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UniProtKB - Q9BTY2 (FUCO2_HUMAN)

>sp|Q9BTY2|FUCO2_HUMAN Plasma alpha-L-fucosidase OS=Homo sapiens OX=9606 GN=FUCA2 PE=1 SV=2
MRPQELPRLAFPLLLLLLLLLPPPPCPAHSATRFDPTWESLDARQLPAWFDQAKFGIFIH
WGVFSVPSFGSEWFWWYWQKEKIPKYVEFMKDNYPPSFKYEDFGPLFTAKFFNANQWADI
FQASGAKYIVLTSKHHEGFTLWGSEYSWNWNAIDEGPKRDIVKELEVAIRNRTDLRFGLY
YSLFEWFHPLFLEDESSSFHKRQFPVSKTLPELYELVNNYQPEVLWSDGDGGAPDQYWNS
TGFLAWLYNESPVRGTVVTNDRWGAGSICKHGGFYTCSDRYNPGHLLPHKWENCMTIDKL
SWGYRREAGISDYLTIEELVKQLVETVSCGGNLLMNIGPTLDGTISVVFEERLRQMGSWL
KVNGEAIYETHTWRSQNDTVTPDVWYTSKPKEKLVYAIFLKWPTSGQLFLGHPKAILGAT
EVKLLGHGQPLNWISLEQNGIMVELPQLTIHQMPCKWGWALALTNVI

Entry version 159 (25 May 2022)
Sequence version 2 (28 Jul 2009)
Previous versions | rss

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Protein

Plasma alpha-L-fucosidase

Gene

FUCA2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Catalytic activityⁱ

an α-L-fucoside
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H₂O
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
=
an alcohol
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
L-fucose
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
PROSITE-ProRule annotation
Manual assertion according to rulesⁱ
- PROSITE-ProRule:PRU10054
EC:
3.2.1.51
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
- Search reactions for this EC number in Rhea.
PROSITE-ProRule annotation
Manual assertion according to rulesⁱ
- PROSITE-ProRule:PRU10054
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
an α-L-fucoside
zoom
+
H₂O
=
an alcohol
zoom
+
L-fucose
zoom

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	294	May be important for catalysisPROSITE-ProRule annotation		1

GO - Molecular functionⁱ

alpha-L-fucosidase activity
Source: UniProtKB
Inferred from direct assayⁱ
- "Role for alpha-L-fucosidase in the control of Helicobacter pylori-infected gastric cancer cells."
  Liu T.W., Ho C.W., Huang H.H., Chang S.M., Popat S.D., Wang Y.T., Wu M.S., Chen Y.J., Lin C.H.
  Proc Natl Acad Sci U S A 106:14581-14586(2009) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosidase, Hydrolase

Molecular function

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAⁱ	3.2.1.51, 2681
PathwayCommonsⁱ	Q9BTY2
Reactomeⁱ	R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-6798695, Neutrophil degranulation R-HSA-8957275, Post-translational protein phosphorylation
SABIO-RKⁱ	Q9BTY2
SignaLinkⁱ	Q9BTY2

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GH29, Glycoside Hydrolase Family 29

CAZyⁱ

GH29, Glycoside Hydrolase Family 29

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Plasma alpha-L-fucosidase (EC:3.2.1.51) Alternative name(s): Alpha-L-fucoside fucohydrolase 2 Short name: Alpha-L-fucosidase 2
Gene namesⁱ	Name:FUCA2 ORF Names:PSEC0151, UNQ227/PRO260
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4008, FUCA2
MIMⁱ	136820, gene+phenotype
neXtProtⁱ	NX_Q9BTY2
VEuPathDBⁱ	HostDB:ENSG00000001036

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2519
MIMⁱ	136820, gene+phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000001036
PharmGKBⁱ	PA28424

Miscellaneous databases

Pharosⁱ	Q9BTY2, Tchem

Pharosⁱ

Q9BTY2, Tchem

Chemistry databases

ChEMBLⁱ	CHEMBL2271

ChEMBLⁱ

CHEMBL2271

Genetic variation databases

BioMutaⁱ	FUCA2
DMDMⁱ	254763296

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 28	Sequence analysisAdd BLAST		28
ChainⁱPRO_0000010312	29 – 467	Plasma alpha-L-fucosidaseAdd BLAST		439

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	171	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	239	N-linked (GlcNAc...) asparagine1 Publication	1
Modified residueⁱ	301	Phosphoserine; by FAM20C1 Publication	1
Glycosylationⁱ	377	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q9BTY2
jPOSTⁱ	Q9BTY2
MassIVEⁱ	Q9BTY2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BTY2
PaxDbⁱ	Q9BTY2
PeptideAtlas More...PeptideAtlasⁱ	Q9BTY2
PRIDEⁱ	Q9BTY2
ProteomicsDBⁱ	69462 79030 [Q9BTY2-1]

PTM databases

GlyConnectⁱ	1608, 3 N-Linked glycans (1 site)
GlyGenⁱ	Q9BTY2, 4 sites, 2 N-linked glycans (1 site)
iPTMnetⁱ	Q9BTY2
PhosphoSitePlusⁱ	Q9BTY2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000001036, Expressed in layer of synovial tissue and 203 other tissues
ExpressionAtlasⁱ	Q9BTY2, baseline and differential
Genevisibleⁱ	Q9BTY2, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000001036, Tissue enhanced (parathyroid)

HPAⁱ

ENSG00000001036, Tissue enhanced (parathyroid)

Interactionⁱ

Subunit structureⁱ

Homotetramer.

By similarity

Binary interactionsⁱ

Hide details

Q9BTY2

With	#Exp.	IntAct
GUCD1 - isoform 2 [Q96NT3-2]	3	EBI-9050116,EBI-11978177
HOXA1 [P49639]	3	EBI-9050116,EBI-740785
KRTAP4-12 [Q9BQ66]	3	EBI-9050116,EBI-739863
KRTAP5-2 [Q701N4]	3	EBI-9050116,EBI-11958178
KRTAP5-3 [Q6L8H2]	3	EBI-9050116,EBI-11974251
LCE1A [Q5T7P2]	3	EBI-9050116,EBI-11962058
LCE1B [Q5T7P3]	3	EBI-9050116,EBI-10245913
LCE1E [Q5T753]	3	EBI-9050116,EBI-11955335
LCE4A [Q5TA78]	3	EBI-9050116,EBI-10246358
MEOX2 [P50222]	4	EBI-9050116,EBI-748397
NUFIP2 [Q7Z417]	3	EBI-9050116,EBI-1210753
PIN1 [Q13526]	3	EBI-9050116,EBI-714158
TNPO2 - isoform 2 [O14787-2]	3	EBI-9050116,EBI-12076664
VWC2 [Q2TAL6]	3	EBI-9050116,EBI-11957238
WNT11 [O96014]	3	EBI-9050116,EBI-8058160

Protein-protein interaction databases

BioGRIDⁱ	108795, 50 interactors
IntActⁱ	Q9BTY2, 34 interactors
Molecular INTeraction database More...MINTⁱ	Q9BTY2
STRINGⁱ	9606.ENSP00000002165

Chemistry databases

BindingDBⁱ

Q9BTY2

Miscellaneous databases

RNActⁱ	Q9BTY2, protein

RNActⁱ

Q9BTY2, protein

Structureⁱ

3D structure databases

AlphaFoldDBⁱ	Q9BTY2
SMRⁱ	Q9BTY2
ModBaseⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the glycosyl hydrolase 29 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3340, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000035378
HOGENOMⁱ	CLU_002934_1_1_1
InParanoidⁱ	Q9BTY2
OMAⁱ	PDFTYQE
Database of Orthologous Groups More...OrthoDBⁱ	929780at2759
PhylomeDBⁱ	Q9BTY2
TreeFamⁱ	TF313034

Family and domain databases

Gene3Dⁱ	2.60.40.1180, 1 hit
InterProⁱ	View protein in InterPro IPR016286, FUC_metazoa-typ IPR031919, Fucosidase_C IPR000933, Glyco_hydro_29 IPR018526, Glyco_hydro_29_CS IPR013780, Glyco_hydro_b IPR017853, Glycoside_hydrolase_SF
PANTHERⁱ	PTHR10030, PTHR10030, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01120, Alpha_L_fucos, 1 hit PF16757, Fucosidase_C, 1 hit
PIRSFⁱ	PIRSF001092, Alpha-L-fucosidase, 1 hit
PRINTSⁱ	PR00741, GLHYDRLASE29
SMARTⁱ	View protein in SMART SM00812, Alpha_L_fucos, 1 hit
SUPFAMⁱ	SSF51445, SSF51445, 1 hit
PROSITEⁱ	View protein in PROSITE PS00385, ALPHA_L_FUCOSIDASE, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9BTY2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPQELPRLA FPLLLLLLLL LPPPPCPAHS ATRFDPTWES LDARQLPAWF 
        60         70         80         90        100
DQAKFGIFIH WGVFSVPSFG SEWFWWYWQK EKIPKYVEFM KDNYPPSFKY 
       110        120        130        140        150
EDFGPLFTAK FFNANQWADI FQASGAKYIV LTSKHHEGFT LWGSEYSWNW 
       160        170        180        190        200
NAIDEGPKRD IVKELEVAIR NRTDLRFGLY YSLFEWFHPL FLEDESSSFH 
       210        220        230        240        250
KRQFPVSKTL PELYELVNNY QPEVLWSDGD GGAPDQYWNS TGFLAWLYNE 
       260        270        280        290        300
SPVRGTVVTN DRWGAGSICK HGGFYTCSDR YNPGHLLPHK WENCMTIDKL 
       310        320        330        340        350
SWGYRREAGI SDYLTIEELV KQLVETVSCG GNLLMNIGPT LDGTISVVFE 
       360        370        380        390        400
ERLRQMGSWL KVNGEAIYET HTWRSQNDTV TPDVWYTSKP KEKLVYAIFL 
       410        420        430        440        450
KWPTSGQLFL GHPKAILGAT EVKLLGHGQP LNWISLEQNG IMVELPQLTI 
       460 
HQMPCKWGWA LALTNVI

Length:467

Mass (Da):54,067

Last modified:July 28, 2009 - v2

Checksum:ⁱA42AA6B369A3AC39

Isoform 2 (identifier: Q9BTY2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
138-165: GFTLWGSEYSWNWNAIDEGPKRDIVKEL → ATCRDSFMWRKSFDEYWAHTRWHHFCSF
166-467: Missing.

« Hide

        10         20         30         40         50
MRPQELPRLA FPLLLLLLLL LPPPPCPAHS ATRFDPTWES LDARQLPAWF 
        60         70         80         90        100
DQAKFGIFIH WGVFSVPSFG SEWFWWYWQK EKIPKYVEFM KDNYPPSFKY 
       110        120        130        140        150
EDFGPLFTAK FFNANQWADI FQASGAKYIV LTSKHHEATC RDSFMWRKSF 
       160 
DEYWAHTRWH HFCSF

Show »

Length:165

Mass (Da):19,835

Checksum:ⁱ0427DB86CD215820

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q7Z6V2	Q7Z6V2_HUMAN		Alpha-L-fucosidase Alpha-L-fucosidase, EC 3.2.1.51	FUCA2	109	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	400	L → P in BAC11633 (PubMed:16303743).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_055822	233	A → E. Corresponds to variant dbSNP:rs11155297Ensembl.	1
Natural variantⁱVAR_022444	356	M → V3 PublicationsCorresponds to variant dbSNP:rs3762002Ensembl.	1
Natural variantⁱVAR_022445	371	H → Y3 PublicationsCorresponds to variant dbSNP:rs3762001Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_057004	138 – 165	GFTLW…IVKEL → ATCRDSFMWRKSFDEYWAHT RWHHFCSF in isoform 2. 1 PublicationAdd BLAST		28
Alternative sequenceⁱVSP_057005	166 – 467	Missing in isoform 2. 1 PublicationAdd BLAST		302

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358551 mRNA Translation: AAQ88915.1 AK296485 mRNA Translation: BAG59123.1 AK075458 mRNA Translation: BAC11633.1 AL031320 Genomic DNA No translation available. BC003060 mRNA Translation: AAH03060.1 BC051268 mRNA Translation: AAH51268.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5200.1 [Q9BTY2-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_114409.2, NM_032020.4 [Q9BTY2-1]

Genome annotation databases

Ensemblⁱ	ENST00000002165.11; ENSP00000002165.5; ENSG00000001036.14
GeneIDⁱ	2519
KEGGⁱ	hsa:2519
MANE-Selectⁱ	ENST00000002165.11; ENSP00000002165.5; NM_032020.5; NP_114409.2
UCSC genome browser More...UCSCⁱ	uc003qjm.4, human [Q9BTY2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BTY2	Plasma alpha-L-fucosidase		PONAB		465	UniRef90_Q9BTY2
Alpha-L-fucosidase 2		CALJA		530
Alpha-L-fucosidase		GORGO		468
Alpha-L-fucosidase		MANLE		465
Alpha-L-fucosidase		CHLSB		465
+44

Protein	Similar proteins		Species	Score	Length	Source
Q9BTY2	Plasma alpha-L-fucosidase		PONAB		465	UniRef50_Q9BTY2
Alpha-L-fucosidase 2		CALJA		530
Alpha-L-fucosidase		GORGO		468
Alpha-L-fucosidase		Ugandan red Colobus		465
Alpha-L-fucosidase		MANLE		465
+242
Q9BTY2-2	Plasma alpha-L-fucosidase		MICOH		201	UniRef50_Q9BTY2-2

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358551 mRNA Translation: AAQ88915.1 AK296485 mRNA Translation: BAG59123.1 AK075458 mRNA Translation: BAC11633.1 AL031320 Genomic DNA No translation available. BC003060 mRNA Translation: AAH03060.1 BC051268 mRNA Translation: AAH51268.1
CCDSⁱ	CCDS5200.1 [Q9BTY2-1]
RefSeqⁱ	NP_114409.2, NM_032020.4 [Q9BTY2-1]

3D structure databases

AlphaFoldDBⁱ	Q9BTY2
SMRⁱ	Q9BTY2
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	108795, 50 interactors
IntActⁱ	Q9BTY2, 34 interactors
MINTⁱ	Q9BTY2
STRINGⁱ	9606.ENSP00000002165

Chemistry databases

BindingDBⁱ	Q9BTY2
ChEMBLⁱ	CHEMBL2271

Protein family/group databases

CAZyⁱ	GH29, Glycoside Hydrolase Family 29

CAZyⁱ

GH29, Glycoside Hydrolase Family 29

PTM databases

GlyConnectⁱ	1608, 3 N-Linked glycans (1 site)
GlyGenⁱ	Q9BTY2, 4 sites, 2 N-linked glycans (1 site)
iPTMnetⁱ	Q9BTY2
PhosphoSitePlusⁱ	Q9BTY2

Genetic variation databases

BioMutaⁱ	FUCA2
DMDMⁱ	254763296

Proteomic databases

EPDⁱ	Q9BTY2
jPOSTⁱ	Q9BTY2
MassIVEⁱ	Q9BTY2
MaxQBⁱ	Q9BTY2
PaxDbⁱ	Q9BTY2
PeptideAtlasⁱ	Q9BTY2
PRIDEⁱ	Q9BTY2
ProteomicsDBⁱ	69462 79030 [Q9BTY2-1]

Protocols and materials databases

Antibodypediaⁱ	33149, 347 antibodies from 28 providers
The DNASU plasmid repository More...DNASUⁱ	2519

Genome annotation databases

Ensemblⁱ	ENST00000002165.11; ENSP00000002165.5; ENSG00000001036.14
GeneIDⁱ	2519
KEGGⁱ	hsa:2519
MANE-Selectⁱ	ENST00000002165.11; ENSP00000002165.5; NM_032020.5; NP_114409.2
UCSCⁱ	uc003qjm.4, human [Q9BTY2-1]

Organism-specific databases

CTDⁱ	2519
DisGeNETⁱ	2519
GeneCardsⁱ	FUCA2
HGNCⁱ	HGNC:4008, FUCA2
HPAⁱ	ENSG00000001036, Tissue enhanced (parathyroid)
MIMⁱ	136820, gene+phenotype
neXtProtⁱ	NX_Q9BTY2
OpenTargetsⁱ	ENSG00000001036
PharmGKBⁱ	PA28424
VEuPathDBⁱ	HostDB:ENSG00000001036
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3340, Eukaryota
GeneTreeⁱ	ENSGT00440000035378
HOGENOMⁱ	CLU_002934_1_1_1
InParanoidⁱ	Q9BTY2
OMAⁱ	PDFTYQE
OrthoDBⁱ	929780at2759
PhylomeDBⁱ	Q9BTY2
TreeFamⁱ	TF313034

Enzyme and pathway databases

BRENDAⁱ	3.2.1.51, 2681
PathwayCommonsⁱ	Q9BTY2
Reactomeⁱ	R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-6798695, Neutrophil degranulation R-HSA-8957275, Post-translational protein phosphorylation
SABIO-RKⁱ	Q9BTY2
SignaLinkⁱ	Q9BTY2

Miscellaneous databases

BioGRID-ORCSⁱ	2519, 9 hits in 1079 CRISPR screens
ChiTaRSⁱ	FUCA2, human
GeneWikiⁱ	FUCA2
GenomeRNAiⁱ	2519
Pharosⁱ	Q9BTY2, Tchem
Protein Ontology More...PROⁱ	PR:Q9BTY2
RNActⁱ	Q9BTY2, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000001036, Expressed in layer of synovial tissue and 203 other tissues
ExpressionAtlasⁱ	Q9BTY2, baseline and differential
Genevisibleⁱ	Q9BTY2, HS

Family and domain databases

Gene3Dⁱ	2.60.40.1180, 1 hit
InterProⁱ	View protein in InterPro IPR016286, FUC_metazoa-typ IPR031919, Fucosidase_C IPR000933, Glyco_hydro_29 IPR018526, Glyco_hydro_29_CS IPR013780, Glyco_hydro_b IPR017853, Glycoside_hydrolase_SF
PANTHERⁱ	PTHR10030, PTHR10030, 1 hit
Pfamⁱ	View protein in Pfam PF01120, Alpha_L_fucos, 1 hit PF16757, Fucosidase_C, 1 hit
PIRSFⁱ	PIRSF001092, Alpha-L-fucosidase, 1 hit
PRINTSⁱ	PR00741, GLHYDRLASE29
SMARTⁱ	View protein in SMART SM00812, Alpha_L_fucos, 1 hit
SUPFAMⁱ	SSF51445, SSF51445, 1 hit
PROSITEⁱ	View protein in PROSITE PS00385, ALPHA_L_FUCOSIDASE, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FUCO2_HUMAN
Accessionⁱ	Q9BTY2Primary (citable) accession number: Q9BTY2 Secondary accession number(s): E9PEB6 , Q7Z6V1, Q7Z6Y2, Q8NBK4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
	Last sequence update:	July 28, 2009
	Last modified:	May 25, 2022
	This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BTY2 (FUCO2_HUMAN)

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Plasma alpha-L-fucosidase

FUCA2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Lysosome

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q9BTY2

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ