Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 132 (13 Feb 2019)
Sequence version 2 (25 Nov 2008)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Uroplakin-3b

Gene

UPK3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.90.2.2 the uroplakin 2/3 (upk2/3) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uroplakin-3b
Short name:
UP3b
Alternative name(s):
Uroplakin IIIb
Short name:
UPIIIb
p35
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UPK3B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000243566.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21444 UPK3B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611887 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BT76

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 240LumenalSequence analysisAdd BLAST211
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei241 – 266HelicalSequence analysisAdd BLAST26
Topological domaini267 – 320CytoplasmicSequence analysisAdd BLAST54

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
105375355

Open Targets

More...
OpenTargetsi
ENSG00000243566

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134952181

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UPK3B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002264030 – 320Uroplakin-3bAdd BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BT76

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BT76

PeptideAtlas

More...
PeptideAtlasi
Q9BT76

PRoteomics IDEntifications database

More...
PRIDEi
Q9BT76

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78956
78957 [Q9BT76-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BT76

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BT76

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000243566 Expressed in 117 organ(s), highest expression level in lower esophagus mucosa

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BT76 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA010506

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with uroplakin-1B (UPK1B).

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123295, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000257632

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9BT76

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the uroplakin-3 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IS9T Eukaryota
ENOG41123W4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153392

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293265

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG079326

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BT76

Identification of Orthologs from Complete Genome Data

More...
OMAi
WLLHGEA

Database of Orthologous Groups

More...
OrthoDBi
1269506at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BT76

TreeFam database of animal gene trees

More...
TreeFami
TF336628

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024831 Uroplakin-3
IPR024828 Uroplakin-3b

The PANTHER Classification System

More...
PANTHERi
PTHR15446 PTHR15446, 1 hit
PTHR15446:SF15 PTHR15446:SF15, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BT76-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLPWGQPHL GLQMLLLALN CLRPSLSLGE WGSWMDASSQ TQGAGGPAGV
60 70 80 90 100
IGPWAPAPLR LGEAAPGTPT PVSVAHLLSP VATELVPYTP QITAWDLEGK
110 120 130 140 150
VTATTFSLEQ PRCVFDGLAS ASDTVWLVVA FSNASRGFQN PETLADIPAS
160 170 180 190 200
PQLLTDGHYM TLPLSPDQLP CGDPMAGSGG APVLRVGHDH GCHQQPFCNA
210 220 230 240 250
PLPGPGPYRE DPRIHRHLAR AAKWQHDRHY LHPLFSGRPP TLGLLGSLYH
260 270 280 290 300
ALLQPVVAGG GPGAAADRLL HGQALHDPPH PTQRGRHTAG GLQAWPGPPP
310 320
QPQPLAWPLC MGLGEMGRWE
Length:320
Mass (Da):33,882
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i64A1FE268A8BB0EB
GO
Isoform 2 (identifier: Q9BT76-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-83: Missing.

Show »
Length:265
Mass (Da):28,537
Checksum:i0709A06F2BC7148F
GO
Isoform 3 (identifier: Q9BT76-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-83: Missing.
     210-320: EDPRIHRHLA...MGLGEMGRWE → VKFLLMDTRG...GLDPLPSLSP

Show »
Length:276
Mass (Da):29,791
Checksum:i9A94B2A6E69DEEBD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YVS6A0A0J9YVS6_HUMAN
Uroplakin-3b
UPK3B
265Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAO89507 differs from that shown. Reason: Frameshift at position 210.Curated
The sequence AAS07526 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034561293Q → R. Corresponds to variant dbSNP:rs1636632Ensembl.1
Natural variantiVAR_047805319W → R3 PublicationsCorresponds to variant dbSNP:rs1799126Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03732729 – 83Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST55
Alternative sequenceiVSP_054295210 – 320EDPRI…MGRWE → VKFLLMDTRGSPRAETKWSD PITLHQGKTPGSIDTWPGRR SGSMIVITSILSSLAGLLLL AFLAASTMRFSSLWWPEEAP EQLRIGSFMGKRYMTHHIPP REAATLPVGCKPGLDPLPSL SP in isoform 3. CuratedAdd BLAST111

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY233462 mRNA Translation: AAO89507.1 Frameshift.
AK056760 mRNA Translation: BAG51807.1
AK290096 mRNA Translation: BAF82785.1
AC004980 Genomic DNA No translation available.
AC006972 Genomic DNA No translation available.
AC007003 Genomic DNA No translation available.
AC114737 Genomic DNA No translation available.
AC007078 Genomic DNA Translation: AAS07526.1 Sequence problems.
BC004304 mRNA Translation: AAH04304.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS87512.1 [Q9BT76-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001334613.1, NM_001347684.1 [Q9BT76-3]
NP_085047.1, NM_030570.3
NP_872624.1, NM_182683.2
NP_872625.1, NM_182684.2
XP_005250669.1, XM_005250612.3
XP_006716203.1, XM_006716140.3
XP_006716204.1, XM_006716141.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.488861

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000257632; ENSP00000257632; ENSG00000243566 [Q9BT76-1]
ENST00000334348; ENSP00000334938; ENSG00000243566 [Q9BT76-3]
ENST00000394849; ENSP00000378319; ENSG00000243566 [Q9BT76-2]
ENST00000448265; ENSP00000441284; ENSG00000276184
ENST00000615976; ENSP00000479568; ENSG00000276184

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
105375355

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:105375355

UCSC genome browser

More...
UCSCi
uc033ayx.2 human [Q9BT76-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY233462 mRNA Translation: AAO89507.1 Frameshift.
AK056760 mRNA Translation: BAG51807.1
AK290096 mRNA Translation: BAF82785.1
AC004980 Genomic DNA No translation available.
AC006972 Genomic DNA No translation available.
AC007003 Genomic DNA No translation available.
AC114737 Genomic DNA No translation available.
AC007078 Genomic DNA Translation: AAS07526.1 Sequence problems.
BC004304 mRNA Translation: AAH04304.1
CCDSiCCDS87512.1 [Q9BT76-3]
RefSeqiNP_001334613.1, NM_001347684.1 [Q9BT76-3]
NP_085047.1, NM_030570.3
NP_872624.1, NM_182683.2
NP_872625.1, NM_182684.2
XP_005250669.1, XM_005250612.3
XP_006716203.1, XM_006716140.3
XP_006716204.1, XM_006716141.3
UniGeneiHs.488861

3D structure databases

ProteinModelPortaliQ9BT76
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123295, 2 interactors
STRINGi9606.ENSP00000257632

Protein family/group databases

TCDBi8.A.90.2.2 the uroplakin 2/3 (upk2/3) family

PTM databases

iPTMnetiQ9BT76
PhosphoSitePlusiQ9BT76

Polymorphism and mutation databases

BioMutaiUPK3B

Proteomic databases

jPOSTiQ9BT76
PaxDbiQ9BT76
PeptideAtlasiQ9BT76
PRIDEiQ9BT76
ProteomicsDBi78956
78957 [Q9BT76-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
80761
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257632; ENSP00000257632; ENSG00000243566 [Q9BT76-1]
ENST00000334348; ENSP00000334938; ENSG00000243566 [Q9BT76-3]
ENST00000394849; ENSP00000378319; ENSG00000243566 [Q9BT76-2]
ENST00000448265; ENSP00000441284; ENSG00000276184
ENST00000615976; ENSP00000479568; ENSG00000276184
GeneIDi105375355
KEGGihsa:105375355
UCSCiuc033ayx.2 human [Q9BT76-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
105375355
DisGeNETi105375355
EuPathDBiHostDB:ENSG00000243566.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
UPK3B
HGNCiHGNC:21444 UPK3B
HPAiHPA010506
MIMi611887 gene
neXtProtiNX_Q9BT76
OpenTargetsiENSG00000243566
PharmGKBiPA134952181

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IS9T Eukaryota
ENOG41123W4 LUCA
GeneTreeiENSGT00940000153392
HOGENOMiHOG000293265
HOVERGENiHBG079326
InParanoidiQ9BT76
OMAiWLLHGEA
OrthoDBi1269506at2759
PhylomeDBiQ9BT76
TreeFamiTF336628

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
UPK3B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
105375355

Protein Ontology

More...
PROi
PR:Q9BT76

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000243566 Expressed in 117 organ(s), highest expression level in lower esophagus mucosa
GenevisibleiQ9BT76 HS

Family and domain databases

InterProiView protein in InterPro
IPR024831 Uroplakin-3
IPR024828 Uroplakin-3b
PANTHERiPTHR15446 PTHR15446, 1 hit
PTHR15446:SF15 PTHR15446:SF15, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUPK3B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BT76
Secondary accession number(s): A6NHH5
, A8K231, A8MZA8, B3KPU5, Q75MM5, Q86W06
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: November 25, 2008
Last modified: February 13, 2019
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again