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UniProtKB - Q9BTL4 (IER2_HUMAN)

Entry version 130 (07 Apr 2021)
Sequence version 1 (01 Jun 2001)
Previous versions | rss
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Protein

Immediate early response gene 2 protein

Gene

IER2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BTL4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Immediate early response gene 2 protein
Alternative name(s):
Protein ETR101
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IER2Imported
Synonyms:ETR1011 Publication, PIP921 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:28871, IER2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BTL4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000160888.6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9592

Open Targets

More...OpenTargetsi		ENSG00000160888

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134982230

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BTL4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IER2

Domain mapping of disease mutations (DMDM)

More...DMDMi		73920026

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001904351 – 223Immediate early response gene 2 proteinAdd BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BTL4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BTL4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BTL4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BTL4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BTL4

PeptideAtlas

More...PeptideAtlasi		Q9BTL4

PRoteomics IDEntifications database

More...PRIDEi		Q9BTL4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78996

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BTL4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BTL4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in activated T-cells (at protein level) (PubMed:22120713). Expression increases in metastatic tumor cells (at protein level) (PubMed:22120713).1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By growth factors and 12-O-tetradecanoylphorbol-13-acetate (TPA).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000160888, Expressed in epithelium of mammary gland and 248 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BTL4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BTL4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000160888, Tissue enhanced (blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114959, 32 interactors

Protein interaction database and analysis system

More...IntActi		Q9BTL4, 21 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000465617

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BTL4, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IER family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S19F, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00900000141021

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_1234685_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BTL4

Identification of Orthologs from Complete Genome Data

More...OMAi		CRPADNM

Database of Orthologous Groups

More...OrthoDBi		1503216at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BTL4

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008653, IER

The PANTHER Classification System

More...PANTHERi		PTHR15895, PTHR15895, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05760, IER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9BTL4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVQKEAQRI MTLSVWKMYH SRMQRGGLRL HRSLQLSLVM RSARELYLSA 
        60         70         80         90        100
KVEALEPEVS LPAALPSDPR LHPPREAEST AETATPDGEH PFPEPMDTQE 
       110        120        130        140        150
APTAEETSAC CAPRPAKVSR KRRSSSLSDG GDAGLVPSKK ARLEEKEEEE 
       160        170        180        190        200
GASSEVADRL QPPPAQAEGA FPNLARVLQR RFSGLLNCSP AAPPTAPPAC 
       210        220 
EAKPACRPAD SMLNVLVRAV VAF
Length:223
Mass (Da):24,196
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCDC40214CCE0C2EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti165A → G in AAA35814 (PubMed:2061303).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057581133A → V1 PublicationCorresponds to variant dbSNP:rs1042164Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M62831 mRNA Translation: AAA35814.1
CR450352 mRNA Translation: CAG29348.1
BT019466 mRNA Translation: AAV38273.1
BC003625 mRNA Translation: AAH03625.1
BC072432 mRNA Translation: AAH72432.1
BC110647 mRNA Translation: AAI10648.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12295.1

Protein sequence database of the Protein Information Resource

More...PIRi		A40866

NCBI Reference Sequences

More...RefSeqi		NP_004898.2, NM_004907.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000292433; ENSP00000292433; ENSG00000160888
ENST00000587885; ENSP00000467294; ENSG00000160888
ENST00000588173; ENSP00000465617; ENSG00000160888

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9592

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9592

UCSC genome browser

More...UCSCi		uc002mwr.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62831 mRNA Translation: AAA35814.1
CR450352 mRNA Translation: CAG29348.1
BT019466 mRNA Translation: AAV38273.1
BC003625 mRNA Translation: AAH03625.1
BC072432 mRNA Translation: AAH72432.1
BC110647 mRNA Translation: AAI10648.1
CCDSiCCDS12295.1
PIRiA40866
RefSeqiNP_004898.2, NM_004907.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi114959, 32 interactors
IntActiQ9BTL4, 21 interactors
STRINGi9606.ENSP00000465617

PTM databases

iPTMnetiQ9BTL4
PhosphoSitePlusiQ9BTL4

Genetic variation databases

BioMutaiIER2
DMDMi73920026

Proteomic databases

EPDiQ9BTL4
jPOSTiQ9BTL4
MassIVEiQ9BTL4
MaxQBiQ9BTL4
PaxDbiQ9BTL4
PeptideAtlasiQ9BTL4
PRIDEiQ9BTL4
ProteomicsDBi78996

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		13536, 119 antibodies

The DNASU plasmid repository

More...DNASUi		9592

Genome annotation databases

EnsembliENST00000292433; ENSP00000292433; ENSG00000160888
ENST00000587885; ENSP00000467294; ENSG00000160888
ENST00000588173; ENSP00000465617; ENSG00000160888
GeneIDi9592
KEGGihsa:9592
UCSCiuc002mwr.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9592
DisGeNETi9592

GeneCards: human genes, protein and diseases

More...GeneCardsi		IER2
HGNCiHGNC:28871, IER2
HPAiENSG00000160888, Tissue enhanced (blood)
neXtProtiNX_Q9BTL4
OpenTargetsiENSG00000160888
PharmGKBiPA134982230
VEuPathDBiHostDB:ENSG00000160888.6

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S19F, Eukaryota
GeneTreeiENSGT00900000141021
HOGENOMiCLU_1234685_0_0_1
InParanoidiQ9BTL4
OMAiCRPADNM
OrthoDBi1503216at2759
PhylomeDBiQ9BTL4

Enzyme and pathway databases

PathwayCommonsiQ9BTL4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9592, 19 hits in 996 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IER2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9592
PharosiQ9BTL4, Tbio

Protein Ontology

More...PROi		PR:Q9BTL4
RNActiQ9BTL4, protein

Gene expression databases

BgeeiENSG00000160888, Expressed in epithelium of mammary gland and 248 other tissues
ExpressionAtlasiQ9BTL4, baseline and differential
GenevisibleiQ9BTL4, HS

Family and domain databases

InterProiView protein in InterPro
IPR008653, IER
PANTHERiPTHR15895, PTHR15895, 1 hit
PfamiView protein in Pfam
PF05760, IER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIER2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BTL4
Secondary accession number(s): Q03827, Q2TAZ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2001
Last modified: April 7, 2021
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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