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UniProtKB - Q9BTE6 (AASD1_HUMAN)

Entry version 158 (12 Aug 2020)
Sequence version 2 (06 Feb 2007)
Previous versions | rss
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Protein

Alanyl-tRNA editing protein Aarsd1

Gene

AARSD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala).By similarity

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi109ZincSequence analysis1
Metal bindingi113ZincSequence analysis1
Metal bindingi209ZincSequence analysis1
Metal bindingi213ZincSequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein biosynthesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BTE6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alanyl-tRNA editing protein Aarsd1
Alternative name(s):
Alanyl-tRNA synthetase domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AARSD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000108825.17
HostDB:ENSG00000266967.6

Human Gene Nomenclature Database

More...HGNCi		HGNC:28417, AARSD1
HGNC:43946, PTGES3L-AARSD1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613212, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BTE6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000108825
ENSG00000266967

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142670464

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BTE6, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AARSD1

Domain mapping of disease mutations (DMDM)

More...DMDMi		125987702

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002774651 – 412Alanyl-tRNA editing protein Aarsd1Add BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei174PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BTE6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BTE6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BTE6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BTE6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BTE6

PeptideAtlas

More...PeptideAtlasi		Q9BTE6

PRoteomics IDEntifications database

More...PRIDEi		Q9BTE6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78985 [Q9BTE6-1]
78986 [Q9BTE6-2]
78987 [Q9BTE6-3]

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00827636

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BTE6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BTE6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000108825, Expressed in testis and 110 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BTE6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BTE6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000108825, Tissue enhanced (skeletal)
ENSG00000266967, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123290, 101 interactors
3190353, 7 interactors

Protein interaction database and analysis system

More...IntActi		Q9BTE6, 166 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000400870

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BTE6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BTE6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2105, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156241

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004485_7_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BTE6

KEGG Orthology (KO)

More...KOi		K07050

Identification of Orthologs from Complete Genome Data

More...OMAi		DREFKYD

Database of Orthologous Groups

More...OrthoDBi		910848at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BTE6

TreeFam database of animal gene trees

More...TreeFami		TF323735

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018165, Ala-tRNA-synth_IIc_core
IPR018163, Thr/Ala-tRNA-synth_IIc_edit
IPR009000, Transl_B-barrel_sf
IPR012947, tRNA_SAD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07973, tRNA_SAD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00863, tRNA_SAD, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50447, SSF50447, 1 hit
SSF55186, SSF55186, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50860, AA_TRNA_LIGASE_II_ALA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BTE6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFWCQRDSY AREFTTTVVS CCPAELQTEG SNGKKEVLSG FQVVLEDTVL 
        60         70         80         90        100
FPEGGGQPDD RGTINDISVL RVTRRGEQAD HFTQTPLDPG SQVLVRVDWE 
       110        120        130        140        150
RRFDHMQQHS GQHLITAVAD HLFKLKTTSW ELGRFRSAIE LDTPSMTAEQ 
       160        170        180        190        200
VAAIEQSVNE KIRDRLPVNV RELSLDDPEV EQVSGRGLPD DHAGPIRVVN 
       210        220        230        240        250
IEGVDSNMCC GTHVSNLSDL QVIKILGTEK GKKNRTNLIF LSGNRVLKWM 
       260        270        280        290        300
ERSHGTEKAL TALLKCGAED HVEAVKKLQN STKILQKNNL NLLRDLAVHI 
       310        320        330        340        350
AHSLRNSPDW GGVVILHRKE GDSEFMNIIA NEIGSEETLL FLTVGDEKGG 
       360        370        380        390        400
GLFLLAGPPA SVETLGPRVA EVLEGKGAGK KGRFQGKATK MSRRMEAQAL 
       410 
LQDYISTQSA KE
Length:412
Mass (Da):45,480
Last modified:February 6, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E14B6274C6EF897
GO
Isoform 2 (identifier: Q9BTE6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MAFWCQRDSYARE → MEFCVEDSTD...RPPPAMDDLD

Note: Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein.Curated
Show »
Length:525
Mass (Da):58,753
Checksum:i04F376DFD308BC68
GO
Isoform 3 (identifier: Q9BTE6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MAFWCQRDSYARE → MFSLPLNCSP...RPPPAMDDLD

Note: Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein.Curated
Show »
Length:586
Mass (Da):65,702
Checksum:iBA9D4A890AA69180
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J5N1C9J5N1_HUMAN
PTGES3L-AARSD1 readthrough
PTGES3L-AARSD1
495Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
L7N2F4L7N2F4_HUMAN
Alanyl-tRNA-editing protein Aarsd1
AARSD1
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JUA3C9JUA3_HUMAN
PTGES3L-AARSD1 readthrough
PTGES3L-AARSD1
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7N799K7N799_HUMAN
Alanyl-tRNA-editing protein Aarsd1
AARSD1
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C054H7C054_HUMAN
PTGES3L-AARSD1 readthrough
PTGES3L-AARSD1
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
L7N2F6L7N2F6_HUMAN
PTGES3L-AARSD1 readthrough
PTGES3L-AARSD1
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
L7N2F5L7N2F5_HUMAN
Alanyl-tRNA-editing protein Aarsd1
AARSD1
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1K1H7C1K1_HUMAN
Alanyl-tRNA-editing protein Aarsd1
AARSD1
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQ85K7EQ85_HUMAN
Alanyl-tRNA-editing protein Aarsd1
AARSD1
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0230141 – 13MAFWC…SYARE → MEFCVEDSTDVHVLIEDHRI VFSCKNADGVELYNEIEFYA KVNSKDSQDKRSSRSITCFV RKWKEKVAWPRLTKEDIKPV WLSVDFDNWRDWEGDEEMEL AHVEHYAELLKKVSTKRPPP AMDDLD in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_0431421 – 13MAFWC…SYARE → MFSLPLNCSPDHIRRGSCWG RPQDLKIAAPAWNSKCHPGA GAAMARQHARTLWYDRPRYV FMEFCVEDSTDVHVLIEDHR IVFSCKNADGVELYNEIEFY AKVNSKDSQDKRSSRSITCF VRKWKEKVAWPRLTKEDIKP VWLSVDFDNWRDWEGDEEME LAHVEHYAELLKKVSTKRPP PAMDDLD in isoform 3. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK295447 mRNA Translation: BAG58385.1
CR608238 mRNA No translation available.
AC055866 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60903.1
BC004172 mRNA Translation: AAH04172.1
BC019324 mRNA Translation: AAH19324.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS58552.1 [Q9BTE6-1]

NCBI Reference Sequences

More...RefSeqi		NP_001129514.2, NM_001136042.2 [Q9BTE6-3]
NP_001248363.1, NM_001261434.1 [Q9BTE6-1]
NP_079543.1, NM_025267.3 [Q9BTE6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000360221; ENSP00000353355; ENSG00000108825 [Q9BTE6-2]
ENST00000409399; ENSP00000386621; ENSG00000108825 [Q9BTE6-3]
ENST00000421990; ENSP00000409924; ENSG00000108825 [Q9BTE6-3]
ENST00000427569; ENSP00000400870; ENSG00000266967 [Q9BTE6-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100885850
80755

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:100885850
hsa:80755

UCSC genome browser

More...UCSCi		uc002icd.3, human [Q9BTE6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295447 mRNA Translation: BAG58385.1
CR608238 mRNA No translation available.
AC055866 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60903.1
BC004172 mRNA Translation: AAH04172.1
BC019324 mRNA Translation: AAH19324.1
CCDSiCCDS58552.1 [Q9BTE6-1]
RefSeqiNP_001129514.2, NM_001136042.2 [Q9BTE6-3]
NP_001248363.1, NM_001261434.1 [Q9BTE6-1]
NP_079543.1, NM_025267.3 [Q9BTE6-2]

3D structure databases

SMRiQ9BTE6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123290, 101 interactors
3190353, 7 interactors
IntActiQ9BTE6, 166 interactors
STRINGi9606.ENSP00000400870

PTM databases

iPTMnetiQ9BTE6
PhosphoSitePlusiQ9BTE6

Polymorphism and mutation databases

BioMutaiAARSD1
DMDMi125987702

2D gel databases

REPRODUCTION-2DPAGEiIPI00827636

Proteomic databases

EPDiQ9BTE6
jPOSTiQ9BTE6
MassIVEiQ9BTE6
MaxQBiQ9BTE6
PaxDbiQ9BTE6
PeptideAtlasiQ9BTE6
PRIDEiQ9BTE6
ProteomicsDBi78985 [Q9BTE6-1]
78986 [Q9BTE6-2]
78987 [Q9BTE6-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17173, 78 antibodies
67174, 177 antibodies

The DNASU plasmid repository

More...DNASUi		80755

Genome annotation databases

EnsembliENST00000360221; ENSP00000353355; ENSG00000108825 [Q9BTE6-2]
ENST00000409399; ENSP00000386621; ENSG00000108825 [Q9BTE6-3]
ENST00000421990; ENSP00000409924; ENSG00000108825 [Q9BTE6-3]
ENST00000427569; ENSP00000400870; ENSG00000266967 [Q9BTE6-1]
GeneIDi100885850
80755
KEGGihsa:100885850
hsa:80755
UCSCiuc002icd.3, human [Q9BTE6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		100885850
80755
EuPathDBiHostDB:ENSG00000108825.17
HostDB:ENSG00000266967.6

GeneCards: human genes, protein and diseases

More...GeneCardsi		AARSD1
PTGES3L-AARSD1
HGNCiHGNC:28417, AARSD1
HGNC:43946, PTGES3L-AARSD1
HPAiENSG00000108825, Tissue enhanced (skeletal)
ENSG00000266967, Low tissue specificity
MIMi613212, gene
neXtProtiNX_Q9BTE6
OpenTargetsiENSG00000108825
ENSG00000266967
PharmGKBiPA142670464

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2105, Eukaryota
GeneTreeiENSGT00940000156241
HOGENOMiCLU_004485_7_0_1
InParanoidiQ9BTE6
KOiK07050
OMAiDREFKYD
OrthoDBi910848at2759
PhylomeDBiQ9BTE6
TreeFamiTF323735

Enzyme and pathway databases

PathwayCommonsiQ9BTE6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		100885850, 14 hits in 839 CRISPR screens
80755, 8 hits in 868 CRISPR screens
PharosiQ9BTE6, Tdark

Protein Ontology

More...PROi		PR:Q9BTE6
RNActiQ9BTE6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000108825, Expressed in testis and 110 other tissues
ExpressionAtlasiQ9BTE6, baseline and differential
GenevisibleiQ9BTE6, HS

Family and domain databases

InterProiView protein in InterPro
IPR018165, Ala-tRNA-synth_IIc_core
IPR018163, Thr/Ala-tRNA-synth_IIc_edit
IPR009000, Transl_B-barrel_sf
IPR012947, tRNA_SAD
PfamiView protein in Pfam
PF07973, tRNA_SAD, 1 hit
SMARTiView protein in SMART
SM00863, tRNA_SAD, 1 hit
SUPFAMiSSF50447, SSF50447, 1 hit
SSF55186, SSF55186, 1 hit
PROSITEiView protein in PROSITE
PS50860, AA_TRNA_LIGASE_II_ALA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAASD1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BTE6
Secondary accession number(s): B4DI73
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: August 12, 2020
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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