MED10

Functionⁱ

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

GO - Molecular functionⁱ

transcription coregulator activity Source: InterPro
ubiquitin protein ligase activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
stem cell population maintenance Source: Ensembl
transcription initiation from RNA polymerase II promoter Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-212436 Generic Transcription Pathway R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Reactomeⁱ

R-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mediator of RNA polymerase II transcription subunit 10 Alternative name(s): Mediator complex subunit 10 Transformation-related gene 17 protein Short name: TRG-17 Transformation-related gene 20 protein Short name: TRG-20
Gene namesⁱ	Name:MED10 ORF Names:L6, TRG17, TRG20
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000133398.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28760 MED10
MIMⁱ	612382 gene
neXtProtⁱ	NX_Q9BTT4

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000133398
PharmGKBⁱ	PA144596412

Polymorphism and mutation databases

BioMutaⁱ	MED10
DMDMⁱ	74733145

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000303151	1 – 135	Mediator of RNA polymerase II transcription subunit 10Add BLAST		135

Proteomic databases

EPDⁱ	Q9BTT4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BTT4
PaxDbⁱ	Q9BTT4
PeptideAtlas More...PeptideAtlasⁱ	Q9BTT4
PRIDEⁱ	Q9BTT4
ProteomicsDBⁱ	79008
TopDownProteomicsⁱ	Q9BTT4

PTM databases

iPTMnetⁱ	Q9BTT4
PhosphoSitePlusⁱ	Q9BTT4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000133398 Expressed in 188 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_MED10
Genevisibleⁱ	Q9BTT4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042795 HPA054188

HPAⁱ

HPA042795
HPA054188

Interactionⁱ

Subunit structureⁱ

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MED7	O43513	5	EBI-394354,EBI-394632

With

Entry

#Exp.

IntAct

Notes

MED7

O43513

5

EBI-394354,EBI-394632

Protein-protein interaction databases

BioGridⁱ	123974, 72 interactors
ComplexPortalⁱ	CPX-3227 Core mediator complex
CORUMⁱ	Q9BTT4
Database of interacting proteins More...DIPⁱ	DIP-31457N
IntActⁱ	Q9BTT4, 74 interactors
Molecular INTeraction database More...MINTⁱ	Q9BTT4
STRINGⁱ	9606.ENSP00000255764

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BTT4
SMRⁱ	Q9BTT4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Mediator complex subunit 10 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3046 Eukaryota ENOG4111QA2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014501
HOGENOMⁱ	HOG000006789
HOVERGENⁱ	HBG107408
InParanoidⁱ	Q9BTT4
KEGG Orthology (KO) More...KOⁱ	K15151
OMAⁱ	RNEQVKG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Y09
PhylomeDBⁱ	Q9BTT4
TreeFamⁱ	TF315096

Family and domain databases

InterProⁱ	View protein in InterPro IPR019145 Mediator_Med10
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09748 Med10, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9BTT4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAEKFDHLEE HLEKFVENIR QLGIIVSDFQ PSSQAGLNQK LNFIVTGLQD 
        60         70         80         90        100
IDKCRQQLHD ITVPLEVFEY IDQGRNPQLY TKECLERALA KNEQVKGKID 
       110        120        130 
TMKKFKSLLI QELSKVFPED MAKYRSIRGE DHPPS

Length:135

Mass (Da):15,688

Last modified:June 1, 2001 - v1

Checksum:ⁱF804CD76770149E1

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY598325 mRNA Translation: AAT06736.1 AY277599 mRNA Translation: AAQ18038.1 AY453397 mRNA Translation: AAS47514.1 FJ515848 Genomic DNA Translation: ACS13739.1 CH471102 Genomic DNA Translation: EAX08110.1 BC003353 mRNA Translation: AAH03353.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34134.1
NCBI Reference Sequences More...RefSeqⁱ	NP_115662.2, NM_032286.2
UniGeneⁱ	Hs.13885

Genome annotation databases

Ensemblⁱ	ENST00000255764; ENSP00000255764; ENSG00000133398
GeneIDⁱ	84246
KEGGⁱ	hsa:84246
UCSC genome browser More...UCSCⁱ	uc003jdo.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BTT4	Mediator of RNA polymerase II transcription subunit 10		BOVIN		135	UniRef100_Q9BTT4
Mediator of RNA polymerase II transcription subunit 10		PONAB		135
Mediator of RNA polymerase II transcription subunit 10		PANTR		135
Mediator of RNA polymerase II transcription subunit 10		CALJA		135
Mediator of RNA polymerase II transcription subunit 10		ODORO		135
+16

Protein	Similar proteins		Species	Score	Length	Source
Q9BTT4	Mediator of RNA polymerase II transcription subunit 10		BOVIN		135	UniRef90_Q9BTT4
Mediator of RNA polymerase II transcription subunit 10		PONAB		135
Mediator of RNA polymerase II transcription subunit 10		MOUSE		135
Mediator of RNA polymerase II transcription subunit 10		MACFA		135
Mediator of RNA polymerase II transcription subunit 10		XENLA		135
+103

Protein	Similar proteins		Species	Score	Length	Source
Q9BTT4	Mediator of RNA polymerase II transcription subunit 10		BOVIN		135	UniRef50_Q9BTT4
Mediator of RNA polymerase II transcription subunit 10		PONAB		135
Mediator of RNA polymerase II transcription subunit 10		MOUSE		135
Mediator of RNA polymerase II transcription subunit 10		XENTR		135
Mediator of RNA polymerase II transcription subunit 10		MACFA		135
+182

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY598325 mRNA Translation: AAT06736.1 AY277599 mRNA Translation: AAQ18038.1 AY453397 mRNA Translation: AAS47514.1 FJ515848 Genomic DNA Translation: ACS13739.1 CH471102 Genomic DNA Translation: EAX08110.1 BC003353 mRNA Translation: AAH03353.1
CCDSⁱ	CCDS34134.1
RefSeqⁱ	NP_115662.2, NM_032286.2
UniGeneⁱ	Hs.13885

3D structure databases

ProteinModelPortalⁱ	Q9BTT4
SMRⁱ	Q9BTT4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123974, 72 interactors
ComplexPortalⁱ	CPX-3227 Core mediator complex
CORUMⁱ	Q9BTT4
DIPⁱ	DIP-31457N
IntActⁱ	Q9BTT4, 74 interactors
MINTⁱ	Q9BTT4
STRINGⁱ	9606.ENSP00000255764

PTM databases

iPTMnetⁱ	Q9BTT4
PhosphoSitePlusⁱ	Q9BTT4

Polymorphism and mutation databases

BioMutaⁱ	MED10
DMDMⁱ	74733145

Proteomic databases

EPDⁱ	Q9BTT4
MaxQBⁱ	Q9BTT4
PaxDbⁱ	Q9BTT4
PeptideAtlasⁱ	Q9BTT4
PRIDEⁱ	Q9BTT4
ProteomicsDBⁱ	79008
TopDownProteomicsⁱ	Q9BTT4

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	84246
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000255764; ENSP00000255764; ENSG00000133398
GeneIDⁱ	84246
KEGGⁱ	hsa:84246
UCSCⁱ	uc003jdo.4 human

Organism-specific databases

CTDⁱ	84246
EuPathDBⁱ	HostDB:ENSG00000133398.3
GeneCardsⁱ	MED10
HGNCⁱ	HGNC:28760 MED10
HPAⁱ	HPA042795 HPA054188
MIMⁱ	612382 gene
neXtProtⁱ	NX_Q9BTT4
OpenTargetsⁱ	ENSG00000133398
PharmGKBⁱ	PA144596412
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3046 Eukaryota ENOG4111QA2 LUCA
GeneTreeⁱ	ENSGT00390000014501
HOGENOMⁱ	HOG000006789
HOVERGENⁱ	HBG107408
InParanoidⁱ	Q9BTT4
KOⁱ	K15151
OMAⁱ	RNEQVKG
OrthoDBⁱ	EOG091G0Y09
PhylomeDBⁱ	Q9BTT4
TreeFamⁱ	TF315096

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-212436 Generic Transcription Pathway R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Reactomeⁱ

R-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Miscellaneous databases

ChiTaRSⁱ	MED10 human
GenomeRNAiⁱ	84246
Protein Ontology More...PROⁱ	PR:Q9BTT4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000133398 Expressed in 188 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_MED10
Genevisibleⁱ	Q9BTT4 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019145 Mediator_Med10
Pfamⁱ	View protein in Pfam PF09748 Med10, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MED10_HUMAN
Accessionⁱ	Q9BTT4Primary (citable) accession number: Q9BTT4 Secondary accession number(s): C6G491
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

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UniParc

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UniProtKB - Q9BTT4 (MED10_HUMAN)

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Mediator of RNA polymerase II transcription subunit 10

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ