Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

N-acetyltransferase 9

Gene

NAT9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

SignaLinkiQ9BTE0

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyltransferase 9 (EC:2.3.1.-)
Alternative name(s):
Embryo brain-specific protein
Gene namesi
Name:NAT9
Synonyms:EBS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000109065.11
HGNCiHGNC:23133 NAT9
neXtProtiNX_Q9BTE0

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi26151
OpenTargetsiENSG00000109065
PharmGKBiPA142671281

Polymorphism and mutation databases

BioMutaiNAT9
DMDMi74752333

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002868741 – 207N-acetyltransferase 9Add BLAST207

Proteomic databases

MaxQBiQ9BTE0
PaxDbiQ9BTE0
PeptideAtlasiQ9BTE0
PRIDEiQ9BTE0
ProteomicsDBi78979
78980 [Q9BTE0-2]

PTM databases

iPTMnetiQ9BTE0
PhosphoSitePlusiQ9BTE0

Expressioni

Gene expression databases

BgeeiENSG00000109065
CleanExiHS_NAT9
ExpressionAtlasiQ9BTE0 baseline and differential
GenevisibleiQ9BTE0 HS

Organism-specific databases

HPAiHPA021820
HPA057149

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EEF1E1O433244EBI-711919,EBI-1048486

Protein-protein interaction databases

BioGridi117582, 14 interactors
IntActiQ9BTE0, 9 interactors
MINTiQ9BTE0
STRINGi9606.ENSP00000350467

Structurei

3D structure databases

ProteinModelPortaliQ9BTE0
SMRiQ9BTE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 180N-acetyltransferaseAdd BLAST146

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4135 Eukaryota
ENOG4111P75 LUCA
GeneTreeiENSGT00390000012745
HOGENOMiHOG000189068
HOVERGENiHBG104444
InParanoidiQ9BTE0
PhylomeDBiQ9BTE0
TreeFamiTF315021

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
PfamiView protein in Pfam
PF13302 Acetyltransf_3, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BTE0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLNQNTLLL GKKVVLVPYT SEHVPSRYHE WMKSEELQRL TASEPLTLEQ
60 70 80 90 100
EYAMQCSWQE DADKCTFIVL DAEKWQAQPG ATEESCMVGD VNLFLTDLED
110 120 130 140 150
LTLGEIEVMI AEPSCRGKGL GTEAVLAMLS YGVTTLGLTK FEAKIGQGNE
160 170 180 190 200
PSIRMFQKLH FEQVATSSVF QEVTLRLTVS ESEHQWLLEQ TSHVEEKPYR

DGSAEPC
Length:207
Mass (Da):23,361
Last modified:June 1, 2001 - v1
Checksum:i1265AC8D2B2B376F
GO
Isoform 2 (identifier: Q9BTE0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-26: Missing.

Show »
Length:206
Mass (Da):23,274
Checksum:iF79555F806B352BF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126L → P in CAB43370 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03222556C → R. Corresponds to variant dbSNP:rs2305213Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02523126Missing in isoform 2. 4 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY632082 mRNA Translation: AAU25819.1
AK312958 mRNA Translation: BAG35797.1
AL050269 mRNA Translation: CAB43370.1
CH471099 Genomic DNA Translation: EAW89197.1
BC004195 mRNA Translation: AAH04195.1
BC004225 mRNA Translation: AAH04225.1
CCDSiCCDS11706.1 [Q9BTE0-1]
CCDS77102.1 [Q9BTE0-2]
PIRiT08699
RefSeqiNP_001292006.1, NM_001305077.1 [Q9BTE0-2]
NP_001292007.1, NM_001305078.1 [Q9BTE0-1]
NP_001292008.1, NM_001305079.1
NP_001292009.1, NM_001305080.1
NP_001292010.1, NM_001305081.1
NP_001292011.1, NM_001305082.1
NP_001292012.1, NM_001305083.1
NP_001292013.1, NM_001305084.1
NP_001292014.1, NM_001305085.1
NP_001292015.1, NM_001305086.1
NP_001292016.1, NM_001305087.1
NP_001292017.1, NM_001305088.1
NP_056469.2, NM_015654.4 [Q9BTE0-1]
UniGeneiHs.144058

Genome annotation databases

EnsembliENST00000357814; ENSP00000350467; ENSG00000109065 [Q9BTE0-1]
ENST00000580301; ENSP00000462019; ENSG00000109065 [Q9BTE0-2]
GeneIDi26151
KEGGihsa:26151
UCSCiuc002jlq.3 human [Q9BTE0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNAT9_HUMAN
AccessioniPrimary (citable) accession number: Q9BTE0
Secondary accession number(s): B2R7F0, Q9BTD0, Q9Y3T3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health