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Protein

Synaptotagmin-11

Gene

SYT11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.By similarity

Cofactori

Ca2+By similarityNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi188Calcium 1By similarity1
Metal bindingi188Calcium 2By similarity1
Metal bindingi195Calcium 1By similarity1
Metal bindingi249Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi250Calcium 1By similarity1
Metal bindingi250Calcium 2By similarity1
Metal bindingi250Calcium 3By similarity1
Metal bindingi253Calcium 3By similarity1
Metal bindingi256Calcium 2By similarity1
Metal bindingi256Calcium 3By similarity1

GO - Molecular functioni

  • beta-tubulin binding Source: Ensembl
  • clathrin binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • phosphatidylserine binding Source: GO_Central
  • protein homodimerization activity Source: ParkinsonsUK-UCL
  • SNARE binding Source: GO_Central
  • translation initiation factor binding Source: Ensembl
  • ubiquitin protein ligase binding Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-11
Alternative name(s):
Synaptotagmin XI
Short name:
SytXI
Gene namesi
Name:SYT11
Synonyms:KIAA0080
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000132718.8
HGNCiHGNC:19239 SYT11
MIMi608741 gene
neXtProtiNX_Q9BT88

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15VesicularSequence analysisAdd BLAST15
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 431CytoplasmicSequence analysisAdd BLAST395

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi23208
OpenTargetsiENSG00000132718
PharmGKBiPA134898675

Polymorphism and mutation databases

BioMutaiSYT11
DMDMi215273917

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839691 – 431Synaptotagmin-11Add BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei134PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated and targeted to the proteasome complex for degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9BT88
MaxQBiQ9BT88
PaxDbiQ9BT88
PeptideAtlasiQ9BT88
PRIDEiQ9BT88
ProteomicsDBi78960

PTM databases

iPTMnetiQ9BT88
PhosphoSitePlusiQ9BT88

Expressioni

Gene expression databases

BgeeiENSG00000132718 Expressed in 198 organ(s), highest expression level in caudate nucleus
CleanExiHS_SYT11
GenevisibleiQ9BT88 HS

Organism-specific databases

HPAiHPA064091

Interactioni

Subunit structurei

Homodimer. Can also form heterodimers (By similarity). Interacts with PRKN.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116815, 10 interactors
ELMiQ9BT88
IntActiQ9BT88, 5 interactors
MINTiQ9BT88
STRINGi9606.ENSP00000357307

Structurei

3D structure databases

ProteinModelPortaliQ9BT88
SMRiQ9BT88
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini174 – 262C2 1PROSITE-ProRule annotationAdd BLAST89
Domaini304 – 397C2 2PROSITE-ProRule annotationAdd BLAST94

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
ENOG410XRME LUCA
GeneTreeiENSGT00760000118973
HOGENOMiHOG000232126
HOVERGENiHBG005010
InParanoidiQ9BT88
KOiK19911
OMAiFIYDIPP
OrthoDBiEOG091G09ZN
PhylomeDBiQ9BT88
TreeFamiTF315600

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001565 Synaptotagmin
IPR028699 SYT11
PANTHERiPTHR10024:SF115 PTHR10024:SF115, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits

Sequencei

Sequence statusi: Complete.

Q9BT88-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEITNIRPS FDVSPVVAGL IGASVLVVCV SVTVFVWSCC HQQAEKKQKN
60 70 80 90 100
PPYKFIHMLK GISIYPETLS NKKKIIKVRR DKDGPGREGG RRNLLVDAAE
110 120 130 140 150
AGLLSRDKDP RGPSSGSCID QLPIKMDYGE ELRSPITSLT PGESKTTSPS
160 170 180 190 200
SPEEDVMLGS LTFSVDYNFP KKALVVTIQE AHGLPVMDDQ TQGSDPYIKM
210 220 230 240 250
TILPDKRHRV KTRVLRKTLD PVFDETFTFY GIPYSQLQDL VLHFLVLSFD
260 270 280 290 300
RFSRDDVIGE VMVPLAGVDP STGKVQLTRD IIKRNIQKCI SRGELQVSLS
310 320 330 340 350
YQPVAQRMTV VVLKARHLPK MDITGLSGNP YVKVNVYYGR KRIAKKKTHV
360 370 380 390 400
KKCTLNPIFN ESFIYDIPTD LLPDISIEFL VIDFDRTTKN EVVGRLILGA
410 420 430
HSVTASGAEH WREVCESPRK PVAKWHSLSE Y
Length:431
Mass (Da):48,297
Last modified:November 25, 2008 - v2
Checksum:i5C8667D2C23D758E
GO

Sequence cautioni

The sequence BAA07527 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50N → S in BAB55186 (PubMed:14702039).Curated1
Sequence conflicti268V → A in BAB55186 (PubMed:14702039).Curated1
Sequence conflicti359F → L in CAH18653 (PubMed:17974005).Curated1
Sequence conflicti370D → G in CAH18653 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04765648Q → H4 PublicationsCorresponds to variant dbSNP:rs822522Ensembl.1
Natural variantiVAR_047657231G → V1 PublicationCorresponds to variant dbSNP:rs17853892Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38522 mRNA Translation: BAA07527.2 Different initiation.
AK027540 mRNA Translation: BAB55186.1
AK074931 mRNA Translation: BAC11300.1
CR749792 mRNA Translation: CAH18653.1
AL139128 Genomic DNA No translation available.
BC004291 mRNA Translation: AAH04291.1
BC013690 mRNA Translation: AAH13690.1
BC039205 mRNA Translation: AAH39205.1
CCDSiCCDS1122.1
RefSeqiNP_689493.3, NM_152280.4
UniGeneiHs.32984

Genome annotation databases

EnsembliENST00000368324; ENSP00000357307; ENSG00000132718
GeneIDi23208
KEGGihsa:23208
UCSCiuc001fmg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38522 mRNA Translation: BAA07527.2 Different initiation.
AK027540 mRNA Translation: BAB55186.1
AK074931 mRNA Translation: BAC11300.1
CR749792 mRNA Translation: CAH18653.1
AL139128 Genomic DNA No translation available.
BC004291 mRNA Translation: AAH04291.1
BC013690 mRNA Translation: AAH13690.1
BC039205 mRNA Translation: AAH39205.1
CCDSiCCDS1122.1
RefSeqiNP_689493.3, NM_152280.4
UniGeneiHs.32984

3D structure databases

ProteinModelPortaliQ9BT88
SMRiQ9BT88
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116815, 10 interactors
ELMiQ9BT88
IntActiQ9BT88, 5 interactors
MINTiQ9BT88
STRINGi9606.ENSP00000357307

PTM databases

iPTMnetiQ9BT88
PhosphoSitePlusiQ9BT88

Polymorphism and mutation databases

BioMutaiSYT11
DMDMi215273917

Proteomic databases

EPDiQ9BT88
MaxQBiQ9BT88
PaxDbiQ9BT88
PeptideAtlasiQ9BT88
PRIDEiQ9BT88
ProteomicsDBi78960

Protocols and materials databases

DNASUi23208
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368324; ENSP00000357307; ENSG00000132718
GeneIDi23208
KEGGihsa:23208
UCSCiuc001fmg.4 human

Organism-specific databases

CTDi23208
DisGeNETi23208
EuPathDBiHostDB:ENSG00000132718.8
GeneCardsiSYT11
H-InvDBiHIX0001138
HGNCiHGNC:19239 SYT11
HPAiHPA064091
MIMi608741 gene
neXtProtiNX_Q9BT88
OpenTargetsiENSG00000132718
PharmGKBiPA134898675
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
ENOG410XRME LUCA
GeneTreeiENSGT00760000118973
HOGENOMiHOG000232126
HOVERGENiHBG005010
InParanoidiQ9BT88
KOiK19911
OMAiFIYDIPP
OrthoDBiEOG091G09ZN
PhylomeDBiQ9BT88
TreeFamiTF315600

Enzyme and pathway databases

ReactomeiR-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRSiSYT11 human
GeneWikiiSYT11
GenomeRNAii23208
PROiPR:Q9BT88
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132718 Expressed in 198 organ(s), highest expression level in caudate nucleus
CleanExiHS_SYT11
GenevisibleiQ9BT88 HS

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001565 Synaptotagmin
IPR028699 SYT11
PANTHERiPTHR10024:SF115 PTHR10024:SF115, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSYT11_HUMAN
AccessioniPrimary (citable) accession number: Q9BT88
Secondary accession number(s): Q14998
, Q5W0D4, Q68CT5, Q8IXU3, Q96SU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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