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UniProtKB - Q9BTT6 (LRRC1_HUMAN)

Entry version 165 (29 Sep 2021)
Sequence version 1 (01 Jun 2001)
Previous versions | rss
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Protein

Leucine-rich repeat-containing protein 1

Gene

LRRC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BTT6

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9696270, RND2 GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 1
Alternative name(s):
LANO adapter protein
LAP and no PDZ protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC1
Synonyms:LANO
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14307, LRRC1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608195, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BTT6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000137269

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55227

Open Targets

More...OpenTargetsi		ENSG00000137269

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30460

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BTT6, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LRRC1

Domain mapping of disease mutations (DMDM)

More...DMDMi		50401149

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000844891 – 524Leucine-rich repeat-containing protein 1Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei480PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BTT6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BTT6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BTT6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BTT6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BTT6

PeptideAtlas

More...PeptideAtlasi		Q9BTT6

PRoteomics IDEntifications database

More...PRIDEi		Q9BTT6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		79009 [Q9BTT6-1]
79010 [Q9BTT6-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9BTT6, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BTT6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BTT6

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9BTT6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed strongly in testis and placenta, followed by heart, lung, kidney, thyroid, trachea, colon, prostate and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000137269, Expressed in oviduct epithelium and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BTT6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BTT6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000137269, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DLG1 and DLG4. May form a complex with DLG1 and ERBIN, where interaction between LRRC1 and ERBIN is indirect.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120522, 44 interactors

Protein interaction database and analysis system

More...IntActi		Q9BTT6, 24 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000359925

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BTT6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BTT6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati11 – 34LRR 1Add BLAST24
Repeati35 – 58LRR 2Add BLAST24
Repeati60 – 81LRR 3Add BLAST22
Repeati83 – 105LRR 4Add BLAST23
Repeati107 – 126LRR 5Add BLAST20
Repeati127 – 149LRR 6Add BLAST23
Repeati150 – 172LRR 7Add BLAST23
Repeati173 – 196LRR 8Add BLAST24
Repeati198 – 218LRR 9Add BLAST21
Repeati219 – 242LRR 10Add BLAST24
Repeati244 – 264LRR 11Add BLAST21
Repeati265 – 288LRR 12Add BLAST24
Repeati290 – 310LRR 13Add BLAST21
Repeati311 – 334LRR 14Add BLAST24
Repeati336 – 356LRR 15Add BLAST21
Repeati357 – 380LRR 16Add BLAST24
Repeati382 – 405LRR 17Add BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili484 – 512Sequence analysisAdd BLAST29

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0619, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154025

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000288_18_15_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BTT6

Identification of Orthologs from Complete Genome Data

More...OMAi		VHLKDLW

Database of Orthologous Groups

More...OrthoDBi		992188at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BTT6

TreeFam database of animal gene trees

More...TreeFami		TF351429

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13855, LRR_8, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00369, LRR_TYP, 13 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51450, LRR, 16 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BTT6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFHCIPLWRC NRHVESIDKR HCSLVYVPEE IYRYARSLEE LLLDANQLRE 
        60         70         80         90        100
LPEQFFQLVK LRKLGLSDNE IQRLPPEIAN FMQLVELDVS RNEIPEIPES 
       110        120        130        140        150
ISFCKALQVA DFSGNPLTRL PESFPELQNL TCLSVNDISL QSLPENIGNL 
       160        170        180        190        200
YNLASLELRE NLLTYLPDSL TQLRRLEELD LGNNEIYNLP ESIGALLHLK 
       210        220        230        240        250
DLWLDGNQLS ELPQEIGNLK NLLCLDVSEN RLERLPEEIS GLTSLTDLVI 
       260        270        280        290        300
SQNLLETIPD GIGKLKKLSI LKVDQNRLTQ LPEAVGECES LTELVLTENQ 
       310        320        330        340        350
LLTLPKSIGK LKKLSNLNAD RNKLVSLPKE IGGCCSLTVF CVRDNRLTRI 
       360        370        380        390        400
PAEVSQATEL HVLDVAGNRL LHLPLSLTAL KLKALWLSDN QSQPLLTFQT 
       410        420        430        440        450
DTDYTTGEKI LTCVLLPQLP SEPTCQENLP RCGALENLVN DVSDEAWNER 
       460        470        480        490        500
AVNRVSAIRF VEDEKDEEDN ETRTLLRRAT PHPGELKHMK KTVENLRNDM 
       510        520 
NAAKGLDSNK NEVNHAIDRV TTSV
Length:524
Mass (Da):59,242
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB40251635C90469C
GO
Isoform 2 (identifier: Q9BTT6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-197: PESIGALL → NQLEPSYI
     198-524: Missing.

Show »
Length:197
Mass (Da):22,943
Checksum:iEFDCA28B2728D580
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T0G3Q5T0G3_HUMAN
Leucine-rich repeat-containing prot...
LRRC1
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91801 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019431193I → V1 PublicationCorresponds to variant dbSNP:rs9349688Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010912190 – 197PESIGALL → NQLEPSYI in isoform 2. 1 Publication8
Alternative sequenceiVSP_010913198 – 524Missing in isoform 2. 1 PublicationAdd BLAST327

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF359380 mRNA Translation: AAK72246.1
AF332199 mRNA Translation: AAK69623.1
AK021896 mRNA Translation: BAB13929.1
AK001637 mRNA Translation: BAA91801.1 Frameshift.
AL513211 Genomic DNA No translation available.
AL033384 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04430.1
BC003193 mRNA Translation: AAH03193.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4953.2 [Q9BTT6-1]

NCBI Reference Sequences

More...RefSeqi		NP_060684.4, NM_018214.4 [Q9BTT6-1]
XP_011513028.1, XM_011514726.2 [Q9BTT6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000370888; ENSP00000359925; ENSG00000137269 [Q9BTT6-1]
ENST00000487251; ENSP00000435217; ENSG00000137269 [Q9BTT6-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55227

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55227

UCSC genome browser

More...UCSCi		uc003pcd.2, human [Q9BTT6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF359380 mRNA Translation: AAK72246.1
AF332199 mRNA Translation: AAK69623.1
AK021896 mRNA Translation: BAB13929.1
AK001637 mRNA Translation: BAA91801.1 Frameshift.
AL513211 Genomic DNA No translation available.
AL033384 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04430.1
BC003193 mRNA Translation: AAH03193.1
CCDSiCCDS4953.2 [Q9BTT6-1]
RefSeqiNP_060684.4, NM_018214.4 [Q9BTT6-1]
XP_011513028.1, XM_011514726.2 [Q9BTT6-1]

3D structure databases

SMRiQ9BTT6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120522, 44 interactors
IntActiQ9BTT6, 24 interactors
STRINGi9606.ENSP00000359925

PTM databases

GlyGeniQ9BTT6, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9BTT6
PhosphoSitePlusiQ9BTT6
SwissPalmiQ9BTT6

Genetic variation databases

BioMutaiLRRC1
DMDMi50401149

Proteomic databases

EPDiQ9BTT6
jPOSTiQ9BTT6
MassIVEiQ9BTT6
MaxQBiQ9BTT6
PaxDbiQ9BTT6
PeptideAtlasiQ9BTT6
PRIDEiQ9BTT6
ProteomicsDBi79009 [Q9BTT6-1]
79010 [Q9BTT6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17278, 93 antibodies

The DNASU plasmid repository

More...DNASUi		55227

Genome annotation databases

EnsembliENST00000370888; ENSP00000359925; ENSG00000137269 [Q9BTT6-1]
ENST00000487251; ENSP00000435217; ENSG00000137269 [Q9BTT6-2]
GeneIDi55227
KEGGihsa:55227
UCSCiuc003pcd.2, human [Q9BTT6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55227
DisGeNETi55227

GeneCards: human genes, protein and diseases

More...GeneCardsi		LRRC1
HGNCiHGNC:14307, LRRC1
HPAiENSG00000137269, Low tissue specificity
MIMi608195, gene
neXtProtiNX_Q9BTT6
OpenTargetsiENSG00000137269
PharmGKBiPA30460
VEuPathDBiHostDB:ENSG00000137269

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0619, Eukaryota
GeneTreeiENSGT00940000154025
HOGENOMiCLU_000288_18_15_1
InParanoidiQ9BTT6
OMAiVHLKDLW
OrthoDBi992188at2759
PhylomeDBiQ9BTT6
TreeFamiTF351429

Enzyme and pathway databases

PathwayCommonsiQ9BTT6
ReactomeiR-HSA-9696270, RND2 GTPase cycle

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55227, 29 hits in 1010 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LRRC1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55227
PharosiQ9BTT6, Tbio

Protein Ontology

More...PROi		PR:Q9BTT6
RNActiQ9BTT6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000137269, Expressed in oviduct epithelium and 217 other tissues
ExpressionAtlasiQ9BTT6, baseline and differential
GenevisibleiQ9BTT6, HS

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
PfamiView protein in Pfam
PF13855, LRR_8, 3 hits
SMARTiView protein in SMART
SM00369, LRR_TYP, 13 hits
PROSITEiView protein in PROSITE
PS51450, LRR, 16 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRRC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BTT6
Secondary accession number(s): Q5TGN3, Q9HAC0, Q9NVF1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: September 29, 2021
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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