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Protein

Mini-chromosome maintenance complex-binding protein

Gene

MCMBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.2 Publications

GO - Molecular functioni

  • chromatin binding Source: UniProtKB

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • DNA-dependent DNA replication Source: UniProtKB
  • sister chromatid cohesion Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division, DNA replication, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Mini-chromosome maintenance complex-binding protein
Short name:
MCM-BP
Short name:
MCM-binding protein
Gene namesi
Name:MCMBP
Synonyms:C10orf119
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000197771.12
HGNCiHGNC:25782 MCMBP
MIMi610909 gene
neXtProtiNX_Q9BTE3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79892
OpenTargetsiENSG00000197771
PharmGKBiPA134862625

Polymorphism and mutation databases

BioMutaiMCMBP
DMDMi71153001

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000898271 – 642Mini-chromosome maintenance complex-binding proteinAdd BLAST642

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei154PhosphoserineCombined sources1
Modified residuei160PhosphothreonineCombined sources1
Modified residuei167PhosphoserineCombined sources1
Modified residuei298PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BTE3
MaxQBiQ9BTE3
PaxDbiQ9BTE3
PeptideAtlasiQ9BTE3
PRIDEiQ9BTE3
ProteomicsDBi78982
78983 [Q9BTE3-2]
78984 [Q9BTE3-3]

PTM databases

iPTMnetiQ9BTE3
PhosphoSitePlusiQ9BTE3

Expressioni

Gene expression databases

BgeeiENSG00000197771 Expressed in 213 organ(s), highest expression level in oocyte
CleanExiHS_C10orf119
ExpressionAtlasiQ9BTE3 baseline and differential
GenevisibleiQ9BTE3 HS

Organism-specific databases

HPAiCAB013792
HPA038481

Interactioni

Subunit structurei

Interacts with the MCM complex: associates with the MCM3-7 complex which lacks MCM2, while it does not interact with the MCM complex when MCM2 is present (MCM2-7 complex). Interacts with the RPA complex, when composed of all RPA1, RPA2 and RPA3 components, but not with RPA1 or RPA2 alone.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi122976, 56 interactors
IntActiQ9BTE3, 27 interactors
MINTiQ9BTE3
STRINGi9606.ENSP00000353098

Structurei

3D structure databases

ProteinModelPortaliQ9BTE3
SMRiQ9BTE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MCMBP family.Curated

Phylogenomic databases

eggNOGiKOG2545 Eukaryota
ENOG410XNU0 LUCA
GeneTreeiENSGT00390000017265
HOGENOMiHOG000237536
HOVERGENiHBG059839
InParanoidiQ9BTE3
OMAiVDMRKAN
OrthoDBiEOG091G09IO
PhylomeDBiQ9BTE3
TreeFamiTF324793

Family and domain databases

InterProiView protein in InterPro
IPR019140 MCM_complex-bd
PANTHERiPTHR13489 PTHR13489, 1 hit
PfamiView protein in Pfam
PF09739 MCM_bind, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BTE3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPCGEDWLSH PLGIVQGFFA QNGVNPDWEK KVIEYFKEKL KENNAPKWVP
60 70 80 90 100
SLNEVPLHYL KPNSFVKFRC MIQDMFDPEF YMGVYETVNQ NTKAHVLHFG
110 120 130 140 150
KYRDVAECGP QQELDLNSPR NTTLERQTFY CVPVPGESTW VKEAYVNANQ
160 170 180 190 200
ARVSPSTSYT PSRHKRSYED DDDMDLQPNK QKDQHAGARQ AGSVGGLQWC
210 220 230 240 250
GEPKRLETEA STGQQLNSLN LSSPFDLNFP LPGEKGPACL VKVYEDWDCF
260 270 280 290 300
KVNDILELYG ILSVDPVLSI LNNDERDASA LLDPMECTDT AEEQRVHSPP
310 320 330 340 350
ASLVPRIHVI LAQKLQHINP LLPACLNKEE SKTCKFVSSF MSELSPVRAE
360 370 380 390 400
LLGFLTHALL GDSLAAEYLI LHLISTVYTR RDVLPLGKFT VNLSGCPRNS
410 420 430 440 450
TFTEHLYRII QHLVPASFRL QMTIENMNHL KFIPHKDYTA NRLVSGLLQL
460 470 480 490 500
PSNTSLVIDE TLLEQGQLDT PGVHNVTALS NLITWQKVDY DFSYHQMEFP
510 520 530 540 550
CNINVFITSE GRSLLPADCQ IHLQPQLIPP NMEEYMNSLL SAVLPSVLNK
560 570 580 590 600
FRIYLTLLRF LEYSISDEIT KAVEDDFVEM RKNDPQSITA DDLHQLLVVA
610 620 630 640
RCLSLSAGQT TLSRERWLRA KQLESLRRTR LQQQKCVNGN EL
Length:642
Mass (Da):72,980
Last modified:July 19, 2005 - v2
Checksum:iD9EA81646F1D50E2
GO
Isoform 2 (identifier: Q9BTE3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     334-335: Missing.

Show »
Length:640
Mass (Da):72,749
Checksum:iF7B4B5237F033E09
GO
Isoform 3 (identifier: Q9BTE3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: Missing.
     334-335: Missing.

Note: No experimental confirmation available.
Show »
Length:467
Mass (Da):52,652
Checksum:i723B4CAC74EC4791
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti164H → Y in CAG33580 (Ref. 2) Curated1
Sequence conflicti350E → V in CAG33580 (Ref. 2) Curated1
Sequence conflicti610T → A in BAG52809 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0407211 – 173Missing in isoform 3. CuratedAdd BLAST173
Alternative sequenceiVSP_014707334 – 335Missing in isoform 2 and isoform 3. 2 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023143 mRNA Translation: BAB14427.1
AK094075 mRNA Translation: BAG52809.1
CR457299 mRNA Translation: CAG33580.1
AC027672 Genomic DNA No translation available.
BC000935 mRNA Translation: AAH00935.1
BC004183 mRNA Translation: AAH04183.1
BC007219 mRNA Translation: AAH07219.1
CCDSiCCDS58099.1 [Q9BTE3-2]
CCDS7617.1 [Q9BTE3-1]
RefSeqiNP_001243307.1, NM_001256378.1 [Q9BTE3-2]
NP_001243308.1, NM_001256379.1 [Q9BTE3-3]
NP_079110.1, NM_024834.3 [Q9BTE3-1]
UniGeneiHs.124246

Genome annotation databases

EnsembliENST00000360003; ENSP00000353098; ENSG00000197771 [Q9BTE3-1]
ENST00000369077; ENSP00000358073; ENSG00000197771 [Q9BTE3-2]
GeneIDi79892
KEGGihsa:79892
UCSCiuc001leq.3 human [Q9BTE3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023143 mRNA Translation: BAB14427.1
AK094075 mRNA Translation: BAG52809.1
CR457299 mRNA Translation: CAG33580.1
AC027672 Genomic DNA No translation available.
BC000935 mRNA Translation: AAH00935.1
BC004183 mRNA Translation: AAH04183.1
BC007219 mRNA Translation: AAH07219.1
CCDSiCCDS58099.1 [Q9BTE3-2]
CCDS7617.1 [Q9BTE3-1]
RefSeqiNP_001243307.1, NM_001256378.1 [Q9BTE3-2]
NP_001243308.1, NM_001256379.1 [Q9BTE3-3]
NP_079110.1, NM_024834.3 [Q9BTE3-1]
UniGeneiHs.124246

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KG9X-ray1.70B152-161[»]
ProteinModelPortaliQ9BTE3
SMRiQ9BTE3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122976, 56 interactors
IntActiQ9BTE3, 27 interactors
MINTiQ9BTE3
STRINGi9606.ENSP00000353098

PTM databases

iPTMnetiQ9BTE3
PhosphoSitePlusiQ9BTE3

Polymorphism and mutation databases

BioMutaiMCMBP
DMDMi71153001

Proteomic databases

EPDiQ9BTE3
MaxQBiQ9BTE3
PaxDbiQ9BTE3
PeptideAtlasiQ9BTE3
PRIDEiQ9BTE3
ProteomicsDBi78982
78983 [Q9BTE3-2]
78984 [Q9BTE3-3]

Protocols and materials databases

DNASUi79892
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360003; ENSP00000353098; ENSG00000197771 [Q9BTE3-1]
ENST00000369077; ENSP00000358073; ENSG00000197771 [Q9BTE3-2]
GeneIDi79892
KEGGihsa:79892
UCSCiuc001leq.3 human [Q9BTE3-1]

Organism-specific databases

CTDi79892
DisGeNETi79892
EuPathDBiHostDB:ENSG00000197771.12
GeneCardsiMCMBP
HGNCiHGNC:25782 MCMBP
HPAiCAB013792
HPA038481
MIMi610909 gene
neXtProtiNX_Q9BTE3
OpenTargetsiENSG00000197771
PharmGKBiPA134862625
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2545 Eukaryota
ENOG410XNU0 LUCA
GeneTreeiENSGT00390000017265
HOGENOMiHOG000237536
HOVERGENiHBG059839
InParanoidiQ9BTE3
OMAiVDMRKAN
OrthoDBiEOG091G09IO
PhylomeDBiQ9BTE3
TreeFamiTF324793

Miscellaneous databases

ChiTaRSiMCMBP human
GenomeRNAii79892
PROiPR:Q9BTE3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197771 Expressed in 213 organ(s), highest expression level in oocyte
CleanExiHS_C10orf119
ExpressionAtlasiQ9BTE3 baseline and differential
GenevisibleiQ9BTE3 HS

Family and domain databases

InterProiView protein in InterPro
IPR019140 MCM_complex-bd
PANTHERiPTHR13489 PTHR13489, 1 hit
PfamiView protein in Pfam
PF09739 MCM_bind, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMCMBP_HUMAN
AccessioniPrimary (citable) accession number: Q9BTE3
Secondary accession number(s): B3KSP7
, Q6IA56, Q9BVT9, Q9H916
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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