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Protein

CDK5 and ABL1 enzyme substrate 2

Gene

CABLES2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Unknown. Probably involved in G1-S cell cycle transition.

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-HSA-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkiQ9BTV7

Names & Taxonomyi

Protein namesi
Recommended name:
CDK5 and ABL1 enzyme substrate 2
Alternative name(s):
Interactor with CDK3 2
Short name:
Ik3-2
Gene namesi
Name:CABLES2
Synonyms:C20orf150
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000149679.11
HGNCiHGNC:16143 CABLES2
neXtProtiNX_Q9BTV7

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000149679
PharmGKBiPA25692

Polymorphism and mutation databases

BioMutaiCABLES2
DMDMi109940186

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000805121 – 478CDK5 and ABL1 enzyme substrate 2Add BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei130PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BTV7
MaxQBiQ9BTV7
PaxDbiQ9BTV7
PeptideAtlasiQ9BTV7
PRIDEiQ9BTV7
ProteomicsDBi79015

PTM databases

iPTMnetiQ9BTV7
PhosphoSitePlusiQ9BTV7

Miscellaneous databases

PMAP-CutDBiQ9BTV7

Expressioni

Gene expression databases

BgeeiENSG00000149679
CleanExiHS_CABLES2
ExpressionAtlasiQ9BTV7 baseline and differential
GenevisibleiQ9BTV7 HS

Organism-specific databases

HPAiHPA052138

Interactioni

Subunit structurei

Binds to CDK3, CDK5 and ABL1. The C-terminal cyclin-box-like region binds to CDK5 (By similarity).By similarity

Protein-protein interaction databases

BioGridi123628, 8 interactors
IntActiQ9BTV7, 1 interactor
STRINGi9606.ENSP00000279101

Structurei

3D structure databases

ProteinModelPortaliQ9BTV7
SMRiQ9BTV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 6Poly-Ala5
Compositional biasi10 – 110Pro-richAdd BLAST101

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

eggNOGiKOG4164 Eukaryota
ENOG4110WYV LUCA
GeneTreeiENSGT00400000022086
HOGENOMiHOG000231236
HOVERGENiHBG050759
InParanoidiQ9BTV7
OMAiRVTSQRC
OrthoDBiEOG091G0CHB
PhylomeDBiQ9BTV7
TreeFamiTF323936

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR012388 CABLES1/2
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N
PANTHERiPTHR22896 PTHR22896, 2 hits
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
PIRSFiPIRSF025798 Cables, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BTV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAAGGAP GPAPGPAGPP PPAAPTSAAR APPQALRRRG DSRRRQAALF
60 70 80 90 100
FLNNISLDGR PPSLGPGGEK PPPPPAEARE PPAPPPPEPP TGLPARTPAP
110 120 130 140 150
QGLLSPTQVP TGLGLDGQRQ RKRVTSQRCS LEFLEDAVGC APAQRTKHTS
160 170 180 190 200
GSPRHKGLKK THFIKNMRQY DTRNSRIVLI CAKRSLCAAF SVLPYGEGLR
210 220 230 240 250
ISDLRVDSQK QRHPSGGVSV SSEMVFELEG VELGADGKVV SYAKFLYPTN
260 270 280 290 300
ALVTHKSDSH GLLPTPRPSV PRTLPGSRHK PAPTKSAPAS TELGSDVGDT
310 320 330 340 350
LEYNPNLLDD PQWPCGKHKR VLIFASYMTT VIEYVKPSDL KKDMNETFRE
360 370 380 390 400
KFPHVKLTLS KIRSLKREMR SLSEECSLEP VTVAMAYVYF EKLVLQGKLS
410 420 430 440 450
KQNRKLCAGA CVLLAAKISS DLRKSGVTQL IDKLEERFRF NRRDLIGFEF
460 470
TVLVALELAL YLPENQVLPH YRRLTQQF
Length:478
Mass (Da):52,235
Last modified:May 30, 2006 - v3
Checksum:i98E99EC72F7573EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti277S → P in AAH03122 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026532428T → K1 PublicationCorresponds to variant dbSNP:rs6089219Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121832 Genomic DNA No translation available.
BC003122 mRNA Translation: AAH03122.1
CCDSiCCDS33503.1
RefSeqiNP_112492.2, NM_031215.2
UniGeneiHs.301040

Genome annotation databases

EnsembliENST00000279101; ENSP00000279101; ENSG00000149679
GeneIDi81928
KEGGihsa:81928
UCSCiuc002ycv.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCABL2_HUMAN
AccessioniPrimary (citable) accession number: Q9BTV7
Secondary accession number(s): Q5JWL0, Q9BYK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: May 30, 2006
Last modified: July 18, 2018
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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