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Protein

Alanyl-tRNA editing protein Aarsd1

Gene

AARSD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala).By similarity

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi109ZincSequence analysis1
Metal bindingi113ZincSequence analysis1
Metal bindingi209ZincSequence analysis1
Metal bindingi213ZincSequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein biosynthesis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alanyl-tRNA editing protein Aarsd1
Alternative name(s):
Alanyl-tRNA synthetase domain-containing protein 1
Gene namesi
Name:AARSD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108825.17
HostDB:ENSG00000266967.6
HGNCiHGNC:28417 AARSD1
HGNC:43946 PTGES3L-AARSD1
MIMi613212 gene
neXtProtiNX_Q9BTE6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000108825
ENSG00000266967
PharmGKBiPA142670464

Polymorphism and mutation databases

BioMutaiAARSD1
DMDMi125987702

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002774651 – 412Alanyl-tRNA editing protein Aarsd1Add BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BTE6
MaxQBiQ9BTE6
PaxDbiQ9BTE6
PeptideAtlasiQ9BTE6
PRIDEiQ9BTE6
ProteomicsDBi78985
78986 [Q9BTE6-2]
78987 [Q9BTE6-3]

2D gel databases

REPRODUCTION-2DPAGEiIPI00827636

PTM databases

iPTMnetiQ9BTE6
PhosphoSitePlusiQ9BTE6

Expressioni

Gene expression databases

BgeeiENSG00000108825
CleanExiHS_AARSD1
ExpressionAtlasiQ9BTE6 baseline and differential
GenevisibleiQ9BTE6 HS

Organism-specific databases

HPAiHPA021408
HPA022869
HPA023714

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Q96BE02EBI-9357295,EBI-9356686

Protein-protein interaction databases

BioGridi123290, 97 interactors
3190353, 7 interactors
IntActiQ9BTE6, 125 interactors
STRINGi9606.ENSP00000386621

Structurei

3D structure databases

ProteinModelPortaliQ9BTE6
SMRiQ9BTE6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2105 Eukaryota
KOG3158 Eukaryota
COG2872 LUCA
GeneTreeiENSGT00510000046493
HOGENOMiHOG000230967
HOVERGENiHBG080017
InParanoidiQ9BTE6
KOiK07050
OMAiDREFKYD
OrthoDBiEOG091G0K2Q
PhylomeDBiQ9BTE6
TreeFamiTF323735

Family and domain databases

InterProiView protein in InterPro
IPR018165 Ala-tRNA-synth_IIc_core
IPR018164 Ala-tRNA-synth_IIc_N
IPR018163 Thr/Ala-tRNA-synth_IIc_edit
IPR009000 Transl_B-barrel_sf
IPR012947 tRNA_SAD
PfamiView protein in Pfam
PF01411 tRNA-synt_2c, 1 hit
PF07973 tRNA_SAD, 1 hit
SMARTiView protein in SMART
SM00863 tRNA_SAD, 1 hit
SUPFAMiSSF50447 SSF50447, 1 hit
SSF55186 SSF55186, 1 hit
PROSITEiView protein in PROSITE
PS50860 AA_TRNA_LIGASE_II_ALA, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BTE6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFWCQRDSY AREFTTTVVS CCPAELQTEG SNGKKEVLSG FQVVLEDTVL
60 70 80 90 100
FPEGGGQPDD RGTINDISVL RVTRRGEQAD HFTQTPLDPG SQVLVRVDWE
110 120 130 140 150
RRFDHMQQHS GQHLITAVAD HLFKLKTTSW ELGRFRSAIE LDTPSMTAEQ
160 170 180 190 200
VAAIEQSVNE KIRDRLPVNV RELSLDDPEV EQVSGRGLPD DHAGPIRVVN
210 220 230 240 250
IEGVDSNMCC GTHVSNLSDL QVIKILGTEK GKKNRTNLIF LSGNRVLKWM
260 270 280 290 300
ERSHGTEKAL TALLKCGAED HVEAVKKLQN STKILQKNNL NLLRDLAVHI
310 320 330 340 350
AHSLRNSPDW GGVVILHRKE GDSEFMNIIA NEIGSEETLL FLTVGDEKGG
360 370 380 390 400
GLFLLAGPPA SVETLGPRVA EVLEGKGAGK KGRFQGKATK MSRRMEAQAL
410
LQDYISTQSA KE
Length:412
Mass (Da):45,480
Last modified:February 6, 2007 - v2
Checksum:i2E14B6274C6EF897
GO
Isoform 2 (identifier: Q9BTE6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MAFWCQRDSYARE → MEFCVEDSTD...RPPPAMDDLD

Note: Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available.
Show »
Length:525
Mass (Da):58,753
Checksum:i04F376DFD308BC68
GO
Isoform 3 (identifier: Q9BTE6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MAFWCQRDSYARE → MFSLPLNCSP...RPPPAMDDLD

Note: Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available.
Show »
Length:586
Mass (Da):65,702
Checksum:iBA9D4A890AA69180
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0230141 – 13MAFWC…SYARE → MEFCVEDSTDVHVLIEDHRI VFSCKNADGVELYNEIEFYA KVNSKDSQDKRSSRSITCFV RKWKEKVAWPRLTKEDIKPV WLSVDFDNWRDWEGDEEMEL AHVEHYAELLKKVSTKRPPP AMDDLD in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_0431421 – 13MAFWC…SYARE → MFSLPLNCSPDHIRRGSCWG RPQDLKIAAPAWNSKCHPGA GAAMARQHARTLWYDRPRYV FMEFCVEDSTDVHVLIEDHR IVFSCKNADGVELYNEIEFY AKVNSKDSQDKRSSRSITCF VRKWKEKVAWPRLTKEDIKP VWLSVDFDNWRDWEGDEEME LAHVEHYAELLKKVSTKRPP PAMDDLD in isoform 3. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295447 mRNA Translation: BAG58385.1
CR608238 mRNA No translation available.
AC055866 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60903.1
BC004172 mRNA Translation: AAH04172.1
BC019324 mRNA Translation: AAH19324.1
CCDSiCCDS58552.1 [Q9BTE6-1]
RefSeqiNP_001129514.2, NM_001136042.2 [Q9BTE6-3]
NP_001248363.1, NM_001261434.1 [Q9BTE6-1]
NP_079543.1, NM_025267.3 [Q9BTE6-2]
UniGeneiHs.317403

Genome annotation databases

EnsembliENST00000360221; ENSP00000353355; ENSG00000108825 [Q9BTE6-2]
ENST00000409399; ENSP00000386621; ENSG00000108825 [Q9BTE6-3]
ENST00000421990; ENSP00000409924; ENSG00000108825 [Q9BTE6-3]
ENST00000427569; ENSP00000400870; ENSG00000266967 [Q9BTE6-1]
GeneIDi100885850
80755
KEGGihsa:100885850
hsa:80755
UCSCiuc002icd.3 human [Q9BTE6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAASD1_HUMAN
AccessioniPrimary (citable) accession number: Q9BTE6
Secondary accession number(s): B4DI73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: July 18, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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