Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 139 (02 Jun 2021)
Sequence version 1 (01 Jun 2001)
Previous versions | rss
Add a publicationFeedback
Protein

DCN1-like protein 5

Gene

DCUN1D5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contributes to the neddylation of all cullins by transfering NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs) (PubMed:26906416, PubMed:23201271, PubMed:19617556).

May play a role in DNA damage response and may participate to cell proliferation and anchorage-independent cell growth (PubMed:23098533, PubMed:24192928).

5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.3.2.32, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9BTE7

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8951664, Neddylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DCN1-like protein 5Curated
Short name:
DCNL51 Publication
Alternative name(s):
DCUN1 domain-containing protein 5
Defective in cullin neddylation protein 1-like protein 5
Squamous cell carcinoma-related oncogene 51 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCUN1D5Imported
Synonyms:SCCRO51 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28409, DCUN1D5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616522, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BTE7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000137692.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi5 – 8KKRK → AAAA: Affects nucleus localization. 1 Publication4
Mutagenesisi195D → A: Loss of interaction with CUL1, CUL2, CUL3, CUL4A, CUL5, CAND1 and RBX1; when associated with R-219 and A-225. Does not affect localization at nucleus; when associated with R-219 and A-225. 1 Publication1
Mutagenesisi195D → N: Loss of interaction with RBX1, CUL1 and CAND1. 1 Publication1
Mutagenesisi219A → R: Loss of interaction with RBX1, CUL1 and CAND1. Loss of interaction with CUL1, CUL2, CUL3, CUL4A, CUL5, CAND1 and RBX1; when associated with A-195 and A-225. Does not affect localization at nucleus; when associated with A-195 and A-225. 2 Publications1
Mutagenesisi225D → A: Loss of interaction with CUL1, CUL2, CUL3, CUL4A, CUL5, CAND1 and RBX1; when associated with A-195 and R-219. Does not affect localization at nucleus; when associated with A-195 and R-219. 1 Publication1
Mutagenesisi225D → N: Loss of interaction with RBX1, CUL1, CUL2, CUL3 and CAND1. Does not affect interaction with UBE2M and NEDD8. Fails to augment Cul3 neddylation beyond basal levels. 1 Publication1
Mutagenesisi226E → A: Loss of interaction with RBX1, CUL1, CUL2, CUL3 and CAND1. Does not affect interaction with UBE2M and NEDD8. Fails to augment Cul3 neddylation beyond basal levels. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
84259

Open Targets

More...
OpenTargetsi
ENSG00000137692

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672011

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BTE7, Tdark

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4295937

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DCUN1D5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74733117

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002541711 – 237DCN1-like protein 5Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei9PhosphoserineCombined sources1
Modified residuei41PhosphoserineCombined sources1 Publication1
Modified residuei48PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-41 is independent of cullin's interaction and neddylation. Phosphorylated in response to both TICAM1 and MYD88 dependent Toll-like receptor (TLR) pathway activation (By similarity). Phosphorylated in response to IL1B stimulation (PubMed:29958295).By similarity1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BTE7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BTE7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BTE7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BTE7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BTE7

PeptideAtlas

More...
PeptideAtlasi
Q9BTE7

PRoteomics IDEntifications database

More...
PRIDEi
Q9BTE7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78988

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BTE7

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9BTE7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BTE7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Weakly expressed in testis, skin and immune tissues (thymus, spleen and lymph nodes).1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is decreased in a time-dependent manner after UVC exposure.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137692, Expressed in secondary oocyte and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BTE7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BTE7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000137692, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a complex that contains DCUN1D5, CUL1 and RBX1; this interaction is bridged by CUL1 (PubMed:24192928, PubMed:26906416).

Interacts (via the DCUN1 domain) with the unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5; these interactions promote the cullin neddylation and the identity of the cullin dictates the affinity of the interaction (PubMed:24192928, PubMed:26906416, PubMed:23201271).

Interacts (via DCUN1 domain) with UBE2M (N-terminally acetylated form) and probably with UBE2F (N-terminally acetylated form) (PubMed:24192928, PubMed:23201271). May also interact with regulators or subunits of cullin-RING ligases such as RBX1, RNF7, ELOB and DDB1; these interactions are bridged by cullins (PubMed:26906416).

Interacts with CAND1; this interaction is bridged by cullins and strongly inhibits the neddylation of cullins. These CAND-cullin-DCNL complexes can only be neddylated in the presence of a substrate adapter (PubMed:24192928, PubMed:26906416).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123986, 50 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BTE7, 26 interactors

Molecular INTeraction database

More...
MINTi
Q9BTE7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000260247

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9BTE7

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BTE7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BTE7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 232DCUN1PROSITE-ProRule annotationAdd BLAST187

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DCUN1 domain, also known as PONY domain, mediates the interaction with different cullins (PubMed:23201271, PubMed:24192928). The DCUN1 domain mediates the interaction with the N-terminally acetylated NEDD8-conjugating E2s enzyme leading to the NEDD8 transfer from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes; the neddylation efficiency correlates with the DCUN1D5-cullin and DCUN1D5-E2 interaction affinities (PubMed:23201271).2 Publications

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3077, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156155

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_047042_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BTE7

Identification of Orthologs from Complete Genome Data

More...
OMAi
YKMNARQ

Database of Orthologous Groups

More...
OrthoDBi
1418097at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BTE7

TreeFam database of animal gene trees

More...
TreeFami
TF354270

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.238.200, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014764, DCN-prot
IPR042460, DCN1-like_PONY
IPR005176, PONY_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12281, PTHR12281, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03556, Cullin_binding, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51229, DCUN1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q9BTE7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVKKKRKSP GVAAAVAEDG GLKKCKISSY CRSQPPARLI SGEEHFSSKK
60 70 80 90 100
CLAWFYEYAG PDEVVGPEGM EKFCEDIGVE PENIIMLVLA WKLEAESMGF
110 120 130 140 150
FTKEEWLKGM TSLQCDCTEK LQNKFDFLRS QLNDISSFKN IYRYAFDFAR
160 170 180 190 200
DKDQRSLDID TAKSMLALLL GRTWPLFSVF YQYLEQSKYR VMNKDQWYNV
210 220 230
LEFSRTVHAD LSNYDEDGAW PVLLDEFVEW QKVRQTS
Length:237
Mass (Da):27,508
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F507B6E5D81EF79
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCN4H0YCN4_HUMAN
DCN1-like protein
DCUN1D5
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PM04E9PM04_HUMAN
DCN1-like protein
DCUN1D5
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQV9E9PQV9_HUMAN
DCN1-like protein
DCUN1D5
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQL8J3QQL8_HUMAN
DCN1-like protein
DCUN1D5
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLH8E9PLH8_HUMAN
DCN1-like protein 5
DCUN1D5
30Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLS2E9PLS2_HUMAN
DCN1-like protein 5
DCUN1D5
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PM78E9PM78_HUMAN
DCN1-like protein 5
DCUN1D5
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YD80H0YD80_HUMAN
DCN1-like protein 5
DCUN1D5
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ76805 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti227F → L in AAQ76805 (PubMed:16533400).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK056993 mRNA Translation: BAB71336.1
BC004169 mRNA Translation: AAH04169.1
AY364246 mRNA Translation: AAQ76805.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8325.1

NCBI Reference Sequences

More...
RefSeqi
NP_115675.1, NM_032299.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000260247; ENSP00000260247; ENSG00000137692

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84259

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84259

UCSC genome browser

More...
UCSCi
uc001phm.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056993 mRNA Translation: BAB71336.1
BC004169 mRNA Translation: AAH04169.1
AY364246 mRNA Translation: AAQ76805.1 Frameshift.
CCDSiCCDS8325.1
RefSeqiNP_115675.1, NM_032299.3

3D structure databases

SMRiQ9BTE7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123986, 50 interactors
IntActiQ9BTE7, 26 interactors
MINTiQ9BTE7
STRINGi9606.ENSP00000260247

Chemistry databases

BindingDBiQ9BTE7
ChEMBLiCHEMBL4295937

PTM databases

iPTMnetiQ9BTE7
MetOSiteiQ9BTE7
PhosphoSitePlusiQ9BTE7

Genetic variation databases

BioMutaiDCUN1D5
DMDMi74733117

Proteomic databases

EPDiQ9BTE7
jPOSTiQ9BTE7
MassIVEiQ9BTE7
MaxQBiQ9BTE7
PaxDbiQ9BTE7
PeptideAtlasiQ9BTE7
PRIDEiQ9BTE7
ProteomicsDBi78988

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
45452, 27 antibodies

The DNASU plasmid repository

More...
DNASUi
84259

Genome annotation databases

EnsembliENST00000260247; ENSP00000260247; ENSG00000137692
GeneIDi84259
KEGGihsa:84259
UCSCiuc001phm.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84259
DisGeNETi84259

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DCUN1D5
HGNCiHGNC:28409, DCUN1D5
HPAiENSG00000137692, Low tissue specificity
MIMi616522, gene
neXtProtiNX_Q9BTE7
OpenTargetsiENSG00000137692
PharmGKBiPA142672011
VEuPathDBiHostDB:ENSG00000137692.11

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3077, Eukaryota
GeneTreeiENSGT00940000156155
HOGENOMiCLU_047042_3_1_1
InParanoidiQ9BTE7
OMAiYKMNARQ
OrthoDBi1418097at2759
PhylomeDBiQ9BTE7
TreeFamiTF354270

Enzyme and pathway databases

BRENDAi2.3.2.32, 2681
PathwayCommonsiQ9BTE7
ReactomeiR-HSA-8951664, Neddylation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
84259, 13 hits in 995 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DCUN1D5, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84259
PharosiQ9BTE7, Tdark

Protein Ontology

More...
PROi
PR:Q9BTE7
RNActiQ9BTE7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137692, Expressed in secondary oocyte and 217 other tissues
ExpressionAtlasiQ9BTE7, baseline and differential
GenevisibleiQ9BTE7, HS

Family and domain databases

Gene3Di1.10.238.200, 1 hit
InterProiView protein in InterPro
IPR014764, DCN-prot
IPR042460, DCN1-like_PONY
IPR005176, PONY_dom
PANTHERiPTHR12281, PTHR12281, 1 hit
PfamiView protein in Pfam
PF03556, Cullin_binding, 1 hit
PROSITEiView protein in PROSITE
PS51229, DCUN1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCNL5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BTE7
Secondary accession number(s): Q3ZTT2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2001
Last modified: June 2, 2021
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again