UniProtKB - Q9BTL4 (IER2_HUMAN)
Protein
Immediate early response gene 2 protein
Gene
IER2
Organism
Homo sapiens (Human)
Status
Functioni
DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713).By similarity2 Publications
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
GO - Biological processi
- cell motility Source: UniProtKB
- neuron differentiation Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- response to fibroblast growth factor Source: UniProtKB
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9BTL4 |
Names & Taxonomyi
Protein namesi | Recommended name: Immediate early response gene 2 proteinAlternative name(s): Protein ETR101 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000160888.6 |
HGNCi | HGNC:28871, IER2 |
neXtProti | NX_Q9BTL4 |
Subcellular locationi
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9592 |
OpenTargetsi | ENSG00000160888 |
PharmGKBi | PA134982230 |
Miscellaneous databases
Pharosi | Q9BTL4, Tbio |
Polymorphism and mutation databases
BioMutai | IER2 |
DMDMi | 73920026 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000190435 | 1 – 223 | Immediate early response gene 2 proteinAdd BLAST | 223 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9BTL4 |
jPOSTi | Q9BTL4 |
MassIVEi | Q9BTL4 |
MaxQBi | Q9BTL4 |
PaxDbi | Q9BTL4 |
PeptideAtlasi | Q9BTL4 |
PRIDEi | Q9BTL4 |
ProteomicsDBi | 78996 |
PTM databases
iPTMneti | Q9BTL4 |
PhosphoSitePlusi | Q9BTL4 |
Expressioni
Tissue specificityi
Expressed in activated T-cells (at protein level) (PubMed:22120713). Expression increases in metastatic tumor cells (at protein level) (PubMed:22120713).1 Publication
Inductioni
By growth factors and 12-O-tetradecanoylphorbol-13-acetate (TPA).1 Publication
Gene expression databases
Bgeei | ENSG00000160888, Expressed in epithelium of mammary gland and 248 other tissues |
ExpressionAtlasi | Q9BTL4, baseline and differential |
Genevisiblei | Q9BTL4, HS |
Organism-specific databases
HPAi | ENSG00000160888, Tissue enhanced (blood) |
Interactioni
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 114959, 31 interactors |
IntActi | Q9BTL4, 21 interactors |
STRINGi | 9606.ENSP00000465617 |
Miscellaneous databases
RNActi | Q9BTL4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the IER family.Curated
Phylogenomic databases
eggNOGi | ENOG502S19F, Eukaryota |
GeneTreei | ENSGT00900000141021 |
HOGENOMi | CLU_1234685_0_0_1 |
InParanoidi | Q9BTL4 |
OMAi | CRPADNM |
OrthoDBi | 1503216at2759 |
PhylomeDBi | Q9BTL4 |
Family and domain databases
InterProi | View protein in InterPro IPR008653, IER |
PANTHERi | PTHR15895, PTHR15895, 1 hit |
Pfami | View protein in Pfam PF05760, IER, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9BTL4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEVQKEAQRI MTLSVWKMYH SRMQRGGLRL HRSLQLSLVM RSARELYLSA
60 70 80 90 100
KVEALEPEVS LPAALPSDPR LHPPREAEST AETATPDGEH PFPEPMDTQE
110 120 130 140 150
APTAEETSAC CAPRPAKVSR KRRSSSLSDG GDAGLVPSKK ARLEEKEEEE
160 170 180 190 200
GASSEVADRL QPPPAQAEGA FPNLARVLQR RFSGLLNCSP AAPPTAPPAC
210 220
EAKPACRPAD SMLNVLVRAV VAF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 165 | A → G in AAA35814 (PubMed:2061303).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057581 | 133 | A → V1 PublicationCorresponds to variant dbSNP:rs1042164Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M62831 mRNA Translation: AAA35814.1 CR450352 mRNA Translation: CAG29348.1 BT019466 mRNA Translation: AAV38273.1 BC003625 mRNA Translation: AAH03625.1 BC072432 mRNA Translation: AAH72432.1 BC110647 mRNA Translation: AAI10648.1 |
CCDSi | CCDS12295.1 |
PIRi | A40866 |
RefSeqi | NP_004898.2, NM_004907.2 |
Genome annotation databases
Ensembli | ENST00000292433; ENSP00000292433; ENSG00000160888 ENST00000587885; ENSP00000467294; ENSG00000160888 ENST00000588173; ENSP00000465617; ENSG00000160888 |
GeneIDi | 9592 |
KEGGi | hsa:9592 |
UCSCi | uc002mwr.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M62831 mRNA Translation: AAA35814.1 CR450352 mRNA Translation: CAG29348.1 BT019466 mRNA Translation: AAV38273.1 BC003625 mRNA Translation: AAH03625.1 BC072432 mRNA Translation: AAH72432.1 BC110647 mRNA Translation: AAI10648.1 |
CCDSi | CCDS12295.1 |
PIRi | A40866 |
RefSeqi | NP_004898.2, NM_004907.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 114959, 31 interactors |
IntActi | Q9BTL4, 21 interactors |
STRINGi | 9606.ENSP00000465617 |
PTM databases
iPTMneti | Q9BTL4 |
PhosphoSitePlusi | Q9BTL4 |
Polymorphism and mutation databases
BioMutai | IER2 |
DMDMi | 73920026 |
Proteomic databases
EPDi | Q9BTL4 |
jPOSTi | Q9BTL4 |
MassIVEi | Q9BTL4 |
MaxQBi | Q9BTL4 |
PaxDbi | Q9BTL4 |
PeptideAtlasi | Q9BTL4 |
PRIDEi | Q9BTL4 |
ProteomicsDBi | 78996 |
Protocols and materials databases
Antibodypediai | 13536, 118 antibodies |
DNASUi | 9592 |
Genome annotation databases
Ensembli | ENST00000292433; ENSP00000292433; ENSG00000160888 ENST00000587885; ENSP00000467294; ENSG00000160888 ENST00000588173; ENSP00000465617; ENSG00000160888 |
GeneIDi | 9592 |
KEGGi | hsa:9592 |
UCSCi | uc002mwr.4, human |
Organism-specific databases
CTDi | 9592 |
DisGeNETi | 9592 |
EuPathDBi | HostDB:ENSG00000160888.6 |
GeneCardsi | IER2 |
HGNCi | HGNC:28871, IER2 |
HPAi | ENSG00000160888, Tissue enhanced (blood) |
neXtProti | NX_Q9BTL4 |
OpenTargetsi | ENSG00000160888 |
PharmGKBi | PA134982230 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S19F, Eukaryota |
GeneTreei | ENSGT00900000141021 |
HOGENOMi | CLU_1234685_0_0_1 |
InParanoidi | Q9BTL4 |
OMAi | CRPADNM |
OrthoDBi | 1503216at2759 |
PhylomeDBi | Q9BTL4 |
Enzyme and pathway databases
PathwayCommonsi | Q9BTL4 |
Miscellaneous databases
BioGRID-ORCSi | 9592, 14 hits in 846 CRISPR screens |
ChiTaRSi | IER2, human |
GenomeRNAii | 9592 |
Pharosi | Q9BTL4, Tbio |
PROi | PR:Q9BTL4 |
RNActi | Q9BTL4, protein |
Gene expression databases
Bgeei | ENSG00000160888, Expressed in epithelium of mammary gland and 248 other tissues |
ExpressionAtlasi | Q9BTL4, baseline and differential |
Genevisiblei | Q9BTL4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008653, IER |
PANTHERi | PTHR15895, PTHR15895, 1 hit |
Pfami | View protein in Pfam PF05760, IER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IER2_HUMAN | |
Accessioni | Q9BTL4Primary (citable) accession number: Q9BTL4 Secondary accession number(s): Q03827, Q2TAZ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations