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UniProtKB - Q9BSW7 (SYT17_HUMAN)
Protein
Synaptotagmin-17
Gene
SYT17
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in dendrite formation by melanocytes (PubMed:23999003).
1 PublicationGO - Molecular functioni
- calcium-dependent phospholipid binding Source: GO_Central
- calcium ion binding Source: GO_Central
- clathrin binding Source: GO_Central
- phosphatidylserine binding Source: GO_Central
- SNARE binding Source: GO_Central
- syntaxin binding Source: GO_Central
GO - Biological processi
- calcium-ion regulated exocytosis Source: GO_Central
- cell differentiation Source: UniProtKB-KW
- cellular response to calcium ion Source: GO_Central
- positive regulation of dendrite extension Source: UniProtKB
- regulation of calcium ion-dependent exocytosis Source: GO_Central
- regulation of dopamine secretion Source: GO_Central
- vesicle-mediated transport Source: GO_Central
Keywordsi
Biological process | Differentiation |
Enzyme and pathway databases
PathwayCommonsi | Q9BSW7 |
SignaLinki | Q9BSW7 |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptotagmin-17Alternative name(s): Protein B/K Synaptotagmin XVII Short name: SytXVII |
Gene namesi | Name:SYT17 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24119, SYT17 |
neXtProti | NX_Q9BSW7 |
VEuPathDBi | HostDB:ENSG00000103528 |
Subcellular locationi
Other locations
- Membrane By similarity; Peripheral membrane protein By similarity
Golgi apparatus
- trans-Golgi network Source: Ensembl
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- exocytic vesicle Source: GO_Central
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 51760 |
OpenTargetsi | ENSG00000103528 |
PharmGKBi | PA142670841 |
Miscellaneous databases
Pharosi | Q9BSW7, Tbio |
Genetic variation databases
BioMutai | SYT17 |
DMDMi | 74752317 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000311936 | 1 – 474 | Synaptotagmin-17Add BLAST | 474 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 118 | PhosphoserineBy similarity | 1 | |
Modified residuei | 119 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q9BSW7 |
MaxQBi | Q9BSW7 |
PaxDbi | Q9BSW7 |
PeptideAtlasi | Q9BSW7 |
PRIDEi | Q9BSW7 |
ProteomicsDBi | 78932 |
PTM databases
iPTMneti | Q9BSW7 |
PhosphoSitePlusi | Q9BSW7 |
Expressioni
Tissue specificityi
Expressed abundantly in brain (frontal and temporal lobes, hippocampus, hypothalamus, amygdala, substantia nigra, and pituitary), kidney, and prostate. Expressed in fetal brain, kidney and lung (PubMed:16672768). Expressed in melanocytes (PubMed:23999003).2 Publications
Gene expression databases
Bgeei | ENSG00000103528, Expressed in middle temporal gyrus and 215 other tissues |
ExpressionAtlasi | Q9BSW7, baseline and differential |
Genevisiblei | Q9BSW7, HS |
Organism-specific databases
HPAi | ENSG00000103528, Tissue enhanced (brain, parathyroid gland) |
Interactioni
Binary interactionsi
Q9BSW7
GO - Molecular functioni
- clathrin binding Source: GO_Central
- SNARE binding Source: GO_Central
- syntaxin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 119717, 52 interactors |
IntActi | Q9BSW7, 49 interactors |
STRINGi | 9606.ENSP00000347538 |
Miscellaneous databases
RNActi | Q9BSW7, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9BSW7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9BSW7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 184 – 310 | C2 1PROSITE-ProRule annotationAdd BLAST | 127 | |
Domaini | 321 – 455 | C2 2PROSITE-ProRule annotationAdd BLAST | 135 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 60 – 112 | DisorderedSequence analysisAdd BLAST | 53 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 79 – 112 | Polar residuesSequence analysisAdd BLAST | 34 |
Sequence similaritiesi
Belongs to the synaptotagmin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG1028, Eukaryota |
GeneTreei | ENSGT00940000158939 |
InParanoidi | Q9BSW7 |
OMAi | CDGARQD |
OrthoDBi | 925064at2759 |
PhylomeDBi | Q9BSW7 |
TreeFami | TF315600 |
Family and domain databases
Gene3Di | 2.60.40.150, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR001565, Synaptotagmin IPR014705, SYT17 |
PANTHERi | PTHR10024:SF348, PTHR10024:SF348, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 2 hits |
PRINTSi | PR00399, SYNAPTOTAGMN |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
SUPFAMi | SSF49562, SSF49562, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q9BSW7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAYIQLEPLN EGFLSRISGL LLCRWTCRHC CQKCYESSCC QSSEDEVEIL
60 70 80 90 100
GPFPAQTPPW LMASRSSDKD GDSVHTASEV PLTPRTNSPD GRRSSSDTSK
110 120 130 140 150
STYSLTRRIS SLESRRPSSP LIDIKPIEFG VLSAKKEPIQ PSVLRRTYNP
160 170 180 190 200
DDYFRKFEPH LYSLDSNSDD VDSLTDEEIL SKYQLGMLHF STQYDLLHNH
210 220 230 240 250
LTVRVIEARD LPPPISHDGS RQDMAHSNPY VKICLLPDQK NSKQTGVKRK
260 270 280 290 300
TQKPVFEERY TFEIPFLEAQ RRTLLLTVVD FDKFSRHCVI GKVSVPLCEV
310 320 330 340 350
DLVKGGHWWK ALIPSSQNEV ELGELLLSLN YLPSAGRLNV DVIRAKQLLQ
360 370 380 390 400
TDVSQGSDPF VKIQLVHGLK LVKTKKTSFL RGTIDPFYNE SFSFKVPQEE
410 420 430 440 450
LENASLVFTV FGHNMKSSND FIGRIVIGQY SSGPSETNHW RRMLNTHRTA
460 470
VEQWHSLRSR AECDRVSPAS LEVT
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BN78 | H3BN78_HUMAN | Synaptotagmin XVII | SYT17 | 470 | Annotation score: | ||
H3BRH9 | H3BRH9_HUMAN | Synaptotagmin XVII | SYT17 hCG_38025 | 413 | Annotation score: | ||
H3BQZ6 | H3BQZ6_HUMAN | Synaptotagmin XVII | SYT17 | 392 | Annotation score: | ||
H3BSX1 | H3BSX1_HUMAN | Synaptotagmin XVII | SYT17 | 168 | Annotation score: | ||
H3BMD4 | H3BMD4_HUMAN | Synaptotagmin-17 | SYT17 | 93 | Annotation score: | ||
H3BSP0 | H3BSP0_HUMAN | Synaptotagmin-17 | SYT17 | 79 | Annotation score: | ||
H3BSU5 | H3BSU5_HUMAN | Synaptotagmin-17 | SYT17 | 142 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 66 | S → G in AAF37825 (PubMed:16672768).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF220560 mRNA Translation: AAF37825.1 CH471186 Genomic DNA Translation: EAW50274.1 BC004518 mRNA Translation: AAH04518.1 AC003003 Genomic DNA Translation: AAC05436.1 |
CCDSi | CCDS10575.1 |
RefSeqi | NP_057608.2, NM_016524.3 |
Genome annotation databases
Ensembli | ENST00000355377; ENSP00000347538; ENSG00000103528 |
GeneIDi | 51760 |
KEGGi | hsa:51760 |
MANE-Selecti | ENST00000355377.7; ENSP00000347538.2; NM_016524.4; NP_057608.2 |
UCSCi | uc002dfw.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF220560 mRNA Translation: AAF37825.1 CH471186 Genomic DNA Translation: EAW50274.1 BC004518 mRNA Translation: AAH04518.1 AC003003 Genomic DNA Translation: AAC05436.1 |
CCDSi | CCDS10575.1 |
RefSeqi | NP_057608.2, NM_016524.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2ENP | NMR | - | A | 181-315 | [»] | |
SMRi | Q9BSW7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119717, 52 interactors |
IntActi | Q9BSW7, 49 interactors |
STRINGi | 9606.ENSP00000347538 |
PTM databases
iPTMneti | Q9BSW7 |
PhosphoSitePlusi | Q9BSW7 |
Genetic variation databases
BioMutai | SYT17 |
DMDMi | 74752317 |
Proteomic databases
MassIVEi | Q9BSW7 |
MaxQBi | Q9BSW7 |
PaxDbi | Q9BSW7 |
PeptideAtlasi | Q9BSW7 |
PRIDEi | Q9BSW7 |
ProteomicsDBi | 78932 |
Protocols and materials databases
Antibodypediai | 25349, 147 antibodies from 22 providers |
DNASUi | 51760 |
Genome annotation databases
Ensembli | ENST00000355377; ENSP00000347538; ENSG00000103528 |
GeneIDi | 51760 |
KEGGi | hsa:51760 |
MANE-Selecti | ENST00000355377.7; ENSP00000347538.2; NM_016524.4; NP_057608.2 |
UCSCi | uc002dfw.4, human |
Organism-specific databases
CTDi | 51760 |
DisGeNETi | 51760 |
GeneCardsi | SYT17 |
HGNCi | HGNC:24119, SYT17 |
HPAi | ENSG00000103528, Tissue enhanced (brain, parathyroid gland) |
neXtProti | NX_Q9BSW7 |
OpenTargetsi | ENSG00000103528 |
PharmGKBi | PA142670841 |
VEuPathDBi | HostDB:ENSG00000103528 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1028, Eukaryota |
GeneTreei | ENSGT00940000158939 |
InParanoidi | Q9BSW7 |
OMAi | CDGARQD |
OrthoDBi | 925064at2759 |
PhylomeDBi | Q9BSW7 |
TreeFami | TF315600 |
Enzyme and pathway databases
PathwayCommonsi | Q9BSW7 |
SignaLinki | Q9BSW7 |
Miscellaneous databases
BioGRID-ORCSi | 51760, 6 hits in 1039 CRISPR screens |
ChiTaRSi | SYT17, human |
EvolutionaryTracei | Q9BSW7 |
GenomeRNAii | 51760 |
Pharosi | Q9BSW7, Tbio |
PROi | PR:Q9BSW7 |
RNActi | Q9BSW7, protein |
Gene expression databases
Bgeei | ENSG00000103528, Expressed in middle temporal gyrus and 215 other tissues |
ExpressionAtlasi | Q9BSW7, baseline and differential |
Genevisiblei | Q9BSW7, HS |
Family and domain databases
Gene3Di | 2.60.40.150, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR001565, Synaptotagmin IPR014705, SYT17 |
PANTHERi | PTHR10024:SF348, PTHR10024:SF348, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 2 hits |
PRINTSi | PR00399, SYNAPTOTAGMN |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
SUPFAMi | SSF49562, SSF49562, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | SYT17_HUMAN | |
Accessioni | Q9BSW7Primary (citable) accession number: Q9BSW7 Secondary accession number(s): O43330, Q9NZ18 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 4, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families