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Protein

Alpha-tocopherol transfer protein-like

Gene

TTPAL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a protein that binds a hydrophobic ligand.Curated

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-tocopherol transfer protein-like
Gene namesi
Name:TTPAL
Synonyms:C20orf121
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000124120.10
HGNCiHGNC:16114 TTPAL
neXtProtiNX_Q9BTX7

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124120
PharmGKBiPA162407296

Polymorphism and mutation databases

BioMutaiTTPAL
DMDMi76803550

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002107721 – 342Alpha-tocopherol transfer protein-likeAdd BLAST342

Proteomic databases

EPDiQ9BTX7
MaxQBiQ9BTX7
PaxDbiQ9BTX7
PeptideAtlasiQ9BTX7
PRIDEiQ9BTX7
ProteomicsDBi79028

PTM databases

iPTMnetiQ9BTX7
PhosphoSitePlusiQ9BTX7

Expressioni

Gene expression databases

BgeeiENSG00000124120 Expressed in 206 organ(s), highest expression level in liver
CleanExiHS_TTPAL
ExpressionAtlasiQ9BTX7 baseline and differential
GenevisibleiQ9BTX7 HS

Organism-specific databases

HPAiHPA046957
HPA066532

Interactioni

Protein-protein interaction databases

BioGridi122598, 9 interactors
IntActiQ9BTX7, 1 interactor
STRINGi9606.ENSP00000262605

Structurei

3D structure databases

ProteinModelPortaliQ9BTX7
SMRiQ9BTX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 282CRAL-TRIOPROSITE-ProRule annotationAdd BLAST166

Phylogenomic databases

eggNOGiKOG1471 Eukaryota
ENOG410XRSQ LUCA
GeneTreeiENSGT00550000074253
HOGENOMiHOG000293421
HOVERGENiHBG101124
InParanoidiQ9BTX7
OMAiQCDDSMR
OrthoDBiEOG091G0KN0
PhylomeDBiQ9BTX7

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR011074 CRAL/TRIO_N_dom
IPR036273 CRAL/TRIO_N_dom_sf
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF03765 CRAL_TRIO_N, 1 hit
SMARTiView protein in SMART
SM01100 CRAL_TRIO_N, 1 hit
SM00516 SEC14, 1 hit
SUPFAMiSSF46938 SSF46938, 1 hit
SSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9BTX7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEESDSLRT SPSVASLSEN ELPPPPEPPG YVCSLTEDLV TKAREELQEK
60 70 80 90 100
PEWRLRDVQA LRDMVRKEYP NLSTSLDDAF LLRFLRARKF DYDRALQLLV
110 120 130 140 150
NYHSCRRSWP EVFNNLKPSA LKDVLASGFL TVLPHTDPRG CHVVCIRPDR
160 170 180 190 200
WIPSNYPITE NIRAIYLTLE KLIQSEETQV NGIVILADYK GVSLSKASHF
210 220 230 240 250
GPFIAKKVIG ILQDGFPIRI KAVHVVNEPR IFKGIFAIIK PFLKEKIANR
260 270 280 290 300
FFLHGSDLNS LHTNLPRSIL PKEYGGTAGE LDTATWNAVL LASEDDFVKE
310 320 330 340
FCQPVPACDS ILGQTLLPEG LTSDAQCDDS LRAVKSQLYS CY
Length:342
Mass (Da):38,515
Last modified:September 27, 2005 - v2
Checksum:i56EDFC06C6D85CFB
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5QPC2Q5QPC2_HUMAN
Alpha-tocopherol transfer protein-l...
TTPAL
279Annotation score:
A6PVK2A6PVK2_HUMAN
Alpha-tocopherol transfer protein-l...
TTPAL
154Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061788278A → G. Corresponds to variant dbSNP:rs59069332Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132772 Genomic DNA No translation available.
Z97053 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75918.1
CH471077 Genomic DNA Translation: EAW75919.1
BC003071 mRNA Translation: AAH03071.2
CCDSiCCDS13332.2
RefSeqiNP_001034288.1, NM_001039199.2
NP_077307.2, NM_024331.4
XP_011527345.1, XM_011529043.2
XP_011527346.1, XM_011529044.2
UniGeneiHs.283869

Genome annotation databases

EnsembliENST00000262605; ENSP00000262605; ENSG00000124120
ENST00000372904; ENSP00000361995; ENSG00000124120
GeneIDi79183
KEGGihsa:79183
UCSCiuc002xmc.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132772 Genomic DNA No translation available.
Z97053 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75918.1
CH471077 Genomic DNA Translation: EAW75919.1
BC003071 mRNA Translation: AAH03071.2
CCDSiCCDS13332.2
RefSeqiNP_001034288.1, NM_001039199.2
NP_077307.2, NM_024331.4
XP_011527345.1, XM_011529043.2
XP_011527346.1, XM_011529044.2
UniGeneiHs.283869

3D structure databases

ProteinModelPortaliQ9BTX7
SMRiQ9BTX7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122598, 9 interactors
IntActiQ9BTX7, 1 interactor
STRINGi9606.ENSP00000262605

PTM databases

iPTMnetiQ9BTX7
PhosphoSitePlusiQ9BTX7

Polymorphism and mutation databases

BioMutaiTTPAL
DMDMi76803550

Proteomic databases

EPDiQ9BTX7
MaxQBiQ9BTX7
PaxDbiQ9BTX7
PeptideAtlasiQ9BTX7
PRIDEiQ9BTX7
ProteomicsDBi79028

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262605; ENSP00000262605; ENSG00000124120
ENST00000372904; ENSP00000361995; ENSG00000124120
GeneIDi79183
KEGGihsa:79183
UCSCiuc002xmc.3 human

Organism-specific databases

CTDi79183
EuPathDBiHostDB:ENSG00000124120.10
GeneCardsiTTPAL
HGNCiHGNC:16114 TTPAL
HPAiHPA046957
HPA066532
neXtProtiNX_Q9BTX7
OpenTargetsiENSG00000124120
PharmGKBiPA162407296
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1471 Eukaryota
ENOG410XRSQ LUCA
GeneTreeiENSGT00550000074253
HOGENOMiHOG000293421
HOVERGENiHBG101124
InParanoidiQ9BTX7
OMAiQCDDSMR
OrthoDBiEOG091G0KN0
PhylomeDBiQ9BTX7

Miscellaneous databases

ChiTaRSiTTPAL human
GenomeRNAii79183
PROiPR:Q9BTX7

Gene expression databases

BgeeiENSG00000124120 Expressed in 206 organ(s), highest expression level in liver
CleanExiHS_TTPAL
ExpressionAtlasiQ9BTX7 baseline and differential
GenevisibleiQ9BTX7 HS

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR011074 CRAL/TRIO_N_dom
IPR036273 CRAL/TRIO_N_dom_sf
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF03765 CRAL_TRIO_N, 1 hit
SMARTiView protein in SMART
SM01100 CRAL_TRIO_N, 1 hit
SM00516 SEC14, 1 hit
SUPFAMiSSF46938 SSF46938, 1 hit
SSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTTPAL_HUMAN
AccessioniPrimary (citable) accession number: Q9BTX7
Secondary accession number(s): E1P5X3
, Q5QPC1, Q9H1G2, Q9NQG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: September 27, 2005
Last modified: September 12, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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