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UniProtKB - Q9BSW7 (SYT17_HUMAN)

Entry version 151 (07 Oct 2020)
Sequence version 1 (01 Jun 2001)
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Protein

Synaptotagmin-17

Gene

SYT17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in dendrite formation by melanocytes (PubMed:23999003).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BSW7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptotagmin-17
Alternative name(s):
Protein B/K
Synaptotagmin XVII
Short name:
SytXVII
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYT17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000103528.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:24119, SYT17

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BSW7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		51760

Open Targets

More...OpenTargetsi		ENSG00000103528

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142670841

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BSW7, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SYT17

Domain mapping of disease mutations (DMDM)

More...DMDMi		74752317

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003119361 – 474Synaptotagmin-17Add BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei118PhosphoserineBy similarity1
Modified residuei119PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BSW7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BSW7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BSW7

PeptideAtlas

More...PeptideAtlasi		Q9BSW7

PRoteomics IDEntifications database

More...PRIDEi		Q9BSW7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78932

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BSW7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BSW7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed abundantly in brain (frontal and temporal lobes, hippocampus, hypothalamus, amygdala, substantia nigra, and pituitary), kidney, and prostate. Expressed in fetal brain, kidney and lung (PubMed:16672768). Expressed in melanocytes (PubMed:23999003).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000103528, Expressed in middle temporal gyrus and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BSW7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BSW7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000103528, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q9BSW7
With#Exp.IntAct
AK8 [Q96MA6]3EBI-745392,EBI-8466265
BLZF1 [Q9H2G9]3EBI-745392,EBI-2548012
CBY2 - isoform 2 [Q8NA61-2]3EBI-745392,EBI-11524851
CCDC102B [Q68D86]3EBI-745392,EBI-10171570
CCNB1IP1 [Q9NPC3]3EBI-745392,EBI-745269
CEP63 [Q96MT8]3EBI-745392,EBI-741977
CEP70 [Q8NHQ1]3EBI-745392,EBI-739624
CHMP4A [Q9BY43]6EBI-745392,EBI-747981
CHMP4A - isoform 2 [Q9BY43-2]3EBI-745392,EBI-12178895
COG6 [Q9Y2V7]3EBI-745392,EBI-3866319
DEPDC5 - isoform 2 [O75140-2]3EBI-745392,EBI-12366971
EXOC8 [Q8IYI6]3EBI-745392,EBI-742102
FAM9B [Q8IZU0]4EBI-745392,EBI-10175124
FLJ13057 [Q53SE7]3EBI-745392,EBI-10172181
FRMD6 - isoform 2 [Q96NE9-2]3EBI-745392,EBI-13213391
GOLGA2 [Q08379]3EBI-745392,EBI-618309
GOLGA6A [Q9NYA3]5EBI-745392,EBI-11163335
HIP1 [O00291]3EBI-745392,EBI-473886
HOOK2 - isoform 2 [Q96ED9-2]3EBI-745392,EBI-10961706
IKZF1 [Q13422]3EBI-745392,EBI-745305
LSM7 [Q9UK45]3EBI-745392,EBI-348372
LZTS1 [Q9Y250]3EBI-745392,EBI-1216080
LZTS2 [Q9BRK4]3EBI-745392,EBI-741037
MAD1L1 [Q9Y6D9]3EBI-745392,EBI-742610
MAJIN - isoform 1 [Q3KP22-3]3EBI-745392,EBI-18015780
MCC [P23508]3EBI-745392,EBI-307531
MEOX1 [P50221]3EBI-745392,EBI-2864512
MEOX2 [P50222]3EBI-745392,EBI-748397
MEOX2 [Q6FHY5]3EBI-745392,EBI-16439278
MID2 - isoform 2 [Q9UJV3-2]10EBI-745392,EBI-10172526
NIF3L1 [Q9GZT8]3EBI-745392,EBI-740897
PFDN5 [Q99471]3EBI-745392,EBI-357275
PIBF1 [Q4G0R1]3EBI-745392,EBI-14066006
PICK1 [Q9NRD5]3EBI-745392,EBI-79165
POF1B - isoform 1 [Q8WVV4-1]3EBI-745392,EBI-11986735
RUNDC3A [Q59EK9]3EBI-745392,EBI-747225
SDCBP2 [Q9H190]3EBI-745392,EBI-742426
SNRNP35 - isoform 2 [Q16560-2]3EBI-745392,EBI-12938570
SSX2IP [Q9Y2D8]3EBI-745392,EBI-2212028
TRAF2 [Q12933]6EBI-745392,EBI-355744
TRIM27 [P14373]3EBI-745392,EBI-719493
TSNAX [Q99598]3EBI-745392,EBI-742638
VPS9D1 [Q9Y2B5]3EBI-745392,EBI-9031083
ZNF438 [Q7Z4V0]3EBI-745392,EBI-11962468
ZNF597 [Q96LX8]3EBI-745392,EBI-9091553
ZRANB1 [Q9UGI0]3EBI-745392,EBI-527853

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119717, 52 interactors

Protein interaction database and analysis system

More...IntActi		Q9BSW7, 50 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000347538

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BSW7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1474
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BSW7

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9BSW7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini184 – 310C2 1PROSITE-ProRule annotationAdd BLAST127
Domaini321 – 455C2 2PROSITE-ProRule annotationAdd BLAST135

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi23 – 40Cys-richAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1028, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158939

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BSW7

KEGG Orthology (KO)

More...KOi		K19915

Identification of Orthologs from Complete Genome Data

More...OMAi		LIPSSQX

Database of Orthologous Groups

More...OrthoDBi		925064at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BSW7

TreeFam database of animal gene trees

More...TreeFami		TF315600

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR001565, Synaptotagmin

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00399, SYNAPTOTAGMN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00239, C2, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q9BSW7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYIQLEPLN EGFLSRISGL LLCRWTCRHC CQKCYESSCC QSSEDEVEIL 
        60         70         80         90        100
GPFPAQTPPW LMASRSSDKD GDSVHTASEV PLTPRTNSPD GRRSSSDTSK 
       110        120        130        140        150
STYSLTRRIS SLESRRPSSP LIDIKPIEFG VLSAKKEPIQ PSVLRRTYNP 
       160        170        180        190        200
DDYFRKFEPH LYSLDSNSDD VDSLTDEEIL SKYQLGMLHF STQYDLLHNH 
       210        220        230        240        250
LTVRVIEARD LPPPISHDGS RQDMAHSNPY VKICLLPDQK NSKQTGVKRK 
       260        270        280        290        300
TQKPVFEERY TFEIPFLEAQ RRTLLLTVVD FDKFSRHCVI GKVSVPLCEV 
       310        320        330        340        350
DLVKGGHWWK ALIPSSQNEV ELGELLLSLN YLPSAGRLNV DVIRAKQLLQ 
       360        370        380        390        400
TDVSQGSDPF VKIQLVHGLK LVKTKKTSFL RGTIDPFYNE SFSFKVPQEE 
       410        420        430        440        450
LENASLVFTV FGHNMKSSND FIGRIVIGQY SSGPSETNHW RRMLNTHRTA 
       460        470 
VEQWHSLRSR AECDRVSPAS LEVT
Length:474
Mass (Da):53,849
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF5D2E86665BCEC8C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BN78H3BN78_HUMAN
Synaptotagmin-17
SYT17
470Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRH9H3BRH9_HUMAN
Synaptotagmin XVII, isoform CRA_a
SYT17 hCG_38025
413Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQZ6H3BQZ6_HUMAN
Synaptotagmin-17
SYT17
392Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMD4H3BMD4_HUMAN
Synaptotagmin-17
SYT17
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSP0H3BSP0_HUMAN
Synaptotagmin-17
SYT17
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSX1H3BSX1_HUMAN
Synaptotagmin-17
SYT17
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSU5H3BSU5_HUMAN
Synaptotagmin-17
SYT17
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti66S → G in AAF37825 (PubMed:16672768).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF220560 mRNA Translation: AAF37825.1
CH471186 Genomic DNA Translation: EAW50274.1
BC004518 mRNA Translation: AAH04518.1
AC003003 Genomic DNA Translation: AAC05436.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10575.1

NCBI Reference Sequences

More...RefSeqi		NP_057608.2, NM_016524.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000355377; ENSP00000347538; ENSG00000103528

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51760

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51760

UCSC genome browser

More...UCSCi		uc002dfw.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220560 mRNA Translation: AAF37825.1
CH471186 Genomic DNA Translation: EAW50274.1
BC004518 mRNA Translation: AAH04518.1
AC003003 Genomic DNA Translation: AAC05436.1
CCDSiCCDS10575.1
RefSeqiNP_057608.2, NM_016524.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ENPNMR-A181-315[»]
SMRiQ9BSW7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119717, 52 interactors
IntActiQ9BSW7, 50 interactors
STRINGi9606.ENSP00000347538

PTM databases

iPTMnetiQ9BSW7
PhosphoSitePlusiQ9BSW7

Polymorphism and mutation databases

BioMutaiSYT17
DMDMi74752317

Proteomic databases

MassIVEiQ9BSW7
MaxQBiQ9BSW7
PaxDbiQ9BSW7
PeptideAtlasiQ9BSW7
PRIDEiQ9BSW7
ProteomicsDBi78932

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25349, 136 antibodies

Genome annotation databases

EnsembliENST00000355377; ENSP00000347538; ENSG00000103528
GeneIDi51760
KEGGihsa:51760
UCSCiuc002dfw.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51760
DisGeNETi51760
EuPathDBiHostDB:ENSG00000103528.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		SYT17
HGNCiHGNC:24119, SYT17
HPAiENSG00000103528, Tissue enhanced (brain)
neXtProtiNX_Q9BSW7
OpenTargetsiENSG00000103528
PharmGKBiPA142670841

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1028, Eukaryota
GeneTreeiENSGT00940000158939
InParanoidiQ9BSW7
KOiK19915
OMAiLIPSSQX
OrthoDBi925064at2759
PhylomeDBiQ9BSW7
TreeFamiTF315600

Enzyme and pathway databases

PathwayCommonsiQ9BSW7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51760, 5 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SYT17, human
EvolutionaryTraceiQ9BSW7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51760
PharosiQ9BSW7, Tbio

Protein Ontology

More...PROi		PR:Q9BSW7
RNActiQ9BSW7, protein

Gene expression databases

BgeeiENSG00000103528, Expressed in middle temporal gyrus and 214 other tissues
ExpressionAtlasiQ9BSW7, baseline and differential
GenevisibleiQ9BSW7, HS

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR001565, Synaptotagmin
PfamiView protein in Pfam
PF00168, C2, 2 hits
PRINTSiPR00399, SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239, C2, 2 hits
PROSITEiView protein in PROSITE
PS50004, C2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYT17_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BSW7
Secondary accession number(s): O43330, Q9NZ18
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: June 1, 2001
Last modified: October 7, 2020
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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