Alanyl-tRNA editing protein Aarsd1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• alanine-tRNA ligase activity Source: InterPro
• ATP binding Source: InterPro
• metal ion binding Source: UniProtKB-KW
• nucleic acid binding Source: InterPro
• Ser-tRNA(Ala) hydrolase activity Source: Ensembl

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• alanyl-tRNA aminoacylation Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MAFWCQRDSY AREFTTTVVS CCPAELQTEG SNGKKEVLSG FQVVLEDTVL 
        60         70         80         90        100
FPEGGGQPDD RGTINDISVL RVTRRGEQAD HFTQTPLDPG SQVLVRVDWE 
       110        120        130        140        150
RRFDHMQQHS GQHLITAVAD HLFKLKTTSW ELGRFRSAIE LDTPSMTAEQ 
       160        170        180        190        200
VAAIEQSVNE KIRDRLPVNV RELSLDDPEV EQVSGRGLPD DHAGPIRVVN 
       210        220        230        240        250
IEGVDSNMCC GTHVSNLSDL QVIKILGTEK GKKNRTNLIF LSGNRVLKWM 
       260        270        280        290        300
ERSHGTEKAL TALLKCGAED HVEAVKKLQN STKILQKNNL NLLRDLAVHI 
       310        320        330        340        350
AHSLRNSPDW GGVVILHRKE GDSEFMNIIA NEIGSEETLL FLTVGDEKGG 
       360        370        380        390        400
GLFLLAGPPA SVETLGPRVA EVLEGKGAGK KGRFQGKATK MSRRMEAQAL 
       410 
LQDYISTQSA KE                                          

        10         20         30         40         50
MEFCVEDSTD VHVLIEDHRI VFSCKNADGV ELYNEIEFYA KVNSKDSQDK 
        60         70         80         90        100
RSSRSITCFV RKWKEKVAWP RLTKEDIKPV WLSVDFDNWR DWEGDEEMEL 
       110        120        130        140        150
AHVEHYAELL KKVSTKRPPP AMDDLDFTTT VVSCCPAELQ TEGSNGKKEV 
       160        170        180        190        200
LSGFQVVLED TVLFPEGGGQ PDDRGTINDI SVLRVTRRGE QADHFTQTPL 
       210        220        230        240        250
DPGSQVLVRV DWERRFDHMQ QHSGQHLITA VADHLFKLKT TSWELGRFRS 
       260        270        280        290        300
AIELDTPSMT AEQVAAIEQS VNEKIRDRLP VNVRELSLDD PEVEQVSGRG 
       310        320        330        340        350
LPDDHAGPIR VVNIEGVDSN MCCGTHVSNL SDLQVIKILG TEKGKKNRTN 
       360        370        380        390        400
LIFLSGNRVL KWMERSHGTE KALTALLKCG AEDHVEAVKK LQNSTKILQK 
       410        420        430        440        450
NNLNLLRDLA VHIAHSLRNS PDWGGVVILH RKEGDSEFMN IIANEIGSEE 
       460        470        480        490        500
TLLFLTVGDE KGGGLFLLAG PPASVETLGP RVAEVLEGKG AGKKGRFQGK 
       510        520 
ATKMSRRMEA QALLQDYIST QSAKE                            

        10         20         30         40         50
MFSLPLNCSP DHIRRGSCWG RPQDLKIAAP AWNSKCHPGA GAAMARQHAR 
        60         70         80         90        100
TLWYDRPRYV FMEFCVEDST DVHVLIEDHR IVFSCKNADG VELYNEIEFY 
       110        120        130        140        150
AKVNSKDSQD KRSSRSITCF VRKWKEKVAW PRLTKEDIKP VWLSVDFDNW 
       160        170        180        190        200
RDWEGDEEME LAHVEHYAEL LKKVSTKRPP PAMDDLDFTT TVVSCCPAEL 
       210        220        230        240        250
QTEGSNGKKE VLSGFQVVLE DTVLFPEGGG QPDDRGTIND ISVLRVTRRG 
       260        270        280        290        300
EQADHFTQTP LDPGSQVLVR VDWERRFDHM QQHSGQHLIT AVADHLFKLK 
       310        320        330        340        350
TTSWELGRFR SAIELDTPSM TAEQVAAIEQ SVNEKIRDRL PVNVRELSLD 
       360        370        380        390        400
DPEVEQVSGR GLPDDHAGPI RVVNIEGVDS NMCCGTHVSN LSDLQVIKIL 
       410        420        430        440        450
GTEKGKKNRT NLIFLSGNRV LKWMERSHGT EKALTALLKC GAEDHVEAVK 
       460        470        480        490        500
KLQNSTKILQ KNNLNLLRDL AVHIAHSLRN SPDWGGVVIL HRKEGDSEFM 
       510        520        530        540        550
NIIANEIGSE ETLLFLTVGD EKGGGLFLLA GPPASVETLG PRVAEVLEGK 
       560        570        580 
GAGKKGRFQG KATKMSRRME AQALLQDYIS TQSAKE                

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 17
   Human chromosome 17: entries, gene names and cross-references to MIM
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. SIMILARITY comments
   Index of protein domains and families