UniProtKB - Q9BTC8 (MTA3_HUMAN)
Metastasis-associated protein MTA3
MTA3
Functioni
Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.
2 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 379 – 406 | GATA-type; atypicalAdd BLAST | 28 |
GO - Molecular functioni
- chromatin binding Source: InterPro
- histone deacetylase binding Source: GO_Central
- protein-containing complex binding Source: Ensembl
- sequence-specific DNA binding Source: InterPro
- transcription coactivator activity Source: GO_Central
- transcription corepressor activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- chromatin remodeling Source: ComplexPortal
- histone deacetylation Source: ComplexPortal
- negative regulation of transcription, DNA-templated Source: CACAO
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of G2/M transition of mitotic cell cycle Source: Ensembl
Keywordsi
Molecular function | DNA-binding |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9BTC8 |
Reactomei | R-HSA-3214815, HDACs deacetylate histones R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-73762, RNA Polymerase I Transcription Initiation R-HSA-8943724, Regulation of PTEN gene transcription R-HSA-9679191, Potential therapeutics for SARS |
SignaLinki | Q9BTC8 |
SIGNORi | Q9BTC8 |
Names & Taxonomyi
Protein namesi | Recommended name: Metastasis-associated protein MTA3 |
Gene namesi | Name:MTA3 Synonyms:KIAA1266 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23784, MTA3 |
MIMi | 609050, gene |
neXtProti | NX_Q9BTC8 |
VEuPathDBi | HostDB:ENSG00000057935 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Nucleus
- nucleoplasm Source: HPA
- NuRD complex Source: BHF-UCL
Other locations
- cytoplasm Source: Ensembl
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 57504 |
MalaCardsi | MTA3 |
OpenTargetsi | ENSG00000057935 |
PharmGKBi | PA134953540 |
Miscellaneous databases
Pharosi | Q9BTC8, Tbio |
Genetic variation databases
BioMutai | MTA3 |
DMDMi | 29840798 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000083498 | 1 – 594 | Metastasis-associated protein MTA3Add BLAST | 594 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 428 | PhosphoserineCombined sources | 1 | |
Modified residuei | 430 | PhosphoserineBy similarity | 1 | |
Modified residuei | 455 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 519 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9BTC8 |
jPOSTi | Q9BTC8 |
MassIVEi | Q9BTC8 |
MaxQBi | Q9BTC8 |
PaxDbi | Q9BTC8 |
PeptideAtlasi | Q9BTC8 |
PRIDEi | Q9BTC8 |
ProteomicsDBi | 78971 [Q9BTC8-1] 78972 [Q9BTC8-2] |
PTM databases
iPTMneti | Q9BTC8 |
MetOSitei | Q9BTC8 |
PhosphoSitePlusi | Q9BTC8 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000057935, Expressed in testis and 208 other tissues |
ExpressionAtlasi | Q9BTC8, baseline and differential |
Genevisiblei | Q9BTC8, HS |
Organism-specific databases
HPAi | ENSG00000057935, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Binary interactionsi
GO - Molecular functioni
- histone deacetylase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 121568, 140 interactors |
ComplexPortali | CPX-880, MBD2/NuRD nucleosome remodeling and deacetylase complex CPX-922, MBD3/NuRD nucleosome remodeling and deacetylase complex |
CORUMi | Q9BTC8 |
DIPi | DIP-47460N |
IntActi | Q9BTC8, 56 interactors |
MINTi | Q9BTC8 |
STRINGi | 9606.ENSP00000383973 |
Miscellaneous databases
RNActi | Q9BTC8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 147 | BAHPROSITE-ProRule annotationAdd BLAST | 147 | |
Domaini | 148 – 259 | ELM2PROSITE-ProRule annotationAdd BLAST | 112 | |
Domaini | 266 – 318 | SANTPROSITE-ProRule annotationAdd BLAST | 53 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 379 – 406 | GATA-type; atypicalAdd BLAST | 28 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3554, Eukaryota |
GeneTreei | ENSGT01030000234573 |
InParanoidi | Q9BTC8 |
OMAi | CHIFQDT |
OrthoDBi | 802091at2759 |
PhylomeDBi | Q9BTC8 |
TreeFami | TF106444 |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 1 hit |
Gene3Di | 2.30.30.490, 1 hit |
InterProi | View protein in InterPro IPR001025, BAH_dom IPR043151, BAH_sf IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR040138, MIER/MTA IPR035170, MTA1_R1 IPR017930, Myb_dom IPR001005, SANT/Myb IPR017884, SANT_dom IPR000679, Znf_GATA |
PANTHERi | PTHR10865, PTHR10865, 1 hit |
Pfami | View protein in Pfam PF01426, BAH, 1 hit PF01448, ELM2, 1 hit PF00320, GATA, 1 hit PF17226, MTA_R1, 1 hit PF00249, Myb_DNA-binding, 1 hit |
SMARTi | View protein in SMART SM00439, BAH, 1 hit SM01189, ELM2, 1 hit SM00717, SANT, 1 hit SM00401, ZnF_GATA, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51038, BAH, 1 hit PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTASGNVEA KVVCFYRRRD
60 70 80 90 100
ISNTLIMLAD KHAKEIEEES ETTVEADLTD KQKHQLKHRE LFLSRQYESL
110 120 130 140 150
PATHIRGKCS VALLNETESV LSYLDKEDTF FYSLVYDPSL KTLLADKGEI
160 170 180 190 200
RVGPRYQADI PEMLLEGESD EREQSKLEVK VWDPNSPLTD RQIDQFLVVA
210 220 230 240 250
RAVGTFARAL DCSSSVRQPS LHMSAAAASR DITLFHAMDT LYRHSYDLSS
260 270 280 290 300
AISVLVPLGG PVLCRDEMEE WSASEASLFE EALEKYGKDF NDIRQDFLPW
310 320 330 340 350
KSLTSIIEYY YMWKTTDRYV QQKRLKAAEA ESKLKQVYIP TYSKPNPNQI
360 370 380 390 400
STSNGKPGAV NGAVGTTFQP QNPLLGRACE SCYATQSHQW YSWGPPNMQC
410 420 430 440 450
RLCAICWLYW KKYGGLKMPT QSEEEKLSPS PTTEDPRVRS HVSRQAMQGM
460 470 480 490 500
PVRNTGSPKS AVKTRQAFFL HTTYFTKFAR QVCKNTLRLR QAARRPFVAI
510 520 530 540 550
NYAAIRAEYA DRHAELSGSP LKSKSTRKPL ACIIGYLEIH PAKKPNVIRS
560 570 580 590
TPSLQTPTTK RMLTTPNHTS LSILGKRNYS HHNGLDELTC CVSD
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EQY4 | E7EQY4_HUMAN | Metastasis-associated protein MTA3 | MTA3 | 514 | Annotation score: | ||
F6RRE2 | F6RRE2_HUMAN | Metastasis associated 1 family, mem... | MTA3 hCG_1783907 | 537 | Annotation score: | ||
E7EV10 | E7EV10_HUMAN | Metastasis-associated protein MTA3 | MTA3 | 590 | Annotation score: | ||
E9PCS8 | E9PCS8_HUMAN | Metastasis-associated protein MTA3 | MTA3 | 392 | Annotation score: | ||
E9PF88 | E9PF88_HUMAN | Metastasis-associated protein MTA3 | MTA3 | 91 | Annotation score: | ||
C9JR73 | C9JR73_HUMAN | Metastasis-associated protein MTA3 | MTA3 | 17 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1 – 9 | MAANMYRVG → ATGGFPRDR in BAA86580 (PubMed:10574462).Curated | 9 | |
Sequence conflicti | 343 | Missing in BAA86580 (PubMed:10574462).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001603 | 509 – 515 | YADRHAE → CKMLLNS in isoform 2. 2 Publications | 7 | |
Alternative sequenceiVSP_001604 | 516 – 594 | Missing in isoform 2. 2 PublicationsAdd BLAST | 79 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB033092 mRNA Translation: BAA86580.1 Different initiation. AK027304 mRNA Translation: BAB55028.1 BC004227 mRNA Translation: AAH04227.1 BC053631 mRNA Translation: AAH53631.1 AL161954 mRNA Translation: CAB82305.1 |
CCDSi | CCDS46267.1 [Q9BTC8-2] CCDS82441.1 [Q9BTC8-1] |
PIRi | T47180 |
RefSeqi | NP_001269684.1, NM_001282755.1 NP_001269685.1, NM_001282756.1 NP_001317371.1, NM_001330442.1 [Q9BTC8-1] NP_065795.1, NM_020744.3 [Q9BTC8-2] |
Genome annotation databases
Ensembli | ENST00000405094; ENSP00000385823; ENSG00000057935 ENST00000407270; ENSP00000385045; ENSG00000057935 [Q9BTC8-2] |
GeneIDi | 57504 |
KEGGi | hsa:57504 |
MANE-Selecti | ENST00000405094.2; ENSP00000385823.1; NM_001330442.2; NP_001317371.1 |
UCSCi | uc002rsq.5, human [Q9BTC8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB033092 mRNA Translation: BAA86580.1 Different initiation. AK027304 mRNA Translation: BAB55028.1 BC004227 mRNA Translation: AAH04227.1 BC053631 mRNA Translation: AAH53631.1 AL161954 mRNA Translation: CAB82305.1 |
CCDSi | CCDS46267.1 [Q9BTC8-2] CCDS82441.1 [Q9BTC8-1] |
PIRi | T47180 |
RefSeqi | NP_001269684.1, NM_001282755.1 NP_001269685.1, NM_001282756.1 NP_001317371.1, NM_001330442.1 [Q9BTC8-1] NP_065795.1, NM_020744.3 [Q9BTC8-2] |
3D structure databases
SMRi | Q9BTC8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121568, 140 interactors |
ComplexPortali | CPX-880, MBD2/NuRD nucleosome remodeling and deacetylase complex CPX-922, MBD3/NuRD nucleosome remodeling and deacetylase complex |
CORUMi | Q9BTC8 |
DIPi | DIP-47460N |
IntActi | Q9BTC8, 56 interactors |
MINTi | Q9BTC8 |
STRINGi | 9606.ENSP00000383973 |
PTM databases
iPTMneti | Q9BTC8 |
MetOSitei | Q9BTC8 |
PhosphoSitePlusi | Q9BTC8 |
Genetic variation databases
BioMutai | MTA3 |
DMDMi | 29840798 |
Proteomic databases
EPDi | Q9BTC8 |
jPOSTi | Q9BTC8 |
MassIVEi | Q9BTC8 |
MaxQBi | Q9BTC8 |
PaxDbi | Q9BTC8 |
PeptideAtlasi | Q9BTC8 |
PRIDEi | Q9BTC8 |
ProteomicsDBi | 78971 [Q9BTC8-1] 78972 [Q9BTC8-2] |
Protocols and materials databases
Antibodypediai | 29760, 270 antibodies from 28 providers |
DNASUi | 57504 |
Genome annotation databases
Ensembli | ENST00000405094; ENSP00000385823; ENSG00000057935 ENST00000407270; ENSP00000385045; ENSG00000057935 [Q9BTC8-2] |
GeneIDi | 57504 |
KEGGi | hsa:57504 |
MANE-Selecti | ENST00000405094.2; ENSP00000385823.1; NM_001330442.2; NP_001317371.1 |
UCSCi | uc002rsq.5, human [Q9BTC8-1] |
Organism-specific databases
CTDi | 57504 |
DisGeNETi | 57504 |
GeneCardsi | MTA3 |
HGNCi | HGNC:23784, MTA3 |
HPAi | ENSG00000057935, Tissue enhanced (lymphoid) |
MalaCardsi | MTA3 |
MIMi | 609050, gene |
neXtProti | NX_Q9BTC8 |
OpenTargetsi | ENSG00000057935 |
PharmGKBi | PA134953540 |
VEuPathDBi | HostDB:ENSG00000057935 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3554, Eukaryota |
GeneTreei | ENSGT01030000234573 |
InParanoidi | Q9BTC8 |
OMAi | CHIFQDT |
OrthoDBi | 802091at2759 |
PhylomeDBi | Q9BTC8 |
TreeFami | TF106444 |
Enzyme and pathway databases
PathwayCommonsi | Q9BTC8 |
Reactomei | R-HSA-3214815, HDACs deacetylate histones R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-73762, RNA Polymerase I Transcription Initiation R-HSA-8943724, Regulation of PTEN gene transcription R-HSA-9679191, Potential therapeutics for SARS |
SignaLinki | Q9BTC8 |
SIGNORi | Q9BTC8 |
Miscellaneous databases
BioGRID-ORCSi | 57504, 18 hits in 1072 CRISPR screens |
ChiTaRSi | MTA3, human |
GeneWikii | MTA3 |
GenomeRNAii | 57504 |
Pharosi | Q9BTC8, Tbio |
PROi | PR:Q9BTC8 |
RNActi | Q9BTC8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000057935, Expressed in testis and 208 other tissues |
ExpressionAtlasi | Q9BTC8, baseline and differential |
Genevisiblei | Q9BTC8, HS |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 1 hit |
Gene3Di | 2.30.30.490, 1 hit |
InterProi | View protein in InterPro IPR001025, BAH_dom IPR043151, BAH_sf IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR040138, MIER/MTA IPR035170, MTA1_R1 IPR017930, Myb_dom IPR001005, SANT/Myb IPR017884, SANT_dom IPR000679, Znf_GATA |
PANTHERi | PTHR10865, PTHR10865, 1 hit |
Pfami | View protein in Pfam PF01426, BAH, 1 hit PF01448, ELM2, 1 hit PF00320, GATA, 1 hit PF17226, MTA_R1, 1 hit PF00249, Myb_DNA-binding, 1 hit |
SMARTi | View protein in SMART SM00439, BAH, 1 hit SM01189, ELM2, 1 hit SM00717, SANT, 1 hit SM00401, ZnF_GATA, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51038, BAH, 1 hit PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MTA3_HUMAN | |
Accessioni | Q9BTC8Primary (citable) accession number: Q9BTC8 Secondary accession number(s): Q9NSP2, Q9ULF4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 28, 2003 |
Last sequence update: | February 28, 2003 | |
Last modified: | February 23, 2022 | |
This is version 190 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot