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Entry version 161 (22 Apr 2020)
Sequence version 3 (23 Jan 2007)
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Protein

Thiamine-triphosphatase

Gene

THTPA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolase highly specific for thiamine triphosphate (ThTP).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 PublicationNote: Binds 1 Mg2+ ion per subunit.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=8 µM for thiamine triphosphate1 Publication
  1. Vmax=59 µmol/min/mg enzyme1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi7MagnesiumBy similarity1
Metal bindingi9MagnesiumBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei11Substrate1
Binding sitei55Substrate1
Binding sitei57Substrate1
Binding sitei65Substrate1
Binding sitei125Substrate1
Metal bindingi145MagnesiumBy similarity1
Metal bindingi157MagnesiumBy similarity1
Binding sitei157Substrate1
Metal bindingi159MagnesiumBy similarity1
Binding sitei193SubstrateCurated1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.1.28 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-196819 Vitamin B1 (thiamin) metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thiamine-triphosphatase (EC:3.6.1.28)
Short name:
ThTPase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:THTPA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18987 THTPA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611612 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BU02

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi11K → A: Mildly decreases enzyme activity. 1 Publication1
Mutagenesisi37D → A: Strongly decreases affinity for thiamine triphosphate and enzyme activity. 1 Publication1
Mutagenesisi39Y → A: Strongly decreases affinity for thiamine triphosphate and enzyme activity. 1 Publication1
Mutagenesisi53W → A: Strongly decreases affinity for thiamine triphosphate and enzyme activity. 1 Publication1
Mutagenesisi65K → A: Strongly decreases enzyme activity. No effect on affinity for thiamine triphosphate. 1 Publication1
Mutagenesisi79Y → A: Decreases enzyme activity. 1 Publication1
Mutagenesisi81E → A: Mildly decreases enzyme activity. 1 Publication1
Mutagenesisi147D → A: Strongly decreases affinity for thiamine triphosphate and enzyme activity. 1 Publication1
Mutagenesisi193K → A: Strongly decreases affinity for thiamine triphosphate and enzyme activity. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000259431

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38774

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BU02 Tbio

Chemistry databases

DrugCentral

More...
DrugCentrali
Q9BU02

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
THTPA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
37538018

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002214902 – 230Thiamine-triphosphataseAdd BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BU02

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9BU02

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BU02

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BU02

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BU02

PeptideAtlas

More...
PeptideAtlasi
Q9BU02

PRoteomics IDEntifications database

More...
PRIDEi
Q9BU02

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
33249
79039 [Q9BU02-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BU02

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9BU02

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BU02

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed but at a low level.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000259431 Expressed in prefrontal cortex and 91 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BU02 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BU02 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000259431 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122595, 17 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BU02, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000288014

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BU02 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1230
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BU02

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9BU02

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 201CYTHPROSITE-ProRule annotationAdd BLAST197

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ThTPase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J0T6 Eukaryota
ENOG4111XGF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005996

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_105907_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BU02

KEGG Orthology (KO)

More...
KOi
K05307

Identification of Orthologs from Complete Genome Data

More...
OMAi
SGPHTEY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BU02

TreeFam database of animal gene trees

More...
TreeFami
TF333398

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07758 ThTPase, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033469 CYTH-like_dom_sf
IPR023577 CYTH_domain
IPR039582 THTPA
IPR012177 ThTPase_euk

The PANTHER Classification System

More...
PANTHERi
PTHR14586 PTHR14586, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01928 CYTH, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036561 ThTPase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01118 CYTH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55154 SSF55154, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51707 CYTH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BU02-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQGLIEVER KFLPGPGTEE RLQELGGTLE YRVTFRDTYY DTPELSLMQA
60 70 80 90 100
DHWLRRREDS GWELKCPGAA GVLGPHTEYK ELTAEPTIVA QLCKVLRADG
110 120 130 140 150
LGAGDVAAVL GPLGLQEVAS FVTKRSAWKL VLLGADEEEP QLRVDLDTAD
160 170 180 190 200
FGYAVGEVEA LVHEEAEVPT ALEKIHRLSS MLGVPAQETA PAKLIVYLQR
210 220 230
FRPQDYQRLL EVNSSRERPQ ETEDPDHCLG
Length:230
Mass (Da):25,566
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49B79C6C1D19D91D
GO
Isoform 2 (identifier: Q9BU02-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-105: LRADGLGAGD → CLHRRQHQPS
     106-230: Missing.

Show »
Length:105
Mass (Da):12,038
Checksum:iD326E9A8991B8A1F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V5Q5G3V5Q5_HUMAN
Thiamine-triphosphatase
THTPA
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5B9G3V5B9_HUMAN
Thiamine-triphosphatase
THTPA
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJU8H0YJU8_HUMAN
Thiamine-triphosphatase
THTPA
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_062152176H → R. Corresponds to variant dbSNP:rs34015250Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04721396 – 105LRADGLGAGD → CLHRRQHQPS in isoform 2. 1 Publication10
Alternative sequenceiVSP_047214106 – 230Missing in isoform 2. 1 PublicationAdd BLAST125

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF432862 mRNA Translation: AAM22403.1
AK057691 mRNA Translation: BAB71546.1
BX161435 mRNA Translation: CAD61907.1
BX378775 mRNA No translation available.
AL135999 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66140.1
CH471078 Genomic DNA Translation: EAW66141.1
BC002984 mRNA Translation: AAH02984.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32053.1 [Q9BU02-1]
CCDS58307.1 [Q9BU02-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001119811.1, NM_001126339.3 [Q9BU02-1]
NP_001242991.1, NM_001256062.2 [Q9BU02-2]
NP_001243250.1, NM_001256321.2 [Q9BU02-2]
NP_001243251.1, NM_001256322.2
NP_001243252.1, NM_001256323.2
NP_077304.1, NM_024328.5 [Q9BU02-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000288014; ENSP00000288014; ENSG00000259431 [Q9BU02-1]
ENST00000404535; ENSP00000384580; ENSG00000259431 [Q9BU02-1]
ENST00000554789; ENSP00000450459; ENSG00000259431 [Q9BU02-2]
ENST00000556015; ENSP00000451835; ENSG00000259431 [Q9BU02-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79178

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79178

UCSC genome browser

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UCSCi
uc001wkg.7 human [Q9BU02-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF432862 mRNA Translation: AAM22403.1
AK057691 mRNA Translation: BAB71546.1
BX161435 mRNA Translation: CAD61907.1
BX378775 mRNA No translation available.
AL135999 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66140.1
CH471078 Genomic DNA Translation: EAW66141.1
BC002984 mRNA Translation: AAH02984.1
CCDSiCCDS32053.1 [Q9BU02-1]
CCDS58307.1 [Q9BU02-2]
RefSeqiNP_001119811.1, NM_001126339.3 [Q9BU02-1]
NP_001242991.1, NM_001256062.2 [Q9BU02-2]
NP_001243250.1, NM_001256321.2 [Q9BU02-2]
NP_001243251.1, NM_001256322.2
NP_001243252.1, NM_001256323.2
NP_077304.1, NM_024328.5 [Q9BU02-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BHDX-ray1.50A/B1-215[»]
3TVLX-ray2.30A/B1-230[»]
SMRiQ9BU02
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi122595, 17 interactors
IntActiQ9BU02, 7 interactors
STRINGi9606.ENSP00000288014

Chemistry databases

DrugCentraliQ9BU02

PTM databases

iPTMnetiQ9BU02
MetOSiteiQ9BU02
PhosphoSitePlusiQ9BU02

Polymorphism and mutation databases

BioMutaiTHTPA
DMDMi37538018

Proteomic databases

EPDiQ9BU02
jPOSTiQ9BU02
MassIVEiQ9BU02
MaxQBiQ9BU02
PaxDbiQ9BU02
PeptideAtlasiQ9BU02
PRIDEiQ9BU02
ProteomicsDBi33249
79039 [Q9BU02-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
55506 191 antibodies

The DNASU plasmid repository

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DNASUi
79178

Genome annotation databases

EnsembliENST00000288014; ENSP00000288014; ENSG00000259431 [Q9BU02-1]
ENST00000404535; ENSP00000384580; ENSG00000259431 [Q9BU02-1]
ENST00000554789; ENSP00000450459; ENSG00000259431 [Q9BU02-2]
ENST00000556015; ENSP00000451835; ENSG00000259431 [Q9BU02-2]
GeneIDi79178
KEGGihsa:79178
UCSCiuc001wkg.7 human [Q9BU02-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79178

GeneCards: human genes, protein and diseases

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GeneCardsi
THTPA
HGNCiHGNC:18987 THTPA
HPAiENSG00000259431 Low tissue specificity
MIMi611612 gene
neXtProtiNX_Q9BU02
OpenTargetsiENSG00000259431
PharmGKBiPA38774

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410J0T6 Eukaryota
ENOG4111XGF LUCA
GeneTreeiENSGT00390000005996
HOGENOMiCLU_105907_0_0_1
InParanoidiQ9BU02
KOiK05307
OMAiSGPHTEY
PhylomeDBiQ9BU02
TreeFamiTF333398

Enzyme and pathway databases

BRENDAi3.6.1.28 2681
ReactomeiR-HSA-196819 Vitamin B1 (thiamin) metabolism

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
THTPA human
EvolutionaryTraceiQ9BU02

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79178
PharosiQ9BU02 Tbio

Protein Ontology

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PROi
PR:Q9BU02
RNActiQ9BU02 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000259431 Expressed in prefrontal cortex and 91 other tissues
ExpressionAtlasiQ9BU02 baseline and differential
GenevisibleiQ9BU02 HS

Family and domain databases

CDDicd07758 ThTPase, 1 hit
InterProiView protein in InterPro
IPR033469 CYTH-like_dom_sf
IPR023577 CYTH_domain
IPR039582 THTPA
IPR012177 ThTPase_euk
PANTHERiPTHR14586 PTHR14586, 1 hit
PfamiView protein in Pfam
PF01928 CYTH, 1 hit
PIRSFiPIRSF036561 ThTPase, 1 hit
SMARTiView protein in SMART
SM01118 CYTH, 1 hit
SUPFAMiSSF55154 SSF55154, 1 hit
PROSITEiView protein in PROSITE
PS51707 CYTH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHTPA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BU02
Secondary accession number(s): D3DS50, G3V4J3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: January 23, 2007
Last modified: April 22, 2020
This is version 161 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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