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Protein

Centromere protein O

Gene

CENPO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex.4 Publications

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein O
Short name:
CENP-O
Alternative name(s):
Interphase centromere complex protein 36
Gene namesi
Name:CENPO
Synonyms:ICEN36, MCM21R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000138092.10
HGNCiHGNC:28152 CENPO
MIMi611504 gene
neXtProtiNX_Q9BU64

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79172
OpenTargetsiENSG00000138092
PharmGKBiPA145149197

Polymorphism and mutation databases

BioMutaiCENPO
DMDMi74733185

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002495021 – 300Centromere protein OAdd BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BU64
MaxQBiQ9BU64
PaxDbiQ9BU64
PeptideAtlasiQ9BU64
PRIDEiQ9BU64
ProteomicsDBi79055
79056 [Q9BU64-2]

PTM databases

iPTMnetiQ9BU64
PhosphoSitePlusiQ9BU64

Expressioni

Gene expression databases

BgeeiENSG00000138092 Expressed in 155 organ(s), highest expression level in lung
CleanExiHS_CENPO
GenevisibleiQ9BU64 HS

Interactioni

Subunit structurei

Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi122589, 37 interactors
CORUMiQ9BU64
IntActiQ9BU64, 30 interactors
MINTiQ9BU64
STRINGi9606.ENSP00000260662

Structurei

3D structure databases

ProteinModelPortaliQ9BU64
SMRiQ9BU64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili18 – 42Sequence analysisAdd BLAST25
Coiled coili83 – 109Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the CENP-O/MCM21 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJSQ Eukaryota
ENOG4111RC4 LUCA
GeneTreeiENSGT00390000016702
HOGENOMiHOG000059658
HOVERGENiHBG080687
InParanoidiQ9BU64
KOiK11507
OMAiQRNPLCN
OrthoDBiEOG091G0HS3
PhylomeDBiQ9BU64
TreeFamiTF335524

Family and domain databases

InterProiView protein in InterPro
IPR018464 CENP-O
PfamiView protein in Pfam
PF09496 CENP-O, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BU64-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEQANPLRPD GESKGGVLAH LERLETQVSR SRKQSEELQS VQAQEGALGT
60 70 80 90 100
KIHKLRRLRD ELRAVVRHRR ASVKACIANV EPNQTVEINE QEALEEKLEN
110 120 130 140 150
VKAILQAYHF TGLSGKLTSR GVCVCISTAF EGNLLDSYFV DLVIQKPLRI
160 170 180 190 200
HHHSVPVFIP LEEIAAKYLQ TNIQHFLFSL CEYLNAYSGR KYQADRLQSD
210 220 230 240 250
FAALLTGPLQ RNPLCNLLSF TYKLDPGGQS FPFCARLLYK DLTATLPTDV
260 270 280 290 300
TVTCQGVEVL STSWEEQRAS HETLFCTKPL HQVFASFTRK GEKLDMSLVS
Length:300
Mass (Da):33,786
Last modified:June 1, 2001 - v1
Checksum:i05A89E12C6847D81
GO
Isoform 2 (identifier: Q9BU64-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MEQANPLRPDGESKG → MAGILASGL

Note: No experimental confirmation available.
Show »
Length:294
Mass (Da):32,989
Checksum:i76D32EB5C95FD332
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti235A → V in BAB55414 (PubMed:14702039).Curated1
Sequence conflicti269A → V in BAB55414 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02742034Q → R1 PublicationCorresponds to variant dbSNP:rs1550116Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0204461 – 15MEQAN…GESKG → MAGILASGL in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027859 mRNA Translation: BAB55414.1
AK315483 mRNA Translation: BAG37867.1
AC012073 Genomic DNA Translation: AAY14786.1
AC013459 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00742.1
CH471053 Genomic DNA Translation: EAX00743.1
BC002870 mRNA Translation: AAH02870.1
CCDSiCCDS1714.1 [Q9BU64-1]
CCDS56113.1 [Q9BU64-2]
RefSeqiNP_001186732.1, NM_001199803.2 [Q9BU64-2]
NP_001309030.1, NM_001322101.1 [Q9BU64-1]
NP_077298.1, NM_024322.3 [Q9BU64-1]
UniGeneiHs.731569

Genome annotation databases

EnsembliENST00000260662; ENSP00000260662; ENSG00000138092 [Q9BU64-1]
ENST00000380834; ENSP00000370214; ENSG00000138092 [Q9BU64-1]
ENST00000473706; ENSP00000417787; ENSG00000138092 [Q9BU64-2]
GeneIDi79172
KEGGihsa:79172
UCSCiuc002rfp.3 human [Q9BU64-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027859 mRNA Translation: BAB55414.1
AK315483 mRNA Translation: BAG37867.1
AC012073 Genomic DNA Translation: AAY14786.1
AC013459 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00742.1
CH471053 Genomic DNA Translation: EAX00743.1
BC002870 mRNA Translation: AAH02870.1
CCDSiCCDS1714.1 [Q9BU64-1]
CCDS56113.1 [Q9BU64-2]
RefSeqiNP_001186732.1, NM_001199803.2 [Q9BU64-2]
NP_001309030.1, NM_001322101.1 [Q9BU64-1]
NP_077298.1, NM_024322.3 [Q9BU64-1]
UniGeneiHs.731569

3D structure databases

ProteinModelPortaliQ9BU64
SMRiQ9BU64
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122589, 37 interactors
CORUMiQ9BU64
IntActiQ9BU64, 30 interactors
MINTiQ9BU64
STRINGi9606.ENSP00000260662

PTM databases

iPTMnetiQ9BU64
PhosphoSitePlusiQ9BU64

Polymorphism and mutation databases

BioMutaiCENPO
DMDMi74733185

Proteomic databases

EPDiQ9BU64
MaxQBiQ9BU64
PaxDbiQ9BU64
PeptideAtlasiQ9BU64
PRIDEiQ9BU64
ProteomicsDBi79055
79056 [Q9BU64-2]

Protocols and materials databases

DNASUi79172
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260662; ENSP00000260662; ENSG00000138092 [Q9BU64-1]
ENST00000380834; ENSP00000370214; ENSG00000138092 [Q9BU64-1]
ENST00000473706; ENSP00000417787; ENSG00000138092 [Q9BU64-2]
GeneIDi79172
KEGGihsa:79172
UCSCiuc002rfp.3 human [Q9BU64-1]

Organism-specific databases

CTDi79172
DisGeNETi79172
EuPathDBiHostDB:ENSG00000138092.10
GeneCardsiCENPO
HGNCiHGNC:28152 CENPO
MIMi611504 gene
neXtProtiNX_Q9BU64
OpenTargetsiENSG00000138092
PharmGKBiPA145149197
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJSQ Eukaryota
ENOG4111RC4 LUCA
GeneTreeiENSGT00390000016702
HOGENOMiHOG000059658
HOVERGENiHBG080687
InParanoidiQ9BU64
KOiK11507
OMAiQRNPLCN
OrthoDBiEOG091G0HS3
PhylomeDBiQ9BU64
TreeFamiTF335524

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68877 Mitotic Prometaphase

Miscellaneous databases

ChiTaRSiCENPO human
GeneWikiiCENPO
GenomeRNAii79172
PROiPR:Q9BU64
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138092 Expressed in 155 organ(s), highest expression level in lung
CleanExiHS_CENPO
GenevisibleiQ9BU64 HS

Family and domain databases

InterProiView protein in InterPro
IPR018464 CENP-O
PfamiView protein in Pfam
PF09496 CENP-O, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCENPO_HUMAN
AccessioniPrimary (citable) accession number: Q9BU64
Secondary accession number(s): B2RDC0
, D6W536, Q53T55, Q96JV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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