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Protein

Plasma alpha-L-fucosidase

Gene

FUCA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei294May be important for catalysisPROSITE-ProRule annotation1

GO - Molecular functioni

  • alpha-L-fucosidase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.51 2681
ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-6798695 Neutrophil degranulation
R-HSA-8957275 Post-translational protein phosphorylation
SABIO-RKiQ9BTY2

Protein family/group databases

CAZyiGH29 Glycoside Hydrolase Family 29

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucoside fucohydrolase 2
Short name:
Alpha-L-fucosidase 2
Gene namesi
Name:FUCA2
ORF Names:PSEC0151, UNQ227/PRO260
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000001036.13
HGNCiHGNC:4008 FUCA2
MIMi136820 gene+phenotype
neXtProtiNX_Q9BTY2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2519
MIMi136820 gene+phenotype
OpenTargetsiENSG00000001036
PharmGKBiPA28424

Chemistry databases

ChEMBLiCHEMBL2271

Polymorphism and mutation databases

BioMutaiFUCA2
DMDMi254763296

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001031229 – 467Plasma alpha-L-fucosidaseAdd BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi239N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei301Phosphoserine; by FAM20C1 Publication1
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9BTY2
MaxQBiQ9BTY2
PaxDbiQ9BTY2
PeptideAtlasiQ9BTY2
PRIDEiQ9BTY2
ProteomicsDBi79030

PTM databases

GlyConnecti1608
iPTMnetiQ9BTY2
PhosphoSitePlusiQ9BTY2

Expressioni

Gene expression databases

BgeeiENSG00000001036 Expressed in 189 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_FUCA2
ExpressionAtlasiQ9BTY2 baseline and differential
GenevisibleiQ9BTY2 HS

Organism-specific databases

HPAiHPA031659
HPA031660
HPA031661

Interactioni

Subunit structurei

Homotetramer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2P502223EBI-9050116,EBI-748397

Protein-protein interaction databases

BioGridi108795, 14 interactors
IntActiQ9BTY2, 18 interactors
STRINGi9606.ENSP00000002165

Chemistry databases

BindingDBiQ9BTY2

Structurei

3D structure databases

ProteinModelPortaliQ9BTY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 29 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3340 Eukaryota
COG3669 LUCA
GeneTreeiENSGT00440000035378
HOGENOMiHOG000029598
HOVERGENiHBG002155
InParanoidiQ9BTY2
KOiK01206
OMAiWNWNAID
OrthoDBiEOG091G085V
PhylomeDBiQ9BTY2
TreeFamiTF313034

Family and domain databases

Gene3Di2.60.40.1180, 1 hit
InterProiView protein in InterPro
IPR016286 FUC_metazoa-typ
IPR031919 Fucosidase_C
IPR000933 Glyco_hydro_29
IPR018526 Glyco_hydro_29_CS
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10030 PTHR10030, 1 hit
PfamiView protein in Pfam
PF01120 Alpha_L_fucos, 1 hit
PF16757 Fucosidase_C, 1 hit
PIRSFiPIRSF001092 Alpha-L-fucosidase, 1 hit
PRINTSiPR00741 GLHYDRLASE29
SMARTiView protein in SMART
SM00812 Alpha_L_fucos, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00385 ALPHA_L_FUCOSIDASE, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BTY2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPQELPRLA FPLLLLLLLL LPPPPCPAHS ATRFDPTWES LDARQLPAWF
60 70 80 90 100
DQAKFGIFIH WGVFSVPSFG SEWFWWYWQK EKIPKYVEFM KDNYPPSFKY
110 120 130 140 150
EDFGPLFTAK FFNANQWADI FQASGAKYIV LTSKHHEGFT LWGSEYSWNW
160 170 180 190 200
NAIDEGPKRD IVKELEVAIR NRTDLRFGLY YSLFEWFHPL FLEDESSSFH
210 220 230 240 250
KRQFPVSKTL PELYELVNNY QPEVLWSDGD GGAPDQYWNS TGFLAWLYNE
260 270 280 290 300
SPVRGTVVTN DRWGAGSICK HGGFYTCSDR YNPGHLLPHK WENCMTIDKL
310 320 330 340 350
SWGYRREAGI SDYLTIEELV KQLVETVSCG GNLLMNIGPT LDGTISVVFE
360 370 380 390 400
ERLRQMGSWL KVNGEAIYET HTWRSQNDTV TPDVWYTSKP KEKLVYAIFL
410 420 430 440 450
KWPTSGQLFL GHPKAILGAT EVKLLGHGQP LNWISLEQNG IMVELPQLTI
460
HQMPCKWGWA LALTNVI
Length:467
Mass (Da):54,067
Last modified:July 28, 2009 - v2
Checksum:iA42AA6B369A3AC39
GO
Isoform 2 (identifier: Q9BTY2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-165: GFTLWGSEYSWNWNAIDEGPKRDIVKEL → ATCRDSFMWRKSFDEYWAHTRWHHFCSF
     166-467: Missing.

Note: No experimental confirmation available.
Show »
Length:165
Mass (Da):19,835
Checksum:i0427DB86CD215820
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7Z6V2Q7Z6V2_HUMAN
Plasma alpha-L-fucosidase
FUCA2
109Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti400L → P in BAC11633 (PubMed:16303743).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055822233A → E. Corresponds to variant dbSNP:rs11155297Ensembl.1
Natural variantiVAR_022444356M → V3 PublicationsCorresponds to variant dbSNP:rs3762002Ensembl.1
Natural variantiVAR_022445371H → Y3 PublicationsCorresponds to variant dbSNP:rs3762001Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057004138 – 165GFTLW…IVKEL → ATCRDSFMWRKSFDEYWAHT RWHHFCSF in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_057005166 – 467Missing in isoform 2. 1 PublicationAdd BLAST302

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358551 mRNA Translation: AAQ88915.1
AK296485 mRNA Translation: BAG59123.1
AK075458 mRNA Translation: BAC11633.1
AL031320 Genomic DNA No translation available.
BC003060 mRNA Translation: AAH03060.1
BC051268 mRNA Translation: AAH51268.1
CCDSiCCDS5200.1 [Q9BTY2-1]
RefSeqiNP_114409.2, NM_032020.4 [Q9BTY2-1]
UniGeneiHs.17680

Genome annotation databases

EnsembliENST00000002165; ENSP00000002165; ENSG00000001036 [Q9BTY2-1]
GeneIDi2519
KEGGihsa:2519
UCSCiuc003qjm.4 human [Q9BTY2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358551 mRNA Translation: AAQ88915.1
AK296485 mRNA Translation: BAG59123.1
AK075458 mRNA Translation: BAC11633.1
AL031320 Genomic DNA No translation available.
BC003060 mRNA Translation: AAH03060.1
BC051268 mRNA Translation: AAH51268.1
CCDSiCCDS5200.1 [Q9BTY2-1]
RefSeqiNP_114409.2, NM_032020.4 [Q9BTY2-1]
UniGeneiHs.17680

3D structure databases

ProteinModelPortaliQ9BTY2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108795, 14 interactors
IntActiQ9BTY2, 18 interactors
STRINGi9606.ENSP00000002165

Chemistry databases

BindingDBiQ9BTY2
ChEMBLiCHEMBL2271

Protein family/group databases

CAZyiGH29 Glycoside Hydrolase Family 29

PTM databases

GlyConnecti1608
iPTMnetiQ9BTY2
PhosphoSitePlusiQ9BTY2

Polymorphism and mutation databases

BioMutaiFUCA2
DMDMi254763296

Proteomic databases

EPDiQ9BTY2
MaxQBiQ9BTY2
PaxDbiQ9BTY2
PeptideAtlasiQ9BTY2
PRIDEiQ9BTY2
ProteomicsDBi79030

Protocols and materials databases

DNASUi2519
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000002165; ENSP00000002165; ENSG00000001036 [Q9BTY2-1]
GeneIDi2519
KEGGihsa:2519
UCSCiuc003qjm.4 human [Q9BTY2-1]

Organism-specific databases

CTDi2519
DisGeNETi2519
EuPathDBiHostDB:ENSG00000001036.13
GeneCardsiFUCA2
H-InvDBiHIX0006268
HGNCiHGNC:4008 FUCA2
HPAiHPA031659
HPA031660
HPA031661
MIMi136820 gene+phenotype
neXtProtiNX_Q9BTY2
OpenTargetsiENSG00000001036
PharmGKBiPA28424
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3340 Eukaryota
COG3669 LUCA
GeneTreeiENSGT00440000035378
HOGENOMiHOG000029598
HOVERGENiHBG002155
InParanoidiQ9BTY2
KOiK01206
OMAiWNWNAID
OrthoDBiEOG091G085V
PhylomeDBiQ9BTY2
TreeFamiTF313034

Enzyme and pathway databases

BRENDAi3.2.1.51 2681
ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-6798695 Neutrophil degranulation
R-HSA-8957275 Post-translational protein phosphorylation
SABIO-RKiQ9BTY2

Miscellaneous databases

ChiTaRSiFUCA2 human
GeneWikiiFUCA2
GenomeRNAii2519
PROiPR:Q9BTY2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000001036 Expressed in 189 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_FUCA2
ExpressionAtlasiQ9BTY2 baseline and differential
GenevisibleiQ9BTY2 HS

Family and domain databases

Gene3Di2.60.40.1180, 1 hit
InterProiView protein in InterPro
IPR016286 FUC_metazoa-typ
IPR031919 Fucosidase_C
IPR000933 Glyco_hydro_29
IPR018526 Glyco_hydro_29_CS
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10030 PTHR10030, 1 hit
PfamiView protein in Pfam
PF01120 Alpha_L_fucos, 1 hit
PF16757 Fucosidase_C, 1 hit
PIRSFiPIRSF001092 Alpha-L-fucosidase, 1 hit
PRINTSiPR00741 GLHYDRLASE29
SMARTiView protein in SMART
SM00812 Alpha_L_fucos, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00385 ALPHA_L_FUCOSIDASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFUCO2_HUMAN
AccessioniPrimary (citable) accession number: Q9BTY2
Secondary accession number(s): E9PEB6
, Q7Z6V1, Q7Z6Y2, Q8NBK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: July 28, 2009
Last modified: November 7, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  6. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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