Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 148 (17 Jun 2020)
Sequence version 2 (18 May 2010)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

THAP domain-containing protein 7

Gene

THAP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1 – 93THAP-typePROSITE-ProRule annotationAdd BLAST93

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
THAP domain-containing protein 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:THAP7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000184436.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23190 THAP7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609518 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BT49

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000184436

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134964580

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BT49 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
THAP7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452927

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000686481 – 309THAP domain-containing protein 7Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei162PhosphoserineCombined sources1
Modified residuei210PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BT49

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BT49

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BT49

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BT49

PeptideAtlas

More...
PeptideAtlasi
Q9BT49

PRoteomics IDEntifications database

More...
PRIDEi
Q9BT49

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78951

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BT49

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BT49

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184436 Expressed in adenohypophysis and 219 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BT49 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000184436 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HDAC3 and nuclear hormone receptor corepressors.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q9BT49
With#Exp.IntAct
ANKRD28 [O15084]3EBI-741350,EBI-359567
CCNDBP1 [O95273]4EBI-741350,EBI-748961
CDC37 [Q16543]3EBI-741350,EBI-295634
CYSRT1 [A8MQ03]3EBI-741350,EBI-3867333
DESI2 [Q9BSY9]3EBI-741350,EBI-12878374
DVL3 [Q92997]3EBI-741350,EBI-739789
EFEMP2 [O95967]3EBI-741350,EBI-743414
FHL3 [Q13643]3EBI-741350,EBI-741101
FSD2 [A1L4K1]3EBI-741350,EBI-5661036
GABARAPL1 [Q9H0R8]3EBI-741350,EBI-746969
GOLGA2 [Q08379]4EBI-741350,EBI-618309
GOLGA6L9 [A6NEM1]3EBI-741350,EBI-5916454
HOXA1 [P49639]3EBI-741350,EBI-740785
KRT27 [Q7Z3Y8]3EBI-741350,EBI-3044087
KRT31 [Q15323]6EBI-741350,EBI-948001
KRT34 [O76011]3EBI-741350,EBI-1047093
KRT40 [Q6A162]3EBI-741350,EBI-10171697
KRTAP10-8 [P60410]6EBI-741350,EBI-10171774
KRTAP17-1 [Q9BYP8]3EBI-741350,EBI-11988175
LDOC1 [O95751]3EBI-741350,EBI-740738
LNX1 [Q8TBB1]3EBI-741350,EBI-739832
LZTS2 [Q9BRK4]6EBI-741350,EBI-741037
MAGOHB [Q96A72]3EBI-741350,EBI-746778
MCC [P23508]3EBI-741350,EBI-307531
MID2 - isoform 2 [Q9UJV3-2]6EBI-741350,EBI-10172526
MTUS2 [Q5JR59]3EBI-741350,EBI-742948
MTUS2 - isoform 2 [Q5JR59-3]6EBI-741350,EBI-11522433
NOTCH2NLA [Q7Z3S9]4EBI-741350,EBI-945833
NOTCH2NLC [P0DPK4]3EBI-741350,EBI-22310682
PHC2 [Q8IXK0]3EBI-741350,EBI-713786
PHF19 [Q5T6S3]3EBI-741350,EBI-2339674
PICK1 [Q9NRD5]3EBI-741350,EBI-79165
PIN1 [Q13526]5EBI-741350,EBI-714158
PNMA2 [Q9UL42]3EBI-741350,EBI-302355
SET [Q01105]7EBI-741350,EBI-1053182
SET - isoform 2 [Q01105-2]5EBI-741350,EBI-7481343
TFIP11 [Q9UBB9]7EBI-741350,EBI-1105213
itself6EBI-741350,EBI-741350
TLE5 - isoform 2 [Q08117-2]3EBI-741350,EBI-11741437
TPM3 [P06753]3EBI-741350,EBI-355607
TRAF1 [Q13077]6EBI-741350,EBI-359224
TRAF2 [Q12933]13EBI-741350,EBI-355744
TRAF5 [O00463]3EBI-741350,EBI-523498
WDYHV1 [Q96HA8]3EBI-741350,EBI-741158
ZRANB1 [Q9UGI0]3EBI-741350,EBI-527853

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123298, 64 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9BT49

Protein interaction database and analysis system

More...
IntActi
Q9BT49, 66 interactors

Molecular INTeraction database

More...
MINTi
Q9BT49

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000215742

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BT49 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BT49

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi229 – 232HCFC1-binding motif (HBM)By similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi139 – 142Poly-Pro4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 93THAP-typePROSITE-ProRule annotationAdd BLAST93

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVKX Eukaryota
ENOG410YA1P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111394

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_050704_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BT49

KEGG Orthology (KO)

More...
KOi
K23208

Identification of Orthologs from Complete Genome Data

More...
OMAi
MQLSNSM

Database of Orthologous Groups

More...
OrthoDBi
1382095at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BT49

TreeFam database of animal gene trees

More...
TreeFami
TF335838

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.180, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026519 THAP7
IPR006612 THAP_Znf
IPR038441 THAP_Znf_sf

The PANTHER Classification System

More...
PANTHERi
PTHR47502 PTHR47502, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05485 THAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00692 DM3, 1 hit
SM00980 THAP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50950 ZF_THAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9BT49-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRHCSAAGC CTRDTRETRN RGISFHRLPK KDNPRRGLWL ANCQRLDPSG
60 70 80 90 100
QGLWDPASEY IYFCSKHFEE DCFELVGISG YHRLKEGAVP TIFESFSKLR
110 120 130 140 150
RTTKTKGHSY PPGPAEVSRL RRCRKRCSEG RGPTTPFSPP PPADVTCFPV
160 170 180 190 200
EEASAPATLP ASPAGRLEPG LSSPFSDLLG PLGAQADEAG CSAQPSPERQ
210 220 230 240 250
PSPLEPRPVS PSAYMLRLPP PAGAYIQNEH SYQVGSALLW KRRAEAALDA
260 270 280 290 300
LDKAQRQLQA CKRREQRLRL RLTKLQQERA REKRAQADAR QTLKEHVQDF

AMQLSSSMA
Length:309
Mass (Da):34,414
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B58685CA759D424
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060277115A → P3 PublicationsCorresponds to variant dbSNP:rs426938Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR456343 mRNA Translation: CAG30229.1
AK315457 mRNA Translation: BAG37844.1
AC002472 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX02919.1
CH471176 Genomic DNA Translation: EAX02921.1
BC004346 mRNA Translation: AAH04346.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13787.1

NCBI Reference Sequences

More...
RefSeqi
NP_001008695.1, NM_001008695.1
NP_085050.2, NM_030573.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000215742; ENSP00000215742; ENSG00000184436
ENST00000399133; ENSP00000382084; ENSG00000184436

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80764

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80764

UCSC genome browser

More...
UCSCi
uc002ztr.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456343 mRNA Translation: CAG30229.1
AK315457 mRNA Translation: BAG37844.1
AC002472 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX02919.1
CH471176 Genomic DNA Translation: EAX02921.1
BC004346 mRNA Translation: AAH04346.1
CCDSiCCDS13787.1
RefSeqiNP_001008695.1, NM_001008695.1
NP_085050.2, NM_030573.2

3D structure databases

SMRiQ9BT49
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123298, 64 interactors
ELMiQ9BT49
IntActiQ9BT49, 66 interactors
MINTiQ9BT49
STRINGi9606.ENSP00000215742

PTM databases

iPTMnetiQ9BT49
PhosphoSitePlusiQ9BT49

Polymorphism and mutation databases

BioMutaiTHAP7
DMDMi296452927

Proteomic databases

jPOSTiQ9BT49
MassIVEiQ9BT49
MaxQBiQ9BT49
PaxDbiQ9BT49
PeptideAtlasiQ9BT49
PRIDEiQ9BT49
ProteomicsDBi78951

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
314 25 antibodies

The DNASU plasmid repository

More...
DNASUi
80764

Genome annotation databases

EnsembliENST00000215742; ENSP00000215742; ENSG00000184436
ENST00000399133; ENSP00000382084; ENSG00000184436
GeneIDi80764
KEGGihsa:80764
UCSCiuc002ztr.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80764
EuPathDBiHostDB:ENSG00000184436.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
THAP7
HGNCiHGNC:23190 THAP7
HPAiENSG00000184436 Low tissue specificity
MIMi609518 gene
neXtProtiNX_Q9BT49
OpenTargetsiENSG00000184436
PharmGKBiPA134964580

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IVKX Eukaryota
ENOG410YA1P LUCA
GeneTreeiENSGT00730000111394
HOGENOMiCLU_050704_0_0_1
InParanoidiQ9BT49
KOiK23208
OMAiMQLSNSM
OrthoDBi1382095at2759
PhylomeDBiQ9BT49
TreeFamiTF335838

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
80764 36 hits in 809 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
THAP7 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
THAP7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80764
PharosiQ9BT49 Tbio

Protein Ontology

More...
PROi
PR:Q9BT49
RNActiQ9BT49 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184436 Expressed in adenohypophysis and 219 other tissues
GenevisibleiQ9BT49 HS

Family and domain databases

Gene3Di3.30.40.180, 1 hit
InterProiView protein in InterPro
IPR026519 THAP7
IPR006612 THAP_Znf
IPR038441 THAP_Znf_sf
PANTHERiPTHR47502 PTHR47502, 1 hit
PfamiView protein in Pfam
PF05485 THAP, 1 hit
SMARTiView protein in SMART
SM00692 DM3, 1 hit
SM00980 THAP, 1 hit
PROSITEiView protein in PROSITE
PS50950 ZF_THAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHAP7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BT49
Secondary accession number(s): B2RD97, D3DX40
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: May 18, 2010
Last modified: June 17, 2020
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again