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Protein

DCN1-like protein 5

Gene

DCUN1D5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cullin family protein binding Source: GO_Central
  • ubiquitin conjugating enzyme binding Source: GO_Central
  • ubiquitin-like protein binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
DCN1-like protein 5
Alternative name(s):
DCUN1 domain-containing protein 5
Defective in cullin neddylation protein 1-like protein 5
Gene namesi
Name:DCUN1D5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000137692.11
HGNCiHGNC:28409 DCUN1D5
MIMi616522 gene
neXtProtiNX_Q9BTE7

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi84259
OpenTargetsiENSG00000137692
PharmGKBiPA142672011

Polymorphism and mutation databases

BioMutaiDCUN1D5
DMDMi74733117

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002541711 – 237DCN1-like protein 5Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Modified residuei41PhosphoserineCombined sources1
Modified residuei48PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BTE7
MaxQBiQ9BTE7
PaxDbiQ9BTE7
PeptideAtlasiQ9BTE7
PRIDEiQ9BTE7
ProteomicsDBi78988

PTM databases

iPTMnetiQ9BTE7
PhosphoSitePlusiQ9BTE7

Expressioni

Gene expression databases

BgeeiENSG00000137692 Expressed in 202 organ(s), highest expression level in secondary oocyte
CleanExiHS_DCUN1D5
ExpressionAtlasiQ9BTE7 baseline and differential
GenevisibleiQ9BTE7 HS

Organism-specific databases

HPAiHPA050863

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LNX1Q8TBB13EBI-3924013,EBI-739832

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123986, 39 interactors
IntActiQ9BTE7, 15 interactors
MINTiQ9BTE7
STRINGi9606.ENSP00000260247

Structurei

3D structure databases

ProteinModelPortaliQ9BTE7
SMRiQ9BTE7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 232DCUN1PROSITE-ProRule annotationAdd BLAST187

Phylogenomic databases

eggNOGiKOG3077 Eukaryota
ENOG410XTIJ LUCA
GeneTreeiENSGT00550000074529
HOGENOMiHOG000241761
HOVERGENiHBG106637
InParanoidiQ9BTE7
KOiK17824
OMAiQKRCLTW
OrthoDBiEOG091G0L81
PhylomeDBiQ9BTE7
TreeFamiTF354270

Family and domain databases

InterProiView protein in InterPro
IPR014764 DCN-prot
IPR005176 PONY_dom
PANTHERiPTHR12281 PTHR12281, 1 hit
PfamiView protein in Pfam
PF03556 Cullin_binding, 1 hit
PROSITEiView protein in PROSITE
PS51229 DCUN1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q9BTE7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVKKKRKSP GVAAAVAEDG GLKKCKISSY CRSQPPARLI SGEEHFSSKK
60 70 80 90 100
CLAWFYEYAG PDEVVGPEGM EKFCEDIGVE PENIIMLVLA WKLEAESMGF
110 120 130 140 150
FTKEEWLKGM TSLQCDCTEK LQNKFDFLRS QLNDISSFKN IYRYAFDFAR
160 170 180 190 200
DKDQRSLDID TAKSMLALLL GRTWPLFSVF YQYLEQSKYR VMNKDQWYNV
210 220 230
LEFSRTVHAD LSNYDEDGAW PVLLDEFVEW QKVRQTS
Length:237
Mass (Da):27,508
Last modified:June 1, 2001 - v1
Checksum:i4F507B6E5D81EF79
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCN4H0YCN4_HUMAN
DCN1-like protein
DCUN1D5
195Annotation score:
E9PM04E9PM04_HUMAN
DCN1-like protein
DCUN1D5
152Annotation score:
E9PQV9E9PQV9_HUMAN
DCN1-like protein
DCUN1D5
84Annotation score:
J3QQL8J3QQL8_HUMAN
DCN1-like protein
DCUN1D5
42Annotation score:
H0YD80H0YD80_HUMAN
DCN1-like protein 5
DCUN1D5
68Annotation score:
E9PLH8E9PLH8_HUMAN
DCN1-like protein 5
DCUN1D5
30Annotation score:
E9PM78E9PM78_HUMAN
DCN1-like protein 5
DCUN1D5
67Annotation score:
E9PLS2E9PLS2_HUMAN
DCN1-like protein 5
DCUN1D5
71Annotation score:

Sequence cautioni

The sequence AAQ76805 differs from that shown. Reason: Frameshift at positions 222 and 232.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti227F → L in AAQ76805 (PubMed:16533400).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056993 mRNA Translation: BAB71336.1
BC004169 mRNA Translation: AAH04169.1
AY364246 mRNA Translation: AAQ76805.1 Frameshift.
CCDSiCCDS8325.1
RefSeqiNP_115675.1, NM_032299.3
UniGeneiHs.503716

Genome annotation databases

EnsembliENST00000260247; ENSP00000260247; ENSG00000137692
GeneIDi84259
KEGGihsa:84259
UCSCiuc001phm.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056993 mRNA Translation: BAB71336.1
BC004169 mRNA Translation: AAH04169.1
AY364246 mRNA Translation: AAQ76805.1 Frameshift.
CCDSiCCDS8325.1
RefSeqiNP_115675.1, NM_032299.3
UniGeneiHs.503716

3D structure databases

ProteinModelPortaliQ9BTE7
SMRiQ9BTE7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123986, 39 interactors
IntActiQ9BTE7, 15 interactors
MINTiQ9BTE7
STRINGi9606.ENSP00000260247

PTM databases

iPTMnetiQ9BTE7
PhosphoSitePlusiQ9BTE7

Polymorphism and mutation databases

BioMutaiDCUN1D5
DMDMi74733117

Proteomic databases

EPDiQ9BTE7
MaxQBiQ9BTE7
PaxDbiQ9BTE7
PeptideAtlasiQ9BTE7
PRIDEiQ9BTE7
ProteomicsDBi78988

Protocols and materials databases

DNASUi84259
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260247; ENSP00000260247; ENSG00000137692
GeneIDi84259
KEGGihsa:84259
UCSCiuc001phm.4 human

Organism-specific databases

CTDi84259
DisGeNETi84259
EuPathDBiHostDB:ENSG00000137692.11
GeneCardsiDCUN1D5
HGNCiHGNC:28409 DCUN1D5
HPAiHPA050863
MIMi616522 gene
neXtProtiNX_Q9BTE7
OpenTargetsiENSG00000137692
PharmGKBiPA142672011
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3077 Eukaryota
ENOG410XTIJ LUCA
GeneTreeiENSGT00550000074529
HOGENOMiHOG000241761
HOVERGENiHBG106637
InParanoidiQ9BTE7
KOiK17824
OMAiQKRCLTW
OrthoDBiEOG091G0L81
PhylomeDBiQ9BTE7
TreeFamiTF354270

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation

Miscellaneous databases

GenomeRNAii84259
PROiPR:Q9BTE7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137692 Expressed in 202 organ(s), highest expression level in secondary oocyte
CleanExiHS_DCUN1D5
ExpressionAtlasiQ9BTE7 baseline and differential
GenevisibleiQ9BTE7 HS

Family and domain databases

InterProiView protein in InterPro
IPR014764 DCN-prot
IPR005176 PONY_dom
PANTHERiPTHR12281 PTHR12281, 1 hit
PfamiView protein in Pfam
PF03556 Cullin_binding, 1 hit
PROSITEiView protein in PROSITE
PS51229 DCUN1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDCNL5_HUMAN
AccessioniPrimary (citable) accession number: Q9BTE7
Secondary accession number(s): Q3ZTT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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