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Protein

Transcription factor SOX-7

Gene

SOX7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi45 – 113HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3769402 Deactivation of the beta-catenin transactivating complex

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-7
Gene namesi
Name:SOX7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000171056.7
HGNCiHGNC:18196 SOX7
MIMi612202 gene
neXtProtiNX_Q9BT81

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi83595
OpenTargetsiENSG00000171056
ENSG00000258724
PharmGKBiPA38307

Polymorphism and mutation databases

DMDMi20532272

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487311 – 388Transcription factor SOX-7Add BLAST388

Proteomic databases

EPDiQ9BT81
MaxQBiQ9BT81
PaxDbiQ9BT81
PeptideAtlasiQ9BT81
PRIDEiQ9BT81
ProteomicsDBi78959

PTM databases

iPTMnetiQ9BT81
PhosphoSitePlusiQ9BT81

Expressioni

Tissue specificityi

Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation.2 Publications

Developmental stagei

In 8 week-old embryo, expressed in brain, tongue, heart, liver, lung and vertebrae.1 Publication

Gene expression databases

BgeeiENSG00000171056 Expressed in 197 organ(s), highest expression level in penis
CleanExiHS_SOX7
GenevisibleiQ9BT81 HS

Organism-specific databases

HPAiHPA009065

Interactioni

Subunit structurei

Interacts with CTNNB1/beta-catenin; this interaction may lead to the proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GLRX3O760033EBI-7239117,EBI-374781

Protein-protein interaction databases

BioGridi123691, 6 interactors
IntActiQ9BT81, 5 interactors
MINTiQ9BT81
STRINGi9606.ENSP00000301921

Structurei

3D structure databases

ProteinModelPortaliQ9BT81
SMRiQ9BT81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 388Sox C-terminalPROSITE-ProRule annotationAdd BLAST121

Phylogenomic databases

eggNOGiENOG410IPZD Eukaryota
ENOG410XP3W LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000069999
HOVERGENiHBG000517
InParanoidiQ9BT81
KOiK09270
OMAiPHINGAV
OrthoDBiEOG091G0CYU
PhylomeDBiQ9BT81
TreeFamiTF321918

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR033392 Sox7/17/18_central
IPR021934 Sox_C
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12067 Sox17_18_mid, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
PS51516 SOX_C, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BT81-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASLLGAYPW PEGLECPALD AELSDGQSPP AVPRPPGDKG SESRIRRPMN
60 70 80 90 100
AFMVWAKDER KRLAVQNPDL HNAELSKMLG KSWKALTLSQ KRPYVDEAER
110 120 130 140 150
LRLQHMQDYP NYKYRPRRKK QAKRLCKRVD PGFLLSSLSR DQNALPEKRS
160 170 180 190 200
GSRGALGEKE DRGEYSPGTA LPSLRGCYHE GPAGGGGGGT PSSVDTYPYG
210 220 230 240 250
LPTPPEMSPL DVLEPEQTFF SSPCQEEHGH PRRIPHLPGH PYSPEYAPSP
260 270 280 290 300
LHCSHPLGSL ALGQSPGVSM MSPVPGCPPS PAYYSPATYH PLHSNLQAHL
310 320 330 340 350
GQLSPPPEHP GFDALDQLSQ VELLGDMDRN EFDQYLNTPG HPDSATGAMA
360 370 380
LSGHVPVSQV TPTGPTETSL ISVLADATAT YYNSYSVS
Length:388
Mass (Da):42,197
Last modified:June 1, 2001 - v1
Checksum:iDBA0EFE440DC2A74
GO
Isoform 2 (identifier: Q9BT81-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MASLLGAYPW...LHNAELSKML → MSMLAERRRK...NRVHYMKFTK

Note: No experimental confirmation available.
Show »
Length:440
Mass (Da):48,522
Checksum:i65DD815F859467D3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0566671 – 79MASLL…LSKML → MSMLAERRRKQKWAVDPQNT AWSNDDSKFGQRMLEKMGWS KGKGLGAQEQGATDHIKVQV KNNHLGLGATINNEDNWIAH QDDFNQLLAELNTCHGQETT DSSDKKEKKSFSLEEKSKIS KNRVHYMKFTK in isoform 2. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ409320 mRNA Translation: CAC84226.1
BT006693 mRNA Translation: AAP35339.1
AK055556 mRNA Translation: BAB70955.1
AK296724 mRNA Translation: BAG59312.1
AC011008 Genomic DNA No translation available.
AC105001 Genomic DNA No translation available.
BC071947 mRNA Translation: AAH71947.1
CCDSiCCDS5977.1 [Q9BT81-1]
RefSeqiNP_113627.1, NM_031439.3 [Q9BT81-1]
UniGeneiHs.709543

Genome annotation databases

EnsembliENST00000304501; ENSP00000301921; ENSG00000171056 [Q9BT81-1]
ENST00000646538; ENSP00000495029; ENSG00000285438 [Q9BT81-1]
GeneIDi83595
KEGGihsa:83595
UCSCiuc003wtf.5 human [Q9BT81-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ409320 mRNA Translation: CAC84226.1
BT006693 mRNA Translation: AAP35339.1
AK055556 mRNA Translation: BAB70955.1
AK296724 mRNA Translation: BAG59312.1
AC011008 Genomic DNA No translation available.
AC105001 Genomic DNA No translation available.
BC071947 mRNA Translation: AAH71947.1
CCDSiCCDS5977.1 [Q9BT81-1]
RefSeqiNP_113627.1, NM_031439.3 [Q9BT81-1]
UniGeneiHs.709543

3D structure databases

ProteinModelPortaliQ9BT81
SMRiQ9BT81
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123691, 6 interactors
IntActiQ9BT81, 5 interactors
MINTiQ9BT81
STRINGi9606.ENSP00000301921

PTM databases

iPTMnetiQ9BT81
PhosphoSitePlusiQ9BT81

Polymorphism and mutation databases

DMDMi20532272

Proteomic databases

EPDiQ9BT81
MaxQBiQ9BT81
PaxDbiQ9BT81
PeptideAtlasiQ9BT81
PRIDEiQ9BT81
ProteomicsDBi78959

Protocols and materials databases

DNASUi83595
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304501; ENSP00000301921; ENSG00000171056 [Q9BT81-1]
ENST00000646538; ENSP00000495029; ENSG00000285438 [Q9BT81-1]
GeneIDi83595
KEGGihsa:83595
UCSCiuc003wtf.5 human [Q9BT81-1]

Organism-specific databases

CTDi83595
DisGeNETi83595
EuPathDBiHostDB:ENSG00000171056.7
GeneCardsiSOX7
HGNCiHGNC:18196 SOX7
HPAiHPA009065
MIMi612202 gene
neXtProtiNX_Q9BT81
OpenTargetsiENSG00000171056
ENSG00000258724
PharmGKBiPA38307
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPZD Eukaryota
ENOG410XP3W LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000069999
HOVERGENiHBG000517
InParanoidiQ9BT81
KOiK09270
OMAiPHINGAV
OrthoDBiEOG091G0CYU
PhylomeDBiQ9BT81
TreeFamiTF321918

Enzyme and pathway databases

ReactomeiR-HSA-3769402 Deactivation of the beta-catenin transactivating complex

Miscellaneous databases

ChiTaRSiSOX7 human
GenomeRNAii83595
PROiPR:Q9BT81
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171056 Expressed in 197 organ(s), highest expression level in penis
CleanExiHS_SOX7
GenevisibleiQ9BT81 HS

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR033392 Sox7/17/18_central
IPR021934 Sox_C
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12067 Sox17_18_mid, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
PS51516 SOX_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOX7_HUMAN
AccessioniPrimary (citable) accession number: Q9BT81
Secondary accession number(s): B4DKV0, Q53YD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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