UniProtKB - Q9BTT6 (LRRC1_HUMAN)
Protein
Leucine-rich repeat-containing protein 1
Gene
LRRC1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Leucine-rich repeat-containing protein 1Alternative name(s): LANO adapter protein LAP and no PDZ protein |
Gene namesi | Name:LRRC1 Synonyms:LANO |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14307, LRRC1 |
MIMi | 608195, gene |
neXtProti | NX_Q9BTT6 |
VEuPathDBi | HostDB:ENSG00000137269.14 |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
- Membrane 1 Publication; Peripheral membrane protein 1 Publication
Note: Localized at the basolateral side of epithelial cells.
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 55227 |
OpenTargetsi | ENSG00000137269 |
PharmGKBi | PA30460 |
Miscellaneous databases
Pharosi | Q9BTT6, Tbio |
Genetic variation databases
BioMutai | LRRC1 |
DMDMi | 50401149 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084489 | 1 – 524 | Leucine-rich repeat-containing protein 1Add BLAST | 524 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 480 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9BTT6 |
jPOSTi | Q9BTT6 |
MassIVEi | Q9BTT6 |
MaxQBi | Q9BTT6 |
PaxDbi | Q9BTT6 |
PeptideAtlasi | Q9BTT6 |
PRIDEi | Q9BTT6 |
ProteomicsDBi | 79009 [Q9BTT6-1] 79010 [Q9BTT6-2] |
PTM databases
iPTMneti | Q9BTT6 |
PhosphoSitePlusi | Q9BTT6 |
SwissPalmi | Q9BTT6 |
Expressioni
Tissue specificityi
Expressed strongly in testis and placenta, followed by heart, lung, kidney, thyroid, trachea, colon, prostate and pancreas.1 Publication
Gene expression databases
Bgeei | ENSG00000137269, Expressed in oviduct epithelium and 217 other tissues |
ExpressionAtlasi | Q9BTT6, baseline and differential |
Genevisiblei | Q9BTT6, HS |
Organism-specific databases
HPAi | ENSG00000137269, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with DLG1 and DLG4. May form a complex with DLG1 and ERBIN, where interaction between LRRC1 and ERBIN is indirect.
1 PublicationProtein-protein interaction databases
BioGRIDi | 120522, 40 interactors |
IntActi | Q9BTT6, 23 interactors |
MINTi | Q9BTT6 |
STRINGi | 9606.ENSP00000359925 |
Miscellaneous databases
RNActi | Q9BTT6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 11 – 34 | LRR 1Add BLAST | 24 | |
Repeati | 35 – 58 | LRR 2Add BLAST | 24 | |
Repeati | 60 – 81 | LRR 3Add BLAST | 22 | |
Repeati | 83 – 105 | LRR 4Add BLAST | 23 | |
Repeati | 107 – 126 | LRR 5Add BLAST | 20 | |
Repeati | 127 – 149 | LRR 6Add BLAST | 23 | |
Repeati | 150 – 172 | LRR 7Add BLAST | 23 | |
Repeati | 173 – 196 | LRR 8Add BLAST | 24 | |
Repeati | 198 – 218 | LRR 9Add BLAST | 21 | |
Repeati | 219 – 242 | LRR 10Add BLAST | 24 | |
Repeati | 244 – 264 | LRR 11Add BLAST | 21 | |
Repeati | 265 – 288 | LRR 12Add BLAST | 24 | |
Repeati | 290 – 310 | LRR 13Add BLAST | 21 | |
Repeati | 311 – 334 | LRR 14Add BLAST | 24 | |
Repeati | 336 – 356 | LRR 15Add BLAST | 21 | |
Repeati | 357 – 380 | LRR 16Add BLAST | 24 | |
Repeati | 382 – 405 | LRR 17Add BLAST | 24 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 484 – 512 | Sequence analysisAdd BLAST | 29 |
Keywords - Domaini
Coiled coil, Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000154025 |
HOGENOMi | CLU_000288_18_15_1 |
InParanoidi | Q9BTT6 |
OMAi | GNRIECF |
OrthoDBi | 992188at2759 |
PhylomeDBi | Q9BTT6 |
TreeFami | TF351429 |
Family and domain databases
Gene3Di | 3.80.10.10, 3 hits |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF13855, LRR_8, 3 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 13 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 16 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9BTT6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFHCIPLWRC NRHVESIDKR HCSLVYVPEE IYRYARSLEE LLLDANQLRE
60 70 80 90 100
LPEQFFQLVK LRKLGLSDNE IQRLPPEIAN FMQLVELDVS RNEIPEIPES
110 120 130 140 150
ISFCKALQVA DFSGNPLTRL PESFPELQNL TCLSVNDISL QSLPENIGNL
160 170 180 190 200
YNLASLELRE NLLTYLPDSL TQLRRLEELD LGNNEIYNLP ESIGALLHLK
210 220 230 240 250
DLWLDGNQLS ELPQEIGNLK NLLCLDVSEN RLERLPEEIS GLTSLTDLVI
260 270 280 290 300
SQNLLETIPD GIGKLKKLSI LKVDQNRLTQ LPEAVGECES LTELVLTENQ
310 320 330 340 350
LLTLPKSIGK LKKLSNLNAD RNKLVSLPKE IGGCCSLTVF CVRDNRLTRI
360 370 380 390 400
PAEVSQATEL HVLDVAGNRL LHLPLSLTAL KLKALWLSDN QSQPLLTFQT
410 420 430 440 450
DTDYTTGEKI LTCVLLPQLP SEPTCQENLP RCGALENLVN DVSDEAWNER
460 470 480 490 500
AVNRVSAIRF VEDEKDEEDN ETRTLLRRAT PHPGELKHMK KTVENLRNDM
510 520
NAAKGLDSNK NEVNHAIDRV TTSV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5T0G3 | Q5T0G3_HUMAN | Leucine-rich repeat-containing prot... | LRRC1 | 154 | Annotation score: |
Sequence cautioni
The sequence BAA91801 differs from that shown. Reason: Frameshift.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019431 | 193 | I → V1 PublicationCorresponds to variant dbSNP:rs9349688Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010912 | 190 – 197 | PESIGALL → NQLEPSYI in isoform 2. 1 Publication | 8 | |
Alternative sequenceiVSP_010913 | 198 – 524 | Missing in isoform 2. 1 PublicationAdd BLAST | 327 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF359380 mRNA Translation: AAK72246.1 AF332199 mRNA Translation: AAK69623.1 AK021896 mRNA Translation: BAB13929.1 AK001637 mRNA Translation: BAA91801.1 Frameshift. AL513211 Genomic DNA No translation available. AL033384 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04430.1 BC003193 mRNA Translation: AAH03193.1 |
CCDSi | CCDS4953.2 [Q9BTT6-1] |
RefSeqi | NP_060684.4, NM_018214.4 [Q9BTT6-1] XP_011513028.1, XM_011514726.2 [Q9BTT6-1] |
Genome annotation databases
Ensembli | ENST00000370888; ENSP00000359925; ENSG00000137269 [Q9BTT6-1] ENST00000487251; ENSP00000435217; ENSG00000137269 [Q9BTT6-2] |
GeneIDi | 55227 |
KEGGi | hsa:55227 |
UCSCi | uc003pcd.2, human [Q9BTT6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF359380 mRNA Translation: AAK72246.1 AF332199 mRNA Translation: AAK69623.1 AK021896 mRNA Translation: BAB13929.1 AK001637 mRNA Translation: BAA91801.1 Frameshift. AL513211 Genomic DNA No translation available. AL033384 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04430.1 BC003193 mRNA Translation: AAH03193.1 |
CCDSi | CCDS4953.2 [Q9BTT6-1] |
RefSeqi | NP_060684.4, NM_018214.4 [Q9BTT6-1] XP_011513028.1, XM_011514726.2 [Q9BTT6-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120522, 40 interactors |
IntActi | Q9BTT6, 23 interactors |
MINTi | Q9BTT6 |
STRINGi | 9606.ENSP00000359925 |
PTM databases
iPTMneti | Q9BTT6 |
PhosphoSitePlusi | Q9BTT6 |
SwissPalmi | Q9BTT6 |
Genetic variation databases
BioMutai | LRRC1 |
DMDMi | 50401149 |
Proteomic databases
EPDi | Q9BTT6 |
jPOSTi | Q9BTT6 |
MassIVEi | Q9BTT6 |
MaxQBi | Q9BTT6 |
PaxDbi | Q9BTT6 |
PeptideAtlasi | Q9BTT6 |
PRIDEi | Q9BTT6 |
ProteomicsDBi | 79009 [Q9BTT6-1] 79010 [Q9BTT6-2] |
Protocols and materials databases
Antibodypediai | 17278, 91 antibodies |
DNASUi | 55227 |
Genome annotation databases
Ensembli | ENST00000370888; ENSP00000359925; ENSG00000137269 [Q9BTT6-1] ENST00000487251; ENSP00000435217; ENSG00000137269 [Q9BTT6-2] |
GeneIDi | 55227 |
KEGGi | hsa:55227 |
UCSCi | uc003pcd.2, human [Q9BTT6-1] |
Organism-specific databases
CTDi | 55227 |
DisGeNETi | 55227 |
GeneCardsi | LRRC1 |
HGNCi | HGNC:14307, LRRC1 |
HPAi | ENSG00000137269, Low tissue specificity |
MIMi | 608195, gene |
neXtProti | NX_Q9BTT6 |
OpenTargetsi | ENSG00000137269 |
PharmGKBi | PA30460 |
VEuPathDBi | HostDB:ENSG00000137269.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000154025 |
HOGENOMi | CLU_000288_18_15_1 |
InParanoidi | Q9BTT6 |
OMAi | GNRIECF |
OrthoDBi | 992188at2759 |
PhylomeDBi | Q9BTT6 |
TreeFami | TF351429 |
Enzyme and pathway databases
PathwayCommonsi | Q9BTT6 |
Miscellaneous databases
BioGRID-ORCSi | 55227, 27 hits in 874 CRISPR screens |
ChiTaRSi | LRRC1, human |
GenomeRNAii | 55227 |
Pharosi | Q9BTT6, Tbio |
PROi | PR:Q9BTT6 |
RNActi | Q9BTT6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137269, Expressed in oviduct epithelium and 217 other tissues |
ExpressionAtlasi | Q9BTT6, baseline and differential |
Genevisiblei | Q9BTT6, HS |
Family and domain databases
Gene3Di | 3.80.10.10, 3 hits |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF13855, LRR_8, 3 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 13 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 16 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LRRC1_HUMAN | |
Accessioni | Q9BTT6Primary (citable) accession number: Q9BTT6 Secondary accession number(s): Q5TGN3, Q9HAC0, Q9NVF1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot