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Protein

Mediator of RNA polymerase II transcription subunit 10

Gene

MED10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 10
Alternative name(s):
Mediator complex subunit 10
Transformation-related gene 17 protein
Short name:
TRG-17
Transformation-related gene 20 protein
Short name:
TRG-20
Gene namesi
Name:MED10
ORF Names:L6, TRG17, TRG20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000133398.3
HGNCiHGNC:28760 MED10
MIMi612382 gene
neXtProtiNX_Q9BTT4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133398
PharmGKBiPA144596412

Polymorphism and mutation databases

BioMutaiMED10
DMDMi74733145

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003031511 – 135Mediator of RNA polymerase II transcription subunit 10Add BLAST135

Proteomic databases

EPDiQ9BTT4
MaxQBiQ9BTT4
PaxDbiQ9BTT4
PeptideAtlasiQ9BTT4
PRIDEiQ9BTT4
ProteomicsDBi79008
TopDownProteomicsiQ9BTT4

PTM databases

iPTMnetiQ9BTT4
PhosphoSitePlusiQ9BTT4

Expressioni

Gene expression databases

BgeeiENSG00000133398 Expressed in 188 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_MED10
GenevisibleiQ9BTT4 HS

Organism-specific databases

HPAiHPA042795
HPA054188

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MED7O435135EBI-394354,EBI-394632

Protein-protein interaction databases

BioGridi123974, 72 interactors
ComplexPortaliCPX-3227 Core mediator complex
CORUMiQ9BTT4
DIPiDIP-31457N
IntActiQ9BTT4, 74 interactors
MINTiQ9BTT4
STRINGi9606.ENSP00000255764

Structurei

3D structure databases

ProteinModelPortaliQ9BTT4
SMRiQ9BTT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 10 family.Curated

Phylogenomic databases

eggNOGiKOG3046 Eukaryota
ENOG4111QA2 LUCA
GeneTreeiENSGT00390000014501
HOGENOMiHOG000006789
HOVERGENiHBG107408
InParanoidiQ9BTT4
KOiK15151
OMAiRNEQVKG
OrthoDBiEOG091G0Y09
PhylomeDBiQ9BTT4
TreeFamiTF315096

Family and domain databases

InterProiView protein in InterPro
IPR019145 Mediator_Med10
PfamiView protein in Pfam
PF09748 Med10, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BTT4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEKFDHLEE HLEKFVENIR QLGIIVSDFQ PSSQAGLNQK LNFIVTGLQD
60 70 80 90 100
IDKCRQQLHD ITVPLEVFEY IDQGRNPQLY TKECLERALA KNEQVKGKID
110 120 130
TMKKFKSLLI QELSKVFPED MAKYRSIRGE DHPPS
Length:135
Mass (Da):15,688
Last modified:June 1, 2001 - v1
Checksum:iF804CD76770149E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598325 mRNA Translation: AAT06736.1
AY277599 mRNA Translation: AAQ18038.1
AY453397 mRNA Translation: AAS47514.1
FJ515848 Genomic DNA Translation: ACS13739.1
CH471102 Genomic DNA Translation: EAX08110.1
BC003353 mRNA Translation: AAH03353.1
CCDSiCCDS34134.1
RefSeqiNP_115662.2, NM_032286.2
UniGeneiHs.13885

Genome annotation databases

EnsembliENST00000255764; ENSP00000255764; ENSG00000133398
GeneIDi84246
KEGGihsa:84246
UCSCiuc003jdo.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598325 mRNA Translation: AAT06736.1
AY277599 mRNA Translation: AAQ18038.1
AY453397 mRNA Translation: AAS47514.1
FJ515848 Genomic DNA Translation: ACS13739.1
CH471102 Genomic DNA Translation: EAX08110.1
BC003353 mRNA Translation: AAH03353.1
CCDSiCCDS34134.1
RefSeqiNP_115662.2, NM_032286.2
UniGeneiHs.13885

3D structure databases

ProteinModelPortaliQ9BTT4
SMRiQ9BTT4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123974, 72 interactors
ComplexPortaliCPX-3227 Core mediator complex
CORUMiQ9BTT4
DIPiDIP-31457N
IntActiQ9BTT4, 74 interactors
MINTiQ9BTT4
STRINGi9606.ENSP00000255764

PTM databases

iPTMnetiQ9BTT4
PhosphoSitePlusiQ9BTT4

Polymorphism and mutation databases

BioMutaiMED10
DMDMi74733145

Proteomic databases

EPDiQ9BTT4
MaxQBiQ9BTT4
PaxDbiQ9BTT4
PeptideAtlasiQ9BTT4
PRIDEiQ9BTT4
ProteomicsDBi79008
TopDownProteomicsiQ9BTT4

Protocols and materials databases

DNASUi84246
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255764; ENSP00000255764; ENSG00000133398
GeneIDi84246
KEGGihsa:84246
UCSCiuc003jdo.4 human

Organism-specific databases

CTDi84246
EuPathDBiHostDB:ENSG00000133398.3
GeneCardsiMED10
HGNCiHGNC:28760 MED10
HPAiHPA042795
HPA054188
MIMi612382 gene
neXtProtiNX_Q9BTT4
OpenTargetsiENSG00000133398
PharmGKBiPA144596412
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3046 Eukaryota
ENOG4111QA2 LUCA
GeneTreeiENSGT00390000014501
HOGENOMiHOG000006789
HOVERGENiHBG107408
InParanoidiQ9BTT4
KOiK15151
OMAiRNEQVKG
OrthoDBiEOG091G0Y09
PhylomeDBiQ9BTT4
TreeFamiTF315096

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Miscellaneous databases

ChiTaRSiMED10 human
GenomeRNAii84246
PROiPR:Q9BTT4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133398 Expressed in 188 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_MED10
GenevisibleiQ9BTT4 HS

Family and domain databases

InterProiView protein in InterPro
IPR019145 Mediator_Med10
PfamiView protein in Pfam
PF09748 Med10, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMED10_HUMAN
AccessioniPrimary (citable) accession number: Q9BTT4
Secondary accession number(s): C6G491
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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