ	hsa:51531
UCSC genome browser More...UCSCⁱ	uc004axv.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length
Q9BU70	Chromosome 9 open reading frame 156, isoform CRA_b		HUMAN		295
UPI000CEFE338		PONAB		476
Nef-associated protein 1		MACMU		444
tRNA methyltransferase O		MACFA		444
Nef-associated protein 1		CALJA		444
+53

Protein	Similar proteins		Species	Score	Length
Q9BU70	Chromosome 9 open reading frame 156, isoform CRA_b		HUMAN		295
UPI000CEFE338		PONAB		476
Nef-associated protein 1		MACMU		444
tRNA methyltransferase O		MACFA		444
tRNA methyltransferase O		CHLSB		444
+58

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK000213 mRNA Translation: BAA91013.1 AL499604 Genomic DNA No translation available. BC002863 mRNA Translation: AAH02863.1 AF151053 mRNA Translation: AAF36139.1 Sequence problems. X86033 mRNA Translation: CAA60025.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6730.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001317654.1, NM_001330725.1 NP_057565.3, NM_016481.4
UniGeneⁱ	Hs.9196

3D structure databases

ProteinModelPortalⁱ	Q9BU70
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119593, 6 interactors
IntActⁱ	Q9BU70, 24 interactors
Molecular INTeraction database More...MINTⁱ	Q9BU70
STRINGⁱ	9606.ENSP00000364260

PTM databases

iPTMnetⁱ	Q9BU70
PhosphoSitePlusⁱ	Q9BU70

Polymorphism and mutation databases

BioMutaⁱ	C9orf156
DMDMⁱ	152112517

Proteomic databases

EPDⁱ	Q9BU70
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BU70
PaxDbⁱ	Q9BU70
PeptideAtlas More...PeptideAtlasⁱ	Q9BU70
PRIDEⁱ	Q9BU70
ProteomicsDBⁱ	79058

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51531
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000375119; ENSP00000364260; ENSG00000136932
GeneIDⁱ	51531
KEGGⁱ	hsa:51531
UCSC genome browser More...UCSCⁱ	uc004axv.2 human

Organism-specific databases

CTDⁱ	51531
DisGeNET More...DisGeNETⁱ	51531
EuPathDBⁱ	HostDB:ENSG00000136932.13
GeneCardsⁱ	TRMO
H-InvDBⁱ	HIX0008217
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30967 TRMO
Human Protein Atlas More...HPAⁱ	HPA021281 HPA052197
neXtProtⁱ	NX_Q9BU70
Open Targets More...OpenTargetsⁱ	ENSG00000136932
PharmGKBⁱ	PA134875112
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2942 Eukaryota COG1720 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004643
HOGENOMⁱ	HOG000231645
HOVERGENⁱ	HBG054288
InParanoidⁱ	Q9BU70
OMAⁱ	FKYFQSA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DXG
PhylomeDBⁱ	Q9BU70
TreeFamⁱ	TF331670

Miscellaneous databases

GenomeRNAiⁱ	51531
Protein Ontology More...PROⁱ	PR:Q9BU70

Gene expression databases

Bgeeⁱ	ENSG00000136932
CleanExⁱ	HS_C9orf156
ExpressionAtlasⁱ	Q9BU70 baseline and differential
Genevisibleⁱ	Q9BU70 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd09281 UPF0066, 1 hit
Gene3Dⁱ	2.40.30.70, 1 hit
InterProⁱ	View protein in InterPro IPR023368 UPF0066_cons_site IPR023370 YaeB-like_N IPR036413 YaeB-like_sf IPR036414 YaeB_N_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01980 UPF0066, 1 hit
SUPFAMⁱ	SSF118196 SSF118196, 2 hits
TIGRFAMsⁱ	TIGR00104 tRNA_TsaA, 1 hit
PROSITEⁱ	View protein in PROSITE PS01318 TSAA_1, 1 hit PS51668 TSAA_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TRMO_HUMAN
Accessionⁱ	Q9BU70Primary (citable) accession number: Q9BU70 Secondary accession number(s): Q5T113 , Q86SK0, Q9NXJ7, Q9P0Q7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
	Last sequence update:	May 29, 2007
	Last modified:	July 18, 2018
	This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - Q9BU70 (TRMO_HUMAN)

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tRNA (adenine(37)-N6)-methyltransferase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ