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  1. 1
    "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Category: Sequences.
    Tissue: Skin.
    Source: UniProtKB/TrEMBL (unreviewed).

    This publication is cited by 50448 other entries.

  2. 2
    "Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling."
    Xia P., Wang L., Moretti P.A., Albanese N., Chai F., Pitson S.M., D'Andrea R.J., Gamble J.R., Vadas M.A.
    J. Biol. Chem. 277:7996-8003(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: These findings show a role for SphK in the signal transduction by TRAF2 specifically leading to activation of NF-kappa B and antiapoptosis.
    Source: GeneRIF:8877.

    This publication is mapped to 12 other entries.

  3. 3
    "[Molecular diversity of sphingosine kinase]."
    Tsukahara T., Mizuno H., Igarashi Y.
    Tanpakushitsu Kakusan Koso 47:509-513(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: synthesize sphingosine 1-phosphate a lipid mediator in intracellular signaling system.
    Source: GeneRIF:8877.

    This publication is mapped to 4 other entries.

  4. 4
    "Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity."
    Lacana E., Maceyka M., Milstien S., Spiegel S.
    J. Biol. Chem. 277:32947-32953(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction, Sequences.
    Annotation: results indicate that SPHK1-interacting protein(SKIP) is a novel protein likely to play a regulatory role in the modulation of SPHK1 activity.
    Source: GeneRIF:8877.

    This publication is cited by 1 and mapped to 4 other entries.

  5. 5
    "PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)."
    Johnson K.R., Becker K.P., Facchinetti M.M., Hannun Y.A., Obeid L.M.
    J. Biol. Chem. 277:35257-35262(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Subcellular Location.
    Annotation: activation and translocation to cell membrane dependent on protein kinase C.
    Source: GeneRIF:8877.

    This publication is mapped to 4 other entries.

  6. 6
    Category: Sequences.
    Annotation: characterization of the nucleotide-binding site of human sphingosine kinase 1 through a combination of site-directed mutagenesis and affinity labeling with the ATP analogue FSBA.
    Source: GeneRIF:8877.

    This publication is mapped to 12 other entries.

  7. 7
    "Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents."
    MacKinnon A.C., Buckley A., Chilvers E.R., Rossi A.G., Haslett C., Sethi T.
    J. Immunol. 169:6394-6400(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: role for sphingosine kinase in the regulation of neutrophil priming.
    Source: GeneRIF:8877.

    This publication is mapped to 4 other entries.

  8. 8
    "Sphingosine kinase modulates microvascular tone and myogenic responses through activation of RhoA/Rho kinase."
    Bolz S.S., Vogel L., Sollinger D., Derwand R., Boer C., Pitson S.M., Spiegel S., Pohl U.
    Circulation 108:342-347(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Resting tone and myogenic responses of isolated hamster resistance arteries increased with forced expression of human Sphk1 in smooth muscle cells.
    Source: GeneRIF:8877.

    This publication is mapped to 4 other entries.

  9. 9
    "Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation."
    Pitson S.M., Moretti P.A., Zebol J.R., Lynn H.E., Xia P., Vadas M.A., Wattenberg B.W.
    EMBO J. 22:5491-5500(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Activation of this enzyme in mediated by ERK1/2 phoshporylation.
    Source: GeneRIF:8877.

    This publication is mapped to 18 other entries.

  10. 10
    "Identification of functional nuclear export sequences in human sphingosine kinase 1."
    Inagaki Y., Li P.Y., Wada A., Mitsutake S., Igarashi Y.
    Biochem. Biophys. Res. Commun. 311:168-173(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: results provide the first evidence of the active nuclear export of SPHK1 and suggest it is mediated by a CRM1-dependent pathway.
    Source: GeneRIF:8877.

    This publication is mapped to 3 other entries.

  11. 11
    "Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus."
    Monick M.M., Cameron K., Powers L.S., Butler N.S., McCoy D., Mallampalli R.K., Hunninghake G.W.
    Am. J. Respir. Cell Mol. Biol. 30:844-852(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Data show that respiratory syncytial virus stimulates sphingosine kinase activity in lung epithelial cells leading to activation of antiapoptotic sphingosine 1-phosphate and subsequently activation of Akt and extracellular signal-related kinase.
    Source: GeneRIF:8877.

    This publication is mapped to 16 other entries.

  12. 12
    "Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53."
    Taha T.A., Osta W., Kozhaya L., Bielawski J., Johnson K.R., Gillanders W.E., Dbaibo G.S., Hannun Y.A., Obeid L.M.
    J. Biol. Chem. 279:20546-20554(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: SK1 is down-regulated by genotoxic stress and basal SK1 function may be necessary for the maintenance of tumor cell growth.
    Source: GeneRIF:8877.

    This publication is mapped to 4 other entries.

  13. 13
    "Genomic organization and mutation analysis of three candidate genes for hereditary neuralgic amyotrophy."
    Hunermund G., Schirmacher A., Ringelstein B., Young P., Watts G.D., Meuleman J., Nelis E., Chance P.F., Timmerman V., Stogbauer F., Kuhlenbaumer G.
    Muscle Nerve 29:601-604(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: hereditary neuralgic amyotrophy is not caused by point mutations of sphingosine kinase 1.
    Source: GeneRIF:8877.

    This publication is mapped to 10 other entries.

  14. 14
    "Sphingosine kinase-1 mediates TNF-alpha-induced MCP-1 gene expression in endothelial cells: upregulation by oscillatory flow."
    Chen X.L., Grey J.Y., Thomas S., Qiu F.H., Medford R.M., Wasserman M.A., Kunsch C.
    Am. J. Physiol. Heart Circ. Physiol. 287:H1452-8(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: SphK1 mediates TNF-alpha-induced MCP-1 gene expression through a p38 MAPK-dependent pathway and may participate in oscillatory flow-mediated proinflammatory signaling pathway in the vasculature.
    Source: GeneRIF:8877.

    This publication is mapped to 17 other entries.

  15. 15
    "Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells."
    Duan H.F., Wu C.T., Lu Y., Wang H., Liu H.J., Zhang Q.W., Jia X.X., Lu Z.Z., Wang L.S.
    Exp. Cell Res. 298:593-601(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: PI3K and ERK/MAPK mediated the activation of sphingosine kinase and would be involved in the HGF-induced migration of endothelial cells.
    Source: GeneRIF:8877.

    This publication is mapped to 4 other entries.

  16. 16
    "Anaphylatoxin signaling in human neutrophils. A key role for sphingosine kinase."
    Ibrahim F.B., Pang S.J., Melendez A.J.
    J. Biol. Chem. 279:44802-44811(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: SPHK plays an important role in the immune-inflammatory pathologies triggered by anaphylatoxins in human neutrophils.
    Source: GeneRIF:8877.

    This publication is mapped to 4 other entries.

  17. 17
    "Identification of genetic and epigenetic similarities of SPHK1/Sphk1 in mammals."
    Imamura T., Miyauchi-Senda N., Tanaka S., Shiota K.
    J. Vet. Med. Sci. 66:1387-1393(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Comparison of base sequence of SPHK1/Sphk1 in human mouse and rat.
    Source: GeneRIF:8877.

    This publication is mapped to 8 other entries.

  18. 18
    "Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members."
    Limaye V., Li X., Hahn C., Xia P., Berndt M.C., Vadas M.A., Gamble J.R.
    Blood 105:3169-3177(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: role for SK in the regulation of vascular phenomena that occur under conditions of stress.
    Source: GeneRIF:8877.

    This publication is mapped to 4 other entries.

  19. 19
    "Effect of a membrane-targeted sphingosine kinase 1 on cell proliferation and survival."
    Safadi-Chamberlain F., Wang L.P., Payne S.G., Lim C.U., Stratford S., Chavez J.A., Fox M.H., Spiegel S., Summers S.A.
    Biochem. J. 388:827-834(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: SK1 has marked effects on cell function with plasma membrane-associated SK having a potent inhibitory effect on the G1-S phase transition [SK1].
    Source: GeneRIF:8877.

    This publication is mapped to 4 other entries.

  20. 20
    "Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism."
    Taha T.A., Kitatani K., Bielawski J., Cho W., Hannun Y.A., Obeid L.M.
    J. Biol. Chem. 280:17196-17202(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: SK1 down-regulation by TNF is dependent on the lysosomal pathway of apoptosis and specifically on cathepsin B which functions as an SK1 protease in cells.
    Source: GeneRIF:8877.

    This publication is mapped to 13 other entries.

  21. 21
    "Sphingosine kinase 1 (SK1) is recruited to nascent phagosomes in human macrophages: inhibition of SK1 translocation by Mycobacterium tuberculosis."
    Thompson C.R., Iyer S.S., Melrose N., VanOosten R., Johnson K., Pitson S.M., Obeid L.M., Kusner D.J.
    J. Immunol. 174:3551-3561(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: model in which M.tuberc. inhibits both the activation and phagosomal translocation of sphingosine kinase 1 to block the localized Ca2+ transients required for phagosome maturation.
    Source: GeneRIF:8877.

    This publication is mapped to 4 other entries.

  22. 22
    "Sphingosine kinase activity and sphingosine-1 phosphate production in rat pancreatic islets and INS-1 cells: response to cytokines."
    Mastrandrea L.D., Sessanna S.M., Laychock S.G.
    Diabetes 54:1429-1436(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Expression, Sequences.
    Annotation: IL-1beta and TNF-alpha induced an early and sustained increase in SPHK activity in INS-1 cells and isolated islets.
    Source: GeneRIF:8877.

    This publication is mapped to 7 other entries.

  23. 23
    "Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators."
    Billich A., Bornancin F., Mechtcheriakova D., Natt F., Huesken D., Baumruker T.
    Cell. Signal. 17:1203-1217(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Findings demonstrate a role of SPHK1 activation in proinflammatory signalling and of SPHK1 basal activity in survival of A549 lung carcinoma cells.
    Source: GeneRIF:8877.

    This publication is mapped to 4 other entries.

  24. 24
    "Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells."
    Sarkar S., Maceyka M., Hait N.C., Paugh S.W., Sankala H., Milstien S., Spiegel S.
    FEBS Lett. 579:5313-5317(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: results suggest that SphK1 may be critical for growth metastasis and chemoresistance of human breast cancers.
    Source: GeneRIF:8877.

    This publication is mapped to 4 other entries.

  25. 25
    "The mechanism of membrane targeting of human sphingosine kinase 1."
    Stahelin R.V., Hwang J.H., Kim J.H., Park Z.Y., Johnson K.R., Obeid L.M., Cho W.
    J. Biol. Chem. 280:43030-43038(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: the specific plasma membrane localization and activation of SK1 is mediated largely by specific lipid-protein interactions.
    Source: GeneRIF:8877.

    This publication is mapped to 4 other entries.

1 to 25 of 217  Show
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