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UniProtKB - Q9BTC8 (MTA3_HUMAN)

Entry version 190 (23 Feb 2022)
Sequence version 2 (28 Feb 2003)
Previous versions | rss
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Protein

Metastasis-associated protein MTA3

Gene

MTA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.

2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri379 – 406GATA-type; atypicalAdd BLAST28

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BTC8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3214815, HDACs deacetylate histones
R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-73762, RNA Polymerase I Transcription Initiation
R-HSA-8943724, Regulation of PTEN gene transcription
R-HSA-9679191, Potential therapeutics for SARS

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9BTC8

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9BTC8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Metastasis-associated protein MTA3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MTA3
Synonyms:KIAA1266
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23784, MTA3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609050, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BTC8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000057935

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		57504

MalaCards human disease database

More...MalaCardsi		MTA3

Open Targets

More...OpenTargetsi		ENSG00000057935

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134953540

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BTC8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MTA3

Domain mapping of disease mutations (DMDM)

More...DMDMi		29840798

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000834981 – 594Metastasis-associated protein MTA3Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei428PhosphoserineCombined sources1
Modified residuei430PhosphoserineBy similarity1
Modified residuei455PhosphothreonineCombined sources1
Modified residuei519PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BTC8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BTC8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BTC8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BTC8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BTC8

PeptideAtlas

More...PeptideAtlasi		Q9BTC8

PRoteomics IDEntifications database

More...PRIDEi		Q9BTC8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78971 [Q9BTC8-1]
78972 [Q9BTC8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BTC8

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9BTC8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BTC8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By estrogen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000057935, Expressed in testis and 208 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BTC8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BTC8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000057935, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD) (PubMed:12705869, PubMed:15454082).

Interacts with BCL6 (PubMed:15454082).

Interacts with NACC2 (PubMed:22926524).

Interacts with PWWP2B (By similarity).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121568, 140 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-880, MBD2/NuRD nucleosome remodeling and deacetylase complex
CPX-922, MBD3/NuRD nucleosome remodeling and deacetylase complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9BTC8

Database of interacting proteins

More...DIPi		DIP-47460N

Protein interaction database and analysis system

More...IntActi		Q9BTC8, 56 interactors

Molecular INTeraction database

More...MINTi		Q9BTC8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000383973

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BTC8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BTC8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 147BAHPROSITE-ProRule annotationAdd BLAST147
Domaini148 – 259ELM2PROSITE-ProRule annotationAdd BLAST112
Domaini266 – 318SANTPROSITE-ProRule annotationAdd BLAST53

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri379 – 406GATA-type; atypicalAdd BLAST28

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3554, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234573

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BTC8

Identification of Orthologs from Complete Genome Data

More...OMAi		CHIFQDT

Database of Orthologous Groups

More...OrthoDBi		802091at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BTC8

TreeFam database of animal gene trees

More...TreeFami		TF106444

Family and domain databases

Conserved Domains Database

More...CDDi		cd00202, ZnF_GATA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.30.490, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001025, BAH_dom
IPR043151, BAH_sf
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR040138, MIER/MTA
IPR035170, MTA1_R1
IPR017930, Myb_dom
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR000679, Znf_GATA

The PANTHER Classification System

More...PANTHERi		PTHR10865, PTHR10865, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01426, BAH, 1 hit
PF01448, ELM2, 1 hit
PF00320, GATA, 1 hit
PF17226, MTA_R1, 1 hit
PF00249, Myb_DNA-binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00439, BAH, 1 hit
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit
SM00401, ZnF_GATA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51038, BAH, 1 hit
PS51156, ELM2, 1 hit
PS51293, SANT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BTC8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTASGNVEA KVVCFYRRRD 
        60         70         80         90        100
ISNTLIMLAD KHAKEIEEES ETTVEADLTD KQKHQLKHRE LFLSRQYESL 
       110        120        130        140        150
PATHIRGKCS VALLNETESV LSYLDKEDTF FYSLVYDPSL KTLLADKGEI 
       160        170        180        190        200
RVGPRYQADI PEMLLEGESD EREQSKLEVK VWDPNSPLTD RQIDQFLVVA 
       210        220        230        240        250
RAVGTFARAL DCSSSVRQPS LHMSAAAASR DITLFHAMDT LYRHSYDLSS 
       260        270        280        290        300
AISVLVPLGG PVLCRDEMEE WSASEASLFE EALEKYGKDF NDIRQDFLPW 
       310        320        330        340        350
KSLTSIIEYY YMWKTTDRYV QQKRLKAAEA ESKLKQVYIP TYSKPNPNQI 
       360        370        380        390        400
STSNGKPGAV NGAVGTTFQP QNPLLGRACE SCYATQSHQW YSWGPPNMQC 
       410        420        430        440        450
RLCAICWLYW KKYGGLKMPT QSEEEKLSPS PTTEDPRVRS HVSRQAMQGM 
       460        470        480        490        500
PVRNTGSPKS AVKTRQAFFL HTTYFTKFAR QVCKNTLRLR QAARRPFVAI 
       510        520        530        540        550
NYAAIRAEYA DRHAELSGSP LKSKSTRKPL ACIIGYLEIH PAKKPNVIRS 
       560        570        580        590 
TPSLQTPTTK RMLTTPNHTS LSILGKRNYS HHNGLDELTC CVSD
Length:594
Mass (Da):67,504
Last modified:February 28, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE773603F65A16DF1
GO
Isoform 2 (identifier: Q9BTC8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     509-515: YADRHAE → CKMLLNS
     516-594: Missing.

Show »
Length:515
Mass (Da):58,814
Checksum:i55E53C5ABC30528C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EQY4E7EQY4_HUMAN
Metastasis-associated protein MTA3
MTA3
514Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RRE2F6RRE2_HUMAN
Metastasis associated 1 family, mem...
MTA3 hCG_1783907
537Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EV10E7EV10_HUMAN
Metastasis-associated protein MTA3
MTA3
590Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PCS8E9PCS8_HUMAN
Metastasis-associated protein MTA3
MTA3
392Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PF88E9PF88_HUMAN
Metastasis-associated protein MTA3
MTA3
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JR73C9JR73_HUMAN
Metastasis-associated protein MTA3
MTA3
17Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86580 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1 – 9MAANMYRVG → ATGGFPRDR in BAA86580 (PubMed:10574462).Curated9
Sequence conflicti343Missing in BAA86580 (PubMed:10574462).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001603509 – 515YADRHAE → CKMLLNS in isoform 2. 2 Publications7
Alternative sequenceiVSP_001604516 – 594Missing in isoform 2. 2 PublicationsAdd BLAST79

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB033092 mRNA Translation: BAA86580.1 Different initiation.
AK027304 mRNA Translation: BAB55028.1
BC004227 mRNA Translation: AAH04227.1
BC053631 mRNA Translation: AAH53631.1
AL161954 mRNA Translation: CAB82305.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46267.1 [Q9BTC8-2]
CCDS82441.1 [Q9BTC8-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T47180

NCBI Reference Sequences

More...RefSeqi		NP_001269684.1, NM_001282755.1
NP_001269685.1, NM_001282756.1
NP_001317371.1, NM_001330442.1 [Q9BTC8-1]
NP_065795.1, NM_020744.3 [Q9BTC8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000405094; ENSP00000385823; ENSG00000057935
ENST00000407270; ENSP00000385045; ENSG00000057935 [Q9BTC8-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57504

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57504

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000405094.2; ENSP00000385823.1; NM_001330442.2; NP_001317371.1

UCSC genome browser

More...UCSCi		uc002rsq.5, human [Q9BTC8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033092 mRNA Translation: BAA86580.1 Different initiation.
AK027304 mRNA Translation: BAB55028.1
BC004227 mRNA Translation: AAH04227.1
BC053631 mRNA Translation: AAH53631.1
AL161954 mRNA Translation: CAB82305.1
CCDSiCCDS46267.1 [Q9BTC8-2]
CCDS82441.1 [Q9BTC8-1]
PIRiT47180
RefSeqiNP_001269684.1, NM_001282755.1
NP_001269685.1, NM_001282756.1
NP_001317371.1, NM_001330442.1 [Q9BTC8-1]
NP_065795.1, NM_020744.3 [Q9BTC8-2]

3D structure databases

SMRiQ9BTC8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121568, 140 interactors
ComplexPortaliCPX-880, MBD2/NuRD nucleosome remodeling and deacetylase complex
CPX-922, MBD3/NuRD nucleosome remodeling and deacetylase complex
CORUMiQ9BTC8
DIPiDIP-47460N
IntActiQ9BTC8, 56 interactors
MINTiQ9BTC8
STRINGi9606.ENSP00000383973

PTM databases

iPTMnetiQ9BTC8
MetOSiteiQ9BTC8
PhosphoSitePlusiQ9BTC8

Genetic variation databases

BioMutaiMTA3
DMDMi29840798

Proteomic databases

EPDiQ9BTC8
jPOSTiQ9BTC8
MassIVEiQ9BTC8
MaxQBiQ9BTC8
PaxDbiQ9BTC8
PeptideAtlasiQ9BTC8
PRIDEiQ9BTC8
ProteomicsDBi78971 [Q9BTC8-1]
78972 [Q9BTC8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29760, 270 antibodies from 28 providers

The DNASU plasmid repository

More...DNASUi		57504

Genome annotation databases

EnsembliENST00000405094; ENSP00000385823; ENSG00000057935
ENST00000407270; ENSP00000385045; ENSG00000057935 [Q9BTC8-2]
GeneIDi57504
KEGGihsa:57504
MANE-SelectiENST00000405094.2; ENSP00000385823.1; NM_001330442.2; NP_001317371.1
UCSCiuc002rsq.5, human [Q9BTC8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57504
DisGeNETi57504

GeneCards: human genes, protein and diseases

More...GeneCardsi		MTA3
HGNCiHGNC:23784, MTA3
HPAiENSG00000057935, Tissue enhanced (lymphoid)
MalaCardsiMTA3
MIMi609050, gene
neXtProtiNX_Q9BTC8
OpenTargetsiENSG00000057935
PharmGKBiPA134953540
VEuPathDBiHostDB:ENSG00000057935

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3554, Eukaryota
GeneTreeiENSGT01030000234573
InParanoidiQ9BTC8
OMAiCHIFQDT
OrthoDBi802091at2759
PhylomeDBiQ9BTC8
TreeFamiTF106444

Enzyme and pathway databases

PathwayCommonsiQ9BTC8
ReactomeiR-HSA-3214815, HDACs deacetylate histones
R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-73762, RNA Polymerase I Transcription Initiation
R-HSA-8943724, Regulation of PTEN gene transcription
R-HSA-9679191, Potential therapeutics for SARS
SignaLinkiQ9BTC8
SIGNORiQ9BTC8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57504, 18 hits in 1072 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MTA3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MTA3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57504
PharosiQ9BTC8, Tbio

Protein Ontology

More...PROi		PR:Q9BTC8
RNActiQ9BTC8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000057935, Expressed in testis and 208 other tissues
ExpressionAtlasiQ9BTC8, baseline and differential
GenevisibleiQ9BTC8, HS

Family and domain databases

CDDicd00202, ZnF_GATA, 1 hit
Gene3Di2.30.30.490, 1 hit
InterProiView protein in InterPro
IPR001025, BAH_dom
IPR043151, BAH_sf
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR040138, MIER/MTA
IPR035170, MTA1_R1
IPR017930, Myb_dom
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR000679, Znf_GATA
PANTHERiPTHR10865, PTHR10865, 1 hit
PfamiView protein in Pfam
PF01426, BAH, 1 hit
PF01448, ELM2, 1 hit
PF00320, GATA, 1 hit
PF17226, MTA_R1, 1 hit
PF00249, Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM00439, BAH, 1 hit
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit
SM00401, ZnF_GATA, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51038, BAH, 1 hit
PS51156, ELM2, 1 hit
PS51293, SANT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTA3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BTC8
Secondary accession number(s): Q9NSP2, Q9ULF4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: February 28, 2003
Last modified: February 23, 2022
This is version 190 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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