UniProtKB - Q9BTX7 (TTPAL_HUMAN)
Protein
Alpha-tocopherol transfer protein-like
Gene
TTPAL
Organism
Homo sapiens (Human)
Status
Functioni
May act as a protein that binds a hydrophobic ligand.Curated
GO - Molecular functioni
- phosphatidylinositol bisphosphate binding Source: GO_Central
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9BTX7 |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-tocopherol transfer protein-like |
Gene namesi | Name:TTPAL Synonyms:C20orf121 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000124120.10 |
HGNCi | HGNC:16114, TTPAL |
neXtProti | NX_Q9BTX7 |
Subcellular locationi
Other locations
- membrane Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 79183 |
OpenTargetsi | ENSG00000124120 |
PharmGKBi | PA162407296 |
Miscellaneous databases
Pharosi | Q9BTX7, Tdark |
Polymorphism and mutation databases
BioMutai | TTPAL |
DMDMi | 76803550 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000210772 | 1 – 342 | Alpha-tocopherol transfer protein-likeAdd BLAST | 342 |
Proteomic databases
EPDi | Q9BTX7 |
jPOSTi | Q9BTX7 |
MassIVEi | Q9BTX7 |
MaxQBi | Q9BTX7 |
PaxDbi | Q9BTX7 |
PeptideAtlasi | Q9BTX7 |
PRIDEi | Q9BTX7 |
ProteomicsDBi | 79028 |
PTM databases
iPTMneti | Q9BTX7 |
PhosphoSitePlusi | Q9BTX7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000124120, Expressed in liver and 221 other tissues |
ExpressionAtlasi | Q9BTX7, baseline and differential |
Genevisiblei | Q9BTX7, HS |
Organism-specific databases
HPAi | ENSG00000124120, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 122598, 10 interactors |
IntActi | Q9BTX7, 1 interactor |
STRINGi | 9606.ENSP00000361995 |
Miscellaneous databases
RNActi | Q9BTX7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 117 – 282 | CRAL-TRIOPROSITE-ProRule annotationAdd BLAST | 166 |
Phylogenomic databases
eggNOGi | KOG1471, Eukaryota |
GeneTreei | ENSGT00940000155407 |
InParanoidi | Q9BTX7 |
OMAi | CLRPDRW |
OrthoDBi | 1031056at2759 |
PhylomeDBi | Q9BTX7 |
Family and domain databases
CDDi | cd00170, SEC14, 1 hit |
Gene3Di | 3.40.525.10, 1 hit |
InterProi | View protein in InterPro IPR001251, CRAL-TRIO_dom IPR036865, CRAL-TRIO_dom_sf IPR011074, CRAL/TRIO_N_dom IPR036273, CRAL/TRIO_N_dom_sf |
Pfami | View protein in Pfam PF00650, CRAL_TRIO, 1 hit PF03765, CRAL_TRIO_N, 1 hit |
SMARTi | View protein in SMART SM01100, CRAL_TRIO_N, 1 hit SM00516, SEC14, 1 hit |
SUPFAMi | SSF46938, SSF46938, 1 hit SSF52087, SSF52087, 1 hit |
PROSITEi | View protein in PROSITE PS50191, CRAL_TRIO, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9BTX7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEESDSLRT SPSVASLSEN ELPPPPEPPG YVCSLTEDLV TKAREELQEK
60 70 80 90 100
PEWRLRDVQA LRDMVRKEYP NLSTSLDDAF LLRFLRARKF DYDRALQLLV
110 120 130 140 150
NYHSCRRSWP EVFNNLKPSA LKDVLASGFL TVLPHTDPRG CHVVCIRPDR
160 170 180 190 200
WIPSNYPITE NIRAIYLTLE KLIQSEETQV NGIVILADYK GVSLSKASHF
210 220 230 240 250
GPFIAKKVIG ILQDGFPIRI KAVHVVNEPR IFKGIFAIIK PFLKEKIANR
260 270 280 290 300
FFLHGSDLNS LHTNLPRSIL PKEYGGTAGE LDTATWNAVL LASEDDFVKE
310 320 330 340
FCQPVPACDS ILGQTLLPEG LTSDAQCDDS LRAVKSQLYS CY
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5QPC2 | Q5QPC2_HUMAN | Alpha-tocopherol transfer protein-l... | TTPAL | 279 | Annotation score: | ||
A6PVK2 | A6PVK2_HUMAN | Alpha-tocopherol transfer protein-l... | TTPAL | 154 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061788 | 278 | A → G. Corresponds to variant dbSNP:rs59069332Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL132772 Genomic DNA No translation available. Z97053 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75918.1 CH471077 Genomic DNA Translation: EAW75919.1 BC003071 mRNA Translation: AAH03071.2 |
CCDSi | CCDS13332.2 |
RefSeqi | NP_001034288.1, NM_001039199.2 NP_077307.2, NM_024331.4 XP_011527345.1, XM_011529043.2 XP_011527346.1, XM_011529044.2 |
Genome annotation databases
Ensembli | ENST00000262605; ENSP00000262605; ENSG00000124120 ENST00000372904; ENSP00000361995; ENSG00000124120 |
GeneIDi | 79183 |
KEGGi | hsa:79183 |
UCSCi | uc002xmc.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL132772 Genomic DNA No translation available. Z97053 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75918.1 CH471077 Genomic DNA Translation: EAW75919.1 BC003071 mRNA Translation: AAH03071.2 |
CCDSi | CCDS13332.2 |
RefSeqi | NP_001034288.1, NM_001039199.2 NP_077307.2, NM_024331.4 XP_011527345.1, XM_011529043.2 XP_011527346.1, XM_011529044.2 |
3D structure databases
SMRi | Q9BTX7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122598, 10 interactors |
IntActi | Q9BTX7, 1 interactor |
STRINGi | 9606.ENSP00000361995 |
PTM databases
iPTMneti | Q9BTX7 |
PhosphoSitePlusi | Q9BTX7 |
Polymorphism and mutation databases
BioMutai | TTPAL |
DMDMi | 76803550 |
Proteomic databases
EPDi | Q9BTX7 |
jPOSTi | Q9BTX7 |
MassIVEi | Q9BTX7 |
MaxQBi | Q9BTX7 |
PaxDbi | Q9BTX7 |
PeptideAtlasi | Q9BTX7 |
PRIDEi | Q9BTX7 |
ProteomicsDBi | 79028 |
Protocols and materials databases
Antibodypediai | 51852, 58 antibodies |
Genome annotation databases
Ensembli | ENST00000262605; ENSP00000262605; ENSG00000124120 ENST00000372904; ENSP00000361995; ENSG00000124120 |
GeneIDi | 79183 |
KEGGi | hsa:79183 |
UCSCi | uc002xmc.3, human |
Organism-specific databases
CTDi | 79183 |
DisGeNETi | 79183 |
EuPathDBi | HostDB:ENSG00000124120.10 |
GeneCardsi | TTPAL |
HGNCi | HGNC:16114, TTPAL |
HPAi | ENSG00000124120, Low tissue specificity |
neXtProti | NX_Q9BTX7 |
OpenTargetsi | ENSG00000124120 |
PharmGKBi | PA162407296 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1471, Eukaryota |
GeneTreei | ENSGT00940000155407 |
InParanoidi | Q9BTX7 |
OMAi | CLRPDRW |
OrthoDBi | 1031056at2759 |
PhylomeDBi | Q9BTX7 |
Enzyme and pathway databases
PathwayCommonsi | Q9BTX7 |
Miscellaneous databases
BioGRID-ORCSi | 79183, 5 hits in 843 CRISPR screens |
ChiTaRSi | TTPAL, human |
GenomeRNAii | 79183 |
Pharosi | Q9BTX7, Tdark |
PROi | PR:Q9BTX7 |
RNActi | Q9BTX7, protein |
Gene expression databases
Bgeei | ENSG00000124120, Expressed in liver and 221 other tissues |
ExpressionAtlasi | Q9BTX7, baseline and differential |
Genevisiblei | Q9BTX7, HS |
Family and domain databases
CDDi | cd00170, SEC14, 1 hit |
Gene3Di | 3.40.525.10, 1 hit |
InterProi | View protein in InterPro IPR001251, CRAL-TRIO_dom IPR036865, CRAL-TRIO_dom_sf IPR011074, CRAL/TRIO_N_dom IPR036273, CRAL/TRIO_N_dom_sf |
Pfami | View protein in Pfam PF00650, CRAL_TRIO, 1 hit PF03765, CRAL_TRIO_N, 1 hit |
SMARTi | View protein in SMART SM01100, CRAL_TRIO_N, 1 hit SM00516, SEC14, 1 hit |
SUPFAMi | SSF46938, SSF46938, 1 hit SSF52087, SSF52087, 1 hit |
PROSITEi | View protein in PROSITE PS50191, CRAL_TRIO, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TTPAL_HUMAN | |
Accessioni | Q9BTX7Primary (citable) accession number: Q9BTX7 Secondary accession number(s): E1P5X3 Q9NQG8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2003 |
Last sequence update: | September 27, 2005 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations