UniProtKB - Q9BTY2 (FUCO2_HUMAN)

BLAST

>sp|Q9BTY2|FUCO2_HUMAN Plasma alpha-L-fucosidase OS=Homo sapiens OX=9606 GN=FUCA2 PE=1 SV=2
MRPQELPRLAFPLLLLLLLLLPPPPCPAHSATRFDPTWESLDARQLPAWFDQAKFGIFIH
WGVFSVPSFGSEWFWWYWQKEKIPKYVEFMKDNYPPSFKYEDFGPLFTAKFFNANQWADI
FQASGAKYIVLTSKHHEGFTLWGSEYSWNWNAIDEGPKRDIVKELEVAIRNRTDLRFGLY
YSLFEWFHPLFLEDESSSFHKRQFPVSKTLPELYELVNNYQPEVLWSDGDGGAPDQYWNS
TGFLAWLYNESPVRGTVVTNDRWGAGSICKHGGFYTCSDRYNPGHLLPHKWENCMTIDKL
SWGYRREAGISDYLTIEELVKQLVETVSCGGNLLMNIGPTLDGTISVVFEERLRQMGSWL
KVNGEAIYETHTWRSQNDTVTPDVWYTSKPKEKLVYAIFLKWPTSGQLFLGHPKAILGAT
EVKLLGHGQPLNWISLEQNGIMVELPQLTIHQMPCKWGWALALTNVI

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History
Entry version 139 (07 Nov 2018)
Sequence version 2 (28 Jul 2009)
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Protein

Plasma alpha-L-fucosidase

Gene

FUCA2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Catalytic activityⁱ

An alpha-L-fucoside + H₂O = L-fucose + an alcohol.PROSITE-ProRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	294	May be important for catalysisPROSITE-ProRule annotation		1

GO - Molecular functionⁱ

alpha-L-fucosidase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19666478

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular protein metabolic process Source: Reactome
fucose metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 19666478
glycoside catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 19666478
neutrophil degranulation Source: Reactome
post-translational protein modification Source: Reactome
regulation of entry of bacterium into host cell
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19666478
response to bacterium
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19666478

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosidase, Hydrolase

Molecular function

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAⁱ	3.2.1.51 2681
Reactomeⁱ	R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-6798695 Neutrophil degranulation R-HSA-8957275 Post-translational protein phosphorylation
SABIO-RKⁱ	Q9BTY2

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GH29 Glycoside Hydrolase Family 29

CAZyⁱ

GH29 Glycoside Hydrolase Family 29

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Plasma alpha-L-fucosidase (EC:3.2.1.51) Alternative name(s): Alpha-L-fucoside fucohydrolase 2 Short name: Alpha-L-fucosidase 2
Gene namesⁱ	Name:FUCA2 ORF Names:PSEC0151, UNQ227/PRO260
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000001036.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4008 FUCA2
MIMⁱ	136820 gene+phenotype
neXtProtⁱ	NX_Q9BTY2

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2519
MIMⁱ	136820 gene+phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000001036
PharmGKBⁱ	PA28424

Chemistry databases

ChEMBLⁱ	CHEMBL2271

ChEMBLⁱ

CHEMBL2271

Polymorphism and mutation databases

BioMutaⁱ	FUCA2
DMDMⁱ	254763296

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 28	Sequence analysisAdd BLAST		28
ChainⁱPRO_0000010312	29 – 467	Plasma alpha-L-fucosidaseAdd BLAST		439

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	171	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	239	N-linked (GlcNAc...) asparagine1 Publication	1
Modified residueⁱ	301	Phosphoserine; by FAM20C1 Publication	1
Glycosylationⁱ	377	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q9BTY2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BTY2
PaxDbⁱ	Q9BTY2
PeptideAtlas More...PeptideAtlasⁱ	Q9BTY2
PRIDEⁱ	Q9BTY2
ProteomicsDBⁱ	79030

PTM databases

GlyConnectⁱ	1608
iPTMnetⁱ	Q9BTY2
PhosphoSitePlusⁱ	Q9BTY2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000001036 Expressed in 189 organ(s), highest expression level in layer of synovial tissue
CleanExⁱ	HS_FUCA2
ExpressionAtlasⁱ	Q9BTY2 baseline and differential
Genevisibleⁱ	Q9BTY2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA031659 HPA031660 HPA031661

HPAⁱ

HPA031659
HPA031660
HPA031661

Interactionⁱ

Subunit structureⁱ

Homotetramer.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MEOX2	P50222	3	EBI-9050116,EBI-748397

With

Entry

#Exp.

IntAct

Notes

MEOX2

P50222

EBI-9050116,EBI-748397

Protein-protein interaction databases

BioGridⁱ	108795, 14 interactors
IntActⁱ	Q9BTY2, 18 interactors
STRINGⁱ	9606.ENSP00000002165

Chemistry databases

BindingDBⁱ

Q9BTY2

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BTY2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the glycosyl hydrolase 29 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3340 Eukaryota COG3669 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000035378
HOGENOMⁱ	HOG000029598
HOVERGENⁱ	HBG002155
InParanoidⁱ	Q9BTY2
KEGG Orthology (KO) More...KOⁱ	K01206
OMAⁱ	WNWNAID
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G085V
PhylomeDBⁱ	Q9BTY2
TreeFamⁱ	TF313034

Family and domain databases

Gene3Dⁱ	2.60.40.1180, 1 hit
InterProⁱ	View protein in InterPro IPR016286 FUC_metazoa-typ IPR031919 Fucosidase_C IPR000933 Glyco_hydro_29 IPR018526 Glyco_hydro_29_CS IPR013780 Glyco_hydro_b IPR017853 Glycoside_hydrolase_SF
PANTHERⁱ	PTHR10030 PTHR10030, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01120 Alpha_L_fucos, 1 hit PF16757 Fucosidase_C, 1 hit
PIRSFⁱ	PIRSF001092 Alpha-L-fucosidase, 1 hit
PRINTSⁱ	PR00741 GLHYDRLASE29
SMARTⁱ	View protein in SMART SM00812 Alpha_L_fucos, 1 hit
SUPFAMⁱ	SSF51445 SSF51445, 1 hit
PROSITEⁱ	View protein in PROSITE PS00385 ALPHA_L_FUCOSIDASE, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9BTY2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPQELPRLA FPLLLLLLLL LPPPPCPAHS ATRFDPTWES LDARQLPAWF 
        60         70         80         90        100
DQAKFGIFIH WGVFSVPSFG SEWFWWYWQK EKIPKYVEFM KDNYPPSFKY 
       110        120        130        140        150
EDFGPLFTAK FFNANQWADI FQASGAKYIV LTSKHHEGFT LWGSEYSWNW 
       160        170        180        190        200
NAIDEGPKRD IVKELEVAIR NRTDLRFGLY YSLFEWFHPL FLEDESSSFH 
       210        220        230        240        250
KRQFPVSKTL PELYELVNNY QPEVLWSDGD GGAPDQYWNS TGFLAWLYNE 
       260        270        280        290        300
SPVRGTVVTN DRWGAGSICK HGGFYTCSDR YNPGHLLPHK WENCMTIDKL 
       310        320        330        340        350
SWGYRREAGI SDYLTIEELV KQLVETVSCG GNLLMNIGPT LDGTISVVFE 
       360        370        380        390        400
ERLRQMGSWL KVNGEAIYET HTWRSQNDTV TPDVWYTSKP KEKLVYAIFL 
       410        420        430        440        450
KWPTSGQLFL GHPKAILGAT EVKLLGHGQP LNWISLEQNG IMVELPQLTI 
       460 
HQMPCKWGWA LALTNVI

Length:467

Mass (Da):54,067

Last modified:July 28, 2009 - v2

Checksum:ⁱA42AA6B369A3AC39

Isoform 2 (identifier: Q9BTY2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
138-165: GFTLWGSEYSWNWNAIDEGPKRDIVKEL → ATCRDSFMWRKSFDEYWAHTRWHHFCSF
166-467: Missing.

« Hide

        10         20         30         40         50
MRPQELPRLA FPLLLLLLLL LPPPPCPAHS ATRFDPTWES LDARQLPAWF 
        60         70         80         90        100
DQAKFGIFIH WGVFSVPSFG SEWFWWYWQK EKIPKYVEFM KDNYPPSFKY 
       110        120        130        140        150
EDFGPLFTAK FFNANQWADI FQASGAKYIV LTSKHHEATC RDSFMWRKSF 
       160 
DEYWAHTRWH HFCSF

Note: No experimental confirmation available.

Show »

Length:165

Mass (Da):19,835

Checksum:ⁱ0427DB86CD215820

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q7Z6V2	Q7Z6V2_HUMAN		Plasma alpha-L-fucosidase Plasma alpha-L-fucosidase	FUCA2	109	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	400	L → P in BAC11633 (PubMed:16303743).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_055822	233	A → E. Corresponds to variant dbSNP:rs11155297Ensembl.	1
Natural variantⁱVAR_022444	356	M → V3 PublicationsCorresponds to variant dbSNP:rs3762002Ensembl.	1
Natural variantⁱVAR_022445	371	H → Y3 PublicationsCorresponds to variant dbSNP:rs3762001Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_057004	138 – 165	GFTLW…IVKEL → ATCRDSFMWRKSFDEYWAHT RWHHFCSF in isoform 2. 1 PublicationAdd BLAST		28
Alternative sequenceⁱVSP_057005	166 – 467	Missing in isoform 2. 1 PublicationAdd BLAST		302

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358551 mRNA Translation: AAQ88915.1 AK296485 mRNA Translation: BAG59123.1 AK075458 mRNA Translation: BAC11633.1 AL031320 Genomic DNA No translation available. BC003060 mRNA Translation: AAH03060.1 BC051268 mRNA Translation: AAH51268.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5200.1 [Q9BTY2-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_114409.2, NM_032020.4 [Q9BTY2-1]
UniGeneⁱ	Hs.17680

Genome annotation databases

Ensemblⁱ	ENST00000002165; ENSP00000002165; ENSG00000001036 [Q9BTY2-1]
GeneIDⁱ	2519
KEGGⁱ	hsa:2519
UCSC genome browser More...UCSCⁱ	uc003qjm.4 human [Q9BTY2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BTY2	Plasma alpha-L-fucosidase		PONAB		465	UniRef90_Q9BTY2
Alpha-L-fucosidase		CALJA		530
Alpha-L-fucosidase		GORGO		468
Alpha-L-fucosidase		MANLE		465
Alpha-L-fucosidase		MACFA		465
+29

Protein	Similar proteins		Species	Score	Length	Source
Q9BTY2	Plasma alpha-L-fucosidase		PONAB		465	UniRef50_Q9BTY2
Alpha-L-fucosidase		CALJA		530
Alpha-L-fucosidase		GORGO		468
Alpha-L-fucosidase		MANLE		465
Alpha-L-fucosidase		NOMLE		465
+222
Q9BTY2-2	Uncharacterized protein		MYOLU		131	UniRef50_Q9BTY2-2
Alpha-L-fucosidase 2		ORYLA		159
UPI0006D70DBF		MYOLU		148

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358551 mRNA Translation: AAQ88915.1 AK296485 mRNA Translation: BAG59123.1 AK075458 mRNA Translation: BAC11633.1 AL031320 Genomic DNA No translation available. BC003060 mRNA Translation: AAH03060.1 BC051268 mRNA Translation: AAH51268.1
CCDSⁱ	CCDS5200.1 [Q9BTY2-1]
RefSeqⁱ	NP_114409.2, NM_032020.4 [Q9BTY2-1]
UniGeneⁱ	Hs.17680

3D structure databases

ProteinModelPortalⁱ	Q9BTY2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108795, 14 interactors
IntActⁱ	Q9BTY2, 18 interactors
STRINGⁱ	9606.ENSP00000002165

Chemistry databases

BindingDBⁱ	Q9BTY2
ChEMBLⁱ	CHEMBL2271

Protein family/group databases

CAZyⁱ	GH29 Glycoside Hydrolase Family 29

CAZyⁱ

GH29 Glycoside Hydrolase Family 29

PTM databases

GlyConnectⁱ	1608
iPTMnetⁱ	Q9BTY2
PhosphoSitePlusⁱ	Q9BTY2

Polymorphism and mutation databases

BioMutaⁱ	FUCA2
DMDMⁱ	254763296

Proteomic databases

EPDⁱ	Q9BTY2
MaxQBⁱ	Q9BTY2
PaxDbⁱ	Q9BTY2
PeptideAtlasⁱ	Q9BTY2
PRIDEⁱ	Q9BTY2
ProteomicsDBⁱ	79030

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2519
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000002165; ENSP00000002165; ENSG00000001036 [Q9BTY2-1]
GeneIDⁱ	2519
KEGGⁱ	hsa:2519
UCSCⁱ	uc003qjm.4 human [Q9BTY2-1]

Organism-specific databases

CTDⁱ	2519
DisGeNETⁱ	2519
EuPathDBⁱ	HostDB:ENSG00000001036.13
GeneCardsⁱ	FUCA2
H-InvDBⁱ	HIX0006268
HGNCⁱ	HGNC:4008 FUCA2
HPAⁱ	HPA031659 HPA031660 HPA031661
MIMⁱ	136820 gene+phenotype
neXtProtⁱ	NX_Q9BTY2
OpenTargetsⁱ	ENSG00000001036
PharmGKBⁱ	PA28424
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3340 Eukaryota COG3669 LUCA
GeneTreeⁱ	ENSGT00440000035378
HOGENOMⁱ	HOG000029598
HOVERGENⁱ	HBG002155
InParanoidⁱ	Q9BTY2
KOⁱ	K01206
OMAⁱ	WNWNAID
OrthoDBⁱ	EOG091G085V
PhylomeDBⁱ	Q9BTY2
TreeFamⁱ	TF313034

Enzyme and pathway databases

BRENDAⁱ	3.2.1.51 2681
Reactomeⁱ	R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-6798695 Neutrophil degranulation R-HSA-8957275 Post-translational protein phosphorylation
SABIO-RKⁱ	Q9BTY2

Miscellaneous databases

ChiTaRSⁱ	FUCA2 human
GeneWikiⁱ	FUCA2
GenomeRNAiⁱ	2519
Protein Ontology More...PROⁱ	PR:Q9BTY2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000001036 Expressed in 189 organ(s), highest expression level in layer of synovial tissue
CleanExⁱ	HS_FUCA2
ExpressionAtlasⁱ	Q9BTY2 baseline and differential
Genevisibleⁱ	Q9BTY2 HS

Family and domain databases

Gene3Dⁱ	2.60.40.1180, 1 hit
InterProⁱ	View protein in InterPro IPR016286 FUC_metazoa-typ IPR031919 Fucosidase_C IPR000933 Glyco_hydro_29 IPR018526 Glyco_hydro_29_CS IPR013780 Glyco_hydro_b IPR017853 Glycoside_hydrolase_SF
PANTHERⁱ	PTHR10030 PTHR10030, 1 hit
Pfamⁱ	View protein in Pfam PF01120 Alpha_L_fucos, 1 hit PF16757 Fucosidase_C, 1 hit
PIRSFⁱ	PIRSF001092 Alpha-L-fucosidase, 1 hit
PRINTSⁱ	PR00741 GLHYDRLASE29
SMARTⁱ	View protein in SMART SM00812 Alpha_L_fucos, 1 hit
SUPFAMⁱ	SSF51445 SSF51445, 1 hit
PROSITEⁱ	View protein in PROSITE PS00385 ALPHA_L_FUCOSIDASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FUCO2_HUMAN
Accessionⁱ	Q9BTY2Primary (citable) accession number: Q9BTY2 Secondary accession number(s): E9PEB6 , Q7Z6V1, Q7Z6Y2, Q8NBK4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
	Last sequence update:	July 28, 2009
	Last modified:	November 7, 2018
	This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BTY2 (FUCO2_HUMAN)

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Plasma alpha-L-fucosidase

FUCA2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Lysosome

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ