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Protein

Proteasome assembly chaperone 3

Gene

PSMG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes.1 Publication

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome assembly chaperone 3
Short name:
PAC-3
Short name:
hPAC3
Gene namesi
Name:PSMG3
Synonyms:C7orf48, PAC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000157778.8
HGNCiHGNC:22420 PSMG3
MIMi617528 gene
neXtProtiNX_Q9BT73

Pathology & Biotechi

Organism-specific databases

DisGeNETi84262
OpenTargetsiENSG00000157778
PharmGKBiPA162400247

Chemistry databases

ChEMBLiCHEMBL1075137

Polymorphism and mutation databases

BioMutaiPSMG3
DMDMi74733099

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002713581 – 122Proteasome assembly chaperone 3Add BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BT73
MaxQBiQ9BT73
PaxDbiQ9BT73
PeptideAtlasiQ9BT73
PRIDEiQ9BT73
ProteomicsDBi78955
TopDownProteomicsiQ9BT73

PTM databases

iPTMnetiQ9BT73
PhosphoSitePlusiQ9BT73

Expressioni

Gene expression databases

BgeeiENSG00000157778
CleanExiHS_PSMG3
ExpressionAtlasiQ9BT73 baseline and differential
GenevisibleiQ9BT73 HS

Organism-specific databases

HPAiHPA023876

Interactioni

Subunit structurei

Homodimer. Interacts with PSMG4. Interacts directly with alpha and beta subunits of the 20S proteasome but dissociates before the formation of half-proteasomes, probably upon recruitment of POMP.2 Publications

Protein-protein interaction databases

BioGridi123989, 58 interactors
CORUMiQ9BT73
IntActiQ9BT73, 3 interactors
MINTiQ9BT73
STRINGi9606.ENSP00000252329

Chemistry databases

BindingDBiQ9BT73

Structurei

Secondary structure

1122
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 16Combined sources8
Beta strandi19 – 27Combined sources9
Beta strandi29 – 38Combined sources10
Beta strandi44 – 50Combined sources7
Beta strandi56 – 59Combined sources4
Beta strandi62 – 69Combined sources8
Helixi73 – 89Combined sources17
Beta strandi94 – 100Combined sources7
Helixi106 – 118Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z5EX-ray2.00A/B1-122[»]
ProteinModelPortaliQ9BT73
SMRiQ9BT73
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BT73

Family & Domainsi

Sequence similaritiesi

Belongs to the PSMG3 family.Curated

Phylogenomic databases

eggNOGiKOG4828 Eukaryota
ENOG410Y6DC LUCA
GeneTreeiENSGT00390000000324
HOGENOMiHOG000006024
HOVERGENiHBG061282
InParanoidiQ9BT73
KOiK11877
OMAiKDHSQAT
OrthoDBiEOG091G10BI
PhylomeDBiQ9BT73
TreeFamiTF300294

Family and domain databases

InterProiView protein in InterPro
IPR018788 Proteasome_assmbl_chp_3
PfamiView protein in Pfam
PF10178 PAC3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BT73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDTPLVISK QKTEVVCGVP TQVVCTAFSS HILVVVTQFG KMGTLVSLEP
60 70 80 90 100
SSVASDVSKP VLTTKVLLGQ DEPLIHVFAK NLVAFVSQEA GNRAVLLAVA
110 120
VKDKSMEGLK ALREVIRVCQ VW
Length:122
Mass (Da):13,104
Last modified:June 1, 2001 - v1
Checksum:iFA3D42A2CF4B88B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093734 Genomic DNA Translation: AAP21867.1
CH236953 Genomic DNA Translation: EAL23945.1
CH471144 Genomic DNA Translation: EAW87212.1
BC004308 mRNA Translation: AAH04308.1
BC027171 mRNA Translation: AAH27171.1
BR000337 mRNA Translation: FAA00325.1
CCDSiCCDS5327.1
RefSeqiNP_001127812.1, NM_001134340.1
NP_115678.1, NM_032302.3
UniGeneiHs.446311

Genome annotation databases

EnsembliENST00000252329; ENSP00000252329; ENSG00000157778
ENST00000288607; ENSP00000288607; ENSG00000157778
ENST00000404674; ENSP00000384799; ENSG00000157778
GeneIDi84262
KEGGihsa:84262
UCSCiuc003skx.3 human

Similar proteinsi

Entry informationi

Entry nameiPSMG3_HUMAN
AccessioniPrimary (citable) accession number: Q9BT73
Secondary accession number(s): A4D216, A8MPW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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