UniProtKB - Q9BTT4 (MED10_HUMAN)
Mediator of RNA polymerase II transcription subunit 10
MED10
Functioni
GO - Molecular functioni
- transcription coregulator activity Source: GO_Central
- ubiquitin protein ligase activity Source: Ensembl
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription initiation from RNA polymerase II promoter Source: Reactome
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9BTT4 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-212436, Generic Transcription Pathway R-HSA-381340, Transcriptional regulation of white adipocyte differentiation |
Names & Taxonomyi
Protein namesi | Recommended name: Mediator of RNA polymerase II transcription subunit 10Alternative name(s): Mediator complex subunit 10 Transformation-related gene 17 protein Short name: TRG-17 Transformation-related gene 20 protein Short name: TRG-20 |
Gene namesi | Name:MED10 ORF Names:L6, TRG17, TRG20 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28760, MED10 |
MIMi | 612382, gene |
neXtProti | NX_Q9BTT4 |
VEuPathDBi | HostDB:ENSG00000133398.3 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- mediator complex Source: GO_Central
- nucleoplasm Source: HPA
Other locations
- chromatin Source: GO_Central
- ubiquitin ligase complex Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000133398 |
PharmGKBi | PA144596412 |
Miscellaneous databases
Pharosi | Q9BTT4, Tdark |
Genetic variation databases
BioMutai | MED10 |
DMDMi | 74733145 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000303151 | 1 – 135 | Mediator of RNA polymerase II transcription subunit 10Add BLAST | 135 |
Proteomic databases
EPDi | Q9BTT4 |
jPOSTi | Q9BTT4 |
MassIVEi | Q9BTT4 |
MaxQBi | Q9BTT4 |
PaxDbi | Q9BTT4 |
PeptideAtlasi | Q9BTT4 |
PRIDEi | Q9BTT4 |
ProteomicsDBi | 79008 |
TopDownProteomicsi | Q9BTT4 |
PTM databases
iPTMneti | Q9BTT4 |
PhosphoSitePlusi | Q9BTT4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000133398, Expressed in quadriceps femoris and 202 other tissues |
Genevisiblei | Q9BTT4, HS |
Organism-specific databases
HPAi | ENSG00000133398, Low tissue specificity |
Interactioni
Subunit structurei
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
3 PublicationsBinary interactionsi
Hide detailsQ9BTT4
Protein-protein interaction databases
BioGRIDi | 123974, 83 interactors |
ComplexPortali | CPX-3227, Core mediator complex |
CORUMi | Q9BTT4 |
DIPi | DIP-31457N |
IntActi | Q9BTT4, 81 interactors |
MINTi | Q9BTT4 |
STRINGi | 9606.ENSP00000255764 |
Miscellaneous databases
RNActi | Q9BTT4, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3046, Eukaryota |
GeneTreei | ENSGT00390000014501 |
HOGENOMi | CLU_096169_3_0_1 |
InParanoidi | Q9BTT4 |
OMAi | GKIDTMT |
OrthoDBi | 1403581at2759 |
PhylomeDBi | Q9BTT4 |
TreeFami | TF315096 |
Family and domain databases
InterProi | View protein in InterPro IPR019145, Mediator_Med10 |
Pfami | View protein in Pfam PF09748, Med10, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAEKFDHLEE HLEKFVENIR QLGIIVSDFQ PSSQAGLNQK LNFIVTGLQD
60 70 80 90 100
IDKCRQQLHD ITVPLEVFEY IDQGRNPQLY TKECLERALA KNEQVKGKID
110 120 130
TMKKFKSLLI QELSKVFPED MAKYRSIRGE DHPPS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY598325 mRNA Translation: AAT06736.1 AY277599 mRNA Translation: AAQ18038.1 AY453397 mRNA Translation: AAS47514.1 FJ515848 Genomic DNA Translation: ACS13739.1 CH471102 Genomic DNA Translation: EAX08110.1 BC003353 mRNA Translation: AAH03353.1 |
CCDSi | CCDS34134.1 |
RefSeqi | NP_115662.2, NM_032286.2 |
Genome annotation databases
Ensembli | ENST00000255764; ENSP00000255764; ENSG00000133398 |
GeneIDi | 84246 |
KEGGi | hsa:84246 |
UCSCi | uc003jdo.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY598325 mRNA Translation: AAT06736.1 AY277599 mRNA Translation: AAQ18038.1 AY453397 mRNA Translation: AAS47514.1 FJ515848 Genomic DNA Translation: ACS13739.1 CH471102 Genomic DNA Translation: EAX08110.1 BC003353 mRNA Translation: AAH03353.1 |
CCDSi | CCDS34134.1 |
RefSeqi | NP_115662.2, NM_032286.2 |
3D structure databases
SMRi | Q9BTT4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123974, 83 interactors |
ComplexPortali | CPX-3227, Core mediator complex |
CORUMi | Q9BTT4 |
DIPi | DIP-31457N |
IntActi | Q9BTT4, 81 interactors |
MINTi | Q9BTT4 |
STRINGi | 9606.ENSP00000255764 |
PTM databases
iPTMneti | Q9BTT4 |
PhosphoSitePlusi | Q9BTT4 |
Genetic variation databases
BioMutai | MED10 |
DMDMi | 74733145 |
Proteomic databases
EPDi | Q9BTT4 |
jPOSTi | Q9BTT4 |
MassIVEi | Q9BTT4 |
MaxQBi | Q9BTT4 |
PaxDbi | Q9BTT4 |
PeptideAtlasi | Q9BTT4 |
PRIDEi | Q9BTT4 |
ProteomicsDBi | 79008 |
TopDownProteomicsi | Q9BTT4 |
Protocols and materials databases
Antibodypediai | 43141, 35 antibodies |
DNASUi | 84246 |
Genome annotation databases
Ensembli | ENST00000255764; ENSP00000255764; ENSG00000133398 |
GeneIDi | 84246 |
KEGGi | hsa:84246 |
UCSCi | uc003jdo.4, human |
Organism-specific databases
CTDi | 84246 |
GeneCardsi | MED10 |
HGNCi | HGNC:28760, MED10 |
HPAi | ENSG00000133398, Low tissue specificity |
MIMi | 612382, gene |
neXtProti | NX_Q9BTT4 |
OpenTargetsi | ENSG00000133398 |
PharmGKBi | PA144596412 |
VEuPathDBi | HostDB:ENSG00000133398.3 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3046, Eukaryota |
GeneTreei | ENSGT00390000014501 |
HOGENOMi | CLU_096169_3_0_1 |
InParanoidi | Q9BTT4 |
OMAi | GKIDTMT |
OrthoDBi | 1403581at2759 |
PhylomeDBi | Q9BTT4 |
TreeFami | TF315096 |
Enzyme and pathway databases
PathwayCommonsi | Q9BTT4 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-212436, Generic Transcription Pathway R-HSA-381340, Transcriptional regulation of white adipocyte differentiation |
Miscellaneous databases
BioGRID-ORCSi | 84246, 475 hits in 1020 CRISPR screens |
ChiTaRSi | MED10, human |
GenomeRNAii | 84246 |
Pharosi | Q9BTT4, Tdark |
PROi | PR:Q9BTT4 |
RNActi | Q9BTT4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000133398, Expressed in quadriceps femoris and 202 other tissues |
Genevisiblei | Q9BTT4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019145, Mediator_Med10 |
Pfami | View protein in Pfam PF09748, Med10, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MED10_HUMAN | |
Accessioni | Q9BTT4Primary (citable) accession number: Q9BTT4 Secondary accession number(s): C6G491 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families