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Protein

LIM domain-containing protein 2

Gene

LIMD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as an activator of the protein-kinase ILK, thereby regulating cell motility (PubMed:24590809).1 Publication

Miscellaneous

May play a role in tumor progression via its ability to activate the ILK protein-kinase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40Zinc 1Combined sources1 Publication1
Metal bindingi43Zinc 1Combined sources1 Publication1
Metal bindingi61Zinc 1; via pros nitrogenCombined sources1 Publication1
Metal bindingi64Zinc 1Combined sources1 Publication1
Metal bindingi67Zinc 2Combined sources1 Publication1
Metal bindingi70Zinc 2Combined sources1 Publication1
Metal bindingi88Zinc 2Combined sources1 Publication1
Metal bindingi91Zinc 2; via pros nitrogenCombined sources1 Publication1

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM domain-containing protein 2Curated
Gene namesi
Name:LIMD2Imported
ORF Names:SB143
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000136490.8
HGNCiHGNC:28142 LIMD2
neXtProtiNX_Q9BT23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi80774
OpenTargetsiENSG00000136490
PharmGKBiPA143485528

Polymorphism and mutation databases

BioMutaiLIMD2
DMDMi74752322

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002512071 – 127LIM domain-containing protein 2Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BT23
MaxQBiQ9BT23
PaxDbiQ9BT23
PeptideAtlasiQ9BT23
PRIDEiQ9BT23
ProteomicsDBi78944

PTM databases

iPTMnetiQ9BT23
PhosphoSitePlusiQ9BT23

Expressioni

Inductioni

Over-expressed in breast, bladder, melanoma and thyroid cancer cell lines and tumors (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000136490
CleanExiHS_LIMD2
ExpressionAtlasiQ9BT23 baseline and differential
GenevisibleiQ9BT23 HS

Organism-specific databases

HPAiHPA062867

Interactioni

Subunit structurei

Interacts with ILK (PubMed:24590809).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PSMA6P609003EBI-2805292,EBI-357793

Protein-protein interaction databases

BioGridi123306, 2 interactors
IntActiQ9BT23, 2 interactors

Structurei

Secondary structure

1127
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi41 – 43Combined sources3
Beta strandi45 – 47Combined sources3
Turni49 – 51Combined sources3
Beta strandi52 – 55Combined sources4
Beta strandi58 – 61Combined sources4
Turni62 – 64Combined sources3
Beta strandi68 – 70Combined sources3
Turni75 – 77Combined sources3
Helixi89 – 94Combined sources6

3D structure databases

ProteinModelPortaliQ9BT23
SMRiQ9BT23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 98LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiENOG410ITI3 Eukaryota
ENOG4111S7F LUCA
GeneTreeiENSGT00510000046839
HOGENOMiHOG000111235
HOVERGENiHBG056520
InParanoidiQ9BT23
OMAiQATPSHE
OrthoDBiEOG091G0043
PhylomeDBiQ9BT23

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BT23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQAAGAAQA TPSHDAKGGG SSTVQRSKSF SLRAQVKETC AACQKTVYPM
60 70 80 90 100
ERLVADKLIF HNSCFCCKHC HTKLSLGSYA ALHGEFYCKP HFQQLFKSKG
110 120
NYDEGFGRKQ HKELWAHKEV DPGTKTA
Length:127
Mass (Da):14,070
Last modified:June 1, 2001 - v1
Checksum:iB63174FCF0486956
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6G → E in AAK67634 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092301 mRNA Translation: BAC03855.1
AY037154 mRNA Translation: AAK67634.1
CH471109 Genomic DNA Translation: EAW94291.1
CH471109 Genomic DNA Translation: EAW94292.1
CH471109 Genomic DNA Translation: EAW94294.1
CH471109 Genomic DNA Translation: EAW94295.1
CH471109 Genomic DNA Translation: EAW94296.1
BC004400 mRNA Translation: AAH04400.1
BC051812 mRNA Translation: AAH51812.1
CCDSiCCDS11641.1
RefSeqiNP_085053.1, NM_030576.3
XP_005257760.1, XM_005257703.1
XP_005257762.1, XM_005257705.3
XP_006722187.1, XM_006722124.1
UniGeneiHs.591166

Genome annotation databases

EnsembliENST00000259006; ENSP00000259006; ENSG00000136490
ENST00000578061; ENSP00000464003; ENSG00000136490
ENST00000578402; ENSP00000462707; ENSG00000136490
GeneIDi80774
KEGGihsa:80774
UCSCiuc002jbj.5 human

Similar proteinsi

Entry informationi

Entry nameiLIMD2_HUMAN
AccessioniPrimary (citable) accession number: Q9BT23
Secondary accession number(s): D3DU16, Q96S91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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