UniProtKB - Q9BTK6 (PAGR1_HUMAN)
Protein
PAXIP1-associated glutamate-rich protein 1
Gene
PAGR1
Organism
Homo sapiens (Human)
Status
Functioni
Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582).By similarityCurated3 Publications
Caution
The terminology of MLL proteins in mammalia is not consistent also concerning the terminology of MLL protein-containing complexes. The decribed MLL2/MLL3 complex is commonly described as MLL3/MLL4 complex in literature.Curated
GO - Molecular functioni
- estrogen receptor binding Source: UniProtKB
GO - Biological processi
- DNA recombination Source: UniProtKB-KW
- DNA repair Source: UniProtKB-KW
- histone H3-K4 methylation Source: GO_Central
- positive regulation of cell cycle G1/S phase transition Source: UniProtKB
- positive regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
Keywordsi
Biological process | DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9BTK6 |
Reactomei | R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis |
SignaLinki | Q9BTK6 |
Names & Taxonomyi
Protein namesi | Recommended name: PAXIP1-associated glutamate-rich protein 1Alternative name(s): Glutamate-rich coactivator interacting with SRC11 Publication Short name: GAS1 Publication PAXIP1-associated protein 1 PTIP-associated protein 1 |
Gene namesi | Name:PAGR1 Synonyms:C16orf53, PA1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000280789.1 |
HGNCi | HGNC:28707, PAGR1 |
MIMi | 612033, gene |
neXtProti | NX_Q9BTK6 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- histone methyltransferase complex Source: MGI
- MLL3/4 complex Source: UniProtKB
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 79447 |
OpenTargetsi | ENSG00000280789 |
PharmGKBi | PA142672260 |
Miscellaneous databases
Pharosi | Q9BTK6, Tbio |
Polymorphism and mutation databases
BioMutai | PAGR1 |
DMDMi | 74733129 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000248334 | 1 – 254 | PAXIP1-associated glutamate-rich protein 1Add BLAST | 254 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 138 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 143 | PhosphoserineBy similarity | 1 | |
Modified residuei | 148 | PhosphoserineBy similarity | 1 | |
Modified residuei | 237 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9BTK6 |
jPOSTi | Q9BTK6 |
MassIVEi | Q9BTK6 |
MaxQBi | Q9BTK6 |
PaxDbi | Q9BTK6 |
PeptideAtlasi | Q9BTK6 |
PRIDEi | Q9BTK6 |
ProteomicsDBi | 78994 |
PTM databases
iPTMneti | Q9BTK6 |
PhosphoSitePlusi | Q9BTK6 |
Expressioni
Tissue specificityi
Ubiquitously expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000280789, Expressed in right hemisphere of cerebellum and 112 other tissues |
Genevisiblei | Q9BTK6, HS |
Organism-specific databases
HPAi | ENSG00000280789, Tissue enhanced (blood) |
Interactioni
Subunit structurei
Component of the KMT2 family MLL2/MLL3 complex (also named ASCOM complex), at least composed of the HMTs KMT2D and/or KMT2C, the common subunits ASH2L, RBBP5, WDR5 and DPY30, and the complex type-specific subunits PAXIP1/PTIP, PAGR1, NCOA6 and KDM6A; PAXIP1 is required for the association with the MLL2/MLL3 complex (PubMed:17500065).
Forms a constitutive complex with PAXIP1/PTIP independently of the MLL2/MLL3 complex (By similarity).
Interacts with NCOA1, ESR1, NR3C1, AR (PubMed:19039327,PubMed:19124460, PubMed:23161582).
By similarity4 PublicationsBinary interactionsi
Hide detailsQ9BTK6
GO - Molecular functioni
- estrogen receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 122672, 15 interactors |
CORUMi | Q9BTK6 |
IntActi | Q9BTK6, 20 interactors |
MINTi | Q9BTK6 |
STRINGi | 9606.ENSP00000476774 |
Miscellaneous databases
RNActi | Q9BTK6, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 116 – 160 | Sufficient for interaction with NCOA11 PublicationAdd BLAST | 45 | |
Regioni | 161 – 254 | Sufficient for interaction with ESR11 PublicationAdd BLAST | 94 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 47 – 160 | Glu-richAdd BLAST | 114 |
Phylogenomic databases
eggNOGi | ENOG502S0T8, Eukaryota |
GeneTreei | ENSGT00390000016049 |
HOGENOMi | CLU_070349_0_0_1 |
InParanoidi | Q9BTK6 |
OMAi | QAWMPPP |
OrthoDBi | 1630689at2759 |
PhylomeDBi | Q9BTK6 |
TreeFami | TF326621 |
Family and domain databases
InterProi | View protein in InterPro IPR028213, PA1 |
PANTHERi | PTHR28467, PTHR28467, 1 hit |
Pfami | View protein in Pfam PF15364, PAXIP1_C, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9BTK6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLARGHGDT AASTAAPLSE EGEVTSGLQA LAVEDTGGPS ASAGKAEDEG
60 70 80 90 100
EGGREETERE GSGGEEAQGE VPSAGGEEPA EEDSEDWCVP CSDEEVELPA
110 120 130 140 150
DGQPWMPPPS EIQRLYELLA AHGTLELQAE ILPRRPPTPE AQSEEERSDE
160 170 180 190 200
EPEAKEEEEE KPHMPTEFDF DDEPVTPKDS LIDRRRTPGS SARSQKREAR
210 220 230 240 250
LDKVLSDMKR HKKLEEQILR TGRDLFSLDS EDPSPASPPL RSSGSSLFPR
QRKY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF195235 mRNA Translation: ABM69249.1 AC009133 Genomic DNA No translation available. AC120114 Genomic DNA No translation available. CH471238 Genomic DNA Translation: EAW79989.1 BC003640 mRNA Translation: AAH03640.1 |
CCDSi | CCDS10655.1 |
RefSeqi | NP_078792.1, NM_024516.3 |
Genome annotation databases
Ensembli | ENST00000320330; ENSP00000326519; ENSG00000280789 |
GeneIDi | 79447 |
KEGGi | hsa:79447 |
UCSCi | uc002dug.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF195235 mRNA Translation: ABM69249.1 AC009133 Genomic DNA No translation available. AC120114 Genomic DNA No translation available. CH471238 Genomic DNA Translation: EAW79989.1 BC003640 mRNA Translation: AAH03640.1 |
CCDSi | CCDS10655.1 |
RefSeqi | NP_078792.1, NM_024516.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 122672, 15 interactors |
CORUMi | Q9BTK6 |
IntActi | Q9BTK6, 20 interactors |
MINTi | Q9BTK6 |
STRINGi | 9606.ENSP00000476774 |
PTM databases
iPTMneti | Q9BTK6 |
PhosphoSitePlusi | Q9BTK6 |
Polymorphism and mutation databases
BioMutai | PAGR1 |
DMDMi | 74733129 |
Proteomic databases
EPDi | Q9BTK6 |
jPOSTi | Q9BTK6 |
MassIVEi | Q9BTK6 |
MaxQBi | Q9BTK6 |
PaxDbi | Q9BTK6 |
PeptideAtlasi | Q9BTK6 |
PRIDEi | Q9BTK6 |
ProteomicsDBi | 78994 |
Protocols and materials databases
Antibodypediai | 75851, 67 antibodies |
DNASUi | 79447 |
Genome annotation databases
Ensembli | ENST00000320330; ENSP00000326519; ENSG00000280789 |
GeneIDi | 79447 |
KEGGi | hsa:79447 |
UCSCi | uc002dug.5, human |
Organism-specific databases
CTDi | 79447 |
DisGeNETi | 79447 |
EuPathDBi | HostDB:ENSG00000280789.1 |
GeneCardsi | PAGR1 |
HGNCi | HGNC:28707, PAGR1 |
HPAi | ENSG00000280789, Tissue enhanced (blood) |
MIMi | 612033, gene |
neXtProti | NX_Q9BTK6 |
OpenTargetsi | ENSG00000280789 |
PharmGKBi | PA142672260 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S0T8, Eukaryota |
GeneTreei | ENSGT00390000016049 |
HOGENOMi | CLU_070349_0_0_1 |
InParanoidi | Q9BTK6 |
OMAi | QAWMPPP |
OrthoDBi | 1630689at2759 |
PhylomeDBi | Q9BTK6 |
TreeFami | TF326621 |
Enzyme and pathway databases
PathwayCommonsi | Q9BTK6 |
Reactomei | R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis |
SignaLinki | Q9BTK6 |
Miscellaneous databases
BioGRID-ORCSi | 79447, 119 hits in 848 CRISPR screens |
ChiTaRSi | PAGR1, human |
GenomeRNAii | 79447 |
Pharosi | Q9BTK6, Tbio |
PROi | PR:Q9BTK6 |
RNActi | Q9BTK6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000280789, Expressed in right hemisphere of cerebellum and 112 other tissues |
Genevisiblei | Q9BTK6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028213, PA1 |
PANTHERi | PTHR28467, PTHR28467, 1 hit |
Pfami | View protein in Pfam PF15364, PAXIP1_C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PAGR1_HUMAN | |
Accessioni | Q9BTK6Primary (citable) accession number: Q9BTK6 Secondary accession number(s): A2ICR6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM