UniProtKB - Q9BTY2 (FUCO2_HUMAN)
Plasma alpha-L-fucosidase
FUCA2
Functioni
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
Catalytic activityi
- EC:3.2.1.51PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 294 | May be important for catalysisPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- alpha-L-fucosidase activity Source: UniProtKB
GO - Biological processi
- fucose metabolic process Source: UniProtKB
- glycoside catabolic process Source: UniProtKB
- regulation of entry of bacterium into host cell Source: UniProtKB
- response to bacterium Source: UniProtKB
Keywordsi
Molecular function | Glycosidase, Hydrolase |
Enzyme and pathway databases
BRENDAi | 3.2.1.51, 2681 |
PathwayCommonsi | Q9BTY2 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-6798695, Neutrophil degranulation R-HSA-8957275, Post-translational protein phosphorylation |
SABIO-RKi | Q9BTY2 |
SignaLinki | Q9BTY2 |
Protein family/group databases
CAZyi | GH29, Glycoside Hydrolase Family 29 |
Names & Taxonomyi
Protein namesi | Recommended name: Plasma alpha-L-fucosidase (EC:3.2.1.51)Alternative name(s): Alpha-L-fucoside fucohydrolase 2 Short name: Alpha-L-fucosidase 2 |
Gene namesi | Name:FUCA2 ORF Names:PSEC0151, UNQ227/PRO260 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4008, FUCA2 |
MIMi | 136820, gene+phenotype |
neXtProti | NX_Q9BTY2 |
VEuPathDBi | HostDB:ENSG00000001036 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Lysosome
- azurophil granule lumen Source: Reactome
- lysosome Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 2519 |
MIMi | 136820, gene+phenotype |
OpenTargetsi | ENSG00000001036 |
PharmGKBi | PA28424 |
Miscellaneous databases
Pharosi | Q9BTY2, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2271 |
Genetic variation databases
BioMutai | FUCA2 |
DMDMi | 254763296 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_0000010312 | 29 – 467 | Plasma alpha-L-fucosidaseAdd BLAST | 439 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 171 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 239 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 301 | Phosphoserine; by FAM20C1 Publication | 1 | |
Glycosylationi | 377 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q9BTY2 |
jPOSTi | Q9BTY2 |
MassIVEi | Q9BTY2 |
MaxQBi | Q9BTY2 |
PaxDbi | Q9BTY2 |
PeptideAtlasi | Q9BTY2 |
PRIDEi | Q9BTY2 |
ProteomicsDBi | 69462 79030 [Q9BTY2-1] |
PTM databases
GlyConnecti | 1608, 3 N-Linked glycans (1 site) |
GlyGeni | Q9BTY2, 4 sites, 2 N-linked glycans (1 site) |
iPTMneti | Q9BTY2 |
PhosphoSitePlusi | Q9BTY2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000001036, Expressed in layer of synovial tissue and 203 other tissues |
ExpressionAtlasi | Q9BTY2, baseline and differential |
Genevisiblei | Q9BTY2, HS |
Organism-specific databases
HPAi | ENSG00000001036, Tissue enhanced (parathyroid) |
Interactioni
Subunit structurei
Homotetramer.
By similarityBinary interactionsi
Q9BTY2
Protein-protein interaction databases
BioGRIDi | 108795, 50 interactors |
IntActi | Q9BTY2, 34 interactors |
MINTi | Q9BTY2 |
STRINGi | 9606.ENSP00000002165 |
Chemistry databases
BindingDBi | Q9BTY2 |
Miscellaneous databases
RNActi | Q9BTY2, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3340, Eukaryota |
GeneTreei | ENSGT00440000035378 |
HOGENOMi | CLU_002934_1_1_1 |
InParanoidi | Q9BTY2 |
OMAi | PDFTYQE |
OrthoDBi | 929780at2759 |
PhylomeDBi | Q9BTY2 |
TreeFami | TF313034 |
Family and domain databases
Gene3Di | 2.60.40.1180, 1 hit |
InterProi | View protein in InterPro IPR016286, FUC_metazoa-typ IPR031919, Fucosidase_C IPR000933, Glyco_hydro_29 IPR018526, Glyco_hydro_29_CS IPR013780, Glyco_hydro_b IPR017853, Glycoside_hydrolase_SF |
PANTHERi | PTHR10030, PTHR10030, 1 hit |
Pfami | View protein in Pfam PF01120, Alpha_L_fucos, 1 hit PF16757, Fucosidase_C, 1 hit |
PIRSFi | PIRSF001092, Alpha-L-fucosidase, 1 hit |
PRINTSi | PR00741, GLHYDRLASE29 |
SMARTi | View protein in SMART SM00812, Alpha_L_fucos, 1 hit |
SUPFAMi | SSF51445, SSF51445, 1 hit |
PROSITEi | View protein in PROSITE PS00385, ALPHA_L_FUCOSIDASE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRPQELPRLA FPLLLLLLLL LPPPPCPAHS ATRFDPTWES LDARQLPAWF
60 70 80 90 100
DQAKFGIFIH WGVFSVPSFG SEWFWWYWQK EKIPKYVEFM KDNYPPSFKY
110 120 130 140 150
EDFGPLFTAK FFNANQWADI FQASGAKYIV LTSKHHEGFT LWGSEYSWNW
160 170 180 190 200
NAIDEGPKRD IVKELEVAIR NRTDLRFGLY YSLFEWFHPL FLEDESSSFH
210 220 230 240 250
KRQFPVSKTL PELYELVNNY QPEVLWSDGD GGAPDQYWNS TGFLAWLYNE
260 270 280 290 300
SPVRGTVVTN DRWGAGSICK HGGFYTCSDR YNPGHLLPHK WENCMTIDKL
310 320 330 340 350
SWGYRREAGI SDYLTIEELV KQLVETVSCG GNLLMNIGPT LDGTISVVFE
360 370 380 390 400
ERLRQMGSWL KVNGEAIYET HTWRSQNDTV TPDVWYTSKP KEKLVYAIFL
410 420 430 440 450
KWPTSGQLFL GHPKAILGAT EVKLLGHGQP LNWISLEQNG IMVELPQLTI
460
HQMPCKWGWA LALTNVI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ7Z6V2 | Q7Z6V2_HUMAN | Alpha-L-fucosidase | FUCA2 | 109 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 400 | L → P in BAC11633 (PubMed:16303743).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055822 | 233 | A → E. Corresponds to variant dbSNP:rs11155297Ensembl. | 1 | |
Natural variantiVAR_022444 | 356 | M → V3 PublicationsCorresponds to variant dbSNP:rs3762002Ensembl. | 1 | |
Natural variantiVAR_022445 | 371 | H → Y3 PublicationsCorresponds to variant dbSNP:rs3762001Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057004 | 138 – 165 | GFTLW…IVKEL → ATCRDSFMWRKSFDEYWAHT RWHHFCSF in isoform 2. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_057005 | 166 – 467 | Missing in isoform 2. 1 PublicationAdd BLAST | 302 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358551 mRNA Translation: AAQ88915.1 AK296485 mRNA Translation: BAG59123.1 AK075458 mRNA Translation: BAC11633.1 AL031320 Genomic DNA No translation available. BC003060 mRNA Translation: AAH03060.1 BC051268 mRNA Translation: AAH51268.1 |
CCDSi | CCDS5200.1 [Q9BTY2-1] |
RefSeqi | NP_114409.2, NM_032020.4 [Q9BTY2-1] |
Genome annotation databases
Ensembli | ENST00000002165.11; ENSP00000002165.5; ENSG00000001036.14 |
GeneIDi | 2519 |
KEGGi | hsa:2519 |
MANE-Selecti | ENST00000002165.11; ENSP00000002165.5; NM_032020.5; NP_114409.2 |
UCSCi | uc003qjm.4, human [Q9BTY2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358551 mRNA Translation: AAQ88915.1 AK296485 mRNA Translation: BAG59123.1 AK075458 mRNA Translation: BAC11633.1 AL031320 Genomic DNA No translation available. BC003060 mRNA Translation: AAH03060.1 BC051268 mRNA Translation: AAH51268.1 |
CCDSi | CCDS5200.1 [Q9BTY2-1] |
RefSeqi | NP_114409.2, NM_032020.4 [Q9BTY2-1] |
3D structure databases
AlphaFoldDBi | Q9BTY2 |
SMRi | Q9BTY2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108795, 50 interactors |
IntActi | Q9BTY2, 34 interactors |
MINTi | Q9BTY2 |
STRINGi | 9606.ENSP00000002165 |
Chemistry databases
BindingDBi | Q9BTY2 |
ChEMBLi | CHEMBL2271 |
Protein family/group databases
CAZyi | GH29, Glycoside Hydrolase Family 29 |
PTM databases
GlyConnecti | 1608, 3 N-Linked glycans (1 site) |
GlyGeni | Q9BTY2, 4 sites, 2 N-linked glycans (1 site) |
iPTMneti | Q9BTY2 |
PhosphoSitePlusi | Q9BTY2 |
Genetic variation databases
BioMutai | FUCA2 |
DMDMi | 254763296 |
Proteomic databases
EPDi | Q9BTY2 |
jPOSTi | Q9BTY2 |
MassIVEi | Q9BTY2 |
MaxQBi | Q9BTY2 |
PaxDbi | Q9BTY2 |
PeptideAtlasi | Q9BTY2 |
PRIDEi | Q9BTY2 |
ProteomicsDBi | 69462 79030 [Q9BTY2-1] |
Protocols and materials databases
Antibodypediai | 33149, 347 antibodies from 28 providers |
DNASUi | 2519 |
Genome annotation databases
Ensembli | ENST00000002165.11; ENSP00000002165.5; ENSG00000001036.14 |
GeneIDi | 2519 |
KEGGi | hsa:2519 |
MANE-Selecti | ENST00000002165.11; ENSP00000002165.5; NM_032020.5; NP_114409.2 |
UCSCi | uc003qjm.4, human [Q9BTY2-1] |
Organism-specific databases
CTDi | 2519 |
DisGeNETi | 2519 |
GeneCardsi | FUCA2 |
HGNCi | HGNC:4008, FUCA2 |
HPAi | ENSG00000001036, Tissue enhanced (parathyroid) |
MIMi | 136820, gene+phenotype |
neXtProti | NX_Q9BTY2 |
OpenTargetsi | ENSG00000001036 |
PharmGKBi | PA28424 |
VEuPathDBi | HostDB:ENSG00000001036 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3340, Eukaryota |
GeneTreei | ENSGT00440000035378 |
HOGENOMi | CLU_002934_1_1_1 |
InParanoidi | Q9BTY2 |
OMAi | PDFTYQE |
OrthoDBi | 929780at2759 |
PhylomeDBi | Q9BTY2 |
TreeFami | TF313034 |
Enzyme and pathway databases
BRENDAi | 3.2.1.51, 2681 |
PathwayCommonsi | Q9BTY2 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-6798695, Neutrophil degranulation R-HSA-8957275, Post-translational protein phosphorylation |
SABIO-RKi | Q9BTY2 |
SignaLinki | Q9BTY2 |
Miscellaneous databases
BioGRID-ORCSi | 2519, 9 hits in 1079 CRISPR screens |
ChiTaRSi | FUCA2, human |
GeneWikii | FUCA2 |
GenomeRNAii | 2519 |
Pharosi | Q9BTY2, Tchem |
PROi | PR:Q9BTY2 |
RNActi | Q9BTY2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000001036, Expressed in layer of synovial tissue and 203 other tissues |
ExpressionAtlasi | Q9BTY2, baseline and differential |
Genevisiblei | Q9BTY2, HS |
Family and domain databases
Gene3Di | 2.60.40.1180, 1 hit |
InterProi | View protein in InterPro IPR016286, FUC_metazoa-typ IPR031919, Fucosidase_C IPR000933, Glyco_hydro_29 IPR018526, Glyco_hydro_29_CS IPR013780, Glyco_hydro_b IPR017853, Glycoside_hydrolase_SF |
PANTHERi | PTHR10030, PTHR10030, 1 hit |
Pfami | View protein in Pfam PF01120, Alpha_L_fucos, 1 hit PF16757, Fucosidase_C, 1 hit |
PIRSFi | PIRSF001092, Alpha-L-fucosidase, 1 hit |
PRINTSi | PR00741, GLHYDRLASE29 |
SMARTi | View protein in SMART SM00812, Alpha_L_fucos, 1 hit |
SUPFAMi | SSF51445, SSF51445, 1 hit |
PROSITEi | View protein in PROSITE PS00385, ALPHA_L_FUCOSIDASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FUCO2_HUMAN | |
Accessioni | Q9BTY2Primary (citable) accession number: Q9BTY2 Secondary accession number(s): E9PEB6 Q8NBK4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | July 28, 2009 | |
Last modified: | May 25, 2022 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families