UniProtKB - Q9BT56 (SPXN_HUMAN)
Spexin
SPX
Functioni
Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity).
By similarityActs as a ligand for galanin receptors GALR2 and GALR3 (PubMed:17284679, PubMed:24517231).
Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes (By similarity).
By similarity2 PublicationsIntracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity).
By similarityGO - Molecular functioni
- neuropeptide hormone activity Source: UniProtKB
- type 2 galanin receptor binding Source: UniProtKB
- type 3 galanin receptor binding Source: UniProtKB
GO - Biological processi
- long-chain fatty acid import into cell Source: UniProtKB
- negative regulation of appetite Source: UniProtKB
- negative regulation of heart rate Source: UniProtKB
- negative regulation of renal sodium excretion Source: UniProtKB
- positive regulation of gastro-intestinal system smooth muscle contraction Source: UniProtKB
- positive regulation of systemic arterial blood pressure Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of sensory perception of pain Source: UniProtKB
Keywordsi
Molecular function | Hormone |
Enzyme and pathway databases
PathwayCommonsi | Q9BT56 |
SignaLinki | Q9BT56 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:SPX Synonyms:C12orf39 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28139, SPX |
MIMi | 619246, gene |
neXtProti | NX_Q9BT56 |
VEuPathDBi | HostDB:ENSG00000134548 |
Subcellular locationi
Extracellular region or secreted
Other locations
Note: Secreted via the classical ER/Golgi-dependent pathway into the extracellular medium largely as a full-length protein without the signal peptide, and not as a hydrolyzed and amidated peptide (PubMed:19193193 and PubMed:17284679). Localized extracellularly surrounding the villous trophoblastic cells. Detected in the serum.
Extracellular region or secreted
- extracellular space Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
- dense core granule Source: UniProtKB
- transport vesicle Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasmic vesicle, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 80763 |
OpenTargetsi | ENSG00000134548 |
PharmGKBi | PA143485369 |
Miscellaneous databases
Pharosi | Q9BT56, Tbio |
Genetic variation databases
BioMutai | SPX |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000430213 | 27 – 116 | SpexinAdd BLAST | 90 | |
PropeptideiPRO_0000363216 | 27 – 35 | 9 | ||
PeptideiPRO_0000042159 | 36 – 49 | Spexin-1Add BLAST | 14 | |
PropeptideiPRO_0000363217 | 50 – 116 | Add BLAST | 67 | |
PeptideiPRO_0000430214 | 53 – 70 | Spexin-2Add BLAST | 18 | |
PropeptideiPRO_0000430215 | 74 – 116 | Add BLAST | 43 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 49 | Glutamine amide1 Publication | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 35 – 36 | Cleavage; by prohormone convertase 2 | 2 | |
Sitei | 52 – 53 | Cleavage; by prohormone convertase 2 | 2 | |
Sitei | 72 – 73 | Cleavage; by prohormone convertase 2 | 2 |
Keywords - PTMi
Amidation, Cleavage on pair of basic residuesProteomic databases
jPOSTi | Q9BT56 |
MassIVEi | Q9BT56 |
PaxDbi | Q9BT56 |
PeptideAtlasi | Q9BT56 |
PRIDEi | Q9BT56 |
ProteomicsDBi | 78952 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000134548, Expressed in adipose tissue of abdominal region and 165 other tissues |
ExpressionAtlasi | Q9BT56, baseline and differential |
Genevisiblei | Q9BT56, HS |
Organism-specific databases
HPAi | ENSG00000134548, Tissue enriched (adipose) |
Interactioni
Binary interactionsi
Q9BT56
With | #Exp. | IntAct |
---|---|---|
MRM1 [Q6IN84] | 3 | EBI-17975052,EBI-5454865 |
GO - Molecular functioni
- neuropeptide hormone activity Source: UniProtKB
- type 2 galanin receptor binding Source: UniProtKB
- type 3 galanin receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 123297, 34 interactors |
IntActi | Q9BT56, 1 interactor |
STRINGi | 9606.ENSP00000256969 |
Miscellaneous databases
RNActi | Q9BT56, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q9BT56 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 55 – 77 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 55 – 69 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SAD1, Eukaryota |
GeneTreei | ENSGT00390000012501 |
HOGENOMi | CLU_169090_0_0_1 |
InParanoidi | Q9BT56 |
OMAi | LETRSHN |
OrthoDBi | 1579616at2759 |
PhylomeDBi | Q9BT56 |
TreeFami | TF333402 |
Family and domain databases
InterProi | View protein in InterPro IPR028126, Spexin |
PANTHERi | PTHR28590, PTHR28590, 1 hit |
Pfami | View protein in Pfam PF15171, Spexin, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MKGLRSLAAT TLALFLVFVF LGNSSCAPQR LLERRNWTPQ AMLYLKGAQG
60 70 80 90 100
RRFISDQSRR KDLSDRPLPE RRSPNPQLLT IPEAATILLA SLQKSPEDEE
110
KNFDQTRFLE DSLLNW
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3ISF3 | A0A3B3ISF3_HUMAN | Spexin | SPX | 75 | Annotation score: | ||
F5GXE5 | F5GXE5_HUMAN | Spexin | SPX | 36 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027273 mRNA Translation: BAG51298.1 AK075342 mRNA Translation: BAG52117.1 CH471094 Genomic DNA Translation: EAW96444.1 BC004336 mRNA Translation: AAH04336.1 |
CCDSi | CCDS31757.1 |
RefSeqi | NP_085049.1, NM_030572.3 |
Genome annotation databases
Ensembli | ENST00000256969.7; ENSP00000256969.2; ENSG00000134548.11 |
GeneIDi | 80763 |
KEGGi | hsa:80763 |
MANE-Selecti | ENST00000256969.7; ENSP00000256969.2; NM_030572.4; NP_085049.1 |
UCSCi | uc001rfa.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027273 mRNA Translation: BAG51298.1 AK075342 mRNA Translation: BAG52117.1 CH471094 Genomic DNA Translation: EAW96444.1 BC004336 mRNA Translation: AAH04336.1 |
CCDSi | CCDS31757.1 |
RefSeqi | NP_085049.1, NM_030572.3 |
3D structure databases
AlphaFoldDBi | Q9BT56 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123297, 34 interactors |
IntActi | Q9BT56, 1 interactor |
STRINGi | 9606.ENSP00000256969 |
Genetic variation databases
BioMutai | SPX |
Proteomic databases
jPOSTi | Q9BT56 |
MassIVEi | Q9BT56 |
PaxDbi | Q9BT56 |
PeptideAtlasi | Q9BT56 |
PRIDEi | Q9BT56 |
ProteomicsDBi | 78952 |
Protocols and materials databases
Antibodypediai | 2438, 24 antibodies from 10 providers |
DNASUi | 80763 |
Genome annotation databases
Ensembli | ENST00000256969.7; ENSP00000256969.2; ENSG00000134548.11 |
GeneIDi | 80763 |
KEGGi | hsa:80763 |
MANE-Selecti | ENST00000256969.7; ENSP00000256969.2; NM_030572.4; NP_085049.1 |
UCSCi | uc001rfa.2, human |
Organism-specific databases
CTDi | 80763 |
DisGeNETi | 80763 |
GeneCardsi | SPX |
HGNCi | HGNC:28139, SPX |
HPAi | ENSG00000134548, Tissue enriched (adipose) |
MIMi | 619246, gene |
neXtProti | NX_Q9BT56 |
OpenTargetsi | ENSG00000134548 |
PharmGKBi | PA143485369 |
VEuPathDBi | HostDB:ENSG00000134548 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SAD1, Eukaryota |
GeneTreei | ENSGT00390000012501 |
HOGENOMi | CLU_169090_0_0_1 |
InParanoidi | Q9BT56 |
OMAi | LETRSHN |
OrthoDBi | 1579616at2759 |
PhylomeDBi | Q9BT56 |
TreeFami | TF333402 |
Enzyme and pathway databases
PathwayCommonsi | Q9BT56 |
SignaLinki | Q9BT56 |
Miscellaneous databases
BioGRID-ORCSi | 80763, 13 hits in 1065 CRISPR screens |
GenomeRNAii | 80763 |
Pharosi | Q9BT56, Tbio |
PROi | PR:Q9BT56 |
RNActi | Q9BT56, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134548, Expressed in adipose tissue of abdominal region and 165 other tissues |
ExpressionAtlasi | Q9BT56, baseline and differential |
Genevisiblei | Q9BT56, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028126, Spexin |
PANTHERi | PTHR28590, PTHR28590, 1 hit |
Pfami | View protein in Pfam PF15171, Spexin, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SPXN_HUMAN | |
Accessioni | Q9BT56Primary (citable) accession number: Q9BT56 Secondary accession number(s): B3KND6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2005 |
Last sequence update: | June 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families