UniProtKB - Q9BTC8 (MTA3_HUMAN)

BLAST

>sp|Q9BTC8|MTA3_HUMAN Metastasis-associated protein MTA3 OS=Homo sapiens OX=9606 GN=MTA3 PE=1 SV=2
MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTASGNVEAKVVCFYRRRDISNTLIMLAD
KHAKEIEEESETTVEADLTDKQKHQLKHRELFLSRQYESLPATHIRGKCSVALLNETESV
LSYLDKEDTFFYSLVYDPSLKTLLADKGEIRVGPRYQADIPEMLLEGESDEREQSKLEVK
VWDPNSPLTDRQIDQFLVVARAVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDT
LYRHSYDLSSAISVLVPLGGPVLCRDEMEEWSASEASLFEEALEKYGKDFNDIRQDFLPW
KSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPTYSKPNPNQISTSNGKPGAV
NGAVGTTFQPQNPLLGRACESCYATQSHQWYSWGPPNMQCRLCAICWLYWKKYGGLKMPT
QSEEEKLSPSPTTEDPRVRSHVSRQAMQGMPVRNTGSPKSAVKTRQAFFLHTTYFTKFAR
QVCKNTLRLRQAARRPFVAINYAAIRAEYADRHAELSGSPLKSKSTRKPLACIIGYLEIH
PAKKPNVIRSTPSLQTPTTKRMLTTPNHTSLSILGKRNYSHHNGLDELTCCVSD

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History
Entry version 170 (07 Nov 2018)
Sequence version 2 (28 Feb 2003)
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Protein

Metastasis-associated protein MTA3

Gene

MTA3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	379 – 406	GATA-type; atypicalAdd BLAST		28

GO - Molecular functionⁱ

chromatin binding Source: InterPro
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
histone deacetylase activity Source: Reactome
histone deacetylase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein-containing complex binding Source: Ensembl
RNA polymerase II repressing transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific DNA binding Source: InterPro
transcription coactivator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription corepressor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

histone deacetylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of transcription, DNA-templated
Source: CACAO
Inferred from mutant phenotypeⁱ
- 15454082
negative regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cell proliferation Source: Ensembl
positive regulation of G2/M transition of mitotic cell cycle Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214815 HDACs deacetylate histones R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-73762 RNA Polymerase I Transcription Initiation R-HSA-8943724 Regulation of PTEN gene transcription
SIGNORⁱ	Q9BTC8

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Metastasis-associated protein MTA3
Gene namesⁱ	Name:MTA3 Synonyms:KIAA1266
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000057935.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23784 MTA3
MIMⁱ	609050 gene
neXtProtⁱ	NX_Q9BTC8

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57504
Open Targets More...OpenTargetsⁱ	ENSG00000057935
PharmGKBⁱ	PA134953540

Polymorphism and mutation databases

DMDMⁱ	29840798

DMDMⁱ

29840798

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000083498	1 – 594	Metastasis-associated protein MTA3Add BLAST		594

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	428	PhosphoserineCombined sources	1
Modified residueⁱ	430	PhosphoserineBy similarity	1
Modified residueⁱ	455	PhosphothreonineCombined sources	1
Modified residueⁱ	519	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9BTC8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BTC8
PaxDbⁱ	Q9BTC8
PeptideAtlas More...PeptideAtlasⁱ	Q9BTC8
PRIDEⁱ	Q9BTC8
ProteomicsDBⁱ	78971 78972 [Q9BTC8-2]

PTM databases

iPTMnetⁱ	Q9BTC8
PhosphoSitePlusⁱ	Q9BTC8

Expressionⁱ

Tissue specificityⁱ

Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells.1 Publication

Inductionⁱ

By estrogen.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000057935 Expressed in 193 organ(s), highest expression level in testis
CleanExⁱ	HS_MTA3
ExpressionAtlasⁱ	Q9BTC8 baseline and differential
Genevisibleⁱ	Q9BTC8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039433

HPAⁱ

HPA039433

Interactionⁱ

Subunit structureⁱ

Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with BCL6. Interacts with NACC2.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
EHMT2	Q96KQ7	18	EBI-2461787,EBI-744366
GATA3	P23771	18	EBI-2461787,EBI-6664760

GO - Molecular functionⁱ

histone deacetylase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II repressing transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121568, 71 interactors
ComplexPortalⁱ	CPX-880 MBD2/NuRD nucleosome remodeling and deacetylase complex CPX-922 MBD3/NuRD nucleosome remodeling and deacetylase complex
CORUMⁱ	Q9BTC8
Database of interacting proteins More...DIPⁱ	DIP-47460N
IntActⁱ	Q9BTC8, 46 interactors
Molecular INTeraction database More...MINTⁱ	Q9BTC8
STRINGⁱ	9606.ENSP00000385045

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BTC8
SMRⁱ	Q9BTC8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 147	BAHPROSITE-ProRule annotationAdd BLAST	147
Domainⁱ	148 – 259	ELM2PROSITE-ProRule annotationAdd BLAST	112
Domainⁱ	266 – 318	SANTPROSITE-ProRule annotationAdd BLAST	53

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	379 – 406	GATA-type; atypicalAdd BLAST		28

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3554 Eukaryota ENOG410XSAJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00580000081398
HOGENOMⁱ	HOG000045387
HOVERGENⁱ	HBG002598
InParanoidⁱ	Q9BTC8
KEGG Orthology (KO) More...KOⁱ	K11660
OMAⁱ	HAPRSHR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04Z4
PhylomeDBⁱ	Q9BTC8
TreeFamⁱ	TF106444

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00202 ZnF_GATA, 1 hit
InterProⁱ	View protein in InterPro IPR001025 BAH_dom IPR000949 ELM2_dom IPR009057 Homeobox-like_sf IPR035170 MTA1_R1 IPR001005 SANT/Myb IPR017884 SANT_dom IPR000679 Znf_GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01426 BAH, 1 hit PF01448 ELM2, 1 hit PF00320 GATA, 1 hit PF17226 MTA_R1, 1 hit
SMARTⁱ	View protein in SMART SM00439 BAH, 1 hit SM01189 ELM2, 1 hit SM00717 SANT, 1 hit SM00401 ZnF_GATA, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS51038 BAH, 1 hit PS51156 ELM2, 1 hit PS51293 SANT, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9BTC8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTASGNVEA KVVCFYRRRD 
        60         70         80         90        100
ISNTLIMLAD KHAKEIEEES ETTVEADLTD KQKHQLKHRE LFLSRQYESL 
       110        120        130        140        150
PATHIRGKCS VALLNETESV LSYLDKEDTF FYSLVYDPSL KTLLADKGEI 
       160        170        180        190        200
RVGPRYQADI PEMLLEGESD EREQSKLEVK VWDPNSPLTD RQIDQFLVVA 
       210        220        230        240        250
RAVGTFARAL DCSSSVRQPS LHMSAAAASR DITLFHAMDT LYRHSYDLSS 
       260        270        280        290        300
AISVLVPLGG PVLCRDEMEE WSASEASLFE EALEKYGKDF NDIRQDFLPW 
       310        320        330        340        350
KSLTSIIEYY YMWKTTDRYV QQKRLKAAEA ESKLKQVYIP TYSKPNPNQI 
       360        370        380        390        400
STSNGKPGAV NGAVGTTFQP QNPLLGRACE SCYATQSHQW YSWGPPNMQC 
       410        420        430        440        450
RLCAICWLYW KKYGGLKMPT QSEEEKLSPS PTTEDPRVRS HVSRQAMQGM 
       460        470        480        490        500
PVRNTGSPKS AVKTRQAFFL HTTYFTKFAR QVCKNTLRLR QAARRPFVAI 
       510        520        530        540        550
NYAAIRAEYA DRHAELSGSP LKSKSTRKPL ACIIGYLEIH PAKKPNVIRS 
       560        570        580        590 
TPSLQTPTTK RMLTTPNHTS LSILGKRNYS HHNGLDELTC CVSD

Length:594

Mass (Da):67,504

Last modified:February 28, 2003 - v2

Checksum:ⁱE773603F65A16DF1

Isoform 2 (identifier: Q9BTC8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
509-515: YADRHAE → CKMLLNS
516-594: Missing.

« Hide

        10         20         30         40         50
MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTASGNVEA KVVCFYRRRD 
        60         70         80         90        100
ISNTLIMLAD KHAKEIEEES ETTVEADLTD KQKHQLKHRE LFLSRQYESL 
       110        120        130        140        150
PATHIRGKCS VALLNETESV LSYLDKEDTF FYSLVYDPSL KTLLADKGEI 
       160        170        180        190        200
RVGPRYQADI PEMLLEGESD EREQSKLEVK VWDPNSPLTD RQIDQFLVVA 
       210        220        230        240        250
RAVGTFARAL DCSSSVRQPS LHMSAAAASR DITLFHAMDT LYRHSYDLSS 
       260        270        280        290        300
AISVLVPLGG PVLCRDEMEE WSASEASLFE EALEKYGKDF NDIRQDFLPW 
       310        320        330        340        350
KSLTSIIEYY YMWKTTDRYV QQKRLKAAEA ESKLKQVYIP TYSKPNPNQI 
       360        370        380        390        400
STSNGKPGAV NGAVGTTFQP QNPLLGRACE SCYATQSHQW YSWGPPNMQC 
       410        420        430        440        450
RLCAICWLYW KKYGGLKMPT QSEEEKLSPS PTTEDPRVRS HVSRQAMQGM 
       460        470        480        490        500
PVRNTGSPKS AVKTRQAFFL HTTYFTKFAR QVCKNTLRLR QAARRPFVAI 
       510 
NYAAIRAECK MLLNS

Show »

Length:515

Mass (Da):58,814

Checksum:ⁱ55E53C5ABC30528C

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6W5A2	D6W5A2_HUMAN	Metastasis associated 1 family, mem... Metastasis associated 1 family, member 3, isoform CRA_a (Metastasis-associated protein MTA3)	MTA3 hCG_1783907	537	Annotation score:
E7EQY4	E7EQY4_HUMAN	Metastasis-associated protein MTA3 Metastasis-associated protein MTA3	MTA3	514	Annotation score:
E7EV10	E7EV10_HUMAN	Metastasis-associated protein MTA3 Metastasis-associated protein MTA3	MTA3	590	Annotation score:
E9PCS8	E9PCS8_HUMAN	Metastasis-associated protein MTA3 Metastasis-associated protein MTA3	MTA3	392	Annotation score:
E9PF88	E9PF88_HUMAN	Metastasis-associated protein MTA3 Metastasis-associated protein MTA3	MTA3	91	Annotation score:
C9JR73	C9JR73_HUMAN	Metastasis-associated protein MTA3 Metastasis-associated protein MTA3	MTA3	17	Annotation score:

Sequence cautionⁱ

The sequence BAA86580 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	1 – 9	MAANMYRVG → ATGGFPRDR in BAA86580 (PubMed:10574462).Curated		9
Sequence conflictⁱ	343	Missing in BAA86580 (PubMed:10574462).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_001603	509 – 515	YADRHAE → CKMLLNS in isoform 2. 2 Publications		7
Alternative sequenceⁱVSP_001604	516 – 594	Missing in isoform 2. 2 PublicationsAdd BLAST		79

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB033092 mRNA Translation: BAA86580.1 Different initiation. AK027304 mRNA Translation: BAB55028.1 BC004227 mRNA Translation: AAH04227.1 BC053631 mRNA Translation: AAH53631.1 AL161954 mRNA Translation: CAB82305.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS46267.1 [Q9BTC8-2] CCDS82441.1 [Q9BTC8-1]
PIRⁱ	T47180
NCBI Reference Sequences More...RefSeqⁱ	NP_001269684.1, NM_001282755.1 NP_001269685.1, NM_001282756.1 NP_001317371.1, NM_001330442.1 [Q9BTC8-1] NP_065795.1, NM_020744.3 [Q9BTC8-2]
UniGeneⁱ	Hs.435413 Hs.646800 Hs.745162

Genome annotation databases

Ensemblⁱ	ENST00000405094; ENSP00000385823; ENSG00000057935 [Q9BTC8-1] ENST00000407270; ENSP00000385045; ENSG00000057935 [Q9BTC8-2]
GeneIDⁱ	57504
KEGGⁱ	hsa:57504
UCSC genome browser More...UCSCⁱ	uc002rsq.5 human [Q9BTC8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BTC8	MTA3 isoform 10		PANTR		594	UniRef100_Q9BTC8
Uncharacterized protein		CERAT		594
Uncharacterized protein		RHIRO		594
Uncharacterized protein		NOMLE		594
Metastasis associated 1 family member 3		GORGO		594
Q9BTC8-2	MTA3 isoform 5		PANTR		515	UniRef100_K7A705
Metastasis-associated protein MTA3		MACMU		515
MTA3 isoform 7		PONAB		515
Uncharacterized protein tmp_locus_6 (Fragment)		HUMAN		218
UPI0003E75BD3		COLAP		459

Protein	Similar proteins		Species	Score	Length	Source
Q9BTC8	Metastasis-associated protein MTA3	)	MOUSE		591	UniRef90_Q9BTC8
Metastasis-associated protein MTA3		BOVIN		590
MTA3 isoform 10		PANTR		594
Uncharacterized protein		CERAT		594
Uncharacterized protein		RHIRO		594
+162
Q9BTC8-2	Isoform 2 of Metastasis-associated protein MTA3		MOUSE		512	UniRef90_Q924K8-2
MTA3 isoform 5		PANTR		515
Metastasis-associated protein MTA3		MACMU		515
MTA3 isoform 7		PONAB		515
Uncharacterized protein tmp_locus_6 (Fragment)		HUMAN		218
+51

Protein	Similar proteins		Species	Score	Length	Source
Q9BTC8	Metastasis-associated protein MTA2		HUMAN		668	UniRef50_O94776
Metastasis-associated protein MTA2		MOUSE		668
Metastasis-associated protein MTA3		BOVIN		590
MTA2 isoform 1		PANTR		668
Uncharacterized protein		PANPA		668
+685
Q9BTC8-2	Isoform 2 of Metastasis-associated protein MTA3		MOUSE		512	UniRef50_Q924K8-2
Metastasis-associated protein MTA3		MACMU		515
MTA3 isoform 5		PANTR		515
MTA3 isoform 7		PONAB		515
Uncharacterized protein tmp_locus_6 (Fragment)		HUMAN		218
+57

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB033092 mRNA Translation: BAA86580.1 Different initiation. AK027304 mRNA Translation: BAB55028.1 BC004227 mRNA Translation: AAH04227.1 BC053631 mRNA Translation: AAH53631.1 AL161954 mRNA Translation: CAB82305.1
CCDSⁱ	CCDS46267.1 [Q9BTC8-2] CCDS82441.1 [Q9BTC8-1]
PIRⁱ	T47180
RefSeqⁱ	NP_001269684.1, NM_001282755.1 NP_001269685.1, NM_001282756.1 NP_001317371.1, NM_001330442.1 [Q9BTC8-1] NP_065795.1, NM_020744.3 [Q9BTC8-2]
UniGeneⁱ	Hs.435413 Hs.646800 Hs.745162

3D structure databases

ProteinModelPortalⁱ	Q9BTC8
SMRⁱ	Q9BTC8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121568, 71 interactors
ComplexPortalⁱ	CPX-880 MBD2/NuRD nucleosome remodeling and deacetylase complex CPX-922 MBD3/NuRD nucleosome remodeling and deacetylase complex
CORUMⁱ	Q9BTC8
DIPⁱ	DIP-47460N
IntActⁱ	Q9BTC8, 46 interactors
MINTⁱ	Q9BTC8
STRINGⁱ	9606.ENSP00000385045

PTM databases

iPTMnetⁱ	Q9BTC8
PhosphoSitePlusⁱ	Q9BTC8

Polymorphism and mutation databases

DMDMⁱ	29840798

DMDMⁱ

29840798

Proteomic databases

EPDⁱ	Q9BTC8
MaxQBⁱ	Q9BTC8
PaxDbⁱ	Q9BTC8
PeptideAtlasⁱ	Q9BTC8
PRIDEⁱ	Q9BTC8
ProteomicsDBⁱ	78971 78972 [Q9BTC8-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	57504
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000405094; ENSP00000385823; ENSG00000057935 [Q9BTC8-1] ENST00000407270; ENSP00000385045; ENSG00000057935 [Q9BTC8-2]
GeneIDⁱ	57504
KEGGⁱ	hsa:57504
UCSCⁱ	uc002rsq.5 human [Q9BTC8-1]

Organism-specific databases

CTDⁱ	57504
DisGeNETⁱ	57504
EuPathDBⁱ	HostDB:ENSG00000057935.13
GeneCardsⁱ	MTA3
HGNCⁱ	HGNC:23784 MTA3
HPAⁱ	HPA039433
MIMⁱ	609050 gene
neXtProtⁱ	NX_Q9BTC8
OpenTargetsⁱ	ENSG00000057935
PharmGKBⁱ	PA134953540
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3554 Eukaryota ENOG410XSAJ LUCA
GeneTreeⁱ	ENSGT00580000081398
HOGENOMⁱ	HOG000045387
HOVERGENⁱ	HBG002598
InParanoidⁱ	Q9BTC8
KOⁱ	K11660
OMAⁱ	HAPRSHR
OrthoDBⁱ	EOG091G04Z4
PhylomeDBⁱ	Q9BTC8
TreeFamⁱ	TF106444

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214815 HDACs deacetylate histones R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-73762 RNA Polymerase I Transcription Initiation R-HSA-8943724 Regulation of PTEN gene transcription
SIGNORⁱ	Q9BTC8

Miscellaneous databases

ChiTaRSⁱ	MTA3 human
GeneWikiⁱ	MTA3
GenomeRNAiⁱ	57504
Protein Ontology More...PROⁱ	PR:Q9BTC8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000057935 Expressed in 193 organ(s), highest expression level in testis
CleanExⁱ	HS_MTA3
ExpressionAtlasⁱ	Q9BTC8 baseline and differential
Genevisibleⁱ	Q9BTC8 HS

Family and domain databases

CDDⁱ	cd00202 ZnF_GATA, 1 hit
InterProⁱ	View protein in InterPro IPR001025 BAH_dom IPR000949 ELM2_dom IPR009057 Homeobox-like_sf IPR035170 MTA1_R1 IPR001005 SANT/Myb IPR017884 SANT_dom IPR000679 Znf_GATA
Pfamⁱ	View protein in Pfam PF01426 BAH, 1 hit PF01448 ELM2, 1 hit PF00320 GATA, 1 hit PF17226 MTA_R1, 1 hit
SMARTⁱ	View protein in SMART SM00439 BAH, 1 hit SM01189 ELM2, 1 hit SM00717 SANT, 1 hit SM00401 ZnF_GATA, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS51038 BAH, 1 hit PS51156 ELM2, 1 hit PS51293 SANT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MTA3_HUMAN
Accessionⁱ	Q9BTC8Primary (citable) accession number: Q9BTC8 Secondary accession number(s): Q9NSP2, Q9ULF4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 28, 2003
	Last sequence update:	February 28, 2003
	Last modified:	November 7, 2018
	This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9BTC8 (MTA3_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Metastasis-associated protein MTA3

MTA3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ