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Protein

Fibronectin type III and SPRY domain-containing protein 1

Gene

FSD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in microtubule organization and stabilization.2 Publications

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • cytoplasmic microtubule organization Source: UniProtKB
  • protein homooligomerization Source: UniProtKB
  • regulation of cell division Source: UniProtKB
  • regulation of cytokinesis Source: UniProtKB
  • regulation of mitotic spindle organization Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Fibronectin type III and SPRY domain-containing protein 1
Alternative name(s):
MID1-related protein 1
Microtubule-associated protein GLFND
Gene namesi
Name:FSD1
Synonyms:GLFND, MIR1
ORF Names:VLP27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105255.10
HGNCiHGNC:13745 FSD1
MIMi609828 gene
neXtProtiNX_Q9BTV5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi313S → A in mitosis, remained associated with microtubules; when associated with A-317; A-322 and A-324. 1 Publication1
Mutagenesisi313S → D: Reduced ability to associate with microtubules; when associated with D-317; E-322 and D-324. 1 Publication1
Mutagenesisi317S → A in mitosis, remained associated with microtubules; when associated with A-313; A-322 and A-324. 1 Publication1
Mutagenesisi317S → D: Reduced ability to associate with microtubules; when associated with D-313; E-322 and D-324. 1 Publication1
Mutagenesisi322T → A in mitosis, remained associated with microtubules; when associated with A-313; A-317 and A-324. 1 Publication1
Mutagenesisi322T → E: Reduced ability to associate with microtubules; when associated with D-313; D-317 and D-324. 1 Publication1
Mutagenesisi324S → A in mitosis, remained associated with microtubules; when associated with A-313; A-317 and A-322. 1 Publication1
Mutagenesisi324S → D: Reduced ability to associate with microtubules; when associated with D-313; D-317 and E-322. 1 Publication1

Organism-specific databases

DisGeNETi79187
OpenTargetsiENSG00000105255
PharmGKBiPA134882882

Polymorphism and mutation databases

BioMutaiFSD1
DMDMi74733152

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003165371 – 496Fibronectin type III and SPRY domain-containing protein 1Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei310Omega-N-methylarginineBy similarity1
Modified residuei320Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ9BTV5
MaxQBiQ9BTV5
PaxDbiQ9BTV5
PeptideAtlasiQ9BTV5
PRIDEiQ9BTV5
ProteomicsDBi79013

PTM databases

iPTMnetiQ9BTV5
PhosphoSitePlusiQ9BTV5

Expressioni

Tissue specificityi

Highly expressed in brain tissues, including cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Lower expression in spinal chord.2 Publications

Gene expression databases

BgeeiENSG00000105255
CleanExiHS_FSD1
ExpressionAtlasiQ9BTV5 baseline and differential
GenevisibleiQ9BTV5 HS

Organism-specific databases

HPAiHPA043141

Interactioni

Subunit structurei

Oligomerization is required for binding to microtubules.

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi122600, 62 interactors
IntActiQ9BTV5, 4 interactors
STRINGi9606.ENSP00000221856

Structurei

3D structure databases

ProteinModelPortaliQ9BTV5
SMRiQ9BTV5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini105 – 162COSPROSITE-ProRule annotationAdd BLAST58
Domaini164 – 268Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST105
Domaini268 – 477B30.2/SPRYPROSITE-ProRule annotationAdd BLAST210

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili4 – 99Sequence analysisAdd BLAST96

Domaini

B30.2 box contains a microtubule-binding site.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410ITFY Eukaryota
ENOG410ZECU LUCA
GeneTreeiENSGT00760000118878
HOGENOMiHOG000231656
HOVERGENiHBG107931
InParanoidiQ9BTV5
OMAiAFMVWNG
OrthoDBiEOG091G072W
PhylomeDBiQ9BTV5
TreeFamiTF333654

Family and domain databases

CDDicd00063 FN3, 1 hit
cd12901 SPRY_PRY_FSD1, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003649 Bbox_C
IPR013320 ConA-like_dom_sf
IPR017903 COS_domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR035742 SPRY/PRY_FSD1
IPR003877 SPRY_dom
PfamiView protein in Pfam
PF00041 fn3, 1 hit
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00502 BBC, 1 hit
SM00060 FN3, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS51262 COS, 1 hit
PS50853 FN3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BTV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEQREALRK IIKTLAVKNE EIQSFIYSLK QMLLNVEANS AKVQEDLEAE
60 70 80 90 100
FQSLFSLLEE LKEGMLMKIK QDRASRTYEL QNQLAACTRA LESSEELLET
110 120 130 140 150
ANQTLQAMDS EDFPQAAKQI KDGVTMAPAF RLSLKAKVSD NMSHLMVDFA
160 170 180 190 200
QERQMLQALK FLPVPSAPVI DLAESLVADN CVTLVWRMPD EDSKIDHYVL
210 220 230 240 250
EYRRTNFEGP PRLKEDQPWM VIEGIRQTEY TLTGLKFDMK YMNFRVKACN
260 270 280 290 300
KAVAGEFSEP VTLETPAFMF RLDASTSHQN LRVDDLSVEW DAMGGKVQDI
310 320 330 340 350
KAREKDGKGR TASPINSPAR GTPSPKRMPS GRGGRDRFTA ESYTVLGDTL
360 370 380 390 400
IDGGEHYWEV RYEPDSKAFG VGVAYRSLGR FEQLGKTAAS WCLHVNNWLQ
410 420 430 440 450
VSFTAKHANK VKVLDAPVPD CLGVHCDFHQ GLLSFYNART KQVLHTFKTR
460 470 480 490
FTQPLLPAFT VWCGSFQVTT GLQVPSAVRC LQKRGSATSS SNTSLT
Length:496
Mass (Da):55,820
Last modified:June 1, 2001 - v1
Checksum:i0FE7B18F14C80D46
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti295G → R in BAB13885 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038385232L → V1 PublicationCorresponds to variant dbSNP:rs35139245Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF316829 mRNA Translation: AAK26747.1
AY032617 mRNA Translation: AAK51145.1
AK021750 mRNA Translation: BAB13885.1
AK315661 mRNA Translation: BAG38027.1
BC003124 mRNA Translation: AAH03124.1
CCDSiCCDS12127.1
RefSeqiNP_077309.1, NM_024333.2
UniGeneiHs.28144

Genome annotation databases

EnsembliENST00000221856; ENSP00000221856; ENSG00000105255
GeneIDi79187
KEGGihsa:79187
UCSCiuc002lzy.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFSD1_HUMAN
AccessioniPrimary (citable) accession number: Q9BTV5
Secondary accession number(s): B2RDT0, Q9BXN0, Q9HAG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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