UniProtKB - Q9BTX7 (TTPAL_HUMAN)

BLAST

>sp|Q9BTX7|TTPAL_HUMAN Alpha-tocopherol transfer protein-like OS=Homo sapiens OX=9606 GN=TTPAL PE=1 SV=2
MSEESDSLRTSPSVASLSENELPPPPEPPGYVCSLTEDLVTKAREELQEKPEWRLRDVQA
LRDMVRKEYPNLSTSLDDAFLLRFLRARKFDYDRALQLLVNYHSCRRSWPEVFNNLKPSA
LKDVLASGFLTVLPHTDPRGCHVVCIRPDRWIPSNYPITENIRAIYLTLEKLIQSEETQV
NGIVILADYKGVSLSKASHFGPFIAKKVIGILQDGFPIRIKAVHVVNEPRIFKGIFAIIK
PFLKEKIANRFFLHGSDLNSLHTNLPRSILPKEYGGTAGELDTATWNAVLLASEDDFVKE
FCQPVPACDSILGQTLLPEGLTSDAQCDDSLRAVKSQLYSCY

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History
Entry version 132 (12 Sep 2018)
Sequence version 2 (27 Sep 2005)
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Protein

Alpha-tocopherol transfer protein-like

Gene

TTPAL

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May act as a protein that binds a hydrophobic ligand.Curated

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alpha-tocopherol transfer protein-like
Gene namesⁱ	Name:TTPAL Synonyms:C20orf121
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000124120.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16114 TTPAL
neXtProtⁱ	NX_Q9BTX7

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000124120
PharmGKBⁱ	PA162407296

Polymorphism and mutation databases

BioMutaⁱ	TTPAL
DMDMⁱ	76803550

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000210772	1 – 342	Alpha-tocopherol transfer protein-likeAdd BLAST		342

Proteomic databases

EPDⁱ	Q9BTX7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BTX7
PaxDbⁱ	Q9BTX7
PeptideAtlas More...PeptideAtlasⁱ	Q9BTX7
PRIDEⁱ	Q9BTX7
ProteomicsDBⁱ	79028

PTM databases

iPTMnetⁱ	Q9BTX7
PhosphoSitePlusⁱ	Q9BTX7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000124120 Expressed in 206 organ(s), highest expression level in liver
CleanExⁱ	HS_TTPAL
ExpressionAtlasⁱ	Q9BTX7 baseline and differential
Genevisibleⁱ	Q9BTX7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA046957 HPA066532

HPAⁱ

HPA046957
HPA066532

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	122598, 9 interactors
IntActⁱ	Q9BTX7, 1 interactor
STRINGⁱ	9606.ENSP00000262605

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BTX7
SMRⁱ	Q9BTX7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	117 – 282	CRAL-TRIOPROSITE-ProRule annotationAdd BLAST		166

Phylogenomic databases

eggNOGⁱ	KOG1471 Eukaryota ENOG410XRSQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074253
HOGENOMⁱ	HOG000293421
HOVERGENⁱ	HBG101124
InParanoidⁱ	Q9BTX7
OMAⁱ	QCDDSMR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KN0
PhylomeDBⁱ	Q9BTX7

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00170 SEC14, 1 hit
Gene3Dⁱ	3.40.525.10, 1 hit
InterProⁱ	View protein in InterPro IPR001251 CRAL-TRIO_dom IPR036865 CRAL-TRIO_dom_sf IPR011074 CRAL/TRIO_N_dom IPR036273 CRAL/TRIO_N_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00650 CRAL_TRIO, 1 hit PF03765 CRAL_TRIO_N, 1 hit
SMARTⁱ	View protein in SMART SM01100 CRAL_TRIO_N, 1 hit SM00516 SEC14, 1 hit
SUPFAMⁱ	SSF46938 SSF46938, 1 hit SSF52087 SSF52087, 1 hit
PROSITEⁱ	View protein in PROSITE PS50191 CRAL_TRIO, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q9BTX7-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MSEESDSLRT SPSVASLSEN ELPPPPEPPG YVCSLTEDLV TKAREELQEK 
        60         70         80         90        100
PEWRLRDVQA LRDMVRKEYP NLSTSLDDAF LLRFLRARKF DYDRALQLLV 
       110        120        130        140        150
NYHSCRRSWP EVFNNLKPSA LKDVLASGFL TVLPHTDPRG CHVVCIRPDR 
       160        170        180        190        200
WIPSNYPITE NIRAIYLTLE KLIQSEETQV NGIVILADYK GVSLSKASHF 
       210        220        230        240        250
GPFIAKKVIG ILQDGFPIRI KAVHVVNEPR IFKGIFAIIK PFLKEKIANR 
       260        270        280        290        300
FFLHGSDLNS LHTNLPRSIL PKEYGGTAGE LDTATWNAVL LASEDDFVKE 
       310        320        330        340 
FCQPVPACDS ILGQTLLPEG LTSDAQCDDS LRAVKSQLYS CY

Length:342

Mass (Da):38,515

Last modified:September 27, 2005 - v2

Checksum:ⁱ56EDFC06C6D85CFB

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5QPC2	Q5QPC2_HUMAN	Alpha-tocopherol transfer protein-l... Alpha-tocopherol transfer protein-like	TTPAL	279	Annotation score:
A6PVK2	A6PVK2_HUMAN	Alpha-tocopherol transfer protein-l... Alpha-tocopherol transfer protein-like	TTPAL	154	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_061788	278	A → G. Corresponds to variant dbSNP:rs59069332Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL132772 Genomic DNA No translation available. Z97053 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75918.1 CH471077 Genomic DNA Translation: EAW75919.1 BC003071 mRNA Translation: AAH03071.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13332.2
NCBI Reference Sequences More...RefSeqⁱ	NP_001034288.1, NM_001039199.2 NP_077307.2, NM_024331.4 XP_011527345.1, XM_011529043.2 XP_011527346.1, XM_011529044.2
UniGeneⁱ	Hs.283869

Genome annotation databases

Ensemblⁱ	ENST00000262605; ENSP00000262605; ENSG00000124120 ENST00000372904; ENSP00000361995; ENSG00000124120
GeneIDⁱ	79183
KEGGⁱ	hsa:79183
UCSC genome browser More...UCSCⁱ	uc002xmc.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q9BTX7	Alpha tocopherol transfer protein like		GORGO		342	UniRef100_Q9BTX7
cDNA, FLJ94708		HUMAN		279

Protein	Similar proteins		Species	Score	Length	Source
Q9BTX7	Alpha-tocopherol transfer protein-like		MOUSE		343	UniRef90_Q9D3D0
Alpha-tocopherol transfer protein-like		PONAB		342
alpha-tocopherol transfer protein-like isoform X1		TURTR		364
alpha-tocopherol transfer protein-like isoform X1		LIPVE		364
alpha-tocopherol transfer protein-like isoform X1		DELLE		364
+113

Protein	Similar proteins		Species	Score	Length	Source
Q9BTX7	Alpha-tocopherol transfer protein-like		MOUSE		343	UniRef50_Q9D3D0
Alpha-tocopherol transfer protein-like		PONAB		342
alpha-tocopherol transfer protein-like isoform X1		PHYCD		364
alpha-tocopherol transfer protein-like isoform X1		DELLE		364
alpha-tocopherol transfer protein-like isoform X1		LIPVE		364
+345

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL132772 Genomic DNA No translation available. Z97053 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75918.1 CH471077 Genomic DNA Translation: EAW75919.1 BC003071 mRNA Translation: AAH03071.2
CCDSⁱ	CCDS13332.2
RefSeqⁱ	NP_001034288.1, NM_001039199.2 NP_077307.2, NM_024331.4 XP_011527345.1, XM_011529043.2 XP_011527346.1, XM_011529044.2
UniGeneⁱ	Hs.283869

3D structure databases

ProteinModelPortalⁱ	Q9BTX7
SMRⁱ	Q9BTX7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122598, 9 interactors
IntActⁱ	Q9BTX7, 1 interactor
STRINGⁱ	9606.ENSP00000262605

PTM databases

iPTMnetⁱ	Q9BTX7
PhosphoSitePlusⁱ	Q9BTX7

Polymorphism and mutation databases

BioMutaⁱ	TTPAL
DMDMⁱ	76803550

Proteomic databases

EPDⁱ	Q9BTX7
MaxQBⁱ	Q9BTX7
PaxDbⁱ	Q9BTX7
PeptideAtlasⁱ	Q9BTX7
PRIDEⁱ	Q9BTX7
ProteomicsDBⁱ	79028

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000262605; ENSP00000262605; ENSG00000124120 ENST00000372904; ENSP00000361995; ENSG00000124120
GeneIDⁱ	79183
KEGGⁱ	hsa:79183
UCSCⁱ	uc002xmc.3 human

Organism-specific databases

CTDⁱ	79183
EuPathDBⁱ	HostDB:ENSG00000124120.10
GeneCardsⁱ	TTPAL
HGNCⁱ	HGNC:16114 TTPAL
HPAⁱ	HPA046957 HPA066532
neXtProtⁱ	NX_Q9BTX7
OpenTargetsⁱ	ENSG00000124120
PharmGKBⁱ	PA162407296
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1471 Eukaryota ENOG410XRSQ LUCA
GeneTreeⁱ	ENSGT00550000074253
HOGENOMⁱ	HOG000293421
HOVERGENⁱ	HBG101124
InParanoidⁱ	Q9BTX7
OMAⁱ	QCDDSMR
OrthoDBⁱ	EOG091G0KN0
PhylomeDBⁱ	Q9BTX7

Miscellaneous databases

ChiTaRSⁱ	TTPAL human
GenomeRNAiⁱ	79183
Protein Ontology More...PROⁱ	PR:Q9BTX7

Gene expression databases

Bgeeⁱ	ENSG00000124120 Expressed in 206 organ(s), highest expression level in liver
CleanExⁱ	HS_TTPAL
ExpressionAtlasⁱ	Q9BTX7 baseline and differential
Genevisibleⁱ	Q9BTX7 HS

Family and domain databases

CDDⁱ	cd00170 SEC14, 1 hit
Gene3Dⁱ	3.40.525.10, 1 hit
InterProⁱ	View protein in InterPro IPR001251 CRAL-TRIO_dom IPR036865 CRAL-TRIO_dom_sf IPR011074 CRAL/TRIO_N_dom IPR036273 CRAL/TRIO_N_dom_sf
Pfamⁱ	View protein in Pfam PF00650 CRAL_TRIO, 1 hit PF03765 CRAL_TRIO_N, 1 hit
SMARTⁱ	View protein in SMART SM01100 CRAL_TRIO_N, 1 hit SM00516 SEC14, 1 hit
SUPFAMⁱ	SSF46938 SSF46938, 1 hit SSF52087 SSF52087, 1 hit
PROSITEⁱ	View protein in PROSITE PS50191 CRAL_TRIO, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TTPAL_HUMAN
Accessionⁱ	Q9BTX7Primary (citable) accession number: Q9BTX7 Secondary accession number(s): E1P5X3 , Q5QPC1, Q9H1G2, Q9NQG8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
	Last sequence update:	September 27, 2005
	Last modified:	September 12, 2018
	This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM

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UniProtKB - Q9BTX7 (TTPAL_HUMAN)

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Alpha-tocopherol transfer protein-like

TTPAL

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ