Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Metastasis-associated protein MTA3

Gene

MTA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri379 – 406GATA-type; atypicalAdd BLAST28

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-3214815 HDACs deacetylate histones
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-8943724 Regulation of PTEN gene transcription
SIGNORiQ9BTC8

Names & Taxonomyi

Protein namesi
Recommended name:
Metastasis-associated protein MTA3
Gene namesi
Name:MTA3
Synonyms:KIAA1266
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000057935.13
HGNCiHGNC:23784 MTA3
MIMi609050 gene
neXtProtiNX_Q9BTC8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57504
OpenTargetsiENSG00000057935
PharmGKBiPA134953540

Polymorphism and mutation databases

DMDMi29840798

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000834981 – 594Metastasis-associated protein MTA3Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei428PhosphoserineCombined sources1
Modified residuei430PhosphoserineBy similarity1
Modified residuei455PhosphothreonineCombined sources1
Modified residuei519PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BTC8
MaxQBiQ9BTC8
PaxDbiQ9BTC8
PeptideAtlasiQ9BTC8
PRIDEiQ9BTC8
ProteomicsDBi78971
78972 [Q9BTC8-2]

PTM databases

iPTMnetiQ9BTC8
PhosphoSitePlusiQ9BTC8

Expressioni

Tissue specificityi

Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells.1 Publication

Inductioni

By estrogen.1 Publication

Gene expression databases

BgeeiENSG00000057935 Expressed in 193 organ(s), highest expression level in testis
CleanExiHS_MTA3
ExpressionAtlasiQ9BTC8 baseline and differential
GenevisibleiQ9BTC8 HS

Organism-specific databases

HPAiHPA039433

Interactioni

Subunit structurei

Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with BCL6. Interacts with NACC2.3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi121568, 70 interactors
ComplexPortaliCPX-880 MBD2/NuRD nucleosome remodeling and deacetylase complex
CPX-922 MBD3/NuRD nucleosome remodeling and deacetylase complex
CORUMiQ9BTC8
DIPiDIP-47460N
IntActiQ9BTC8, 46 interactors
MINTiQ9BTC8
STRINGi9606.ENSP00000385045

Structurei

3D structure databases

ProteinModelPortaliQ9BTC8
SMRiQ9BTC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 147BAHPROSITE-ProRule annotationAdd BLAST147
Domaini148 – 259ELM2PROSITE-ProRule annotationAdd BLAST112
Domaini266 – 318SANTPROSITE-ProRule annotationAdd BLAST53

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri379 – 406GATA-type; atypicalAdd BLAST28

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3554 Eukaryota
ENOG410XSAJ LUCA
GeneTreeiENSGT00580000081398
HOGENOMiHOG000045387
HOVERGENiHBG002598
InParanoidiQ9BTC8
KOiK11660
OMAiHGPHGML
OrthoDBiEOG091G04Z4
PhylomeDBiQ9BTC8
TreeFamiTF106444

Family and domain databases

CDDicd00202 ZnF_GATA, 1 hit
InterProiView protein in InterPro
IPR001025 BAH_dom
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR035170 MTA1_R1
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR000679 Znf_GATA
PfamiView protein in Pfam
PF01426 BAH, 1 hit
PF01448 ELM2, 1 hit
PF00320 GATA, 1 hit
PF17226 MTA_R1, 1 hit
SMARTiView protein in SMART
SM00439 BAH, 1 hit
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00401 ZnF_GATA, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51038 BAH, 1 hit
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9BTC8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTASGNVEA KVVCFYRRRD
60 70 80 90 100
ISNTLIMLAD KHAKEIEEES ETTVEADLTD KQKHQLKHRE LFLSRQYESL
110 120 130 140 150
PATHIRGKCS VALLNETESV LSYLDKEDTF FYSLVYDPSL KTLLADKGEI
160 170 180 190 200
RVGPRYQADI PEMLLEGESD EREQSKLEVK VWDPNSPLTD RQIDQFLVVA
210 220 230 240 250
RAVGTFARAL DCSSSVRQPS LHMSAAAASR DITLFHAMDT LYRHSYDLSS
260 270 280 290 300
AISVLVPLGG PVLCRDEMEE WSASEASLFE EALEKYGKDF NDIRQDFLPW
310 320 330 340 350
KSLTSIIEYY YMWKTTDRYV QQKRLKAAEA ESKLKQVYIP TYSKPNPNQI
360 370 380 390 400
STSNGKPGAV NGAVGTTFQP QNPLLGRACE SCYATQSHQW YSWGPPNMQC
410 420 430 440 450
RLCAICWLYW KKYGGLKMPT QSEEEKLSPS PTTEDPRVRS HVSRQAMQGM
460 470 480 490 500
PVRNTGSPKS AVKTRQAFFL HTTYFTKFAR QVCKNTLRLR QAARRPFVAI
510 520 530 540 550
NYAAIRAEYA DRHAELSGSP LKSKSTRKPL ACIIGYLEIH PAKKPNVIRS
560 570 580 590
TPSLQTPTTK RMLTTPNHTS LSILGKRNYS HHNGLDELTC CVSD
Length:594
Mass (Da):67,504
Last modified:February 28, 2003 - v2
Checksum:iE773603F65A16DF1
GO
Isoform 2 (identifier: Q9BTC8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     509-515: YADRHAE → CKMLLNS
     516-594: Missing.

Show »
Length:515
Mass (Da):58,814
Checksum:i55E53C5ABC30528C
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6W5A2D6W5A2_HUMAN
Metastasis associated 1 family, mem...
MTA3 hCG_1783907
537Annotation score:
E7EQY4E7EQY4_HUMAN
Metastasis-associated protein MTA3
MTA3
514Annotation score:
E7EV10E7EV10_HUMAN
Metastasis-associated protein MTA3
MTA3
590Annotation score:
E9PCS8E9PCS8_HUMAN
Metastasis-associated protein MTA3
MTA3
392Annotation score:
E9PF88E9PF88_HUMAN
Metastasis-associated protein MTA3
MTA3
91Annotation score:
C9JR73C9JR73_HUMAN
Metastasis-associated protein MTA3
MTA3
17Annotation score:

Sequence cautioni

The sequence BAA86580 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 9MAANMYRVG → ATGGFPRDR in BAA86580 (PubMed:10574462).Curated9
Sequence conflicti343Missing in BAA86580 (PubMed:10574462).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001603509 – 515YADRHAE → CKMLLNS in isoform 2. 2 Publications7
Alternative sequenceiVSP_001604516 – 594Missing in isoform 2. 2 PublicationsAdd BLAST79

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033092 mRNA Translation: BAA86580.1 Different initiation.
AK027304 mRNA Translation: BAB55028.1
BC004227 mRNA Translation: AAH04227.1
BC053631 mRNA Translation: AAH53631.1
AL161954 mRNA Translation: CAB82305.1
CCDSiCCDS46267.1 [Q9BTC8-2]
CCDS82441.1 [Q9BTC8-1]
PIRiT47180
RefSeqiNP_001269684.1, NM_001282755.1
NP_001269685.1, NM_001282756.1
NP_001317371.1, NM_001330442.1 [Q9BTC8-1]
NP_065795.1, NM_020744.3 [Q9BTC8-2]
UniGeneiHs.435413
Hs.646800
Hs.745162

Genome annotation databases

EnsembliENST00000405094; ENSP00000385823; ENSG00000057935 [Q9BTC8-1]
ENST00000407270; ENSP00000385045; ENSG00000057935 [Q9BTC8-2]
GeneIDi57504
KEGGihsa:57504
UCSCiuc002rsq.5 human [Q9BTC8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033092 mRNA Translation: BAA86580.1 Different initiation.
AK027304 mRNA Translation: BAB55028.1
BC004227 mRNA Translation: AAH04227.1
BC053631 mRNA Translation: AAH53631.1
AL161954 mRNA Translation: CAB82305.1
CCDSiCCDS46267.1 [Q9BTC8-2]
CCDS82441.1 [Q9BTC8-1]
PIRiT47180
RefSeqiNP_001269684.1, NM_001282755.1
NP_001269685.1, NM_001282756.1
NP_001317371.1, NM_001330442.1 [Q9BTC8-1]
NP_065795.1, NM_020744.3 [Q9BTC8-2]
UniGeneiHs.435413
Hs.646800
Hs.745162

3D structure databases

ProteinModelPortaliQ9BTC8
SMRiQ9BTC8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121568, 70 interactors
ComplexPortaliCPX-880 MBD2/NuRD nucleosome remodeling and deacetylase complex
CPX-922 MBD3/NuRD nucleosome remodeling and deacetylase complex
CORUMiQ9BTC8
DIPiDIP-47460N
IntActiQ9BTC8, 46 interactors
MINTiQ9BTC8
STRINGi9606.ENSP00000385045

PTM databases

iPTMnetiQ9BTC8
PhosphoSitePlusiQ9BTC8

Polymorphism and mutation databases

DMDMi29840798

Proteomic databases

EPDiQ9BTC8
MaxQBiQ9BTC8
PaxDbiQ9BTC8
PeptideAtlasiQ9BTC8
PRIDEiQ9BTC8
ProteomicsDBi78971
78972 [Q9BTC8-2]

Protocols and materials databases

DNASUi57504
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000405094; ENSP00000385823; ENSG00000057935 [Q9BTC8-1]
ENST00000407270; ENSP00000385045; ENSG00000057935 [Q9BTC8-2]
GeneIDi57504
KEGGihsa:57504
UCSCiuc002rsq.5 human [Q9BTC8-1]

Organism-specific databases

CTDi57504
DisGeNETi57504
EuPathDBiHostDB:ENSG00000057935.13
GeneCardsiMTA3
HGNCiHGNC:23784 MTA3
HPAiHPA039433
MIMi609050 gene
neXtProtiNX_Q9BTC8
OpenTargetsiENSG00000057935
PharmGKBiPA134953540
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3554 Eukaryota
ENOG410XSAJ LUCA
GeneTreeiENSGT00580000081398
HOGENOMiHOG000045387
HOVERGENiHBG002598
InParanoidiQ9BTC8
KOiK11660
OMAiHGPHGML
OrthoDBiEOG091G04Z4
PhylomeDBiQ9BTC8
TreeFamiTF106444

Enzyme and pathway databases

ReactomeiR-HSA-3214815 HDACs deacetylate histones
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-8943724 Regulation of PTEN gene transcription
SIGNORiQ9BTC8

Miscellaneous databases

ChiTaRSiMTA3 human
GeneWikiiMTA3
GenomeRNAii57504
PROiPR:Q9BTC8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000057935 Expressed in 193 organ(s), highest expression level in testis
CleanExiHS_MTA3
ExpressionAtlasiQ9BTC8 baseline and differential
GenevisibleiQ9BTC8 HS

Family and domain databases

CDDicd00202 ZnF_GATA, 1 hit
InterProiView protein in InterPro
IPR001025 BAH_dom
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR035170 MTA1_R1
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR000679 Znf_GATA
PfamiView protein in Pfam
PF01426 BAH, 1 hit
PF01448 ELM2, 1 hit
PF00320 GATA, 1 hit
PF17226 MTA_R1, 1 hit
SMARTiView protein in SMART
SM00439 BAH, 1 hit
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00401 ZnF_GATA, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51038 BAH, 1 hit
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMTA3_HUMAN
AccessioniPrimary (citable) accession number: Q9BTC8
Secondary accession number(s): Q9NSP2, Q9ULF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: February 28, 2003
Last modified: September 12, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again