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Protein

Dehydrogenase/reductase SDR family member 4

Gene

DHRS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).By similarity

Miscellaneous

Inhibited by kaempferol, quercetin, genistein and myristic acid.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei169SubstrateBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei182Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi36 – 60NADPBy similarityAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.1.1.300 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5365859 RA biosynthesis pathway
R-HSA-9033241 Peroxisomal protein import

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 4 (EC:1.1.1.184)
Alternative name(s):
NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase
Short name:
CR
Short name:
PHCR
NADPH-dependent retinol dehydrogenase/reductase
Short name:
NRDR
Short name:
humNRDR
Peroxisomal short-chain alcohol dehydrogenase
Short name:
PSCD
SCAD-SRL
Short chain dehydrogenase/reductase family 25C member 2
Short-chain dehydrogenase/reductase family member 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DHRS4
Synonyms:SDR25C2
ORF Names:UNQ851/PRO1800
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000157326.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16985 DHRS4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611596 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BTZ2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10901

Open Targets

More...
OpenTargetsi
ENSG00000157326

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128395792

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00162 Vitamin A

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DHRS4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153604

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000546471 – 278Dehydrogenase/reductase SDR family member 4Add BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei92N6-acetyllysine; alternateBy similarity1
Modified residuei92N6-succinyllysine; alternateBy similarity1
Modified residuei105N6-acetyllysineBy similarity1
Modified residuei216N6-acetyllysine; alternateBy similarity1
Modified residuei216N6-succinyllysine; alternateBy similarity1
Modified residuei220PhosphoserineBy similarity1
Modified residuei227N6-succinyllysineBy similarity1
Modified residuei234N6-succinyllysineBy similarity1
Isoform 5 (identifier: Q9BTZ2-5)
Modified residuei140PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BTZ2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BTZ2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BTZ2

PeptideAtlas

More...
PeptideAtlasi
Q9BTZ2

PRoteomics IDEntifications database

More...
PRIDEi
Q9BTZ2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79032
79033 [Q9BTZ2-2]
79034 [Q9BTZ2-3]
79035 [Q9BTZ2-4]
79036 [Q9BTZ2-5]
79037 [Q9BTZ2-6]
79038 [Q9BTZ2-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BTZ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BTZ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000157326 Expressed in 92 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BTZ2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BTZ2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023972

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116107, 59 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BTZ2, 27 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000326219

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1278
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9BTZ2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BTZ2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9BTZ2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi276 – 278Microbody targeting signal3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0725 Eukaryota
COG1028 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158919

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG105779

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BTZ2

KEGG Orthology (KO)

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KOi
K11147

Identification of Orthologs from Complete Genome Data

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OMAi
FELLGAY

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0G3R

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BTZ2

TreeFam database of animal gene trees

More...
TreeFami
TF315405

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029511 DHRS4-like
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam

The PANTHER Classification System

More...
PANTHERi
PTHR43943:SF8 PTHR43943:SF8, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00081 GDHRDH
PR00080 SDRFAMILY

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00061 ADH_SHORT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BTZ2-1) [UniParc]FASTAAdd to basket
Also known as: SDR-SRL3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHKAGLLGLC ARAWNSVRMA SSGMTRRDPL ANKVALVTAS TDGIGFAIAR
60 70 80 90 100
RLAQDGAHVV VSSRKQQNVD QAVATLQGEG LSVTGTVCHV GKAEDRERLV
110 120 130 140 150
ATAVKLHGGI DILVSNAAVN PFFGSIMDVT EEVWDKTLDI NVKAPALMTK
160 170 180 190 200
AVVPEMEKRG GGSVVIVSSI AAFSPSPGFS PYNVSKTALL GLTKTLAIEL
210 220 230 240 250
APRNIRVNCL APGLIKTSFS RMLWMDKEKE ESMKETLRIR RLGEPEDCAG
260 270
IVSFLCSEDA SYITGETVVV GGGTPSRL
Length:278
Mass (Da):29,537
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3B06A229E1BBE47B
GO
Isoform 2 (identifier: Q9BTZ2-2) [UniParc]FASTAAdd to basket
Also known as: SDR-SRL1

The sequence of this isoform differs from the canonical sequence as follows:
     137-222: Missing.

Show »
Length:192
Mass (Da):20,540
Checksum:i8DA10FF50043F472
GO
Isoform 3 (identifier: Q9BTZ2-3) [UniParc]FASTAAdd to basket
Also known as: SDR-SRL2

The sequence of this isoform differs from the canonical sequence as follows:
     103-222: Missing.

Show »
Length:158
Mass (Da):16,885
Checksum:iDBE966DBD30D0A3E
GO
Isoform 4 (identifier: Q9BTZ2-4) [UniParc]FASTAAdd to basket
Also known as: NRDRB1

The sequence of this isoform differs from the canonical sequence as follows:
     103-136: Missing.

Show »
Length:244
Mass (Da):25,882
Checksum:i25DC4A701E3B76FF
GO
Isoform 5 (identifier: Q9BTZ2-5) [UniParc]FASTAAdd to basket
Also known as: NRDRB2

The sequence of this isoform differs from the canonical sequence as follows:
     103-136: Missing.
     178-222: Missing.

Show »
Length:199
Mass (Da):21,036
Checksum:iE6015FD7DA879EA4
GO
Isoform 6 (identifier: Q9BTZ2-6) [UniParc]FASTAAdd to basket
Also known as: DHRS4L2, NRDRA1

The sequence of this isoform differs from the canonical sequence as follows:
     19-221: Missing.

Show »
Length:75
Mass (Da):8,288
Checksum:iA3C9C3CF43B80FA0
GO
Isoform 7 (identifier: Q9BTZ2-7) [UniParc]FASTAAdd to basket
Also known as: NRDRA2

The sequence of this isoform differs from the canonical sequence as follows:
     137-188: TLDINVKAPA...FSPYNVSKTA → RRLSGDRVFH...LCWHRVFPVL
     189-278: Missing.

Note: Mainly localized in the nucleus.
Show »
Length:188
Mass (Da):20,345
Checksum:i23BD8B69B345AEE8
GO
Isoform 8 (identifier: Q9BTZ2-8) [UniParc]FASTAAdd to basket
Also known as: NRDRB1

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.
     103-136: Missing.

Note: Enhanced dicarbonyl reductase activity. high expression in liver.
Show »
Length:226
Mass (Da):23,917
Checksum:iED701E06FA126565
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GWZ1F5GWZ1_HUMAN
Dehydrogenase/reductase SDR family ...
DHRS4
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNP7H0YNP7_HUMAN
Dehydrogenase/reductase SDR family ...
DHRS4
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD02292 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAL61824 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB18775 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG37057 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti37V → A in BAA91953 (PubMed:14702039).Curated1
Sequence conflicti50R → W in ABC61321 (PubMed:17230527).Curated1
Sequence conflicti89H → M in AAQ13444 (Ref. 4) Curated1
Sequence conflicti102T → M in AAD02292 (PubMed:10333503).Curated1
Sequence conflicti126I → L in AAD02292 (PubMed:10333503).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05727231A → T. Corresponds to variant dbSNP:rs1043442Ensembl.1
Natural variantiVAR_061846202P → S. Corresponds to variant dbSNP:rs1043650Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0449471 – 18Missing in isoform 8. CuratedAdd BLAST18
Alternative sequenceiVSP_03143519 – 221Missing in isoform 6. 1 PublicationAdd BLAST203
Alternative sequenceiVSP_008585103 – 222Missing in isoform 3. 1 PublicationAdd BLAST120
Alternative sequenceiVSP_031436103 – 136Missing in isoform 4, isoform 5 and isoform 8. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_008586137 – 222Missing in isoform 2. 2 PublicationsAdd BLAST86
Alternative sequenceiVSP_031437137 – 188TLDIN…VSKTA → RRLSGDRVFHSSLQSISSLD GQGKRGKHERNPADKKVRRA RGLCWHRVFPVL in isoform 7. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_031438178 – 222Missing in isoform 5. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_031439189 – 278Missing in isoform 7. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF044127 mRNA Translation: AAD02292.1 Different initiation.
AB045131 mRNA Translation: BAB18775.1 Different initiation.
AY071856 mRNA Translation: AAL61824.2 Different initiation.
AF064256 mRNA Translation: AAQ13444.1
AY616182 mRNA Translation: AAT70757.1
DQ344810 mRNA Translation: ABD75823.1
AY943857 mRNA Translation: AAX49568.1
DQ325464 mRNA Translation: ABC61320.1
DQ338571 mRNA Translation: ABC61321.1
AK001870 mRNA Translation: BAA91953.1
AK314448 mRNA Translation: BAG37057.1 Different initiation.
AY358638 mRNA Translation: AAQ89001.1
AL136419 Genomic DNA No translation available.
BC003019 mRNA Translation: AAH03019.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS61408.1 [Q9BTZ2-7]
CCDS61409.1 [Q9BTZ2-2]
CCDS61410.1 [Q9BTZ2-4]
CCDS61411.1 [Q9BTZ2-5]
CCDS61412.1 [Q9BTZ2-3]
CCDS9605.1 [Q9BTZ2-1]

NCBI Reference Sequences

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RefSeqi
NP_001269916.1, NM_001282987.1 [Q9BTZ2-7]
NP_001269917.1, NM_001282988.1 [Q9BTZ2-4]
NP_001269918.1, NM_001282989.1 [Q9BTZ2-2]
NP_001269919.1, NM_001282990.1 [Q9BTZ2-5]
NP_001269920.1, NM_001282991.1 [Q9BTZ2-3]
NP_066284.2, NM_021004.3 [Q9BTZ2-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.528385
Hs.647569
Hs.743442

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000313250; ENSP00000326219; ENSG00000157326 [Q9BTZ2-1]
ENST00000397074; ENSP00000380264; ENSG00000157326 [Q9BTZ2-3]
ENST00000397075; ENSP00000380265; ENSG00000157326 [Q9BTZ2-2]
ENST00000558263; ENSP00000453367; ENSG00000157326 [Q9BTZ2-7]
ENST00000558581; ENSP00000452645; ENSG00000157326 [Q9BTZ2-4]
ENST00000559632; ENSP00000453983; ENSG00000157326 [Q9BTZ2-5]
ENST00000643978; ENSP00000493736; ENSG00000284807 [Q9BTZ2-7]
ENST00000645602; ENSP00000496349; ENSG00000284807 [Q9BTZ2-2]
ENST00000645612; ENSP00000494364; ENSG00000284807 [Q9BTZ2-1]
ENST00000646997; ENSP00000495877; ENSG00000284807 [Q9BTZ2-5]
ENST00000647030; ENSP00000496426; ENSG00000284807 [Q9BTZ2-4]
ENST00000647154; ENSP00000495868; ENSG00000284807 [Q9BTZ2-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10901

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10901

UCSC genome browser

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UCSCi
uc001wla.5 human [Q9BTZ2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044127 mRNA Translation: AAD02292.1 Different initiation.
AB045131 mRNA Translation: BAB18775.1 Different initiation.
AY071856 mRNA Translation: AAL61824.2 Different initiation.
AF064256 mRNA Translation: AAQ13444.1
AY616182 mRNA Translation: AAT70757.1
DQ344810 mRNA Translation: ABD75823.1
AY943857 mRNA Translation: AAX49568.1
DQ325464 mRNA Translation: ABC61320.1
DQ338571 mRNA Translation: ABC61321.1
AK001870 mRNA Translation: BAA91953.1
AK314448 mRNA Translation: BAG37057.1 Different initiation.
AY358638 mRNA Translation: AAQ89001.1
AL136419 Genomic DNA No translation available.
BC003019 mRNA Translation: AAH03019.1
CCDSiCCDS61408.1 [Q9BTZ2-7]
CCDS61409.1 [Q9BTZ2-2]
CCDS61410.1 [Q9BTZ2-4]
CCDS61411.1 [Q9BTZ2-5]
CCDS61412.1 [Q9BTZ2-3]
CCDS9605.1 [Q9BTZ2-1]
RefSeqiNP_001269916.1, NM_001282987.1 [Q9BTZ2-7]
NP_001269917.1, NM_001282988.1 [Q9BTZ2-4]
NP_001269918.1, NM_001282989.1 [Q9BTZ2-2]
NP_001269919.1, NM_001282990.1 [Q9BTZ2-5]
NP_001269920.1, NM_001282991.1 [Q9BTZ2-3]
NP_066284.2, NM_021004.3 [Q9BTZ2-1]
UniGeneiHs.528385
Hs.647569
Hs.743442

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3O4RX-ray1.70A/B/C/D19-278[»]
ProteinModelPortaliQ9BTZ2
SMRiQ9BTZ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116107, 59 interactors
IntActiQ9BTZ2, 27 interactors
STRINGi9606.ENSP00000326219

Chemistry databases

DrugBankiDB00162 Vitamin A

PTM databases

iPTMnetiQ9BTZ2
PhosphoSitePlusiQ9BTZ2

Polymorphism and mutation databases

BioMutaiDHRS4
DMDMi308153604

Proteomic databases

EPDiQ9BTZ2
MaxQBiQ9BTZ2
PaxDbiQ9BTZ2
PeptideAtlasiQ9BTZ2
PRIDEiQ9BTZ2
ProteomicsDBi79032
79033 [Q9BTZ2-2]
79034 [Q9BTZ2-3]
79035 [Q9BTZ2-4]
79036 [Q9BTZ2-5]
79037 [Q9BTZ2-6]
79038 [Q9BTZ2-7]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313250; ENSP00000326219; ENSG00000157326 [Q9BTZ2-1]
ENST00000397074; ENSP00000380264; ENSG00000157326 [Q9BTZ2-3]
ENST00000397075; ENSP00000380265; ENSG00000157326 [Q9BTZ2-2]
ENST00000558263; ENSP00000453367; ENSG00000157326 [Q9BTZ2-7]
ENST00000558581; ENSP00000452645; ENSG00000157326 [Q9BTZ2-4]
ENST00000559632; ENSP00000453983; ENSG00000157326 [Q9BTZ2-5]
ENST00000643978; ENSP00000493736; ENSG00000284807 [Q9BTZ2-7]
ENST00000645602; ENSP00000496349; ENSG00000284807 [Q9BTZ2-2]
ENST00000645612; ENSP00000494364; ENSG00000284807 [Q9BTZ2-1]
ENST00000646997; ENSP00000495877; ENSG00000284807 [Q9BTZ2-5]
ENST00000647030; ENSP00000496426; ENSG00000284807 [Q9BTZ2-4]
ENST00000647154; ENSP00000495868; ENSG00000284807 [Q9BTZ2-3]
GeneIDi10901
KEGGihsa:10901
UCSCiuc001wla.5 human [Q9BTZ2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10901
DisGeNETi10901
EuPathDBiHostDB:ENSG00000157326.18

GeneCards: human genes, protein and diseases

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GeneCardsi
DHRS4
HGNCiHGNC:16985 DHRS4
HPAiHPA023972
MIMi611596 gene
neXtProtiNX_Q9BTZ2
OpenTargetsiENSG00000157326
PharmGKBiPA128395792

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0725 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00940000158919
HOVERGENiHBG105779
InParanoidiQ9BTZ2
KOiK11147
OMAiFELLGAY
OrthoDBiEOG091G0G3R
PhylomeDBiQ9BTZ2
TreeFamiTF315405

Enzyme and pathway databases

BRENDAi1.1.1.300 2681
ReactomeiR-HSA-5365859 RA biosynthesis pathway
R-HSA-9033241 Peroxisomal protein import

Miscellaneous databases

EvolutionaryTraceiQ9BTZ2

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DHRS4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10901

Protein Ontology

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PROi
PR:Q9BTZ2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000157326 Expressed in 92 organ(s), highest expression level in liver
ExpressionAtlasiQ9BTZ2 baseline and differential
GenevisibleiQ9BTZ2 HS

Family and domain databases

InterProiView protein in InterPro
IPR029511 DHRS4-like
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PANTHERiPTHR43943:SF8 PTHR43943:SF8, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDHRS4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BTZ2
Secondary accession number(s): B2RB10
, B7WNS9, D3YTB8, E2QRL8, O95162, Q20CR0, Q2LC19, Q2LE81, Q58IU4, Q6E0Y1, Q6UWU3, Q71UQ6, Q8TD03, Q9H3N5, Q9NV08
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 5, 2010
Last modified: December 5, 2018
This is version 163 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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