UniProtKB - Q9BTE6 (AASD1_HUMAN)
Protein
Alanyl-tRNA editing protein Aarsd1
Gene
AARSD1
Organism
Homo sapiens (Human)
Status
Functioni
Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala).By similarity
Cofactori
Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 109 | ZincSequence analysis | 1 | |
Metal bindingi | 113 | ZincSequence analysis | 1 | |
Metal bindingi | 209 | ZincSequence analysis | 1 | |
Metal bindingi | 213 | ZincSequence analysis | 1 |
GO - Molecular functioni
- alanine-tRNA ligase activity Source: InterPro
- ATP binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
- nucleic acid binding Source: InterPro
- Ser-tRNA(Ala) hydrolase activity Source: GO_Central
GO - Biological processi
- alanyl-tRNA aminoacylation Source: InterPro
- regulation of translational fidelity Source: GO_Central
Keywordsi
Biological process | Protein biosynthesis |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9BTE6 |
Names & Taxonomyi
Protein namesi | Recommended name: Alanyl-tRNA editing protein Aarsd1Alternative name(s): Alanyl-tRNA synthetase domain-containing protein 1 |
Gene namesi | Name:AARSD1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000108825.17 HostDB:ENSG00000266967.6 |
HGNCi | HGNC:28417, AARSD1 HGNC:43946, PTGES3L-AARSD1 |
MIMi | 613212, gene |
neXtProti | NX_Q9BTE6 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000108825 ENSG00000266967 |
PharmGKBi | PA142670464 |
Miscellaneous databases
Pharosi | Q9BTE6, Tdark |
Polymorphism and mutation databases
BioMutai | AARSD1 |
DMDMi | 125987702 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000277465 | 1 – 412 | Alanyl-tRNA editing protein Aarsd1Add BLAST | 412 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 174 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9BTE6 |
jPOSTi | Q9BTE6 |
MassIVEi | Q9BTE6 |
MaxQBi | Q9BTE6 |
PaxDbi | Q9BTE6 |
PeptideAtlasi | Q9BTE6 |
PRIDEi | Q9BTE6 |
ProteomicsDBi | 78985 [Q9BTE6-1] 78986 [Q9BTE6-2] 78987 [Q9BTE6-3] |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00827636 |
PTM databases
iPTMneti | Q9BTE6 |
PhosphoSitePlusi | Q9BTE6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000108825, Expressed in testis and 110 other tissues |
ExpressionAtlasi | Q9BTE6, baseline and differential |
Genevisiblei | Q9BTE6, HS |
Organism-specific databases
HPAi | ENSG00000108825, Tissue enhanced (skeletal) ENSG00000266967, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsIsoform 2 [Q9BTE6-2]
Protein-protein interaction databases
BioGRIDi | 123290, 101 interactors 3190353, 14 interactors |
IntActi | Q9BTE6, 166 interactors |
STRINGi | 9606.ENSP00000400870 |
Miscellaneous databases
RNActi | Q9BTE6, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2105, Eukaryota |
GeneTreei | ENSGT00940000156241 |
HOGENOMi | CLU_004485_7_0_1 |
InParanoidi | Q9BTE6 |
OMAi | DREFKYD |
OrthoDBi | 910848at2759 |
PhylomeDBi | Q9BTE6 |
TreeFami | TF323735 |
Family and domain databases
InterProi | View protein in InterPro IPR018165, Ala-tRNA-synth_IIc_core IPR018163, Thr/Ala-tRNA-synth_IIc_edit IPR009000, Transl_B-barrel_sf IPR012947, tRNA_SAD |
Pfami | View protein in Pfam PF07973, tRNA_SAD, 1 hit |
SMARTi | View protein in SMART SM00863, tRNA_SAD, 1 hit |
SUPFAMi | SSF50447, SSF50447, 1 hit SSF55186, SSF55186, 1 hit |
PROSITEi | View protein in PROSITE PS50860, AA_TRNA_LIGASE_II_ALA, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9BTE6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAFWCQRDSY AREFTTTVVS CCPAELQTEG SNGKKEVLSG FQVVLEDTVL
60 70 80 90 100
FPEGGGQPDD RGTINDISVL RVTRRGEQAD HFTQTPLDPG SQVLVRVDWE
110 120 130 140 150
RRFDHMQQHS GQHLITAVAD HLFKLKTTSW ELGRFRSAIE LDTPSMTAEQ
160 170 180 190 200
VAAIEQSVNE KIRDRLPVNV RELSLDDPEV EQVSGRGLPD DHAGPIRVVN
210 220 230 240 250
IEGVDSNMCC GTHVSNLSDL QVIKILGTEK GKKNRTNLIF LSGNRVLKWM
260 270 280 290 300
ERSHGTEKAL TALLKCGAED HVEAVKKLQN STKILQKNNL NLLRDLAVHI
310 320 330 340 350
AHSLRNSPDW GGVVILHRKE GDSEFMNIIA NEIGSEETLL FLTVGDEKGG
360 370 380 390 400
GLFLLAGPPA SVETLGPRVA EVLEGKGAGK KGRFQGKATK MSRRMEAQAL
410
LQDYISTQSA KE
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J5N1 | C9J5N1_HUMAN | PTGES3L-AARSD1 readthrough | PTGES3L-AARSD1 | 495 | Annotation score: | ||
L7N2F4 | L7N2F4_HUMAN | Alanyl-tRNA-editing protein Aarsd1 | AARSD1 | 140 | Annotation score: | ||
K7N799 | K7N799_HUMAN | Alanyl-tRNA-editing protein Aarsd1 | AARSD1 | 84 | Annotation score: | ||
H7C054 | H7C054_HUMAN | PTGES3L-AARSD1 readthrough | PTGES3L-AARSD1 | 189 | Annotation score: | ||
L7N2F6 | L7N2F6_HUMAN | PTGES3L-AARSD1 readthrough | PTGES3L-AARSD1 | 132 | Annotation score: | ||
L7N2F5 | L7N2F5_HUMAN | Alanyl-tRNA-editing protein Aarsd1 | AARSD1 | 98 | Annotation score: | ||
H7C1K1 | H7C1K1_HUMAN | Alanyl-tRNA-editing protein Aarsd1 | AARSD1 | 79 | Annotation score: | ||
C9JUA3 | C9JUA3_HUMAN | PTGES3L-AARSD1 readthrough | PTGES3L-AARSD1 | 24 | Annotation score: | ||
K7EQ85 | K7EQ85_HUMAN | Alanyl-tRNA-editing protein Aarsd1 | AARSD1 | 94 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023014 | 1 – 13 | MAFWC…SYARE → MEFCVEDSTDVHVLIEDHRI VFSCKNADGVELYNEIEFYA KVNSKDSQDKRSSRSITCFV RKWKEKVAWPRLTKEDIKPV WLSVDFDNWRDWEGDEEMEL AHVEHYAELLKKVSTKRPPP AMDDLD in isoform 2. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_043142 | 1 – 13 | MAFWC…SYARE → MFSLPLNCSPDHIRRGSCWG RPQDLKIAAPAWNSKCHPGA GAAMARQHARTLWYDRPRYV FMEFCVEDSTDVHVLIEDHR IVFSCKNADGVELYNEIEFY AKVNSKDSQDKRSSRSITCF VRKWKEKVAWPRLTKEDIKP VWLSVDFDNWRDWEGDEEME LAHVEHYAELLKKVSTKRPP PAMDDLD in isoform 3. 1 PublicationAdd BLAST | 13 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK295447 mRNA Translation: BAG58385.1 CR608238 mRNA No translation available. AC055866 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60903.1 BC004172 mRNA Translation: AAH04172.1 BC019324 mRNA Translation: AAH19324.1 |
CCDSi | CCDS58552.1 [Q9BTE6-1] |
RefSeqi | NP_001129514.2, NM_001136042.2 [Q9BTE6-3] NP_001248363.1, NM_001261434.1 [Q9BTE6-1] NP_079543.1, NM_025267.3 [Q9BTE6-2] |
Genome annotation databases
Ensembli | ENST00000360221; ENSP00000353355; ENSG00000108825 [Q9BTE6-2] ENST00000409399; ENSP00000386621; ENSG00000108825 [Q9BTE6-3] ENST00000421990; ENSP00000409924; ENSG00000108825 [Q9BTE6-3] ENST00000427569; ENSP00000400870; ENSG00000266967 [Q9BTE6-1] |
GeneIDi | 100885850 80755 |
KEGGi | hsa:100885850 hsa:80755 |
UCSCi | uc002icd.3, human [Q9BTE6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK295447 mRNA Translation: BAG58385.1 CR608238 mRNA No translation available. AC055866 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60903.1 BC004172 mRNA Translation: AAH04172.1 BC019324 mRNA Translation: AAH19324.1 |
CCDSi | CCDS58552.1 [Q9BTE6-1] |
RefSeqi | NP_001129514.2, NM_001136042.2 [Q9BTE6-3] NP_001248363.1, NM_001261434.1 [Q9BTE6-1] NP_079543.1, NM_025267.3 [Q9BTE6-2] |
3D structure databases
SMRi | Q9BTE6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123290, 101 interactors 3190353, 14 interactors |
IntActi | Q9BTE6, 166 interactors |
STRINGi | 9606.ENSP00000400870 |
PTM databases
iPTMneti | Q9BTE6 |
PhosphoSitePlusi | Q9BTE6 |
Polymorphism and mutation databases
BioMutai | AARSD1 |
DMDMi | 125987702 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00827636 |
Proteomic databases
EPDi | Q9BTE6 |
jPOSTi | Q9BTE6 |
MassIVEi | Q9BTE6 |
MaxQBi | Q9BTE6 |
PaxDbi | Q9BTE6 |
PeptideAtlasi | Q9BTE6 |
PRIDEi | Q9BTE6 |
ProteomicsDBi | 78985 [Q9BTE6-1] 78986 [Q9BTE6-2] 78987 [Q9BTE6-3] |
Protocols and materials databases
Antibodypediai | 17173, 78 antibodies 67174, 177 antibodies |
DNASUi | 80755 |
Genome annotation databases
Ensembli | ENST00000360221; ENSP00000353355; ENSG00000108825 [Q9BTE6-2] ENST00000409399; ENSP00000386621; ENSG00000108825 [Q9BTE6-3] ENST00000421990; ENSP00000409924; ENSG00000108825 [Q9BTE6-3] ENST00000427569; ENSP00000400870; ENSG00000266967 [Q9BTE6-1] |
GeneIDi | 100885850 80755 |
KEGGi | hsa:100885850 hsa:80755 |
UCSCi | uc002icd.3, human [Q9BTE6-1] |
Organism-specific databases
CTDi | 100885850 80755 |
EuPathDBi | HostDB:ENSG00000108825.17 HostDB:ENSG00000266967.6 |
GeneCardsi | AARSD1 PTGES3L-AARSD1 |
HGNCi | HGNC:28417, AARSD1 HGNC:43946, PTGES3L-AARSD1 |
HPAi | ENSG00000108825, Tissue enhanced (skeletal) ENSG00000266967, Low tissue specificity |
MIMi | 613212, gene |
neXtProti | NX_Q9BTE6 |
OpenTargetsi | ENSG00000108825 ENSG00000266967 |
PharmGKBi | PA142670464 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2105, Eukaryota |
GeneTreei | ENSGT00940000156241 |
HOGENOMi | CLU_004485_7_0_1 |
InParanoidi | Q9BTE6 |
OMAi | DREFKYD |
OrthoDBi | 910848at2759 |
PhylomeDBi | Q9BTE6 |
TreeFami | TF323735 |
Enzyme and pathway databases
PathwayCommonsi | Q9BTE6 |
Miscellaneous databases
BioGRID-ORCSi | 100885850, 14 hits in 811 CRISPR screens 80755, 8 hits in 840 CRISPR screens |
Pharosi | Q9BTE6, Tdark |
PROi | PR:Q9BTE6 |
RNActi | Q9BTE6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108825, Expressed in testis and 110 other tissues |
ExpressionAtlasi | Q9BTE6, baseline and differential |
Genevisiblei | Q9BTE6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR018165, Ala-tRNA-synth_IIc_core IPR018163, Thr/Ala-tRNA-synth_IIc_edit IPR009000, Transl_B-barrel_sf IPR012947, tRNA_SAD |
Pfami | View protein in Pfam PF07973, tRNA_SAD, 1 hit |
SMARTi | View protein in SMART SM00863, tRNA_SAD, 1 hit |
SUPFAMi | SSF50447, SSF50447, 1 hit SSF55186, SSF55186, 1 hit |
PROSITEi | View protein in PROSITE PS50860, AA_TRNA_LIGASE_II_ALA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AASD1_HUMAN | |
Accessioni | Q9BTE6Primary (citable) accession number: Q9BTE6 Secondary accession number(s): B4DI73 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | February 6, 2007 | |
Last modified: | December 2, 2020 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM