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UniProtKB - Q9BTX3 (TM208_HUMAN)
Protein
Transmembrane protein 208
Gene
TMEM208
Organism
Homo sapiens (Human)
Status
Functioni
May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
1 PublicationGO - Biological processi
- autophagy Source: UniProtKB-KW
- vacuolar protein processing Source: GO_Central
Keywordsi
Biological process | Autophagy |
Enzyme and pathway databases
PathwayCommonsi | Q9BTX3 |
SignaLinki | Q9BTX3 |
Protein family/group databases
TCDBi | 9.B.26.1.1, the regulator of er stress and autophagy tmem208 (tmem208) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 208 |
Gene namesi | Name:TMEM208 ORF Names:HSPC171 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25015, TMEM208 |
neXtProti | NX_Q9BTX3 |
VEuPathDBi | HostDB:ENSG00000168701 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- vacuole Source: GOC
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 25 – 45 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 51 – 68 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 105 – 129 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 29100 |
OpenTargetsi | ENSG00000168701 |
PharmGKBi | PA162406408 |
Miscellaneous databases
Pharosi | Q9BTX3, Tdark |
Genetic variation databases
BioMutai | TMEM208 |
DMDMi | 74733157 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000325967 | 1 – 173 | Transmembrane protein 208Add BLAST | 173 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources1 Publication | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9BTX3 |
jPOSTi | Q9BTX3 |
MassIVEi | Q9BTX3 |
MaxQBi | Q9BTX3 |
PaxDbi | Q9BTX3 |
PeptideAtlasi | Q9BTX3 |
PRIDEi | Q9BTX3 |
ProteomicsDBi | 79025 [Q9BTX3-1] 79026 [Q9BTX3-2] |
TopDownProteomicsi | Q9BTX3-1 [Q9BTX3-1] |
PTM databases
iPTMneti | Q9BTX3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000168701, Expressed in prostate gland and 226 other tissues |
ExpressionAtlasi | Q9BTX3, baseline and differential |
Genevisiblei | Q9BTX3, HS |
Organism-specific databases
HPAi | ENSG00000168701, Low tissue specificity |
Interactioni
Binary interactionsi
Q9BTX3
Protein-protein interaction databases
BioGRIDi | 118868, 50 interactors |
IntActi | Q9BTX3, 25 interactors |
STRINGi | 9606.ENSP00000305892 |
Miscellaneous databases
RNActi | Q9BTX3, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 152 – 173 | DisorderedSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the TMEM208 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3269, Eukaryota |
GeneTreei | ENSGT00390000008139 |
HOGENOMi | CLU_094308_3_0_1 |
InParanoidi | Q9BTX3 |
OMAi | VFMHILA |
OrthoDBi | 1407446at2759 |
PhylomeDBi | Q9BTX3 |
TreeFami | TF318118 |
Family and domain databases
InterProi | View protein in InterPro IPR008506, SND2/TMEM208 |
PANTHERi | PTHR13505, PTHR13505, 1 hit |
Pfami | View protein in Pfam PF05620, TMEM208_SND2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9BTX3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAPKGKVGTR GKKQIFEENR ETLKFYLRII LGANAIYCLV TLVFFYSSAS
60 70 80 90 100
FWAWLALGFS LAVYGASYHS MSSMARAAFS EDGALMDGGM DLNMEQGMAE
110 120 130 140 150
HLKDVILLTA IVQVLSCFSL YVWSFWLLAP GRALYLLWVN VLGPWFTADS
160 170
GTPAPEHNEK RQRRQERRQM KRL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KRY7 | J3KRY7_HUMAN | Transmembrane protein 208 | TMEM208 HSPC171, hCG_28833 | 103 | Annotation score: | ||
H3BMW4 | H3BMW4_HUMAN | Transmembrane protein 208 | TMEM208 | 140 | Annotation score: | ||
J3QRY9 | J3QRY9_HUMAN | Transmembrane protein 208 | TMEM208 | 36 | Annotation score: |
Sequence cautioni
The sequence AAF29134 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 90 | M → T in AAF29134 (PubMed:11042152).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039958 | 82 | D → Y1 PublicationCorresponds to variant dbSNP:rs17851038Ensembl. | 1 | |
Natural variantiVAR_053933 | 102 | L → P. Corresponds to variant dbSNP:rs11553801Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_032505 | 101 – 173 | Missing in isoform 2. 2 PublicationsAdd BLAST | 73 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF161519 mRNA Translation: AAF29134.1 Frameshift. CH471092 Genomic DNA Translation: EAW83106.1 CH471092 Genomic DNA Translation: EAW83107.1 BC003080 mRNA Translation: AAH03080.1 BC021109 mRNA Translation: AAH21109.1 BC013412 mRNA Translation: AAH13412.1 |
CCDSi | CCDS45511.1 [Q9BTX3-1] |
RefSeqi | NP_001305146.1, NM_001318217.1 NP_054906.2, NM_014187.3 [Q9BTX3-1] |
Genome annotation databases
Ensembli | ENST00000304800; ENSP00000305892; ENSG00000168701 ENST00000562235; ENSP00000457502; ENSG00000168701 [Q9BTX3-2] |
GeneIDi | 29100 |
KEGGi | hsa:29100 |
MANE-Selecti | ENST00000304800.14; ENSP00000305892.9; NM_014187.4; NP_054906.2 |
UCSCi | uc002esi.3, human [Q9BTX3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF161519 mRNA Translation: AAF29134.1 Frameshift. CH471092 Genomic DNA Translation: EAW83106.1 CH471092 Genomic DNA Translation: EAW83107.1 BC003080 mRNA Translation: AAH03080.1 BC021109 mRNA Translation: AAH21109.1 BC013412 mRNA Translation: AAH13412.1 |
CCDSi | CCDS45511.1 [Q9BTX3-1] |
RefSeqi | NP_001305146.1, NM_001318217.1 NP_054906.2, NM_014187.3 [Q9BTX3-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 118868, 50 interactors |
IntActi | Q9BTX3, 25 interactors |
STRINGi | 9606.ENSP00000305892 |
Protein family/group databases
TCDBi | 9.B.26.1.1, the regulator of er stress and autophagy tmem208 (tmem208) family |
PTM databases
iPTMneti | Q9BTX3 |
Genetic variation databases
BioMutai | TMEM208 |
DMDMi | 74733157 |
Proteomic databases
EPDi | Q9BTX3 |
jPOSTi | Q9BTX3 |
MassIVEi | Q9BTX3 |
MaxQBi | Q9BTX3 |
PaxDbi | Q9BTX3 |
PeptideAtlasi | Q9BTX3 |
PRIDEi | Q9BTX3 |
ProteomicsDBi | 79025 [Q9BTX3-1] 79026 [Q9BTX3-2] |
TopDownProteomicsi | Q9BTX3-1 [Q9BTX3-1] |
Protocols and materials databases
Antibodypediai | 48545, 28 antibodies from 11 providers |
DNASUi | 29100 |
Genome annotation databases
Ensembli | ENST00000304800; ENSP00000305892; ENSG00000168701 ENST00000562235; ENSP00000457502; ENSG00000168701 [Q9BTX3-2] |
GeneIDi | 29100 |
KEGGi | hsa:29100 |
MANE-Selecti | ENST00000304800.14; ENSP00000305892.9; NM_014187.4; NP_054906.2 |
UCSCi | uc002esi.3, human [Q9BTX3-1] |
Organism-specific databases
CTDi | 29100 |
DisGeNETi | 29100 |
GeneCardsi | TMEM208 |
HGNCi | HGNC:25015, TMEM208 |
HPAi | ENSG00000168701, Low tissue specificity |
neXtProti | NX_Q9BTX3 |
OpenTargetsi | ENSG00000168701 |
PharmGKBi | PA162406408 |
VEuPathDBi | HostDB:ENSG00000168701 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3269, Eukaryota |
GeneTreei | ENSGT00390000008139 |
HOGENOMi | CLU_094308_3_0_1 |
InParanoidi | Q9BTX3 |
OMAi | VFMHILA |
OrthoDBi | 1407446at2759 |
PhylomeDBi | Q9BTX3 |
TreeFami | TF318118 |
Enzyme and pathway databases
PathwayCommonsi | Q9BTX3 |
SignaLinki | Q9BTX3 |
Miscellaneous databases
BioGRID-ORCSi | 29100, 46 hits in 1049 CRISPR screens |
ChiTaRSi | TMEM208, human |
GenomeRNAii | 29100 |
Pharosi | Q9BTX3, Tdark |
PROi | PR:Q9BTX3 |
RNActi | Q9BTX3, protein |
Gene expression databases
Bgeei | ENSG00000168701, Expressed in prostate gland and 226 other tissues |
ExpressionAtlasi | Q9BTX3, baseline and differential |
Genevisiblei | Q9BTX3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008506, SND2/TMEM208 |
PANTHERi | PTHR13505, PTHR13505, 1 hit |
Pfami | View protein in Pfam PF05620, TMEM208_SND2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TM208_HUMAN | |
Accessioni | Q9BTX3Primary (citable) accession number: Q9BTX3 Secondary accession number(s): Q05CT0, Q96D25, Q9NZZ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families