NDFIP1

Functionⁱ

Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cell-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). Promotes pancreatic beta cell death through degradation of JUNB and inhibition of the unfolded protein response, leading to reduction of insulin secretion (PubMed:26319551). Restricts the production of proinflammatory cytokines in effector Th17 T-cells by promoting ITCH-mediated ubiquitination and degradation of RORC (By similarity). Together with NDFIP2, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity). Regulates peripheral T-cell tolerance to self and foreign antigens, forcing the exit of naive CD4+ T-cells from the cell cycle before they become effector T-cells (By similarity). Negatively regulates RLR-mediated antiviral response by promoting SMURF1-mediated ubiquitination and subsequent degradation of MAVS (PubMed:23087404). Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus where it mediates KCNH2 degradation (PubMed:26363003). In cortical neurons, mediates the ubiquitination of the divalent metal transporter SLC11A2/DMT1 by NEDD4L, leading to its down-regulation and protection of the cells from cobalt and iron toxicity (PubMed:19706893). Important for normal development of dendrites and dendritic spines in cortex (By similarity). Enhances the ubiquitination of BRAT1 mediated by: NEDD4, NEDD4L and ITCH and is required for the nuclear localization of ubiquitinated BRAT1 (PubMed:25631046). Enhances the ITCH-mediated ubiquitination of MAP3K7 by recruiting E2 ubiquitin-conjugating enzyme UBE2L3 to ITCH (By similarity). Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate (PubMed:20534535). Inhibits cell proliferation by promoting PTEN nuclear localization and changing its signaling specificity (PubMed:25801959).By similarity8 Publications

GO - Molecular functionⁱ

WW domain binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular iron ion homeostasis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18776082
metal ion transport Source: InterPro
negative regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18776082
negative regulation of inflammatory response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of interleukin-4 production
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of isotype switching to IgE isotypes
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of protein transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18776082
negative regulation of T cell proliferation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of transporter activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18776082
negative regulation of type 2 immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of I-kappaB kinase/NF-kappaB signaling
Source: UniProtKB
Inferred from high throughput mutant phenotypeⁱ
- 12761501
positive regulation of protein catabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of protein ubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 25631046
regulation of isotype switching to IgG isotypes
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of lymphocyte differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of myeloid leukocyte differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
vacuolar transport Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: NEDD4 family-interacting protein 1 Alternative name(s): Breast cancer-associated protein SGA-1M NEDD4 WW domain-binding protein 5 Putative MAPK-activating protein PM13 Putative NF-kappa-B-activating protein 164 Putative NFKB and MAPK-activating protein
Gene namesⁱ	Name:NDFIP1 Synonyms:N4WBP5 ORF Names:PSEC0192, PSEC0223
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000131507.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17592 NDFIP1
MIMⁱ	612050 gene
neXtProtⁱ	NX_Q9BT67

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	2 – 116	CytoplasmicSequence analysisAdd BLAST	115
Transmembraneⁱ	117 – 137	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	138 – 143	ExtracellularSequence analysis	6
Transmembraneⁱ	144 – 164	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	165 – 172	CytoplasmicSequence analysis	8
Transmembraneⁱ	173 – 193	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	194 – 221	ExtracellularSequence analysisAdd BLAST	28

Keywords - Cellular componentⁱ

Cell junction, Cell projection, Endosome, Golgi apparatus, Membrane, Secreted, Synapse, Synaptosome

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	41 – 42	PY → AG: Loss of phosphorylation; when associated with 66-S-Y-67 and 75-S-Y-76. Greatly decreases NEDD4-binding; when associated with 66-S-Y-67 and 75-S-Y-76. No effect on PTEN-binding; when associated with 66-S-Y-67 and 75-S-Y-76. 1 Publication	2
Mutagenesisⁱ	66 – 67	SY → AG: Loss of phosphorylation; when associated with 41-P-Y-42 and 75-S-Y-76. Greatly decreases NEDD4-binding; when associated with 41-P-Y-42 and 75-S-Y-76. No effect on PTEN-binding; when associated with 41-P-Y-42 and 75-S-Y-76. 1 Publication	2
Mutagenesisⁱ	75 – 76	SY → AG: Loss of phosphorylation; when associated with 41-P-Y-42 and 66-S-Y-67. Greatly decreases NEDD4-binding; when associated with 41-P-Y-42 and 66-S-Y-67. No effect on PTEN-binding; when associated with 41-P-Y-42 and 66-S-Y-67. 1 Publication	2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	80762
Open Targets More...OpenTargetsⁱ	ENSG00000131507
PharmGKBⁱ	PA134943402

Polymorphism and mutation databases

BioMutaⁱ	NDFIP1
DMDMⁱ	74733098

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000076269	2 – 221	NEDD4 family-interacting protein 1Add BLAST		220

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1

Post-translational modificationⁱ

Ubiquitinated by NEDD4 and ITCH; mono-, di- and polyubiquitinated forms are detected. Ubiquitination regulates its degradation.1 Publication

Undergoes transient tyrosine phosphorylation following EGF stimulation, most probably by catalyzed by SRC. Phosphorylation SRC is enhanced in the presence of NDFIP2 which may act as a scaffold to recruit SRC to NDFIP1.1 Publication

Keywords - PTMⁱ

Acetylation, Ubl conjugation

Proteomic databases

EPDⁱ	Q9BT67
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BT67
PaxDbⁱ	Q9BT67
PeptideAtlas More...PeptideAtlasⁱ	Q9BT67
PRIDEⁱ	Q9BT67
ProteomicsDBⁱ	78953 78954 [Q9BT67-2]

PTM databases

iPTMnetⁱ	Q9BT67
PhosphoSitePlusⁱ	Q9BT67
SwissPalmⁱ	Q9BT67

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta. Also expressed in fetal brain, kidney and lung.1 Publication

Inductionⁱ

Increased protein expression in neuronal cells in response to Co²⁺ or Fe²⁺ ions.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000131507 Expressed in 236 organ(s), highest expression level in primary visual cortex
CleanExⁱ	HS_NDFIP1
Genevisibleⁱ	Q9BT67 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA009682

HPAⁱ

HPA009682

Interactionⁱ

Subunit structureⁱ

Forms heterodimers with NDFIP2 (PubMed:20534535). Interacts with several E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L and WWP2 (PubMed:18776082, PubMed:19706893, PubMed:26363003). The interaction with NEDD4, NEDD4L and ITCH leads to relocalization of these proteins to exosomes and eventually to exosomal secretion (By similarity). Interacts with U2SURP (By similarity). Interacts with SLC11A2/DMT1 (PubMed:18776082, PubMed:19706893). Interacts with PTEN (PubMed:20534535, PubMed:25801959). May interact with phosphorylated EGFR (PubMed:20534535). Interacts with BRAT1 (PubMed:25631046). Interacts with KCNH2 (PubMed:26363003). Interacts with MAVS (PubMed:23087404). Part of a complex containing ITCH, NDFIP1 and MAP3K7 (By similarity). Interacts (via N-terminus) with UBE2L3; the interaction mediates recruitment of UBE2L3 to ITCH (PubMed:25632008).By similarity8 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SLC11A2	P49281	2	EBI-11732799,EBI-4319335

With

Entry

#Exp.

IntAct

Notes

SLC11A2

P49281

2

EBI-11732799,EBI-4319335

GO - Molecular functionⁱ

WW domain binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	123296, 55 interactors
Database of interacting proteins More...DIPⁱ	DIP-48958N
IntActⁱ	Q9BT67, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q9BT67
STRINGⁱ	9606.ENSP00000253814

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BT67
SMRⁱ	Q9BT67
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	2 – 41	Interaction with UBE2L3By similarityAdd BLAST		40
Regionⁱ	42 – 76	Interaction with ITCHBy similarityAdd BLAST		35

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	39 – 42	PPxY motif 1	4
Motifⁱ	64 – 67	PPxY motif 2	4
Motifⁱ	74 – 76	PPxY motif 3	3

Domainⁱ

The PPxY motifs are required for E3 ubiquitin-protein ligase binding and activation and for ubiquitination.1 Publication

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4812 Eukaryota ENOG4111M6U LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012721
HOGENOMⁱ	HOG000038752
HOVERGENⁱ	HBG057103
InParanoidⁱ	Q9BT67
OMAⁱ	IPMQMQV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IMV
PhylomeDBⁱ	Q9BT67
TreeFamⁱ	TF324911

Family and domain databases

InterProⁱ	View protein in InterPro IPR019325 NEDD4/Bsd2
PANTHERⁱ	PTHR13396 PTHR13396, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10176 DUF2370, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9BT67-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALALAALAA VEPACGSRYQ QLQNEEESGE PEQAAGDAPP PYSSISAESA 
        60         70         80         90        100
AYFDYKDESG FPKPPSYNVA TTLPSYDEAE RTKAEATIPL VPGRDEDFVG 
       110        120        130        140        150
RDDFDDADQL RIGNDGIFML TFFMAFLFNW IGFFLSFCLT TSAAGRYGAI 
       160        170        180        190        200
SGFGLSLIKW ILIVRFSTYF PGYFDGQYWL WWVFLVLGFL LFLRGFINYA 
       210        220 
KVRKMPETFS NLPRTRVLFI Y

Length:221

Mass (Da):24,899

Last modified:June 1, 2001 - v1

Checksum:ⁱ526A579D7B32FCA4

GO

Isoform 2 (identifier: Q9BT67-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
76-153: YDEAERTKAE...AGRYGAISGF → CFYDISHLIF...VGCLKAKQEN
154-221: Missing.

« Hide

        10         20         30         40         50
MALALAALAA VEPACGSRYQ QLQNEEESGE PEQAAGDAPP PYSSISAESA 
        60         70         80         90        100
AYFDYKDESG FPKPPSYNVA TTLPSCFYDI SHLIFFIFYL RNMKKKYTKM 
       110        120        130        140        150
VKLLHKSAPA QSDSCKCPFI CCVCISRISI GSRSGYQYIM HRSVGCLKAK 

QEN

Note: No experimental confirmation available.

Show »

Length:153

Mass (Da):16,915

Checksum:ⁱD8A2706965DD8A23

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	20	Q → W in BAC11670 (PubMed:16303743).Curated		1
Sequence conflictⁱ	104	F → L in BAC11670 (PubMed:16303743).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_016474	76 – 153	YDEAE…AISGF → CFYDISHLIFFIFYLRNMKK KYTKMVKLLHKSAPAQSDSC KCPFICCVCISRISIGSRSG YQYIMHRSVGCLKAKQEN in isoform 2. 1 PublicationAdd BLAST		78
Alternative sequenceⁱVSP_016475	154 – 221	Missing in isoform 2. 1 PublicationAdd BLAST		68

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY192728 mRNA Translation: AAP13460.1 AB097010 mRNA Translation: BAC77363.1 AB097037 mRNA Translation: BAC77390.1 AK075495 mRNA Translation: BAC11652.1 AK075524 mRNA Translation: BAC11670.1 AK315481 mRNA Translation: BAG37865.1 CH471062 Genomic DNA Translation: EAW61888.1 CH471062 Genomic DNA Translation: EAW61889.1 BC004317 mRNA Translation: AAH04317.1 AL832993 mRNA Translation: CAH56294.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4273.1 [Q9BT67-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_085048.1, NM_030571.3 [Q9BT67-1]
UniGeneⁱ	Hs.653510 Hs.9788

Genome annotation databases

Ensemblⁱ	ENST00000253814; ENSP00000253814; ENSG00000131507 [Q9BT67-1]
GeneIDⁱ	80762
KEGGⁱ	hsa:80762
UCSC genome browser More...UCSCⁱ	uc003lmi.5 human [Q9BT67-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BT67	NEDD4 family-interacting protein 1		MACMU		221	UniRef100_Q9BT67
Nedd4 family interacting protein 1		PANTR		221
NDFIP1 isoform 1		PONAB		221
Uncharacterized protein		CERAT		221
Uncharacterized protein		PAPAN		221
+8

Protein	Similar proteins		Species	Score	Length	Source
Q9BT67	NEDD4 family-interacting protein 1		RAT		221	UniRef90_Q9BT67
NEDD4 family-interacting protein 1		MACMU		221
Nedd4 family interacting protein 1		PANTR		221
NDFIP1 isoform 1		PONAB		221
Uncharacterized protein		CERAT		221
+92

Protein	Similar proteins		Species	Score	Length	Source
Q9BT67	NEDD4 family-interacting protein 1		RAT		221	UniRef50_Q9BT67
NEDD4 family-interacting protein 1		MACMU		221
Nedd4 family interacting protein 1		PANTR		221
NDFIP1 isoform 1		PONAB		221
Uncharacterized protein		CERAT		221
+334

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY192728 mRNA Translation: AAP13460.1 AB097010 mRNA Translation: BAC77363.1 AB097037 mRNA Translation: BAC77390.1 AK075495 mRNA Translation: BAC11652.1 AK075524 mRNA Translation: BAC11670.1 AK315481 mRNA Translation: BAG37865.1 CH471062 Genomic DNA Translation: EAW61888.1 CH471062 Genomic DNA Translation: EAW61889.1 BC004317 mRNA Translation: AAH04317.1 AL832993 mRNA Translation: CAH56294.1
CCDSⁱ	CCDS4273.1 [Q9BT67-1]
RefSeqⁱ	NP_085048.1, NM_030571.3 [Q9BT67-1]
UniGeneⁱ	Hs.653510 Hs.9788

3D structure databases

ProteinModelPortalⁱ	Q9BT67
SMRⁱ	Q9BT67
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123296, 55 interactors
DIPⁱ	DIP-48958N
IntActⁱ	Q9BT67, 3 interactors
MINTⁱ	Q9BT67
STRINGⁱ	9606.ENSP00000253814

PTM databases

iPTMnetⁱ	Q9BT67
PhosphoSitePlusⁱ	Q9BT67
SwissPalmⁱ	Q9BT67

Polymorphism and mutation databases

BioMutaⁱ	NDFIP1
DMDMⁱ	74733098

Proteomic databases

EPDⁱ	Q9BT67
MaxQBⁱ	Q9BT67
PaxDbⁱ	Q9BT67
PeptideAtlasⁱ	Q9BT67
PRIDEⁱ	Q9BT67
ProteomicsDBⁱ	78953 78954 [Q9BT67-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	80762
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000253814; ENSP00000253814; ENSG00000131507 [Q9BT67-1]
GeneIDⁱ	80762
KEGGⁱ	hsa:80762
UCSCⁱ	uc003lmi.5 human [Q9BT67-1]

Organism-specific databases

CTDⁱ	80762
DisGeNETⁱ	80762
EuPathDBⁱ	HostDB:ENSG00000131507.10
GeneCardsⁱ	NDFIP1
HGNCⁱ	HGNC:17592 NDFIP1
HPAⁱ	HPA009682
MIMⁱ	612050 gene
neXtProtⁱ	NX_Q9BT67
OpenTargetsⁱ	ENSG00000131507
PharmGKBⁱ	PA134943402
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4812 Eukaryota ENOG4111M6U LUCA
GeneTreeⁱ	ENSGT00390000012721
HOGENOMⁱ	HOG000038752
HOVERGENⁱ	HBG057103
InParanoidⁱ	Q9BT67
OMAⁱ	IPMQMQV
OrthoDBⁱ	EOG091G0IMV
PhylomeDBⁱ	Q9BT67
TreeFamⁱ	TF324911

Miscellaneous databases

ChiTaRSⁱ	NDFIP1 human
GenomeRNAiⁱ	80762
Protein Ontology More...PROⁱ	PR:Q9BT67
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000131507 Expressed in 236 organ(s), highest expression level in primary visual cortex
CleanExⁱ	HS_NDFIP1
Genevisibleⁱ	Q9BT67 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019325 NEDD4/Bsd2
PANTHERⁱ	PTHR13396 PTHR13396, 1 hit
Pfamⁱ	View protein in Pfam PF10176 DUF2370, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NFIP1_HUMAN
Accessionⁱ	Q9BT67Primary (citable) accession number: Q9BT67 Secondary accession number(s): B2RDB8 , D3DQF0, Q658T8, Q8N2E3, Q8N2F9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

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UniProtKB - Q9BT67 (NFIP1_HUMAN)

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NEDD4 family-interacting protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Extracellular region or secreted

Golgi apparatus

Other locations

Endosome

Extracellular region or secreted

Golgi apparatus

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ